Details of Drug

Drug General Information (ID: D0589)
Drug Name	Eravacycline
Drug Type	Small molecule
Drug Synonymous	TP-038; TP-120; TP-170; TP-221; TP-271; TP-787; Tetracycline analogs (bacterial infection), Tetraphase Pharmaceuticals; Tetracycline derivatives (bacterial infection), Tetraphase Pharmaceuticals; Fluorocycline antibiotic (oral, bacterial infection), Tetraphase Pharmaceuticals; Tetracycline analogs (iv, antibiotic), Tetraphase Pharmaceuticals; TP-434 (oral, multidrug-resistant bacterial infections); TP-434 (oral, multidrug-resistant bacterial infections), Tetraphase Pharmaceuticals Click to Show/Hide
Disease Class	1A40: Infectious gastroenteritis/colitis; 1E30-1E32: Influenza
Therapeutic Class	Tetracyclines
Structure
Structure	3D Structure		2D Structure
Formula	C27H31FN4O8
InChI	1S/C27H31FN4O8/c1-31(2)20-13-8-11-7-12-14(28)9-15(30-16(33)10-32-5-3-4-6-32)21(34)18(12)22(35)17(11)24(37)27(13,40)25(38)19(23(20)36)26(29)39/h9,11,13,20,34-35,38,40H,3-8,10H2,1-2H3,(H2,29,39)(H,30,33)/t11-,13-,20-,27-/m0/s1
InChIKey	AKLMFDDQCHURPW-ISIOAQNYSA-N
Canonical SMILES	CN(C)C1C2CC3CC4=C(C=C(C(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)NC(=O)CN5CCCC5)F
External Link
	Pubchem ID	54726192
	CAS Number	1207283-85-9
	TTD ID	D0LZ7E
	INTEDE ID	DR2504

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM075 Increased risk of photosensitivity reactions BM077 Increased risk of pseudotumor cerebri BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Eravacycline
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[42], [43]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[42], [43]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[32]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[27]
D0116		Atazanavir	C38H52N6O7	148192	Minor		Inter Info	[27]
D0192		Boceprevir	C27H45N5O5	10324367	Minor		Inter Info	[27]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Minor		Inter Info	[27]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[27]
D0375		Cobicistat	C40H53N7O5S2	25151504	Minor		Inter Info	[27]
D0386		Conivaptan	C32H26N4O2	151171	Minor		Inter Info	[27]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[27]
D1653		Troleandomycin	C41H67NO15	202225	Minor		Inter Info	[27]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Minor		Inter Info	[27]
D0789		Idelalisib	C22H18FN7O	11625818	Minor		Inter Info	[27]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[27]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Minor		Inter Info	[27]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[27]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Minor		Inter Info	[27]
D1063		Mifepristone	C29H35NO2	55245	Minor		Inter Info	[27]
D1117		Nefazodone	C25H32ClN5O2	4449	Minor		Inter Info	[27]
D1119		Nelfinavir	C32H45N3O4S	64143	Minor		Inter Info	[27]
D1315		Posaconazole	C37H42F2N8O4	468595	Minor		Inter Info	[27]
D1415		Ritonavir	C37H48N6O5S2	392622	Minor		Inter Info	[27]
D1541		Telaprevir	C36H53N7O6	3010818	Minor		Inter Info	[27]
D1544		Telithromycin	C43H65N5O10	3002190	Minor		Inter Info	[27]
D1660		Tucatinib	C26H24N8O2	51039094	Minor		Inter Info	[27]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[27]
	CYP450 enzyme induction					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[26], [27]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[27]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[27]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[27]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[26], [27]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[27]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[27]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[27]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[27]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[26], [27]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[27]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[27]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[5], [34]
Pharmacodynamic additive effects
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[24], [25]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[5], [20], [33]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[5], [39], [24], [40], [41]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[5], [20], [33]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[47], [20], [48]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[20], [39], [24], [49]
	Increased risk of pseudotumor cerebri					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0018		Acitretin	C21H26O3	5284513	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0863		Isotretinoin	C20H28O2	5282379	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1626		Tretinoin	C20H28O2	444795	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1702		Vitamin A	C20H30O	445354	Major		Inter Info	[9], [14], [12], [10], [13], [11], [22], [16], [15], [17], [18], [23], [8], [2], [4], [7], [19], [5], [20], [1], [3], [6], [21]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[20], [28]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[20], [29], [30]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[31]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[35], [36], [37]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[35], [36], [37]
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[38]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[35], [36], [37]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[44], [45], [46]

