Details of Drug

Drug General Information (ID: D0628)
Drug Name	Etravirine
Drug Type	Small molecule
Drug Synonymous	Intelence; DAPY deriv; Diaminopyrimidine deriv; R 165335; R165335; TMC 125; TMC125; Intelence (TN); Intelence(TM); R-165335; R165335-TMC125; TMC-125; Etravirine (JAN/USAN/INN); TMC-125/R-165335; 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)-4-pyrimidinyl)oxy)-3,5-dimethyl-benzonitrile; 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE; 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile; 65B; ETR Click to Show/Hide
Disease Class	1C60-1C62: Human immunodeficiency virus disease
Therapeutic Class	Anti-Hiv Agents
Structure
Structure	3D Structure		2D Structure
Formula	C20H15BrN6O
InChI	1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27)
InChIKey	PYGWGZALEOIKDF-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N
External Link
	Pubchem ID	193962
	CAS Number	269055-15-4
	CHEBI ID	63589
	TTD ID	D0BP9C
	INTEDE ID	DR0671
	VARIDT ID	DR00597

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM074 Increased risk of peripheral neuropathy
Relation Graph

Full list of drugs interacting with Etravirine
Affected cellular transport
	Transporter inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[19]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[5], [1], [2], [4]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[145]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 74
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[4]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[40]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[4]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[4]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[4]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[4]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[4]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[4]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[4]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[72]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[4]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[4]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[4]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[4]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[97], [98]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[4]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[4]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[99], [100], [4]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[4]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[4]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[113]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[4]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[4]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[1], [2], [125], [4], [126], [127], [128], [59], [129], [130]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[4]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[4]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[4]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[4]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[4]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[2], [4]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[4]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[4]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[4]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[4]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[4]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[4]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[4]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[4]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[4]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[4]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[1], [2], [181], [182]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[4]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[4]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[4]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[4]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[4]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[4]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[4]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[4]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[4]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[4]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[4]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[4]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[211], [212]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[4]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[4]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[4]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[4]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[4]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[4]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[2], [214], [162]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[4]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[4]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[4]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[4]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[4]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[4]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[4]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[4]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[4]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[4]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[4]
D0208		Brivaracetam	C11H20N2O2	9837243	Minor		Inter Info	[2], [255]
	CYP450 enzyme induction					Drug Num: 287
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1], [2], [3], [4]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[5], [1], [2], [6], [7], [8], [9], [10], [11], [12]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[4]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[1], [2], [13]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[4]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[4]
D0108		Artemether	C16H26O5	68911	Major		Inter Info	[1], [2], [14]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[2], [15]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[16], [17]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[2], [18]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[9], [10], [11]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[20]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[1], [2], [21], [4]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[22]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[1], [23]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[2]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Major		Inter Info	[1], [2], [24], [25], [26]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[27]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[28]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[29]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[4]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[30]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[2], [31]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[32]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[33], [34], [35]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[36]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[37]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[38]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[39], [4]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[1], [41]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[1], [2], [42]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[5], [1], [2], [6], [7], [8], [9], [10], [11], [12]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[2], [43]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[44]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[45]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[1], [46]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[47]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[48]
D1686		Velpatasvir	C49H54N8O8	67683363	Major		Inter Info	[2], [49], [50]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[51]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[52]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[5], [1], [2], [6], [7], [8], [9], [10], [11], [12]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[4]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[2], [53], [54]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[5], [1], [2], [6], [7], [8], [9], [10], [11], [12]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[55]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[4]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[4]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[5], [1], [2], [6], [7], [8], [9], [10], [11], [12]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[4]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[4]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[56]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[4]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[57]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[4]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[39], [4]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[4]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[4]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[58], [59]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[4]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[60], [4]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[4]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[64], [65], [66], [67]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[4]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[4]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[4]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[4]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[4]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[4]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[4]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[4]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[68]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[4]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[4]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[4]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[4]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[69]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[4]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[4]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[4]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[4]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[4]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[4]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[4]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[70]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[71]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[4]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[4]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[4]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[4]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[4]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[4]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[92], [1], [93], [2], [94], [95], [96]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[4]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[4]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[4]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[4]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[4]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[4]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[4]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[92], [1], [2]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[1], [2], [101]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[4]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[4]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[102], [103], [104], [105], [106]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[4]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[2], [107], [108], [109]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[107], [108], [109]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[4]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[110]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[4]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[4]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[1], [2], [101]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[1], [2], [101]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[111], [112]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[4]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[4]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[4]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[4]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[114]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[115]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[116]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[117]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[2], [118], [119]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[4]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[122]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[123], [124]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[131]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[4]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[132]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[1], [133]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[4]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[134]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[1], [2], [135]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[4]