Details of Drug

Drug General Information (ID: D0643)
Drug Name	Fenofibric acid
Drug Type	Small molecule
Drug Synonymous	Fenofibric acid; 42017-89-0; Procetofenic acid; 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid; alpha 1081; NSC 281318; LF 178 acid; UNII-BGF9MN2HU1; 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid; LF 153; FNF Acid; C17H15ClO4; Trilipix; CCRIS 7302; EINECS 255-626-9; BGF9MN2HU1; CHEMBL981; BRN 2058973; CHEBI:83469; 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic Acid; Propanoic acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-; AK117112; 2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoic acid; W-106287 Click to Show/Hide
Disease Class	BA00-BE2Z: Cardiovascular disease
Therapeutic Class	Antihyperammonia Agents
Structure
Structure	3D Structure		2D Structure
Formula	C17H15ClO4
InChI	1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21)
InChIKey	MQOBSOSZFYZQOK-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C(=O)O)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
External Link
	Pubchem ID	64929
	CAS Number	42017-89-0
	CHEBI ID	83469
	TTD ID	D0NF1U
	INTEDE ID	DR2500
	VARIDT ID	DR00651

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM006 Pharmacodynamic additive effects BM003 Complex formation BM013 Competitive binding of plasma proteins BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM072 Increased risk of nephrotoxicity BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Fenofibric acid
Affected gastrointestinal absorption
	Complex formation					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[3], [8], [9]
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[3], [8], [9]
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[3], [8], [9]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[3], [4], [7]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[3], [11], [12]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[13]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[14]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[15]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[3], [11], [12]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[117], [118], [119], [120], [4], [121], [122], [123], [124], [125], [126], [127], [128]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[117], [118], [119], [120], [4], [121], [122], [123], [124], [125], [126], [127], [128]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[129]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[130]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[4], [131]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[132]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[134], [135]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[117], [118], [119], [120], [4], [121], [122], [123], [124], [125], [126], [127], [128]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[120], [4], [136], [137], [138]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[139]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[147], [148], [149], [150]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[4], [151]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[152]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[117], [118], [119], [120], [4], [121], [122], [123], [124], [125], [126], [127], [128]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[147], [148], [149], [150]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[155], [156]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[4], [157]
