Details of Drug

Drug General Information (ID: D0620)
Drug Name	Ethosuximide
Drug Type	Small molecule
Drug Synonymous	Aethosuccimidum; Aethosuximide; Asamid; Atysmal; Capitus; Emeside; Ethosuccimid; Ethosuccimide; Ethosuccinimide; Ethosuxide; Ethosuximidum; Ethylmethylsuccimide; Ethymal; Etomal; Etosuccimide; Etosuximid; Etosuximida; Etosuximide; Mesentol; Pemal; Pemalin; Pentinimid; Peptinimid; Petinimid; Petnidan; Piknolepsin; Pyknolepsinum; Ronton; Simatin; Succimal; Succimitin; Suksilep; Suxilep; Suximal; Suxin; Suxinutin; Thetamid; Thilopemal; Zaraondan; Zarodan; Zarondan; Zarontin; Zartalin; Aethosuximide [German]; Desitin Brand of Ethosuximide; Epileo Petit MAL; Etosuccimide [DCIT]; Etosuximida Faes; Faes Brand of Ethosuximide; Fortbenton Brand of Ethosuximide; Jenapharm Brand of Ethosuximide; Katwijk Brand of Ethosuximide; LAB Brand of Ethosuximide; Parke Davis Brand of Ethosuximide; Pfizer Brand of Ethosuximide; United Drug Brand of Ethosuximide; Warner Lambert Brand of Ethosuximide; Wernigerode Brand of Ethosuximide; Cl 366; E 7138; E0746; H 940; PM 671; CN-10395; Ethosuximidum [INN-Latin]; Etosuximida [INN-Spanish]; Faes, Etosuximida; H-490; N-Ethyl methylsuccinimide; PM-671; Simatin(E); Warner-Lambert Brand of Ethosuximide; Zarondan-Saft; Zarontin (TN); C.I. 366; CN-10,395; Piknole.psi.n; Pyknole.psi.num; Alpha-Ethyl-alpha-methylsuccinimide; Alpha-Methyl-alpha-ethylsuccinimide; Ethosuximide (JP15/USP/INN); Ethosuximide [USAN:INN:BAN:JAN]; Gamma-Methyl-gamma-ethylsuccinimide; Gamma-Methyl-gamma-ethyl-succinimide; Gamma-ethyl-gamma-methyl-succinimide; (+-)-2-Ethyl-2-methylsuccinimide; 2-Ethyl-2-methylsuccinimide; 2-Methyl-2-ethylsuccinimide; 3-Ethyl-3-methyl-2, 5-pyrrolidinedion; 3-Ethyl-3-methyl-2,5-pyrrolidinedione; 3-Ethyl-3-methylpyrrolidine-2,5-dione; 3-Ethyl-3-methylpyrroline-2,5-dione; 3-Ethyl-3-methylsuccinimide; 3-Methyl-3-ethylpyrrolidine-2,5-dione; 3-Methyl-3-ethylsuccinimide Click to Show/Hide
Disease Class	8A61-8A6Z: Epilepsy/seizure
Therapeutic Class	Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	C7H11NO2
InChI	1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChIKey	HAPOVYFOVVWLRS-UHFFFAOYSA-N
Canonical SMILES	CCC1(CC(=O)NC1=O)C
External Link
	Pubchem ID	3291
	CAS Number	77-67-8
	CHEBI ID	4887
	TTD ID	D0Q4XQ
	INTEDE ID	DR0659

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM026 Increased metabolism (Unspecific) BM038 Additive CNS depression effects BM087 Antagonize the effect of antiepileptic agents
Relation Graph

