Details of Drug

Drug General Information (ID: D0629)
Drug Name	Everolimus
Drug Type	Small molecule
Drug Synonymous	Afinitor; Afinitor (TN); CERTICAN(R); Certican; Certican (TN); Everolimus (JAN/USAN/INN); Everolimus [USAN]; MTOR kinase inhibitors; NVP-RAD-001; RAD 001; RAD-001; RAD-001C; RAD001; RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus; SDZ-RAD; Zortress Click to Show/Hide
Disease Class	2C90: Renal cell carcinoma
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C53H83NO14
InChI	1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
InChIKey	HKVAMNSJSFKALM-GKUWKFKPSA-N
Canonical SMILES	CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC
External Link
	Pubchem ID	6442177
	CAS Number	159351-69-6
	CHEBI ID	68478
	TTD ID	D0K3QS
	INTEDE ID	DR0674
	VARIDT ID	DR00224

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM027 Decreased renal excretion due to nephrotoxicity BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM048 Increased risk of angioedema/anaphylactoid reactions BM072 Increased risk of nephrotoxicity BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM109 Increased risk of other adverse reactions (Unspecific) BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Everolimus
Affected cellular transport
	Transporter inhibition					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[15], [71], [72]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[12], [58]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[12], [58]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[12], [58]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[86]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[12], [58]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[12], [58]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[12]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[15], [89]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[90]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[12]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[12], [58]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[12], [58]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[110]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[12], [58]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[12], [58]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[12], [58]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[12]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[12], [58]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 91
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[10], [11], [12], [13]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[12]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[10], [11], [12], [13]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[12]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[10], [11], [12], [13]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[10], [11], [12], [13]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[18], [19], [20], [21], [12], [22]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[12]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[10], [11], [12], [13]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[12]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[12]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[10], [11], [12], [13]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[10], [11], [12], [13]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[10], [11], [12], [13]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[12]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[12]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[12]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[12]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[12]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[12]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[12]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[10], [11], [12], [13]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[12]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[12]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[10], [11], [12], [13]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[12]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[12]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[12]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[10], [11], [12], [13]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[10], [11], [12], [13]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[10], [11], [12], [13]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[12]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[12]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[10], [11], [12], [13]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[10], [11], [12], [13]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[10], [11], [12], [13]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[10], [11], [12], [13]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[10], [11], [12], [13]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[10], [11], [12], [13]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[10], [11], [12], [13]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[10], [11], [12], [13]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[10], [11], [12], [13]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[12]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[10], [11], [12], [13]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[12], [58]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[12], [58]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[10], [15]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[12], [58]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[12], [58]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[12], [58]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[12], [58]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[12], [58]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[70]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[12], [58]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[75]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[79]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[12], [58]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[12], [58]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[12], [58]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[87]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[12], [58]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[12], [58]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[12], [58]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[12], [58]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[12], [58]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[12], [58]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[91]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[10], [15]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[12], [58]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[93]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[12], [58]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[12], [58]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[12], [58]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[12], [58]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[12], [58]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[12], [58]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[12], [58]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[10], [15], [112]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[12], [58]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[12], [58]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[12], [58]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[12], [58]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[12], [58]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[12], [58]
D1056		Micafungin	C56H71N9O23S	477468	Moderate		Inter Info	[12], [58]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[115]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[12], [58]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[12], [58]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[12], [58]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[12], [58]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[117], [110], [118], [119]
