Details of Drug

Details of Drug

 Drug General Information (ID: D0583)
  Drug Name
Epinephrine (topical)
  Drug Type Small molecule
  Drug Synonymous
ADROP; Adnephrine; Adrenal; Adrenalin; Adrenalina; Adrenaline; Adrenalinum; Adrenamine; Adrenan; Adrenapax; Adrenasol; Adrenatrate; Adrenine; Adrenodis; Adrenohorma; Adrenosan; Adrenutol; Adrin; Adrine; Antiasthmatique; Asthmanefrin; Astmahalin; Astminhal; Balmadren; Bernarenin; Biorenine; Bosmin; Brevirenin; Bronkaid; Chelafrin; Corisol; Drenamist; Dylephrin; Epifrin; Epiglaufrin; Epinefrin; Epinefrina; Epinephran; Epinephrin; Epinephrinum; Epipen; Epirenamine; Epirenan; Epirenin; Epitrate; Eppy; Esphygmogenina; Exadrin; Glaucon; Glaucosan; Glauposine; Glycirenan; Haemostasin; Haemostatin; Hektalin; Hemisine; Hemostasin; Hemostatin; Hypernephrin; Hyporenin; IOP; Intranefrin; Iontocaine; Isoptoepinal; Kidoline; Levoadrenaline; Levoepinephrine; Levorenen; Levorenin; Levorenine; Lyophrin; Metanephrin; Methylaminoethanolcatechol; Methylarterenol; Micronefrin; Micronephrine; Mucidrina; Myosthenine; Mytrate; Nephridine; Nieraline; Paranephrin; Primatene; Racepinephrine; Renagladin; Renaglandin; Renaglandulin; Renaleptine; Renalina; Renoform; Renostypricin; Renostypticin; Renostyptin; Scurenaline; Septocaine; Simplene; Sindrenina; Soladren; Sphygmogenin; Stryptirenal; Styptirenal; Supracapsulin; Supradin; Supranefran; Supranephrane; Supranephrine; Supranol; Suprarenaline; Suprarenin; Suprel; Surenine; Surrenine; Susphrine; Takamina; Takamine; Tokamina; Tonogen; Twinject; Vaponefrin; Vasoconstrictine; Vasoconstrictor; Vasodrine; Vasoton; Vasotonin; ADR ADRENALINE; Adrenalin in Oil; Adrenalina [DCIT]; Asmatane Mist; Asthma meter mist; Asthmahaler Mist; Bronkaid Mist; Bronkaid Suspension Mist; Bupivacaine Hcl and Epinephrine; Citanest Forte; EPI E Z PEN JR; EPIPEN E Z PEN; EPIPEN JR; Epi EZ Pen Jr; Epinefrin [Czech]; Epinephrine hydrochloride; Epipen EZ Pen; Primatene Mist; Racemic Epinephrine; Sympathin I; Adrenalin (TN); Adrenalin-Medihaler; Adrenaline (JP15); Adrenaline/Epinephrine; Ana-Guard; Asthma-nefrin; D-Adrenaline; D-Epifrin; D-Epinephrine; Dyspne-Inhal; Epinefrina [INN-Spanish]; Epinephrine (USP); Epinephrinum [INN-Latin]; Epipen (TN); Epipen Auto-Injector; Epipen Jr.; L-Adrenalin; L-Adrenaline; L-Adrenaline Base; L-Epinehphrine; L-Epinephine; L-Epirenamine; L-Methylaminoethanolcatechol; L-epinephrine; Levo-Methylaminoethanolcatechol; Medihaler-Epi; R-Adrenaline; Sus-Phrine; Twinject 0.15; Twinject 0.3; Twinject 0.30; Epinephrine (USP/INN); Epinephrine [USAN:INN:JAN]; Epipen Jr. Auto-Injector; L-Epinephrine (synthetic); SUS-PHRINE SULFITE-FREE; R-(-)-Epinephrine; L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; (-)-(R)-Epinephrine; (-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol; (-)-Adrenalin; (-)-Adrenaline; (-)-R-Epinephrine; (R)-(-)-Adnephrine; (R)-(-)-Adrenaline; (R)-(-)-Epinephrine; (R)-(-)-Epirenamine; (R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; (R)-Adrenaline; (R)-Epinephrine; 1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; 1-Adrenalin; 1-Epinephrine; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; 4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol; 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
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  Disease Class 4A80-4A8Z: Allergic/hypersensitivity disorder
  Therapeutic Class Vasoconstrictor Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C9H13NO3
  InChI 1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
  InChIKey UCTWMZQNUQWSLP-VIFPVBQESA-N
  Canonical SMILES CNCC(C1=CC(=C(C=C1)O)O)O
  External Link
Pubchem ID 5816
CAS Number 51-43-4
CHEBI ID 28918
TTD ID D04PHC