	Increased risk of hypoglycemia					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[23], [80], [97]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [140], [27], [28], [29], [30], [31], [32], [33], [34], [36], [37], [38], [40], [41], [42], [43], [45], [46], [47], [49], [51], [52], [53], [54], [55], [56], [57], [58], [59], [61], [64], [66], [67], [68], [71], [72], [74], [75], [76], [78], [141], [80], [142], [143], [85], [144], [145], [91], [93], [94], [95], [97], [99], [101], [103], [104], [108], [109], [110], [111], [146], [112], [113], [115], [116]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [140], [27], [28], [29], [30], [31], [32], [33], [34], [36], [37], [38], [40], [41], [42], [43], [45], [46], [47], [49], [51], [52], [53], [54], [55], [56], [57], [58], [59], [61], [64], [66], [67], [68], [71], [72], [74], [75], [76], [78], [141], [80], [142], [143], [85], [144], [145], [91], [93], [94], [95], [97], [99], [101], [103], [104], [108], [109], [110], [111], [146], [112], [113], [115], [116]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [140], [27], [28], [29], [30], [31], [32], [33], [34], [36], [37], [38], [40], [41], [42], [43], [45], [46], [47], [49], [51], [52], [53], [54], [55], [56], [57], [58], [59], [61], [64], [66], [67], [68], [71], [72], [74], [75], [76], [78], [141], [80], [142], [143], [85], [144], [145], [91], [93], [94], [95], [97], [99], [101], [103], [104], [108], [109], [110], [111], [146], [112], [113], [115], [116]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [140], [27], [28], [29], [30], [31], [32], [33], [34], [36], [37], [38], [40], [41], [42], [43], [45], [46], [47], [49], [51], [52], [53], [54], [55], [56], [57], [58], [59], [61], [64], [66], [67], [68], [71], [72], [74], [75], [76], [78], [141], [80], [142], [143], [85], [144], [145], [91], [93], [94], [95], [97], [99], [101], [103], [104], [108], [109], [110], [111], [146], [112], [113], [115], [116]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[23], [80], [97]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [140], [27], [28], [29], [30], [31], [32], [33], [34], [36], [37], [38], [40], [41], [42], [43], [45], [46], [47], [49], [51], [52], [53], [54], [55], [56], [57], [58], [59], [61], [64], [66], [67], [68], [71], [72], [74], [75], [76], [78], [141], [80], [142], [143], [85], [144], [145], [91], [93], [94], [95], [97], [99], [101], [103], [104], [108], [109], [110], [111], [146], [112], [113], [115], [116]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[23], [80], [97]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116]
	Increased risk of nephrotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1], [3], [4], [133], [6], [8], [9]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[9], [10]
D0303		Cerivastatin	C26H34FNO5	446156	Major		Inter Info	[9], [10]
D0686		Fluvastatin	C24H26FNO4	446155	Major		Inter Info	[9], [10]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[9], [10]
D1301		Pitavastatin	C25H24FNO4	5282452	Major		Inter Info	[9], [10]
D1329		Pravastatin	C23H36O7	54687	Major		Inter Info	[9], [10]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Major		Inter Info	[9], [10]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[9], [10]
D0421		Daptomycin	C72H101N17O26	16134395	Moderate		Inter Info	[4]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[153], [154]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[153], [154]

References
1	Adkins JC, Faulds D "Micronised fenofibrate: a review of its pharmacodynamic properties and clinical efficacy in the management of dyslipidaemia." Drugs 54 (1997): 615-33. [PMID: 9339964]
2	Ascah KJ, Rock GA, Wells PS "Interaction between fenofibrate and warfarin." Ann Pharmacother 32 (1998): 765-8. [PMID: 9681093]
3	Canadian Pharmacists Association.
4	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5	Harvengt C, Heller F, Desager JP "Hypolipidemic and hypouricemic action of fenofibrate in various types of hyperlipoproteinemias." Artery 7 (1980): 73-82. [PMID: 7247733]
6	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online.".
7	Product Information. Lopid (gemfibrozil). Parke-Davis, Morris Plains, NJ.
8	Product Information. Tricor (fenofibrate). Abbott Pharmaceutical, Abbott Park, IL.
9	Product Information. Trilipix (fenofibric acid). Abbott Pharmaceutical, Abbott Park, IL.
