Details of Drug

Drug General Information (ID: D0571)
Drug Name		Enfortumab vedotin
Drug Type		Monoclonal antibody
Drug Synonymous		DB13007; Enfortumab vedotin; enfortumab vedotin-ejfv Click to Show/Hide
Therapeutic Class		Antineoplastics

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM074 Increased risk of peripheral neuropathy BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Enfortumab vedotin
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[7], [8], [9], [10]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[7], [8], [9], [10]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[7], [8], [9], [10]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[7], [8], [9], [10]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[7], [8], [9], [10]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[7], [8], [9], [10]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[7], [8], [9], [10]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[7], [8], [9], [10]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[7], [8], [9], [10]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[7], [8], [9], [10]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[7], [8], [9], [10]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[7], [8], [9], [10]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[7], [8], [9], [10]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[7], [8], [9], [10]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[7], [8], [9], [10]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[7], [8], [9], [10]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[7], [8], [9], [10]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[7], [8], [9], [10]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[7], [8], [9], [10]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[7], [8], [9], [10]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[7], [8], [9], [10]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[7], [8], [9], [10]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[7], [8], [9], [10]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[7], [8], [9]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[7], [8], [9], [10]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[7], [8], [9], [10]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[7], [8], [9], [10]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[7], [8], [9]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[7], [8], [9], [10]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[7], [8], [9], [10]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[7], [8], [9], [10]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[7], [8], [9], [10]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[7], [8], [9], [10]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[7], [8], [9], [10]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[7], [8], [9], [10]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[7], [8], [9], [10]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[7], [8], [9]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[7], [8], [9], [10]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[7], [8], [9], [10]
	CYP450 enzyme induction					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Minor		Inter Info	[7], [8], [9], [10]
D0255		Carbamazepine	C15H12N2O	2554	Minor		Inter Info	[7], [8], [9], [10]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Minor		Inter Info	[7], [8], [9], [10]
D0697		Fosphenytoin	C16H15N2O6P	56339	Minor		Inter Info	[7], [8], [9], [10]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Minor		Inter Info	[8], [9], [10]
D1078		Mitotane	C14H10Cl4	4211	Minor		Inter Info	[7], [8], [9], [10]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[7], [8], [9], [10]
D1283		Phenytoin	C15H12N2O2	1775	Minor		Inter Info	[7], [8], [9], [10]
D1340		Primidone	C12H14N2O2	4909	Minor		Inter Info	[7], [8], [9], [10]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[8], [9], [10]
D1401		Rifapentine	C47H64N4O12	135403821	Minor		Inter Info	[7], [8], [9], [10]
D1502		St. John's Wort	NA	NA	Minor		Inter Info	[7], [8], [9], [10]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[14], [7], [15]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [16]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[24]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[25]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[26], [27]
D1111		Natalizumab	NA	NA	Major		Inter Info	[28]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [29]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[14], [31]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[26], [27]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[32]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[21], [36], [37]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[42], [43], [44]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[14], [7]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[42], [43], [44]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[54]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[55]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[56]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[55]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[55]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[73]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[74]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [75]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[76]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[79]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[42], [43], [44]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [80]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[81]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[14], [7], [82]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[84]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[85]
	Additive myelosuppressive effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[7], [17], [18]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[14], [19], [20]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[30]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[38]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[14], [7], [70], [71]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[14], [7], [70], [71]
	Increased risk of peripheral neuropathy					Drug Num: 74
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[39], [40], [41]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[39], [40], [41]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[39], [40], [41]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[39], [40], [41]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[39], [40], [41]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[47], [48], [49]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[39], [9], [50]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[39], [40], [41]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[39], [40], [41]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[39], [40], [41]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[39], [40], [41]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[39], [40], [41]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[39], [40], [41]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[39], [40], [41]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[39], [40], [41]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[39], [40], [41]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[39], [40], [41]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[39], [40], [41]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[39], [40], [41]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[39], [40], [41]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[39], [40], [41]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[39], [40], [41]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[39], [40], [41]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[39], [40], [41]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[39], [40], [41]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[39], [40], [41]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[39], [40], [41]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[39], [40], [41]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[39], [40], [41]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[39], [40], [41]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[39], [40], [41]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[39], [40], [41]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[39], [40], [41]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[39], [40], [41]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[39], [40], [41]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[39], [40], [41]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[39], [40], [41]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[39], [40], [41]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[39], [40], [41]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[39], [40], [41]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[39], [40], [41]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[39], [40], [41]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[39], [40], [41]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[39], [40], [41]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[39], [40], [41]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[39], [40], [41]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[39], [40], [41]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[39], [40], [41]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[39], [40], [41]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[39], [40], [41]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[39], [40], [41]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[39], [40], [41]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[39], [40], [41]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[39], [40], [41]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[39], [40], [41]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[39], [40], [41]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[39], [40], [41]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[39], [40], [41]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[39], [40], [41]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[39], [40], [41]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[39], [40], [41]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[39], [40], [41]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[39], [40], [41]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[47], [14], [7], [83]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[39], [40], [41]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[39], [40], [41]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[39], [40], [41]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[39], [40], [41]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[39], [40], [41]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[39], [40], [41]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[39], [40], [41]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[39], [40], [41]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[39], [40], [41]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[47], [86]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 42
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[33], [34], [35]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[33], [34], [35]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[33], [34], [35]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[33], [34], [35]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[33], [34], [35]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[33], [34], [35]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[33], [34], [35]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[33], [34], [35]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[33], [34], [35]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[33], [34], [35]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[33], [34], [35]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[33], [34], [35]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[33], [34], [35]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[33], [34], [35]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[33], [34], [35]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[33], [34], [35]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[33], [34], [35]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[33], [34], [35]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[33], [34], [35]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[33], [34], [35]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[33], [34], [35]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[33], [34], [35]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[33], [34], [35]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[33], [34], [35]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[33], [34], [35]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[33], [34], [35]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[33], [34], [35]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[33], [34], [35]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[33], [34], [35]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[33], [34], [35]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[33], [34], [35]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[33], [34], [35]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[33], [34], [35]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[33], [34], [35]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[33], [34], [35]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[33], [34], [35]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[33], [34], [35]
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[33], [34], [35]
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[11], [12], [13]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[21], [14], [22]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[23]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[11], [12], [13]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[11], [12], [13]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[11], [12], [13]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[11], [12], [13]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[11], [12], [13]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[11], [12], [13]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[11], [12], [13]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[21], [45], [46]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[21], [45], [46]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[21], [45], [46]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[21], [45], [46]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[21], [45], [46]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[60], [21], [14], [61], [62], [63], [45], [64], [65], [66], [46]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[21], [45], [46]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[21], [45], [46]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[21], [45], [46]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[21], [45], [46]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[21], [45], [46]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[72]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[21], [45], [46]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[57], [58], [59]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[57], [58], [59]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[51], [52], [53]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[51], [52], [53]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[67], [68], [69]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[77], [78]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[67], [68], [69]

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