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM018  Non-CYP450 enzyme inhibition
BM041  Additive hypertensive effects
BM078  Increased risk of rapid heart rate
  Relation Graph
 Full list of drugs interacting with Epinephrine (topical)
      Affected intra/extra-hepatic metabolism
   Non-CYP450 enzyme inhibition Drug Num:  13
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0575
 
Entacapone
 
C14H15N3O5
 
5281081 
Moderate    Inter Info   
[11], [12], [13]
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Moderate    Inter Info   
[18], [19], [20]
D1036
 
Methylene blue
 
C16H18ClN3S
 
6099 
Moderate    Inter Info   
[18], [19], [20]
D1182
 
Opicapone
 
C15H10Cl2N4O6
 
135565903 
Moderate    Inter Info   
[11], [12], [13]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[18], [19], [20]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Moderate    Inter Info   
[18], [19], [20]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Moderate    Inter Info   
[18], [19], [20]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[18], [19], [20]
D1437
 
Safinamide
 
C17H19FN2O2
 
131682 
Moderate    Inter Info   
[18], [19], [23]
D1455
 
Selegiline
 
C13H17N
 
26757 
Moderate    Inter Info   
[18], [19], [20]
D1620
 
Tranylcypromine
 
C9H11N
 
19493 
Moderate    Inter Info   
[18], [19], [20]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Moderate    Inter Info   
[18], [19], [20]
D1604
 
Tolcapone
 
C14H11NO5
 
4659569 
Moderate    Inter Info   
[11], [12], [13]
      Pharmacodynamic additive effects
   Additive hypertensive effects Drug Num:  33
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0494
 
Dihydroergotamine
 
C33H37N5O5
 
10531 
Major    Inter Info   
[1], [2], [3]
D0377
 
Cocaine (nasal)
 
C17H21NO4
 
446220 
Major    Inter Info   
[4], [5], [6]
D0378
 
Cocaine (topical)
 
C17H21NO4
 
446220 
Major    Inter Info   
[4], [5], [6]
D0592
 
Ergometrine
 
C19H23N3O2
 
443884 
Major    Inter Info   
[1], [3], [7]
D0593
 
Ergotamine
 
C33H35N5O5
 
8223 
Major    Inter Info   
[1], [3], [7]
D1037
 
Methylergometrine
 
C20H25N3O2
 
8226 
Major    Inter Info   
[1], [3], [7]
D1043
 
Methysergide
 
C21H27N3O2
 
9681 
Major    Inter Info   
[1], [3], [7]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Moderate    Inter Info   
[8], [9], [10]
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Moderate    Inter Info   
[14], [15], [16]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Moderate    Inter Info   
[8], [9], [10]
D0538
 
Droxidopa
 
C9H11NO5
 
92974 
Moderate    Inter Info   
[17]
D0691
 
Formoterol
 
C19H24N2O4
 
3410 
Moderate    Inter Info   
[14], [15], [16]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Moderate    Inter Info   
[14], [15], [16]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Moderate    Inter Info   
[14], [15], [16]
D0879
 