10	Unal A, Torun E, Sipahioglu MH, et al. "Fenofibrate-induced acute renal failure due to massive rhabdomyolysis after coadministration of statin in two patients." Intern Med 47 (2008): 1017-9.[PMID: 18520113]
11	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
12	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
13	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
14	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
15	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
16	Abad S, Moachon L, Blanche P, Bavoux F, Sicard D, Salmon-Ceron D "Possible interaction between glicazide, fluconazole and sulfamethoxazole resulting in severe hypoglycaemia." Br J Clin Pharmacol 52 (2001): 456-7. [PMID: 11678792]
17	Ahmad S "Drug interaction induces hypoglycemia." J Fam Pract 40 (1995): 540-1. [PMID: 7775905]
18	Ahmad S "Gemfibrozil: interaction with glyburide." South Med J 84 (1991): 102. [PMID: 1898783]
19	Aleyassine H, Gardiner RJ "Dual action of antidepressant drugs (MAO inhibitors) on insulin release." Endocrinology 96 (1975): 702-10. [PMID: 1090438]
20	Aleyassine H, Lee SH "Inhibition of insulin release by substrates and inhibitors of monoamine oxidase." Am J Physiol 222 (1972): 565-9. [PMID: 5022664]
21	Almirall J, Montoliu J, Torras A, Revert L "Propoxyphene-induced hypoglycemia in a patient with chronic renal failure." Nephron 53 (1989): 273-5. [PMID: 2797348]
22	Arauz-Pacheco C, Ramirez LC, Rios JM, Raskin P "Hypoglycemia induced by angiotensin-converting enzyme inhibitors in patients with non-insulin-dependent diabetes receiving sulfonylurea therapy." Am J Med 89 (1990): 811-3. [PMID: 2123605]
23	Asplund K, Wiholm BE, Lithner F "Glibenclamide-associated hypoglycaemia: a report on 57 cases." Diabetologia 24 (1983): 412-7. [PMID: 6411511]
24	Baciewicz AM, Swafford WB Jr "Hypoglycemia induced by the interaction of chlorpropamide and co-trimoxazole." Drug Intell Clin Pharm 18 (1984): 309-10. [PMID: 6609055]
25	Barbato M "Another problem with Kinidin." Med J Aust 141 (1984): 685. [PMID: 6436654]
26	Baron SH "Salicylates as hypoglycemic agents." Diabetes Care 5 (1982): 64-71. [PMID: 6754304]
27	Cacoub P, Deray G, Baumelou A, Grimaldi A, Soubrie C, Jacobs C "Disopyramide-induced hypoglycemia: case report and review of the literature." Fundam Clin Pharmacol 3 (1989): 527-35. [PMID: 2691378]
28	Cattaneo AG, Caviezel F, Pozza G "Pharmacological interaction between tolbutamide and acetylsalicylic acid: study on insulin secretion in man." Int J Clin Pharmacol Ther Toxicol 28 (1990): 229-34. [PMID: 2198232]
29	Christensen LK, Hansen JM, Kristensen M "Sulphaphenazole-induced hypoglycemic attacks in tolbutamide-treated diabetics." Lancet 2 (1963): 1298-301. [PMID: 14071924]
30	Cooper AJ, Ashcroft G "Potentiation of insulin hypoglycaemia by M.A.O.I. antidepressant drugs." Lancet 1 (1966): 407-9. [PMID: 4159787]
31	Croxson MS, Shaw DW, Henley PG, Gabriel HDLL "Disopyramide-induced hypoglycaemia and increased serum insulin." N Z Med J July (1987): 407-8. [PMID: 3330586]
32	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
33	Daubresse JC, Daigneux D, Bruwier M, Luyckx A, Lefebvre PJ "Clofibrate and diabetes control in patients treated with oral hypoglycaemic agents." Br J Clin Pharmacol 7 (1979): 599-603. [PMID: 380614]
34	Daubresse JC, Luyckx AS, Lefebvre PJ "Potentiation of hypoglycemic effect of sulfonylureas by clofibrate." N Engl J Med 294 (1976): 613. [PMID: 1246250]
35	David DS, Steere AC Jr, Pi-Sunyer XF, Sakai S, Clark SB "Aspirin-induced hypoglycaemia in a patient on haemodialysis." Lancet 2 (1971): 1092-3. [PMID: 4106934]
36	Davis TM, Karbwang J, Looareesuwan S, et al "Comparative effects of quinine and quinidine on glucose metabolism in healthy volunteers." Br J Clin Pharmacol 30 (1990): 397-403. [PMID: 2223418]
37	de Salcedo I, Gorringe AL, Silva JL, Santos JA "Gemfibrozil in a group of diabetics." Proc R Soc Med 69 (1976): 64-70. [PMID: 1019155]
