Details of Drug

Drug General Information (ID: D0590)
Drug Name	Erdafitinib
Drug Type	Small molecule
Drug Synonymous	1346242-81-6; UNII-890E37NHMV; 890E37NHMV; Erdafitinib [USAN:INN]; Erdafitinib (USAN/INN); GTPL9039; SCHEMBL2583760; CHEMBL3545376; MolPort-044-560-398; JNJ-42756493 (Erdafitinib); s8401; compound 4 [WO2011135376]; ZINC168520308; AKOS030526429; CS-4988; DB12147; AC-30222; 1,2-Ethanediamine, N1-(3,5-dimethoxyphenyl)-N2-(1-methylethyl)-N1-(3-(1-methyl-1H-pyrazol-4-yl)-6-quinoxalinyl)-; HY-18708; AS-35040; KB-333716; D10927; N'-(3,5-dimethoxyphenyl)-N'-[3-(1-methylpyrazol-4-yl)quino Click to Show/Hide
Disease Class	2A80-2A86: Lymphoma; 2C92: Ureteral cancer; 2C94: Bladder cancer; 2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C25H30N6O2
InChI	1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3
InChIKey	OLAHOMJCDNXHFI-UHFFFAOYSA-N
Canonical SMILES	CC(C)NCCN(C1=CC2=NC(=CN=C2C=C1)C3=CN(N=C3)C)C4=CC(=CC(=C4)OC)OC
External Link
	Pubchem ID	67462786
	CAS Number	1346242-81-6
	TTD ID	D0NW0T
	INTEDE ID	DR0595

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Erdafitinib
Affected cellular transport
	Transporter inhibition					Drug Num: 79
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[1]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[1]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[1]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[1]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[1]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[1]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[1]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[1]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[1]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[1]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[5], [1], [6]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[1]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[1]
D0412		Dalfampridine	C5H6N2	1727	Moderate		Inter Info	[5], [1], [6]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[1]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[1]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[1]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[1]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[1]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[5], [1], [6]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[1]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[1]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[1]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[1]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[1]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[1]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Moderate		Inter Info	[1]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[5], [1], [6]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[1]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[1]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[1]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[1]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[1]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[1]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[1]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[5], [1], [6]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[1]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[1]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[1]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[1]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[1]
D1362		Prucalopride	C18H26ClN3O3	3052762	Moderate		Inter Info	[1]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1]
D1402		Rifaximin	C43H51N3O11	6436173	Moderate		Inter Info	[1]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[1]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[1]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[1]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[1]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[1]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[1]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[1]
D1490		Sofosbuvir	C22H29FN3O9P	45375808	Moderate		Inter Info	[1]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1]
D1591		Tipiracil	C9H11ClN4O2	6323266	Moderate		Inter Info	[5], [1], [6]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[1]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[10]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[1]
D1617		Trametinib	C26H23FIN5O4	11707110	Moderate		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[1]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[1]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[1]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[1]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[1]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 60
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[2], [1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[1]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[2], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Major		Inter Info	[3], [4], [1]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[1]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[1]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[1]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[1]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[1]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[1]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[1]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[1]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[7], [8], [1]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[1]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[1]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[1]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[7], [8], [1]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[1]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[1]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[7], [8], [1]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[7], [8], [1]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[1]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[1]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[1]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[1]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[1]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[1]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[1]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[1]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[1]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[1]
	Competitive inhibition of metabolic enzyme					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[1]
Pharmacodynamic additive effects
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[9]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Major		Inter Info	[1]
D0233		Calcifediol	C27H44O2	5283731	Major		Inter Info	[1]
D1753		Calcipotriol (topical)	C27H40O3	5288783	Major		Inter Info	[1]
D0234		Calcitriol	C27H44O3	5280453	Major		Inter Info	[1]
D0235		Calcium acetate	C4H6CaO4	6116	Major		Inter Info	[1]
D0236		Calcium carbonate	CCaO3	10112	Major		Inter Info	[1]
D0238		Calcium citrate	C12H10Ca3O14	13136	Major		Inter Info	[1]
D0242		Calcium glycerophosphate	C3H7CaO6P	120096	Major		Inter Info	[1]
D0244		Calcium Phosphate	Ca3O8P2	24456	Major		Inter Info	[1]
D0328		Cholecalciferol	C27H44O	5280795	Major		Inter Info	[1]
D0495		Dihydrotachysterol	C28H46O	5311071	Major		Inter Info	[1]
D0527		Doxercalciferol	C28H44O2	5281107	Major		Inter Info	[1]
D0971		Magnesium gluconate	C12H22MgO14	11418570	Major		Inter Info	[1]
D1566		Tetraferric tricitrate decahydrate	C18H32Fe4O31	90478690	Major		Inter Info	[1]
D0591		Ergocalciferol	C28H44O	5280793	Major		Inter Info	[1]
D0647		Ferric carboxymaltose	C24H44FeO25-	86278165	Major		Inter Info	[1]
D0850		Iron sucrose	C12H29Fe5Na2O23	91663255	Major		Inter Info	[1]
D0893		Lanthanum carbonate	C3La2O9	168924	Major		Inter Info	[1]
D0967		Magaldrate	AlHMgO5S+2	3086011	Major		Inter Info	[1]
D0968		Magnesium carbonate	CMgO3	11029	Major		Inter Info	[1]
D0969		Magnesium chloride	Cl2H12MgO6	643991	Major		Inter Info	[1]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Major		Inter Info	[1]
D0972		Magnesium glycinate	C4H8MgN2O4	84645	Major		Inter Info	[1]
D0973		Magnesium hydroxide	H2MgO2	14791	Major		Inter Info	[1]
D0974		Magnesium oxide	MgO	14792	Major		Inter Info	[1]
D0975		Magnesium sulfate	MgO4S	24083	Major		Inter Info	[1]
D1086		Monopotassium phosphate	H2KO4P	516951	Major		Inter Info	[1]
D1226		Paricalcitol	C27H44O3	5281104	Major		Inter Info	[1]
D1462		Sevelamer	C6H12ClNO	3085017	Major		Inter Info	[1]
D1891		Sodium glycerophosphate	C3H7Na2O6P	14754	Major		Inter Info	[1]
D1486		Sodium phosphate, monobasic	NA	NA	Major		Inter Info	[1]

References
1	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
2	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
3	Cronk GA, Wheatley WB, Fellers GF, Albright H "The relationship of food intake to the absorption of potassium alpha-phenoxyethyl penicillin and potassium phenoxymethyl penicillin from the gastrointestinal tract." Am J Med Sci 240 (1960): 219-25. [PMID: 13812969]
4	Neuvonen PJ, Elonen E, Pentikainen PJ "Comparative effect of food on absorption of ampicillin and pivampicillin." J Int Med Res 5 (1977): 71-6. [PMID: 838114]
5	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6	Product Information. Tenex (guanfacine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
7	Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
8	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
9	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
10	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.

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