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[136]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[137]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[138]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[139]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[4]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[2], [140]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[4]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[141]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[142]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[4]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[143]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[1], [2], [144]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[146]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[147], [148]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[149], [150]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[2], [151]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[152]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[153]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[1], [2], [154]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[155]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[156]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[2], [157]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[4]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[1], [2], [158]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[159]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[160]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[1], [161]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[2], [162]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[163]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[2], [164], [165]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[166]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[167]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[2], [168]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[5], [2], [169], [170], [171]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[1], [172]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[173]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[174]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[2], [175]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[176]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[4]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[177]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[178]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[1], [2], [179]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[180]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[4]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[4]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[4]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[4]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[111], [183]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[4]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[4]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[4]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[4]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[4]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[4]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[4]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[4]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[185], [186], [191]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[4]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[4]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[4]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1], [2], [199]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[4]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[4]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[4]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[4]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[4]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[1], [200]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[201], [202], [203]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[204]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[4]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[1], [2], [101]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[4]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[1], [2], [101]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[4]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[4]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[205], [206]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[207], [208], [209], [210]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[4]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[4]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[4]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[4]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[4]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[4]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[4]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[4]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[4]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[4]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[4]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[4]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[4]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[213]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[4]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[4]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[215], [1], [216], [217]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[4]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[4]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[4]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[4]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[1], [218], [219], [220], [221]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[4]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[222], [223], [11], [224], [225], [226]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[4]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[227]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[228], [229], [230]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[231]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[232]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[4]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[4]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[4]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[1], [2], [233]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[4]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[1], [2], [234], [235]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[4]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[236]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[4]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[1], [2], [237]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1], [2], [234], [235]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[4]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[4]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[1], [2], [238]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[4]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[4]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[4]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[4]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[4]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[4]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[4]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[241], [1], [2], [242], [243]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2], [244], [245]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[4]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[4]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[4]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[4]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[4]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[4]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[4]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[4]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[4]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[4]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[4]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[2], [247], [248], [249]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[4]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[250]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[2], [251], [252], [253], [254]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[256]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[257], [258], [259]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[260]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[261]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[262]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[263], [264]
Pharmacodynamic additive effects
	Increased risk of peripheral neuropathy					Drug Num: 53
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[61], [62], [63]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[61], [62], [63]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[61], [62], [63]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[61], [62], [63]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[61], [62], [63]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[61], [62], [63]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[61], [62], [63]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[61], [62], [63]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[61], [62], [63]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[61], [62], [63]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[61], [62], [63]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[61], [120], [121]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[61], [62], [63]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[61], [62], [63]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[61], [62], [63]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[61], [62], [63]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[61], [62], [63]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[61], [62], [63]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[61], [62], [63]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[61], [62], [63]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[61], [62], [63]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[61], [62], [63]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[61], [62], [63]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[61], [62], [63]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[61], [62], [63]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[61], [62], [63]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[61], [62], [63]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[61], [62], [63]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[61], [62], [63]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[61], [62], [63]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[61], [62], [63]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[61], [62], [63]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[61], [62], [63]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[61], [62], [63]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[61], [62], [63]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[61], [62], [63]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[61], [62], [63]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[61], [62], [63]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[61], [62], [63]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[239], [1], [2], [240]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[61], [62], [63]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[61], [62], [63]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[239], [246]

References
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159	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
160	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
161	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
162	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
163	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
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165	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
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167	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
168	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
169	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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173	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
174	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
175	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
176	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
177	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
178	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
179	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
180	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
181	Kantola T, Backman JT, Niemi M, Kivisto KT, Neuvonen PJ "Effect of fluconazole on plasma fluvastatin and pravastatin concentrations." Eur J Clin Pharmacol 56 (2000): 225-9. [PMID: 10952477]
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183	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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193	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
194	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
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200	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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