38	Deeg MA, Lipkin EW "Hypoglycemia associated with the use of fluoxetine." West J Med 164 (1996): 262-3. [PMID: 8775944]
39	Diwan PV, Sastry MS, Satyanarayana NV "Potentiation of hypoglycemic response of glibenclamide by piroxicam in rats and humans." Indian J Exp Biol 30 (1992): 317-9. [PMID: 1459600]
40	Feher MD, Amiel S "ACE inhibitors and hypoglycaemia." Lancet 346 (1995): 125-6. [PMID: 7603199]
41	Feldman JM, Chapman B "Monoamine oxidase inhibitors: nature of their interaction with rabbit pancreatic islets to alter insulin secretion." Diabetologia 11 (1975): 487-94. [PMID: 1107123]
42	Ferrari C, Fressati S, Romussi M, et al. "Effects of short-term clofibrate administration on glucose tolerance and insulin secretion in patients with chemical diabetes or hypertriglyceridemia." Metabolism 26 (1977): 129-39. [PMID: 834147]
43	Ferriere M, Lachkar H, Richard JL, Bringer J, Orsetti A, Mirouze J "Captopril and insulin sensitivity." Ann Intern Med 102 (1985): 134-5. [PMID: 3881067]
44	Field JB, Ohta M, Boyle C, Remer A "Potentiation of acetohexamide hypoglycemia by phenylbutazone." N Engl J Med 277 (1967): 889-94. [PMID: 6061822]
45	Fogari R, Zoppi A, Corradi L, Pierangelo L, Mugellini A, Lusardi P "Comparative effects of lisinopril and losartan on insulin sensitivity in the treatment of non diabetic hypertension." Br J Clin Pharmacol 46 (1998): 467-71. [PMID: 9833600]
46	Giugliano D, Ceriello A, Saccomanno F, et al "Effects of salicylate, tolbutamide, and prostaglandin E2 on insulin responses to glucose in noninsulin-dependent diabetes mellitus." J Clin Endocrinol Metab 61 (1985): 160-6. [PMID: 3923028]
47	Goldberg IJ, Brown LK, Rayfield EJ "Disopyramide (norpace)-induced hypoglycemia." Am J Med 69 (1980): 463-6. [PMID: 6998294]
48	Harris EL "Adverse reactions to oral antidiabetic agents." Br Med J 3 (1971): 29-30. [PMID: 5091891]
49	Harrison LC, King-Roach A, Martin FI, Melick RA "The effect of fenfluramine on insulin binding and on basal and insulin-stimulated oxidation of 1-C-glucose by human adipose tissue." Postgrad Med J 51 Suppl 1 (1975): 110-4. [PMID: 1219664]
50	Hartmann D, Korn A, Komjati M, Heinz G, Haefelfinger P, Defoin R, Waldhausl WK "Lack of effect of tenoxicam on dynamic responses to concurrent oral doses of glucose and glibenclamide." Br J Clin Pharmacol 30 (1990): 245-52. [PMID: 2119677]
51	Hayashi S, Horie M, Tsuura Y, Ishida H, Okada Y, Seino Y, Sasayama S "Disopyramide blocks pancreatic ATP-sensitive K+ channels and enhances insulin release." Am J Physiol 265 (1993): c337-42. [PMID: 8368263]
52	Hekimsoy Z, Biberoglu S, Comlekci A, Tarhan O, Mermut C, Biberoglu K "Trimethoprim/sulfamethoxazole-induced hypoglycemia in a malnourished patient with severe infection." Eur J Endocrinol 136 (1997): 3046. [PMID: 9100556]
53	Hellman B "Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells." Metabolism 23 (1974): 839-46. [PMID: 4212254]
54	Herings RMC, Deboer A, Stricker BHC, Leufkens HGM, Porsius A "Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme." Lancet 345 (1995): 1195-8. [PMID: 7739305]
55	Hundal RS, Petersen KF, Mayerson AB, et al "Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes." J Clin Invest 109 (2002): 1321-6. [PMID: 12021247]
56	Iida H, Morita T, Suzuki E, Iwasawa K, Toyooka T, Nakajima T "Hypoglycemia induced by interaction between clarithromycin and disopyramide." Jpn Heart J 40 (1999): 91-6. [PMID: 10370402]
57	Johnson J, Dobmeier M "Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction." DICP 24 (1990): 250-1. [PMID: 2316232]
58	Johnson JA, Kappel JE, Sharif MN "Hypoglycemia secondary to trimethoprim/sulfamethoxazole administration in a renal transplant patient." Ann Pharmacother 27 (1993): 304-6. [PMID: 8453166]
59	Konttinen A, Kuisma I, Ralli R, Pohjola S, Ojala K "The effect of gemfibrozil on serum lipids in diabetic patients." Ann Clin Res 11 (1979): 240-5. [PMID: 398183]