Full list of drugs interacting with Ethosuximide
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[26], [28], [33]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
	CYP450 enzyme inhibition					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[66]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[67], [68], [69]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[71], [72]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[73]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[74]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[22], [78]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[83]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[84]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[86]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[87], [88]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[89]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[67], [68], [69]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[71], [72]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[106]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[107]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[108]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[22], [109]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[110], [79], [111], [112], [113], [114], [115], [116], [117]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[118]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[119]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[79], [22], [120]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[122]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[123]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[127]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[79], [22], [129], [130]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[131]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[22]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[137], [138], [139], [140], [141], [142], [143], [144], [145]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[148]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[150], [151]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[22], [152]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[158]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[159], [160]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[164]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[165]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[184]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[185]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[188], [189], [154]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[79], [22], [190]
	CYP450 enzyme induction					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[22], [40], [41]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[42]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[22], [70]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[76]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[77]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[22], [85]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[79], [90]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[91]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[92], [79], [22], [93]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[102], [103], [96], [104], [105]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[128]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[65], [133], [134]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[22], [136]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[146], [147]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[22], [149]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[79], [22], [155]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[79], [22], [156], [155]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[157]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[22], [161]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[102], [103], [96], [104], [105]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[79], [22], [186], [187]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[102], [103], [96], [104], [105]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[79], [22], [155]
D0255		Carbamazepine	C15H12N2O	2554	Minor		Inter Info	[103], [191]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[192], [193], [194], [195], [196]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[192], [193], [194], [195], [196]
	Competitive inhibition of metabolic enzyme					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[79], [100], [101]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[79], [100], [101]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[103], [105]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[153], [154]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[153], [154]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[153], [154]
	Increased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0688		Folic acid	C19H19N7O6	135398658	Moderate		Inter Info	[124], [125], [126]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 175
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[17], [18], [19]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[20], [21], [22]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[37], [38], [39]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[37], [38], [39]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[37], [38], [39]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[37], [38], [39]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[43], [22], [44]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[37], [38], [39]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[37], [38], [39]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[37], [38], [39]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[37], [38], [39]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[45], [46]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[37], [38], [39]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[37], [38], [39]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[37], [38], [39]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[37], [38], [39]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[37], [38], [39]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[37], [38], [39]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[37], [38], [39]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[37], [38], [39]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[37], [38], [39]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[37], [38], [39]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[37], [38], [39]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[37], [38], [39]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[37], [38], [39]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[37], [38], [39]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[37], [38], [39]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[37], [38], [39]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[37], [38], [39]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[43], [22], [44]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[37], [38], [39]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[37], [38], [39]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[37], [38], [39]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[37], [38], [39]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[37], [38], [39]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[37], [38], [39]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[75]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[37], [38], [39]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[37], [38], [39]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[37], [38], [39]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[37], [38], [39]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[37], [38], [39]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[37], [38], [39]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[37], [38], [39]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[37], [38], [39]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[37], [38], [39]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[37], [38], [39]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[37], [38], [39]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[37], [38], [39]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[37], [38], [39]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[37], [38], [39]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[37], [38], [39]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[37], [38], [39]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[37], [38], [39]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[37], [38], [39]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[37], [38], [39]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[37], [38], [39]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[37], [38], [39]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[37], [38], [39]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[37], [38], [39]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[79], [94]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[37], [38], [39]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[37], [38], [39]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[95], [96], [97], [22], [98]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[37], [38], [39]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[37], [38], [39]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[37], [38], [39]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[99]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[37], [38], [39]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[37], [38], [39]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[37], [38], [39]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[37], [38], [39]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[37], [38], [39]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[37], [38], [39]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[37], [38], [39]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[121]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[37], [38], [39]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[37], [38], [39]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[45], [46]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[37], [38], [39]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[37], [38], [39]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[37], [38], [39]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[37], [38], [39]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[37], [38], [39]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[37], [38], [39]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[37], [38], [39]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[37], [38], [39]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[37], [38], [39]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[37], [38], [39]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[37], [38], [39]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[37], [38], [39]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[37], [38], [39]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[37], [38], [39]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[37], [38], [39]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[37], [38], [39]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[37], [38], [39]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[95], [132], [98]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[37], [38], [39]
D1183		Opium	NA	NA	Moderate		Inter Info	[37], [38], [39]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[37], [38], [39]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[37], [38], [39]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[37], [38], [39]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[37], [38], [39]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[37], [38], [39]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[37], [38], [39]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[37], [38], [39]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[37], [38], [39]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[37], [38], [39]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[37], [38], [39]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[37], [38], [39]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[37], [38], [39]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[37], [38], [39]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[37], [38], [39]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[37], [38], [39]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[37], [38], [39]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[37], [38], [39]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[37], [38], [39]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[37], [38], [39]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[37], [38], [39]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[37], [38], [39]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[37], [38], [39]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[37], [38], [39]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[37], [38], [39]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[37], [38], [39]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[37], [38], [39]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[37], [38], [39]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[37], [38], [39]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[162]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[37], [38], [39]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[37], [38], [39]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[163]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[37], [38], [39]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[37], [38], [39]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[37], [38], [39]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[37], [38], [39]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[37], [38], [39]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[37], [38], [39]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[37], [38], [39]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[37], [38], [39]
D1675		Valerian	NA	NA	Moderate		Inter Info	[37], [38], [39]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[37], [38], [39]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[37], [38], [39]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[37], [38], [39]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[37], [38], [39]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[37], [38], [39]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[37], [38], [39]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[37], [38], [39]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[37], [38], [39]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[37], [38], [39]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[37], [38], [39]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[37], [38], [39]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[37], [38], [39]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[37], [38], [39]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[37], [38], [39]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[37], [38], [39]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[37], [38], [39]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[37], [38], [39]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[37], [38], [39]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[37], [38], [39]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[37], [38], [39]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[37], [38], [39]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[37], [38], [39]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[37], [38], [39]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[37], [38], [39]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[37], [38], [39]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[37], [38], [39]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[37], [38], [39]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[37], [38], [39]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[37], [38], [39]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[37], [38], [39]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[37], [38], [39]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[37], [38], [39]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[37], [38], [39]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[37], [38], [39]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[79], [22], [80], [81], [82]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[79], [22], [80], [81], [82]
D1830		Leucovorin	C20H23N7O7	135403648	Moderate		Inter Info	[124], [125], [126]
D1832		Levoleucovorin	C20H23N7O7	135398559	Moderate		Inter Info	[124], [125], [126]
D1833		Levomefolic acid	C20H25N7O6	135398561	Moderate		Inter Info	[124], [125], [126]
D1834		Levomefolic acid (calcium)	C20H25N7O6	135398561	Moderate		Inter Info	[124], [125], [126]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1243		Pemoline	C9H8N2O2	4723	Moderate		Inter Info	[79], [22], [135]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[47], [48], [49], [50], [51], [52], [53], [54], [22], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65]

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58	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
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60	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
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67	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
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83	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
84	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
85	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
86	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
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121	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
122	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
123	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
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128	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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149	Product Information. Banzel (rufinamide). Eisai Inc, Teaneck, NJ.
150	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
151	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
152	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
153	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
154	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
155	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
156	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
157	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
158	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
159	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
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161	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
162	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
163	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
164	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
165	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
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187	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
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190	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
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193	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
194	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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