Details of Drug

Drug General Information (ID: D0559)
Drug Name	Eliglustat
Drug Type	Small molecule
Drug Synonymous	ELIGLUSTAT; 491833-29-5; Genz 99067; Genz-99067; GENZ-112638; UNII-DR40J4WA67; Eliglustat free base; N-((1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl)octanamide; DR40J4WA67; CHEBI:82752; 491833-29-5 (free base); MFCD19443735; N-[(1r,2r)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide; Eliglustat (Tartrate); Eliglustat [USAN:INN]; Eliglustat (USAN/INN); Eliglustat(Genz-99067); Eliglustat; Genz 99067; SCHEMBL421755; GTPL7536; CHEMBL2110588; DTXSID20964175; EX-A2301; s7852; ZINC72267023; AKOS022185521; CA10006; CCG-101413; CS-5424; DB09039; NCGC00509905-01; BS-17368; HY-14885; N-((1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(pyrrolidin-1-ylmethyl)ethyl)octanamide; Octanamide, N-((1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl)-; D09893; F53213; Q21011224; 1000191-50-3; N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1-pyrrolidinyl)-2-propanyl]octanamide; N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]octanamide; N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-7-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide; N-[1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]octanimidic acid Click to Show/Hide
Therapeutic Class	Metabolic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C23H36N2O4
InChI	InChI=1S/C23H36N2O4/c1-2-3-4-5-6-9-22(26)24-19(17-25-12-7-8-13-25)23(27)18-10-11-20-21(16-18)29-15-14-28-20/h10-11,16,19,23,27H,2-9,12-15,17H2,1H3,(H,24,26)/t19-,23-/m1/s1
InChIKey	FJZZPCZKBUKGGU-AUSIDOKSSA-N
Canonical SMILES	CCCCCCCC(=O)N[C@H](CN1CCCC1)[C@@H](C2=CC3=C(C=C2)OCCO3)O
External Link
External Link	Pubchem ID	23652731

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM076 Increased risk of prolong QT interval
Relation Graph

Full list of drugs interacting with Eliglustat
Affected cellular transport
	Transporter inhibition					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[17], [18], [19]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[21]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[5], [23], [24], [25]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[27]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[3], [5], [78], [79]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[5], [80], [81]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[5], [85]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[86], [87]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[89]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[102], [103], [104]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[109]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[4], [5], [110]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[5], [111], [112]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[5], [114]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[115]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[5], [117]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[5], [118]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[119]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[5], [121]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[4], [123]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[124]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[126]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[127], [81]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[102], [129], [103], [104]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[130]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[131]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[137]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[141]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[145]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[4], [146], [5], [147]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[148]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 164
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1], [2]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[1]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[4], [5], [1], [16]
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2]
D0298		Celecoxib	C17H14F3N3O2S	2662	Major		Inter Info	[1], [2]
D0337		Cimetidine	C10H16N6S	2756	Major		Inter Info	[1], [2]
D0338		Cinacalcet	C22H22F3N	156419	Major		Inter Info	[1], [2]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[4], [5], [1], [16]
D0356		Clobazam	C16H13ClN2O2	2789	Major		Inter Info	[1], [2]
D0367		Clotrimazole	C22H17ClN2	2812	Major		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[4], [5], [1], [16]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[1]
D0424		Darifenacin	C28H30N2O2	444031	Major		Inter Info	[1], [2]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[4], [5], [1], [16]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1]
D0502		Diphenhydramine	C17H21NO	3100	Major		Inter Info	[1], [2]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[1], [2]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[22]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[4], [5], [1], [16]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[4], [5], [1], [16]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Major		Inter Info	[1], [2]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1], [2]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[1]
D0724		Givosiran	C78H139N11O30	119058042	Major		Inter Info	[1], [2]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[4], [5], [1], [16]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[1]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[1]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[26], [2]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1]
D1423		Rolapitant	C25H26F6N2O2	10311306	Major		Inter Info	[1], [2]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[1], [2]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[4], [5], [1], [16]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[4], [5], [1], [16]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[4], [5], [28]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1], [2]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[4], [5], [1], [16]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[4], [5], [1], [16]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[4], [5], [1], [16]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[4], [5], [1], [16]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[4], [5], [1], [16]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[1], [2]
D1057		Miconazole	C18H14Cl4N2O	4189	Major		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1]
D1074		Mirabegron	C21H24N4O2S	9865528	Major		Inter Info	[1], [2]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[4], [5], [1], [16]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[4], [5], [1], [16]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[1], [2]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[1], [2]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[3], [4], [5], [30], [31], [2]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[4], [5], [1], [16]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1], [2]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1], [2]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[1], [2]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[4], [5], [1], [16]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[4], [5], [1], [16]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [2], [58], [59], [60], [61], [62], [63], [64], [65]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[4], [5], [1], [16]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[4], [5], [1], [16]
D1553		Terbinafine	C21H25N	1549008	Major		Inter Info	[1], [2]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [2], [76], [77]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[4], [5], [1], [16]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[1]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[4], [5], [1]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[1]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[4], [5], [1]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[4], [5], [1]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[82]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[83], [81], [84]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[1]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[1]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[4], [5], [1]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[88]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[4], [5], [1]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[4], [5], [1]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[4], [5], [1]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[4], [5], [1]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[90], [91], [92], [93], [94], [95], [2], [96], [97], [98], [99], [100], [101]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[4], [5], [1]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[4], [5], [1]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[4], [5], [105], [106], [81], [107]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[4], [5], [1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[108]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[116]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[120]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[1]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[1]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[1]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[5], [2], [122]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[4], [5], [1]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[1]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[4], [5], [1]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[4], [5], [1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[1]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[4], [5], [1]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[1]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[5], [128]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[1]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[4], [5], [1]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[4], [5], [1]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[4], [5], [1]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[4], [5], [1]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[4], [5], [1]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[4], [5], [1]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[4], [5], [1]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[4], [5], [1]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[4], [5], [1]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[4], [5], [1]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[132], [133], [2], [134], [135]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[4], [5], [1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[4], [5], [1]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[4], [5], [1]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[5], [136], [2]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[4], [5], [1]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[4], [5], [1]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[4], [5], [1]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[1]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[4], [5], [1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[4], [5], [1]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[4], [5], [1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[4], [5], [1]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[138], [139], [140]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[4], [5], [1]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[4], [5], [1]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[4], [5], [1]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[1]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[142], [2], [143], [144]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[149], [150], [2]
	CYP450 enzyme induction					Drug Num: 48
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[4], [1]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[4], [1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[4], [1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[4], [1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[4], [1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[4], [1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[4], [1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[4], [1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[4], [1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[4], [1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[4], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[4], [1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[4], [1]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[1]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[4], [113]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[1]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[1]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[1]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[5], [125]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[1]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[1]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[1]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1]
Pharmacodynamic additive effects
	Increased risk of prolong QT interval					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[3], [4], [5], [20]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[3], [4], [5], [29]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]

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