Details of Drug

Details of Drug

 Drug General Information (ID: D0625)
  Drug Name
Etomidate
  Drug Type Small molecule
  Drug Synonymous
Absele; Amidate; Ethnor; Ethomidate; Etomidato; Etomidatum; Hypnomidate; Radenarcon; Radenarkon; Etomidic acid; R 16659; R 26490; R26490; Amidate (TN); Amidate (pharmaceutical); Amidate, Etomidate; D-Etomidate; Etomidato [INN-Spanish]; Etomidatum [INN-Latin]; R-26490; Etomidate (USAN/INN); Etomidate [USAN:BAN:INN]; Ethyl 3-(1-phenylethyl)imidazole-4-carboxylate; Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate; R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate; (+)-Ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate; (+)-Etomidate; (R)-(+)-1-(alpha-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester; (d)-Etomidate; 1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester; 1-(1-Phenylethyl)-imidazole-5-carboxylic acid, ethyl ester; 1-(alpha-Methylbenzyl)-1H-imidazole-5-carboxylic acid ethyl ester; 1H-Imidazole-5-carboxylic acid, 1-((1R)-1-phenylethyl)-, ethyl ester; 3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester
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  Disease Class 9A76-9A78: Corneal disease
  Therapeutic Class Analgesics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C14H16N2O2
  InChI 1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
  InChIKey NPUKDXXFDDZOKR-LLVKDONJSA-N
  Canonical SMILES CCOC(=O)C1=CN=CN1C(C)C2=CC=CC=C2
  External Link
Pubchem ID 667484
CAS Number 33125-97-2
CHEBI ID 4910
TTD ID D02YPG

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM006  Pharmacodynamic additive effects
BM010  Transporter inhibition
BM036  Additive cardiorespiratory depression effects
BM038  Additive CNS depression effects
BM042  Additive hypotensive effects
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Etomidate
      Affected cellular transport
   Transporter inhibition Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Moderate    Inter Info   
[23], [24], [25]
      Pharmacodynamic additive effects
   Additive cardiorespiratory depression effects Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0698
 
Fospropofol
 
C13H21O5P
 
3038498 
Moderate    Inter Info   
[17], [18], [19]
D1356
 
Propofol
 
C12H18O
 
4943 
Moderate    Inter Info   
[20], [21], [17], [22], [18], [19]
   Additive CNS depression effects Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1485
 
Sodium oxybate
 
C4H7NaO3
 
23663870 
Major    Inter Info   
[4], [5]
D0097
 
Apomorphine
 
C17H17NO2
 
6005 
Moderate    Inter Info   
[9], [10]
D0617
 
Ethanol
 
C2H6O
 
702 
Moderate    Inter Info   
[13], [14], [15], [7], [8]
D0665
 
Flibanserin
 
C20H21F3N4O
 
6918248 
Moderate    Inter Info   
[16]
   Additive hypotensive effects Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0444
 
Deserpidine
 
C32H38N2O8
 
8550 
Moderate    Inter Info   
[11], [12]
D1393
 
Reserpine
 
C33H40N2O9
 
5770 
Moderate    Inter Info   
[11], [12]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Major    Inter Info   
[1], [2], [3]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Major    Inter Info   
[1], [2], [3]
D1455
 
Selegiline
 
C13H17N
 
26757 
Major    Inter Info   
[1], [2], [3]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Major    Inter Info   
[1], [2], [3]
D0143
 
Baclofen
 
C10H12ClNO2
 
2284 
Moderate    Inter Info   
[6], [7], [8]
References
1 Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
2 Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
3 Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
4 Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
5 Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
6 Cerner Multum, Inc. "Australian Product Information.".
7 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
9 Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
10 Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
11 Ziegler CH, Lovette JB "Operative complications after therapy with reserpine and reserpine compounds." JAMA 176 (1961): 114-7
12 Jahr JS, Weber S "Ventricular dysrhythmias following an alfentanil anesthetic in a patient on reserpine for hypertension." Acta Anaesthesiol Scand 35 (1991): 788-9
13 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
14 Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
15 Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
16 Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
17 McClune S, McKay AC, Wright PM, et al "Synergistic interaction between midazolam and propofol." Br J Anaesth 69 (1992): 240-5. [PMID: 1389840]
18 Product Information. Diprivan (propofol). Zeneca Pharmaceuticals, Wilmington, DE.
19 Product Information. Lusedra (fospropofol). Eisai Inc, Teaneck, NJ.
20 Gill SS, Wright EM, Reilly CS "Pharmacokinetic interaction of propofol and fentanyl: single bolus injection study." Br J Anaesth 65 (1990): 760-5. [PMID: 2265045]
21 Hamaoka N, Oda Y, Hase I, Mizutani K, Nakamoto T, Ishizaki T, Asada A "Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study." Clin Pharmacol Ther 66 (1999): 110-7. [PMID: 10460064]
22 Pavlin DJ, Coda B, Shen DD, et al "Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers." Anesthesiology 84 (1996): 23-37. [PMID: 8572340]
23 Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
24 Ho PC, Ghose K, Saville D, Wanwimolruk S "Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers." Eur J Clin Pharmacol 56 (2000): 693-8. [PMID: 11214778]
25 Bunting P, Ramsay TM, Pleuvry BJ. An in-vitro study of the interactions between intravenous induction agents and the calcium antagonists verapamil and nifedipine. J Pharm Pharmacol. 1989 Dec;41(12):840-3.