Ketamine
 
C13H16ClNO
 
3821 
Moderate    Inter Info   
[21], [4], [22]
D0920
 
Levomilnacipran
 
C15H22N2O
 
6917779 
Moderate    Inter Info   
[8], [9], [10]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Moderate    Inter Info   
[14], [15], [16]
D1066
 
Milnacipran
 
C15H22N2O
 
65833 
Moderate    Inter Info   
[8], [9], [10]
D1171
 
Olodaterol
 
C21H26N2O5
 
11504295 
Moderate    Inter Info   
[14], [15], [16]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Moderate    Inter Info   
[14], [15], [16]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Moderate    Inter Info   
[14], [15], [16]
D1374
 
Racepinephrine
 
C9H13NO3
 
838 
Moderate    Inter Info   
[14], [15], [16]
D1414
 
Ritodrine
 
C17H21NO3
 
33572 
Moderate    Inter Info   
[14], [15], [16]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[14], [15], [16]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[14], [15], [16]
D1464
 
Sibutramine
 
C17H26ClN
 
5210 
Moderate    Inter Info   
[24], [25], [26]
D1492
 
Solriamfetol
 
C10H14N2O2
 
10130337 
Moderate    Inter Info   
[27]
D1535
 
Tapentadol
 
C14H23NO
 
9838022 
Moderate    Inter Info   
[8], [9], [10]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Moderate    Inter Info   
[14], [15], [16]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Moderate    Inter Info   
[14], [15], [16]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Moderate    Inter Info   
[14], [15], [16]
D1061
 
Midodrine
 
C12H18N2O4
 
4195 
Moderate    Inter Info   
[4], [7]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Moderate    Inter Info   
[8], [9], [10]
References
1 Barthel W, Glusa E, Koth W "Interactions of dihydroergotamine with etilefrine in human leg veins in vitro and in situ." Int J Clin Pharmacol Ther Toxicol 25 (1987): 63-9. [PMID: 2881898]
2 Buchanan N, Cane RD, Miller M "Symmetrical gangrene of the extremities associated with the use of dopamine subsequent to ergometrine administration." Intensive Care Med 3 (1977): 55-6. [PMID: 561121]
3 Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
4 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5 Thevasagyam M, Jindal M, Allsop P, Oates J "Does epinephrine infiltration in septoplasty make any difference?" Eur Arch Otorhinolaryngol 264 (2007): 1175-8.[PMID: 17530270]
6 Product Information. Cocaine Hydrochloride (cocaine topical). Mallinckrodt Medical Inc, St. Louis, MO.
7 Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
8 Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
9 Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
10 Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
11 Illi A, Sundberg S, Ojala-Karlsson P, Korhonen P, Scheinin M, Gordin A "The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine." Clin Pharmacol Ther 58 (1995): 221-7. [PMID: 7648772]
12 Product Information. Comtan (entacapone) Novartis Pharmaceuticals, East Hanover, NJ.
13 Product Information. Tasmar (tolcapone). Valeant Pharmaceuticals, Costa Mesa, CA.
14 Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
15 Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
16 Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
17 Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
18 Cusson JR, Goldenberg E, Larochelle P "Effect of a novel monoamine-oxidase inhibitor, moclobemide on the sensitivity to intravenous tyramine and norepinephrine in humans." J Clin Pharmacol 31 (1991): 462-7. [PMID: 2050833]
19 Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
20 Thompson DS, Sweet RA, Marzula K, Peredes JC "Lack of interaction of monoamine oxidase inhibitors and epinephrine in an older patient." J Clin Psychopharmacol 17 (1997): 322-3. [PMID: 9241014]
21 Cerner Multum, Inc. "Australian Product Information.".
22 Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
23 Product Information. Xadago (safinamide). US WorldMeds LLC, Louisville , KY.
24 Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
25 Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
26 Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
27 Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.