60	Kradjan WA, Witt DM, Opheim KE, Wood FC "Lack of interaction between glipizide and co-trimoxazole." J Clin Pharmacol 34 (1994): 997-1002. [PMID: 7836551]
61	Kubacka RT, Antla EJ, Juhl RP, Welshman IR "Effects of aspirin and ibuprofen on the pharmacokinetics and pharmacodynamics of glyburide in healthy subjects." Ann Pharmacother 30 (1996): 20-6. [PMID: 8773160]
62	Lozada A, Dujovne CA "Drug interactions with fibric acids." Pharmacol Ther 63 (1994): 163-76. [PMID: 7809177]
63	Lumholtz B, Siersbaek-Nielsen K, Skovsted L, Kampmann J, Hansen JM "Sulfamethizole-induced inhibition of diphenylhydantoin, tolbutamide, and warfarin metabolism." Clin Pharmacol Ther 17 (1975): 731-4. [PMID: 1139863]
64	Morris AD, Newton RW, Boyle DI, et al. "ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes." Diabetes Care 20 (1997): 1363-7. [PMID: 9283780]
65	Morrison PJ, Rogers HJ, Spector RG, Bradbrook ID, John VA "Effect of pirprofen on glibenclamide kinetics and response." Br J Clin Pharmacol 14 (1982): 123-6. [PMID: 6809024]
66	Murakami K, Nambu S, Koh H, Kobayashi M, Shigeta Y "Clofibrate enhances the affinity of insulin receptors in non-insulin dependent diabetes mellitus." Br J Clin Pharmacol 17 (1984): 89-91. [PMID: 6362704]
67	Nakabayashi H, Ito T, Igawa T, Hiraiwa Y, Imamura T, Seta T, Kawato M, Usukura N, Takeda R "Disopyramide induces insulin secretion and plasma glucose diminution: studies using the in situ canine pancreas." Metabolism 38 (1989): 179-83. [PMID: 2643753]
68	Nappi JM, Dhanani S, Lovejoy JR, VanderArk C "Severe hypoglycemia associated with disopyramide." West J Med 138 (1983): 95-7. [PMID: 6404062]
69	Niemi M, Backman JT, Neuvonen M, Laitila J, Neuvonen PJ, Kivisto KT "Effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride." Clin Pharmacol Ther 69 (2001): 194-200. [PMID: 11309547]
70	Nikkila EA, Ylikahri R, Huttunen JK "Gemfibrozil: effect on serum lipids, lipoproteins, postheparin plasma lipase activities and glucose tolerance in primary hypertriglyceridaemia." Proc R Soc Med 69 (1976): 58-63. [PMID: 190608]
71	Paolisso G, Balbi V, Gambardella A, Varricchio G, Tortoriello R, Saccomanno F, Amato L, Varricchio M "Lisinopril administration improves insulin action in aged patients with hypertension." J Hum Hypertens 9 (1995): 541-6. [PMID: 7562882]
72	Pestell RG, Crock PA, Ward GM, Alford FP, Best JD "Fenfluramine increases insulin action in patients with NIDDM." Diabetes Care 12 (1989): 252-8. [PMID: 2495916]
73	Petitpierre B, Perrin L, Rudhardt M, et al "Behaviour of chlorpropamide in renal insufficiency and under the effect of associated drug therapy." Int J Clin Pharmacol 6 (1972): 120-4. [PMID: 4638970]
74	Phillips AF, Matty PJ, Porte PJ, Raye JR "Inhibition of glucose-induced insulin secretion by indomethacin and sodium salicylate in the fetal lamb." Am J Obstet Gynecol 148 (1984): 481-7. [PMID: 6364813]
75	Phillips RE, Looareesuwan S, White NJ, et al "Hypoglycaemia and antimalarial drugs: quinidine and release of insulin." Br Med J 292 (1986): 1319-21. [PMID: 3085830]
76	Pollak PT, Mukherjee SD, Fraser AD "Sertraline-induced hypoglycemia." Ann Pharmacother 35 (2001): 1371-4. [PMID: 11724085]
77	Pond SM, Birkett DJ, Wade DN "Mechanisms of inhibition of tolbutamide metabolism: phenylbutazone, oxyphenbutazone, sulfaphenazole." Clin Pharmacol Ther 22 (1977): 573-9. [PMID: 913025]
78	Prince RL, Larkins RG, Alford FP "The effect of acetylsalicylic acid on plasma glucose and the response of glucose regulatory hormones to intravenous glucose and arginine in insulin treated diabetics and normal subjects." Metabolism 30 (1981): 293-8. [PMID: 7010074]
79	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
80	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
81	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
82	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
83	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
84	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