	CYP450 enzyme induction					Drug Num: 48
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[14], [10], [15], [12], [16]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[14], [10], [15], [12], [16]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[14], [10], [15], [12], [16]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[14], [10], [15], [12], [16]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[14], [10], [15]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[14], [10], [15], [12], [16]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[14], [10], [15], [12], [16]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[14], [10], [15], [12], [16]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[14], [10], [15], [12], [16]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[14], [10], [15]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[14], [10], [15], [12], [16]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[14], [10], [15], [47], [48], [49], [50], [51], [52], [12], [1], [2], [53], [54]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[10], [15], [12]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[10], [15], [12]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[10], [15], [12]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[10], [15], [12]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[10], [15], [12]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[10], [15], [12]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[10], [15], [12]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[10], [15], [12]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[10], [15], [12]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[10], [15], [12]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[10], [15], [12]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[85]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[10], [15], [12]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[10], [15], [12]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[15], [88]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[10], [15], [12]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[92]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[10], [15], [12]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[10], [15], [12]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[15], [98]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[10], [15], [12]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[10], [15], [12]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[10], [15], [12]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[15], [113]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[10], [15], [12]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[10], [15], [12]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[10], [15], [12]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[10], [15], [12]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[10], [15], [12]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[10], [15], [12]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[10], [15], [12]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[10], [15], [12]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[10], [15], [12]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[10], [15], [12]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[10], [15], [12]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[10], [15], [12]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[10], [15], [106], [107], [108]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[4], [5], [6], [7], [8], [9]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[15], [17]
D0614		Etanercept	NA	NA	Major		Inter Info	[4], [5], [6], [7], [8], [9]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[10], [15], [33]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[4], [8], [9]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[36]
D0736		Golimumab	NA	NA	Major		Inter Info	[4], [5], [6], [7], [8], [9]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[15], [38]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[42], [43]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[44]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[45]
D0802		Infliximab	NA	NA	Major		Inter Info	[4], [5], [6], [7], [8], [9]
D1111		Natalizumab	NA	NA	Major		Inter Info	[46]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[67]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[10], [15]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[69]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[83]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[84]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[84]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[84]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[94]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[95]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[15], [96]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[97]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D1410		Risankizumab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[15], [109]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D1583		Tildrakizumab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[15], [59], [60], [61], [62], [63], [64], [65], [66]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[10], [15], [116]
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[10], [34], [35]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[12], [2], [53]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[12], [2], [53]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[12], [2], [53]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[12], [2], [53]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[12], [2], [53]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[12], [2], [53]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[12], [2], [53]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[12], [2], [53]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[12], [2], [53]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[12], [2], [53]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[12], [2], [53]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[12], [2], [53]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[12], [2], [53]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[12], [2], [53]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[12], [2], [53]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[12], [2], [53]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[12], [2], [53]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[12], [2], [53]
	Increased risk of nephrotoxicity					Drug Num: 64
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0022		Acyclovir	C8H11N5O3	135398513	Major		Inter Info	[1], [2], [3]
D0056		Amikacin	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3]
D0075		Amphotericin B	C47H73NO17	5280965	Major		Inter Info	[1], [2], [3]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Major		Inter Info	[1], [2], [3]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Major		Inter Info	[1], [2], [3]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Major		Inter Info	[1], [2], [3]
D0142		Bacitracin	C66H103N17O16S	10909430	Major		Inter Info	[1], [2], [3]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1], [2], [3]
D0252		Capreomycin	C50H88N28O15	3000502	Major		Inter Info	[1], [2], [3]
D0298		Celecoxib	C17H14F3N3O2S	2662	Major		Inter Info	[1], [2], [3]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[1], [2], [3]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Major		Inter Info	[1], [2], [3]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[23], [24], [25], [26], [27], [28], [29]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1], [2], [3]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1], [2], [3]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1], [2], [3]
D0709		Gallium nitrate	GaN3O9	61635	Major		Inter Info	[1], [2], [3]