References
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2	Chan AY, Liu DT, Friedman DI, Gordon LK, Egan RA "Doxycycline and intracranial hypertension." Neurology 64 (2005): 765-6. [PMID: 15728321]
3	Walters BN, Gubbay SS "Tetracycline and benign intracranial hypertension: report of five cases." Br Med J 282 (1981): 19-20. [PMID: 6449976]
4	Donnet A, Dufour H, Graziani N, Grisoli F "Minocycline and benign intracranial hypertension." Biomed Pharmacother 46 (1992): 171-2. [PMID: 1421048]
5	Cerner Multum, Inc. "Australian Product Information.".
6	Yokokura M, Hatake K, Komatsu N, Kajitani H, Miura Y "Toxicity of tretinoin in acute promyelocytic leukaemia." Lancet 343 (1994): 361-2. [PMID: 7905175]
7	Product Information. Achromycin (tetracycline). Lederle Laboratories, Wayne, NJ.
8	Chiu AM, Chuenkongkaew WL, Cornblath WT, Trobe JD, Digre KB, Dotan SA, Musson KH, Eggenberger ER "Minocycline treatment and pseudotumor cerebri syndrome." Am J Ophthalmol 126 (1998): 116-21. [PMID: 9683157]
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10	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
11	Lee AG "Pseudotumor cerebri after treatment with tetracycline and isotretinoin for acne." Cutis 55 (1995): 165-8. [PMID: 7634848]
12	Product Information. Accutane (isotretinoin). Roche Laboratories, Nutley, NJ.
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16	Roytman M, Frumkin A, Bohn TG "Pseudotumor cerebri caused by isotretinoin." Cutis 42 (1988): 399-400. [PMID: 2973971]
17	Product Information. Soriatane (acitretin). Roche Laboratories, Nutley, NJ.
18	Delaney RA, Narayanaswamy TR "Pseudo-tumor cerebri and acne." Mil Med 155 (1990): 511. [PMID: 2146526]
19	Moskowitz Y, Leibowitz E, Ronen M, Aviel E "Pseudotumor cerebri induced by vitamin A combined with minocycline." Ann Ophthalmol 25 (1993): 306-8. [PMID: 8239326]
20	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
21	Weese-Mayer DE, Yang RJ, Mayer JR, Zaparackas Z "Minocycline and Pseudotumor cerebri: The well-known but well-kept secret." Pediatrics 108 (2001): 519-20. [PMID: 11491116]
22	Product Information. Vesanoid (tretinoin). Roche Laboratories, Nutley, NJ.
23	Schmitt K, Schwarz R, Tulzer G, Krieger O, Zoubek A, Gadner H "Toxicity of tretinoin in acute promyelocytic leukaemia." Lancet 343 (1994): 361. [PMID: 7905174]
24	Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
25	Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.
26	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
27	Product Information. Xerava (eravacycline). Tetraphase Pharmaceuticals, Inc, Watertown, MA.
28	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
29	UK government "Typhoid.".
30	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
31	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
32	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
33	Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
34	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
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38	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
39	Multum Information Services, Inc. Expert Review Panel.
40	Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
41	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
42	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
43	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
44	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
45	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
46	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
47	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
48	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
49	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.

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