85	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
86	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
87	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
88	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
89	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
90	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
91	Quevedo SF, Krauss DS, Chazan JA, et al "Fasting hypoglycemia secondary to disopyramide therapy." JAMA 245 (1981): 2424. [PMID: 6785461]
92	Ravic M, Johnston A, Turner P "Clinical pharmacological studies of some possible interactions of lornoxicam with other drugs." Postgrad Med J 66 (1990): s30-4. [PMID: 2126624]
93	Richardson T, Foster J, Mawer GE "Enhancement by sodium salicylate of the blood glucose lowering effect of chlorpropamide-drug interaction or summation of similar effects." Br J Clin Pharmacol 22 (1986): 43-8. [PMID: 3527244]
94	Rubin M, Zakheim B, Pitchumoni C "Disopyramide-induced profound hypoglycemia." N Y State J Med July,Aug,S (1983): 1057-8. [PMID: 6579404]
95	Salmela PI, Sotaniemi EA, Viikari J, et al "Fenfluramine therapy in non-insulin-dependent diabetic patients effects on body weight, glucose homeostasis, serum lipoproteins, and antipyrine metabolism." Diabetes Care 4 (1981): 535-40. [PMID: 6751729]
96	Sawka AM, Burgart V, Zimmerman D "Loss of awareness of hypoglycemia temporally associated with selective serotonin reuptake inhibitors." Diabetes Care 24 (2001): 1845-6. [PMID: 11574457]
97	Semel JD, Wortham E, Karl DM "Fasting hypoglycemia associated with disopyramide." Am Heart J 106 (1983): 1160-1. [PMID: 6356848]
98	Shah SJ, Bhandarkar SD, Satoskar RS "Drug interaction between chlorpropamide and non-steroidal anti-flammatory drugs, ibuprofen and phenylbutazone." Int J Clin Pharmacol Ther Toxicol 22 (1984): 470-2. [PMID: 6500764]
99	Sievenpiper JL, Arnason JT, Leiter LA, Vuksan V "Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia." Eur J Clin Nutr 57 (2003): 243-8. [PMID: 12571655]
100	Sjoberg S, Wiholm BE, Gunnarsson R, Emilsson H, Thunberg E, Christenson I, Ostman J "Lack of pharmacokinetic interaction between glibenclamide and trimethoprim-sulphamethoxazole." Diabet Med 4 (1987): 245-7. [PMID: 2956028]
101	Slade IH, and Iosefa RN "Fatal hypoglycemic coma from the use of tolbutamide in elderly patients: report of two cases." J Am Geriatr Soc 15 (1967): 948-50. [PMID: 6046558]
102	Sone H, Takahashi A, Yamada N "Ibuprofen-related hypoglycemia in a patient receiving sulfonylurea." Ann Intern Med 134 (2001): 344. [PMID: 11182854]
103	Storlien LH, Thorburn AW, Smythe GA, Jenkins AB, Chisholm DJ, Kraegen EW "Effect of d-fenfluramine on basal glucose turnover and fat-feeding-induced insulin resistance in rats." Diabetes 38 (1989): 499-503. [PMID: 2647557]
104	Strathman I, Schubert EN, Cohen A, Nitzberg DM "Hypoglycemia in patients receiving disopyramide phosphate." Drug Intell Clin Pharm 17 (1983): 635-8. [PMID: 6413187]
105	Tannenbaum H, Anderson LG, Soeldner JS "Phenylbutazone-tolbutamide drug interaction." N Engl J Med 290 (1974): 344. [PMID: 4809290]
106	Tran PO, Gleason CE, Robertson RP "Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function." Diabetes 51 (2002): 1772-8. [PMID: 12031964]
107	Tremaine LM, Wilner KD, Preskorn SH "A study of the potential effect of sertraline on the pharmacokinetics and protein binding of tolbutamide." Clin Pharmacokinet 32(Suppl 1) (1997): 31-36. [PMID: 9068933]
108	Turtle JR, Burgess JA "Hypoglycemic action of fenfluramine in diabetes mellitus." Diabetes 22 (1973): 858-67. [PMID: 4749404]
109	Verdy M, Charbonneau L, Verdy I, Belanger R, Bolte E, Chiasson JL "Fenfluramine in the treatment of non-insulin-dependent diabetics: hypoglycemic versus anorectic effect." Int J Obes 7 (1983): 289-97. [PMID: 6629637]
110	Vuksan V, Sievenpiper JL, Koo VY, et al "American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus." Arch Intern Med 160 (2000): 1009-13. [PMID: 10761967]