D0724		Givosiran	C78H139N11O30	119058042	Major		Inter Info	[1], [2], [3]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[15], [37]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[1], [2], [3]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[23], [24], [25], [26], [27], [28], [29]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[23], [24], [25], [26], [27], [28], [29]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[23], [24], [25], [26], [27], [28], [29]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[25], [26], [27]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[23], [24], [25], [26], [27], [28], [29]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[23], [24], [25], [26], [27], [28], [29]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1], [2], [3]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[1], [2], [3]
D1091		Moxetumomab Pasudotox	NA	NA	Major		Inter Info	[1], [2], [3]
D1304		Plazomicin	C25H48N6O10	42613186	Major		Inter Info	[1], [2], [3]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [2], [3]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1], [2], [3]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1], [2], [3]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1], [2], [3]
D0718		Gentamicin	C21H43N5O7	3467	Major		Inter Info	[1], [2], [3]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1], [2], [3]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1], [2], [3]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[23], [24], [25], [26], [27], [28], [29]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[23], [24], [25], [26], [27], [28], [29]
D0876		Kanamycin	C18H36N4O11	6032	Major		Inter Info	[1], [2], [3]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1], [2], [3]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1], [2], [3]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1], [2], [3]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1], [2], [3]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1], [2], [3]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Major		Inter Info	[1], [2], [3]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1], [2], [3]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1], [2], [3]
D1120		Neomycin	C23H46N6O13	8378	Major		Inter Info	[1], [2], [3]
D1126		Netilmicin	C21H41N5O7	441306	Major		Inter Info	[1], [2], [3]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1], [2], [3]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1], [2], [3]
D1310		Polymyxin B	C56H98N16O13	49800004	Major		Inter Info	[1], [2], [3]
D1421		Rofecoxib	C17H14O4S	5090	Major		Inter Info	[1], [2], [3]
D1442		Salsalate	C14H10O5	5161	Major		Inter Info	[1], [2], [3]
D1507		Streptomycin	C21H39N7O12	19649	Major		Inter Info	[1], [2], [3]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1], [2], [3]
D1597		Tobramycin	C18H37N5O9	36294	Major		Inter Info	[1], [2], [3]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1], [2], [3]
D1672		Valaciclovir	C13H20N6O4	135398742	Major		Inter Info	[1], [2], [3]
D1674		Valdecoxib	C16H14N2O3S	119607	Major		Inter Info	[1], [2], [3]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Major		Inter Info	[1], [2], [3]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[68]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[111]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[55], [56], [57]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[55], [56], [57]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[55], [56], [57]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[55], [56], [57]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[55], [56], [57]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[55], [56], [57]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[55], [56], [57]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[55], [56], [57]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[55], [56], [57]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[55], [56], [57]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[55], [56], [57]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[55], [56], [57]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[55], [56], [57]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[55], [56], [57]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[55], [56], [57]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[55], [56], [57]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[55], [56], [57]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[55], [56], [57]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[55], [56], [57]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[55], [56], [57]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[55], [56], [57]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[55], [56], [57]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[55], [56], [57]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[55], [56], [57]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[55], [56], [57]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[55], [56], [57]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[55], [56], [57]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[55], [56], [57]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[55], [56], [57]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[55], [56], [57]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[55], [56], [57]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[55], [56], [57]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[55], [56], [57]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[55], [56], [57]
	Antagonize the effect of antihypertensive agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[55], [56], [57]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[55], [56], [57]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[55], [56], [57]
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[30], [31], [32]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[30], [31], [32]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[30], [31], [32]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[30], [31], [32]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[30], [31], [32]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[39], [10], [40]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[41]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[30], [31], [32]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[30], [31], [32]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[39], [73], [74]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[39], [73], [74]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[39], [73], [74]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[39], [73], [74]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[39], [73], [74]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[39], [73], [74]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[39], [73], [74]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[39], [73], [74]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[99], [39], [10], [100], [101], [102], [73], [103], [104], [105], [74]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[39], [73], [74]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[39], [73], [74]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[39], [73], [74]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[114]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[76], [77], [78]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[76], [77], [78]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[80], [81], [82]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[80], [81], [82]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[80], [81], [82]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[80], [81], [82]
	Antagonize the effects of immunosuppressants					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Minor		Inter Info	[51], [120], [121]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[51], [120], [121]
D1723		Zinc chloride	Cl2Zn	5727	Minor		Inter Info	[51], [120], [121]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[51], [120], [121]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[51], [120], [121]
D1703		Vitamin E	C29H50O2	14985	Minor		Inter Info	[51], [120], [121]

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