111	Vuksan V, Stavro MP, Sievenpiper JL, et al "Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes." Diabetes Care 23 (2000): 1221-6. [PMID: 10977009]
112	Whitcroft IA, Thomas JM, Rawsthorne A, et al "Effects of alpha and beta adrenoceptor blocking drugs and ACE inhibitors on long term glucose and lipid control in hypertensive non-insulin dependent diabetics." Horm Metab Res Suppl 22 (1990): 42-6. [PMID: 1975246]
113	Wiederholt IC, Genco M, Foley JM "Recurrent episodes of hypoglycemia induced by propoxyphene." Neurology 17 (1967): 703-6. [PMID: 6067489]
114	Wing LM, Miners JO "Cotrimoxazole as an inhibitor of oxidative drug metabolism: effects of trimethoprim and sulphamethoxazole separately and combined on tolbutamide disposition." Br J Clin Pharmacol 20 (1985): 482-5. [PMID: 3878154]
115	World Health Organization "WHO Public Assessment Reports (WHOPARs).".
116	Wu B, Sato T, Kiyosue T, Arita M "Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs." Cardiovasc Res 26 (1992): 1095-101. [PMID: 1291087]
117	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
118	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
119	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
120	Cerner Multum, Inc. "Australian Product Information.".
121	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
122	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
123	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
124	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
125	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
126	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
127	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
128	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
129	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
130	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
131	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
132	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
133	deLorgeril M, Boissonnat P, Bizollon CA, et al "Pharmacokinetics of cyclosporine in hyperlipidaemic long-term survivors of heart transplantation: lack of interaction with the lipid-lowering agent, fenofibrate." Eur J Clin Pharmacol 43 (1992): 161-5. [PMID: 1425874]
134	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
135	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
136	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
137	Gilead Sciences, Inc "About Remdesivir.".
138	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
139	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
140	Ben Salem C, Fathallah N, Hmouda H, Bouraoui K "Drug-induced hypoglycaemia: an update." Drug Saf 34 (2011): 21-45. [PMID: 20942513]
141	Product Information. Afrezza (insulin inhalation, rapid acting). MannKind Corporation, Valencia, CA.
142	Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
143	Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
144	Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
145	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
146	Vuorinen-Markkola H, Yki-Jarvinen H "Antihypertensive therapy with enalapril improves glucose storage and insulin sensitivity in hypertensive patients with non-insulin-dependent diabetes mellitus." Metabolism 44 (1995): 85-9. [PMID: 7854171]
147	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
148	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
149	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
150	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
151	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
152	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
153	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
154	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.
155	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
156	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
157	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence