Details of Drug

Drug General Information (ID: D0557)
Drug Name	Eletriptan
Drug Type	Small molecule
Drug Synonymous	Eletriptanum; Relpax; UK 116044; UK116044; Eletriptan (INN); Eletriptan [INN:BAN]; Relpax (TN); UK-116044; UK-116044-04; (R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-Indole; (R)-5-[2-(Benzenesulfonyl)ethyl]-3-[(N-methylpyrrolidin-2-yl)methyl]-1H-indole; 3-(((R)-1-Methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethyl)indole; 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole; 5-[2-(benzenesulfonyl)ethyl]-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indole Click to Show/Hide
Disease Class	8A80: Migraine
Therapeutic Class	Antimigraine Agents
Structure
Structure	3D Structure		2D Structure
Formula	C22H26N2O2S
InChI	1S/C22H26N2O2S/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20/h2-4,7-10,14,16,19,23H,5-6,11-13,15H2,1H3/t19-/m1/s1
InChIKey	PWVXXGRKLHYWKM-LJQANCHMSA-N
Canonical SMILES	CN1CCCC1CC2=CNC3=C2C=C(C=C3)CCS(=O)(=O)C4=CC=CC=C4
External Link
	Pubchem ID	77993
	CAS Number	143322-58-1
	CHEBI ID	50922
	TTD ID	D02DMQ
	VARIDT ID	DR00981

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM046 Additive serotonergic effects BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Eletriptan
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 73
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[103]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[103]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[103]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[103]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[103]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[103]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[103]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[103]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[103]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[103]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[103]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[103]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[103]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[123], [124], [125]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[103]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[103]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[103]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[103]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[103]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[103]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[103]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[103]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[103]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[103]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[103]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[164]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[103]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[103]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[103]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[103]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[103]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[103]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[103]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[103]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[103]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[103]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[103]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[103]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[103]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[188], [189]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[103]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[103]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[103]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[103]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[103]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[103]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[193]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[103]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[103]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[103]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[103]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[103]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[103]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[103]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[103]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[194]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[103]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[103]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[103]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[103]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[103]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[103]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[103]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[103]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[103]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[103]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[103]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[103]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[103]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[103]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[103]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[103]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[103]
	CYP450 enzyme induction					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Moderate		Inter Info	[105], [191]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[192]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[195]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[105], [106], [196], [197]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[106], [198]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[199], [200]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[106], [201]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[105], [106], [204]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[105], [106], [205], [204]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[106], [206]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[105], [106], [204]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[208], [209], [210], [211], [212]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[208], [209], [210], [211], [212]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[202], [203]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[202], [203]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[202], [203]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[165], [166], [167]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[165], [166], [167], [168], [169], [45], [46], [14], [170], [171], [172], [32], [173], [28], [16], [2], [56], [174], [82], [175], [96], [176], [50], [177], [138], [8], [85], [178], [179], [180], [91], [84], [181], [182], [183], [184], [30], [185], [186], [187]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[165], [166], [167], [168], [169], [45], [46], [14], [170], [171], [172], [32], [173], [28], [16], [2], [56], [174], [82], [175], [96], [176], [50], [177], [138], [8], [85], [178], [179], [180], [91], [84], [181], [182], [183], [184], [30], [185], [186], [187]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[165], [166], [167], [168], [169], [45], [46], [14], [170], [171], [172], [32], [173], [28], [16], [2], [56], [174], [82], [175], [96], [176], [50], [177], [138], [8], [85], [178], [179], [180], [91], [84], [181], [182], [183], [184], [30], [185], [186], [187]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[165], [166], [167], [168], [169], [45], [46], [14], [170], [171], [172], [32], [173], [28], [16], [2], [56], [174], [82], [175], [96], [176], [50], [177], [138], [8], [85], [178], [179], [180], [91], [84], [181], [182], [183], [184], [30], [185], [186], [187]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[165], [166], [167]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[165], [166], [167], [168], [169], [45], [46], [14], [170], [171], [172], [32], [173], [28], [16], [2], [56], [174], [82], [175], [96], [176], [50], [177], [138], [8], [85], [178], [179], [180], [91], [84], [181], [182], [183], [184], [30], [185], [186], [187]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[165], [169], [174], [167], [85], [166], [46], [182], [14], [28], [183], [45], [56], [82], [176], [170], [30], [184], [50], [138], [173], [172], [16], [185], [96], [175], [178], [84], [186], [177], [187], [181], [168], [171], [32], [2], [8], [179], [180], [91]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[165], [166], [167], [168], [169], [45], [46], [14], [170], [171], [172], [32], [173], [28], [16], [2], [56], [174], [82], [175], [96], [176], [50], [177], [138], [8], [85], [178], [179], [180], [91], [84], [181], [182], [183], [184], [30], [185], [186], [187]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[165], [166], [167]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[165], [166], [167], [168], [169], [45], [46], [14], [170], [171], [172], [32], [173], [28], [16], [2], [56], [174], [82], [175], [96], [176], [50], [177], [138], [8], [85], [178], [179], [180], [91], [84], [181], [182], [183], [184], [30], [185], [186], [187]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[165], [166], [167], [168], [169], [45], [46], [14], [170], [171], [172], [32], [173], [28], [16], [2], [56], [174], [82], [175], [96], [176], [50], [177], [138], [8], [85], [178], [179], [180], [91], [84], [181], [182], [183], [184], [30], [185], [186], [187]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[165], [166], [167], [168], [169], [45], [46], [14], [170], [171], [172], [32], [173], [28], [16], [2], [56], [174], [82], [175], [96], [176], [50], [177], [138], [8], [85], [178], [179], [180], [91], [84], [181], [182], [183], [184], [30], [185], [186], [187]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[165], [166], [167], [168], [169], [45], [46], [14], [170], [171], [172], [32], [173], [28], [16], [2], [56], [174], [82], [175], [96], [176], [50], [177], [138], [8], [85], [178], [179], [180], [91], [84], [181], [182], [183], [184], [30], [185], [186], [187]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[207]
	Additive hypertensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[190]
	Additive serotonergic effects					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0457		Dexfenfluramine	C12H16F3N	66265	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[104], [105], [106], [107], [108], [109], [110]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[104], [105], [106], [107], [108], [109], [110]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[8], [111], [112], [19], [45], [50], [54], [113], [91]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[114], [115], [116]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[4], [5], [7], [106], [117], [13], [22], [118], [26], [27], [35], [40], [119], [45], [50], [51], [52], [120], [54], [57], [81], [87], [90], [91], [92], [93], [95], [99], [121]
D0952		Lorcaserin	C11H14ClN	11658860	Major		Inter Info	[122]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[8], [111], [112], [19], [45], [50], [54], [113], [91]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [105], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[104], [105], [106], [107], [108], [109], [110]
D1200		Oxitriptan	C11H12N2O3	439280	Major		Inter Info	[10], [58], [60]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[126], [127], [128], [129], [130], [131], [132], [133], [8], [9], [10], [11], [134], [111], [135], [136], [137], [17], [112], [19], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [45], [47], [49], [50], [54], [58], [113], [148], [149], [60], [61], [62], [63], [64], [65], [67], [68], [69], [150], [70], [74], [75], [76], [77], [78], [151], [79], [80], [152], [86], [153], [154], [155], [156], [157], [91], [158], [159], [160], [161], [162], [163]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[104], [105], [106], [107], [108], [109], [110]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[8], [111], [112], [19], [45], [50], [54], [113], [91]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[8], [111], [112], [19], [45], [50], [54], [113], [91]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[8], [21], [23], [31], [45], [50], [54], [71], [91]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[8], [111], [112], [19], [45], [50], [54], [113], [91]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[50], [80], [91]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0041		Almotriptan	C17H25N3O2S	123606	Major		Inter Info	[100], [101], [102]
D0212		Bromocriptine	C32H40BrN5O5	31101	Major		Inter Info	[100], [101], [102]
D0228		Cabergoline	C26H37N5O2	54746	Major		Inter Info	[100], [101], [102]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[100], [101], [102]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[100], [101], [102]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[100], [101], [102]
D0702		Frovatriptan	C14H17N3O	77992	Major		Inter Info	[100], [101], [102]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[100], [101], [102]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[100], [101], [102]
D1110		Naratriptan	C17H25N3O2S	4440	Major		Inter Info	[100], [101], [102]
D1419		Rizatriptan	C15H19N5	5078	Major		Inter Info	[100], [101], [102]
D1521		Sumatriptan	C14H21N3O2S	5358	Major		Inter Info	[100], [101], [102]
D1728		Zolmitriptan	C16H21N3O2	60857	Major		Inter Info	[100], [101], [102]

References
1	Achamallah NS "Visual hallucinations after combining fluoxetine and dextromethorphan ." Am J Psychiatry 149 (1992): 1406. [PMID: 1530079]
2	Ailawadhi S, Sung KW, Carlson LA, Baer MR "Serotonin syndrome caused by interaction between citalopram and fentanyl." J Clin Pharm Ther 32 (2007): 199-202. [PMID: 17381671]
3	Baetz M, Malcolm D "Serotonin syndrome from fluvoxamine and buspirone." Can J Psychiatry 40 (1995): 428-9. [PMID: 8548727]
4	Bergeron L, Boule M, Perreault S "Serotonin toxicity associated with concomitant use of linezolid." Ann Pharmacother 39 (2005): 956-61. [PMID: 15827071]
5	Bernard L, Stern R, Lew D, Hoffmeyer P "Serotonin syndrome after concomitant treatment with linezolid and citalopram." Clin Infect Dis 36 (2003): 1197. [PMID: 12715317]
6	Bhatara VS, Magnus RD, Paul KL, Preskorn SH "Serotonin syndrome induced by venlafaxine and fluoxetine: a case study in polypharmacy and potential pharmacodynamic and pharmacokinetic mechanisms." Ann Pharmacother 32 (1998): 432-6. [PMID: 9562139]
7	Boyer EW, Shannon M "The serotonin syndrome." N Engl J Med 352 (2005): 1112-20. [PMID: 15784664]
8	Chan BSH, Graudins A, Whyte IM, Dawson AH, Braitberg G, Duggin GG "Serotonin syndrome resulting from drug interactions." Med J Aust 169 (1998): 523-5. [PMID: 9861909]
9	Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions. II." J Clin Psychopharmacol 10 (1990): 213-7. [PMID: 2198298]
10	Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions: I. Antidepressants and antipsychotics." J Clin Psychopharmacol 10 (1990): 48-50. [PMID: 1968472]
11	Corkeron MA "Serotonin syndrome - a potentially fatal complication of antidepressant therapy." Med J Aust 163 (1995): 481-2. [PMID: 7476638]
12	Dannawi M "Possible serotonin syndrome after combination of buspirone and St John's Wort." J Psychopharmacol 16 (2002): 401. [PMID: 12503845]
13	DeBellis RJ, Schaefer OP, Liquori M, Volturo GA "Linezolid-associated serotonin syndrome after concomitant treatment with citalopram and mirtazepine in a critically ill bone marrow transplant recipient." J Intensive Care Med 20 (2005): 351-3. [PMID: 16280409]
14	Dougherty JA, Young H, Shafi T "Serotonin syndrome induced by amitriptyline, meperidine, and venlafaxine." Ann Pharmacother 36 (2002): 1647-1648. [PMID: 12243617]
15	Duggal HS, Fetchko J "Serotonin syndrome and atypical antipsychotics." Am J Psychiatry 159 (2002): 672-3. [PMID: 11925312]
16	Egberts AC, ter Borg J, Brodie-Meijer CC "Serotonin syndrome attributed to tramadol addition to paroxetine therapy." Int Clin Psychopharmacol 12 (1997): 181-2. [PMID: 9248876]
17	Fischer P "Serotonin syndrome in the elderly after antidepressive monotherapy." J Clin Psychopharmacol 15 (1995): 440-2. [PMID: 8748434]
18	Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8. [PMID: 10675182]
19	Gardner DM, Lynd LD "Sumatriptan contraindications and the serotonin syndrome." Ann Pharmacother 32 (1998): 33-8. [PMID: 9475817]
20	George TP, Godleski LS "Possible serotonin syndrome with trazodone addition to fluoxetine." Biol Psychiatry 39 (1996): 384-5. [PMID: 8704074]
21	Giese SY, Neborsky R "Serotonin syndrome: potential consequences of Meridia combined with Demerol or fentanyl." Plast Reconstr Surg 107 (2001): 293-4. [PMID: 11176649]
22	Gillman PK "Linezolid and serotonin toxicity." Clin Infect Dis 37 (2003): 1274-5. [PMID: 14557977]
23	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
24	Goldberg RJ, Huk M "Serotonin syndrome from trazodone and buspirone." Psychosomatics 33 (1992): 235-6. [PMID: 1557493]
25	Gordon JB "SSRI's and St. John's Wort: possible toxicity?" Am Fam Physician 57 (1998): 950,953. [PMID: 9518947]
26	Hachem RY, Hicks K, Huen A, Raad I "Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients." Clin Infect Dis 37 (2003): E8-E11. [PMID: 12830431]
27	Hammerness P, Parada H, Abrams A "Linezolid: MAOI Activity and Potential Drug Interactions." Psychosomatics 43 (2002): 248-9. [PMID: 12075044]
28	Hansen TE, Dieter K, Keepers GA "Interaction of fluoxetine and pentazocine." Am J Psychiatry 147 (1990): 949-50. [PMID: 2356884]
29	Harvey AT, Preskorn SH "Interactions of serotonin reuptake inhibitors with tricyclic antidepressants." Arch Gen Psychiatry 52 (1995): 783-4. [PMID: 7654130]
30	Hunter B, Kleinert MM, Osatnik J, Soria E "Serotonergic syndrome and abnormal ocular movements: worsening of rigidity by remifentanil?" Anesth Analg 102 (2006): 1589. [PMID: 16632855]
31	Insel TR, Roy BF, Cohen RM, Murphy DL "Possible development of the serotonin syndrome in man." Am J Psychiatry 139 (1982): 954-5. [PMID: 7091416]
32	Insler SR, Kraenzler EJ, Licina MG, Savage RM, Starr NJ "Cardiac surgery in a patient taking monoamine oxidase inhibitors - an adverse fentanyl reaction." Anesth Analg 78 (1994): 593-7. [PMID: 8109782]
33	Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
34	John L, Perreault MM, Tao T, Blew PG "Serotonin syndrome associated with nefazodone and paroxetine." Ann Emerg Med 29 (1997): 287-9. [PMID: 9018197]
35	Jones SL, Athan E, O'Brien D "Serotonin syndrome due to co-administration of linezolid and venlafaxine." J Antimicrob Chemother 54 (2004): 289-90. [PMID: 15140859]
36	Keegan MT, Brown DR, Rabinstein AA "Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs." Anesth Analg 103 (2006): 1466-8. [PMID: 17122225]
37	Laird LK "Issues in the monopharmacotherapy and polypharmacotherapy of obsessive-compulsive disorder." Psychopharmacol Bull 32 (1996): 569-78. [PMID: 8993077]
38	Lane R, Baldwin D "Selective serotonin reuptake inhibitor--induced serotonin syndrome: review." J Clin Psychopharmacol 17 (1997): 208-21. [PMID: 9169967]
39	Lantz MS, Buchalter E, Giambanco V "St. John's wort and antidepressant drug interactions in the elderly." J Geriatr Psychiatr Neurol 12 (1999): 7-10. [PMID: 10447148]
40	Lavery S, Ravi H, McDaniel WW, Pushkin YR "Linezolid and serotonin syndrome." Psychosomatics 42 (2001): 432-4. [PMID: 11739912]
41	Lee J, Franz L, Goforth HW "Serotonin syndrome in a chronic-pain patient receiving concurrent methadone, ciprofloxacin, and venlafaxine." Psychosomatics 50 (2009): 638-9. [PMID: 19996237]
42	Mackay FJ, Dunn NR, Mann RD "Antidepressants and the serotonin syndrome in general practice." Br J Gen Pract 49 (1999): 871-4. [PMID: 10818650]
43	Manos GH "Possible serotonin syndrome associated with buspirone added to fluoxetine." Ann Pharmacother 34 (2000): 871-4. [PMID: 10928399]
44	Margolese HC, Chouinard G "Serotonin syndrome from addition of low-dose trazodone to nefazodone." Am J Psychiatry 157 (2000): 1022. [PMID: 10831493]
45	Martin TG "Serotonin syndrome." Ann Emerg Med 28 (1996): 520-6. [PMID: 8909274]
46	Mason BJ, Blackburn KH "Possible serotonin syndrome associated with tramadol and sertraline coadministration." Ann Pharmacother 31 (1997): 175-7. [PMID: 9034418]
47	Mathew NT, Tietjen GE, Lucker C "Serotonin syndrome complicating migraine pharmacotherapy." Cephalalgia 16 (1996): 323-7. [PMID: 8869767]
48	Metz A "Interaction between fluoxetine and buspirone." Can J Psychiatry 35 (1990): 722-3. [PMID: 2282624]
49	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
50	Mills KC "Serotonin syndrome: A clinical update." Crit Care Clin 13 (1997): 763. [PMID: 9330840]
51	Morales N, Vermette H "Serotonin syndrome associated with linezolid treatment after discontinuation of fluoxetine." Psychosomatics 46 (2005): 274-5. [PMID: 15883150]
52	Morales-Molina JA, Mateu-de Antonio J, Marin-Casino M, Grau S "Linezolid-associated serotonin syndrome: what we can learn from cases reported so far." J Antimicrob Chemother 56 (2005): 1176-8. [PMID: 16223940]
53	Mugele J, Nanagas KA, Tormoehlen LM "Serotonin Syndrome Associated With MDPV Use: A Case Report." Ann Emerg Med (2012):. [PMID: 22237165]
54	Nierenberg DW, Semprebon M "The central nervous system serotonin syndrome." Clin Pharmacol Ther 53 (1993): 84-8. [PMID: 8257462]
55	Nijhawan PK, Katz G, Winter S "Psychiatric illness and the serotonin syndrome: an emerging adverse drug effect leading to intensive care unit admission." Crit Care Med 24 (1996): 1086-9. [PMID: 8681579]
56	Noble WH, Baker A "MAO inhibitors and coronary artery surgery: a patient death." Can J Anaesth 39 (1992): 1061-6. [PMID: 1464133]
57	Packer S, Berman SA "Serotonin syndrome precipitated by the monoamine oxidase inhibitor linezolid." Am J Psychiatry 164 (2007): 346-7. [PMID: 17267801]
58	Paruchuri P, Godkar D, Anandacoomarswamy D, Sheth K, Niranjan S "Rare case of serotonin syndrome with therapeutic doses of paroxetine." Am J Ther 13 (2006): 550-552. [PMID: 17122538]
59	Perry NK "Venlafaxine-induced serotonin syndrome with relapse following amitriptyline." Postgrad Med J 76 (2000): 254-6. [PMID: 10727586]
60	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
61	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
62	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
63	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
64	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
65	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
66	Product Information. Flexeril (cyclobenzaprine). Merck & Co, Inc, West Point, PA.
67	Product Information. Imitrex (sumatriptan). Glaxo Wellcome, Research Triangle Park, NC.
68	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
69	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
70	Product Information. Maxalt (rizatriptan). Merck & Co, Inc, West Point, PA.
71	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
72	Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
73	Product Information. Oleptro (traZODone). Labopharm Inc, Laval, AL.
74	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
75	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
76	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
77	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
78	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
79	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
80	Product Information. Zomig (zolmitriptan). Zeneca Pharmaceuticals, Wilmington, DE.
81	Product Information. Zyvox (linezolid) Pharmacia and Upjohn, Kalamazoo, MI.
82	Rang ST, Field J, Irving C "Serotonin toxicity caused by an interaction between fentanyl and paroxetine." Can J Anaesth 55 (2008): 521-5. [PMID: 18676387]
83	Reeves RR, Bullen JA "Serotonin syndrome produced by paroxetine and low-dose trazodone." Psychosomatics 36 (1995): 159-60. [PMID: 7724720]
84	Rosebraugh CJ, floxkhart DA, Yasuda SU, Woosley RL "Visual hallucination and tremor induced by sertraline and oxycodone in a bone marrow transplant patient." J Clin Pharmacol 41 (2001): 224-7. [PMID: 11210406]
85	Roy S, Fortier LP "Fentanyl-induced rigidity during emergence from general anesthesia potentiated by venlafexine." Can J Anaesth 50 (2003): 32-5. [PMID: 12514147]
86	Ruiz F "Fluoxetine and the serotonin syndrome." Ann Emerg Med 24 (1994): 983-5. [PMID: 7978579]
87	Shapiro RE, Tepper SJ "The serotonin syndrome, triptans, and the potential for drug-drug interactions." Headache 47 (2007): 266-9. [PMID: 17300366]
88	Skop BP, Finkelstein JA, Mareth TR, Magoon MR, Brown TM "The serotonin syndrome associated wtih paroxetine, an over-the-counter cold remedy, and vascular disease." Am J Emerg Med 12 (1994): 642-4. [PMID: 7945606]
89	Smith DL, Wenegrat BG "A case report of serotonin syndrome associated with combined nefazodone and fluoxetine." J Clin Psychiatry 61 (2000): 146. [PMID: 10732666]
90	Steinberg M, Morin AK "Mild serotonin syndrome associated with concurrent linezolid and fluoxetine." Am J Health Syst Pharm 64 (2007): 59-62. [PMID: 17189581]
91	Sternbach H "The serotonin syndrome." Am J Psychiatry 148 (1991): 705-13. [PMID: 2035713]
92	Strouse TB, Kerrihard TN, Forscher CA, Zakowski P "Serotonin syndrome precipitated by linezolid in a medically ill patient on duloxetine." J Clin Psychopharmacol 26 (2006): 681-683. [PMID: 17110838]
93	Tahir N "Serotonin syndrome as a consequence of drug-resistant infections: an interaction between linezolid and citalopram." J Am Med Dir Assoc 5 (2004): 111-3. [PMID: 14984623]
94	Taylor JJ, Wilson JW, Estes LL "Linezolid and serotonergic drug interactions: a retrospective survey." Clin Infect Dis 43 (2006): 180-7. [PMID: 16779744]
95	Thomas CR, Rosenberg M, Blythe V, Meyer WJ 3rd "Serotonin syndrome and linezolid." J Am Acad Child Adolesc Psychiatry 43 (2004): 790. [PMID: 15213578]
96	Tissot TA "Probable meperidine-induced serotonin syndrome in a patient with a history of fluoxetine use." Anesthesiology 98 (2003): 1511-1512. [PMID: 12766667]
97	Turkel SB, Nadala JG, Wincor MZ "Possible serotonin syndrome in association with 5-HT3 antagonist agents." Psychosomatics 42 (2001): 258-60. [PMID: 11351116]
98	Weiner AL "Meperidine as a potential cause of serotonin syndrome in the emergency department." Acad Emerg Med 6 (1999): 156-8. [PMID: 10051909]
99	Wigen CL, Goetz MB "Serotonin syndrome and linezolid." Clin Infect Dis 34 (2002): 1651-2. [PMID: 12032904]
100	Product Information. Axert (almotriptan) Pharmacia and Upjohn, Kalamazoo, MI.
101	Product Information. Parlodel (bromocriptine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
102	Product Information. Maxalt (rizatriptan). Merck &amp Co, Inc, West Point, PA.
103	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
104	Canadian Pharmacists Association.
105	Cerner Multum, Inc. "Australian Product Information.".
106	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
107	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
108	Product Information. Aloxi (palonosetron). MGI Pharma Inc, Minnetonka, MN.
109	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
110	Product Information. Sancuso (granisetron). ProStrakan Group, Bedminster, NJ.
111	De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5. [PMID: 4379192]
112	Fleishaker JC, Ryan KK, Jansat JM, et al. "Effect of MAO-A inhibition on the pharmacokinetics of almotriptan, an antimigraine agent in humans." Br J Clin Pharmacol 51 (2001): 437-41. [PMID: 11422001]
113	Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7. [PMID: 5655478]
114	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
115	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
116	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
117	Clark DB, Andrus MR, Byrd DC "Drug interactions between linezolid and selective serotonin reuptake inhibitors: case report involving sertraline and review of the literature." Pharmacotherapy 26 (2006): 269-76. [PMID: 16466332]
118	Go AC, Golightly LK, Barber GR, Barron MA "Linezolid interaction with serotonin reuptake inhibitors: report of two cases and incidence assessment." Drug Metabol Drug Interact 25(1-4) (2010): 41-7. [PMID: 21417793]
119	Lorenz RA, Vandenberg AM, Canepa EA "Serotonergic antidepressants and linezolid: a retrospective chart review and presentation of cases." Int J Psychiatry Med 38 (2008): 81-90. [PMID: 18624020]
120	Morrison EK, Rowe AS "Probable drug-drug interaction leading to serotonin syndrome in a patient treated with concomitant buspirone and linezolid in the setting of therapeutic hypothermia." J Clin Pharm Ther 37 (2012): 610-3. [PMID: 22452676]
121	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Serious CNS reactions possible when linezolid (Ayvox) is given to patients taking certain psychiatric medications.".
122	Product Information. Belviq (lorcaserin). Eisai Inc, Teaneck, NJ.
123	He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7. [PMID: 9918590]
124	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
125	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
126	Alvine G, Black DW, Tsuang D "Case of delirium secondary to phenelzine/L-tryptophan combination." J Clin Psychiatry 51 (1990): 311. [PMID: 2365671]
127	Beasley CM Jr, Masica DN, Heiligenstein JH, Wheadon DE, Zerbe RL "Possible monoamine oxidase inhibitor-serotonin uptake inhibitor interaction: fluoxetine clinical data and preclinical findings." J Clin Psychopharmacol 13 (1993): 312-20. [PMID: 8227489]
128	Bem JL, Peck R "Dextromethorphan. An overview of safety issues." Drug Saf 7 (1992): 190-9. [PMID: 1503667]
129	Bhatara VS, Bandettini FC "Possible interaction between sertraline and tranylcypromine." Clin Pharm 12 (1993): 222-5. [PMID: 8491079]
130	Bodner RA, Lynch T, Lewis L, Kahn D "Serotonin syndrome." Neurology 45 (1995): 219-23. [PMID: 7854515]
131	Brannan SK, Talley BJ, Bowden CL "Sertraline and isocarboxazid cause a serotonin syndrome." J Clin Psychopharmacol 14 (1994): 144-5. [PMID: 8195456]
132	Brubacher JR, Hoffman RS, Lurin MJ "Serotonin syndrome from venlafaxine-tranylcypromine interaction." Vet Hum Toxicol 38 (1996): 358-61. [PMID: 8888541]
133	Cetaruk EW, Aaron CK "Hazards of nonprescription medications." Emerg Med Clin North Am 12 (1994): 483-510. [PMID: 8187693]
134	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
135	Diamond S "The use of sumatriptan in patients on monoamine oxidase inhibitors." Neurology 45 (1995): 1039-40. [PMID: 7783861]
136	Diamond S, Pepper BJ, Diamond ML, Freitag FG, Urban GJ, Erdemoglu AK "Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: four patient reports." Neurology 51 (1998): 274-6. [PMID: 9674820]
137	Feighner JP, Boyer WF, Tyler DL, Neborsky RJ "Adverse consequences of fluoxetine-MAOI combination therapy." J Clin Psychiatry 51 (1990): 222-5. [PMID: 2347858]
138	Gillman PK "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity." Br J Anaesth (2005):. [PMID: 16051647]
139	Graber MA, Hoehns TB, Perry PJ "Sertraline-phenelzine drug interaction: a serotonin syndrome reaction." Ann Pharmacother 28 (1994): 732-5. [PMID: 7919561]
140	Graham PM, Ilett KF "Danger of MAOI therapy after fluoxetine withdrawal." Lancet 2 (1988): 1255-6. [PMID: 2903989]
141	Graham PM, Potter JM, Paterson J "Combination monoamine oxidase inhibitor/tricyclic antidepressants interaction." Lancet 2 (1982): 440. [PMID: 6124828]
142	Heisler MA, Guidry JR, Arnecke B "Serotonin syndrome induced by administration of venlafaxine and phenelzine." Ann Pharmacother 30 (1996): 84. [PMID: 8773172]
143	Jacob JE, Wagner ML, Sage JI "Safety of selegiline with cold medications." Ann Pharmacother 37 (2003): 438-41. [PMID: 12639177]
144	Jimenez-Genchi A "Immediate switching from moclobemide to duloxetine may induce serotonin syndrome." J Clin Psychiatry 67 (2006): 1821-1822. [PMID: 17196070]
145	Kline SS, Mauro LS, Scala-Bennett DM, Zick D "Serotonin syndrome versus neuroleptic malignant death syndrome as a cause of death." Clin Pharm 8 (1989): 510-4. [PMID: 2568897]
146	Klysner R, Larsen JK, Sorensen P, Hyllested M, Pedersen BD "Toxic interaction of venlafaxine and isocarboxazide." Lancet 346 (1995): 1298-9. [PMID: 7475741]
147	Levy AB, Bucher P, Votolato N "Myoclonus, hyperreflexia and diaphoresis in patients on phenelzine- tryptophan combination treatment." Can J Psychiatry 30 (1985): 434-6. [PMID: 4063940]
148	Phillips SD, Ringo P "Phenelzine and venlafaxine interaction." Am J Psychiatry 152 (1995): 1400-1. [PMID: 7653704]
149	Pope HG Jr, Jonas JM, Hudson JI, Kafka MP "Toxic reactions to the combination of monoamine oxidase inhibitors and tryptophan." Am J Psychiatry 142 (1985): 491-2. [PMID: 3976924]
150	Product Information. Manerix (moclobemide). Hoffmann-La Roche Limited, Mississauga, IA.
151	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
152	Rivers N, Horner B "Possible lethal reaction between nardil and dextromethorphan." Can Med Assoc J 103 (1970): 85. [PMID: 20311659]
153	Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
154	Sovner R, Wolfe J "Interaction between dextromethorphan and monoamine oxidase inhibitor therapy with isocarboxazid ." N Engl J Med 319 (1988): 1671. [PMID: 3200285]
155	Spiker DG, Pugh DD "Combining tricyclic and monoamine oxidase inhibitor antidepressants." Arch Gen Psychiatry 33 (1976): 828-30. [PMID: 942286]
156	Staufenberg EF, Tantam D "Malignant hyperpyrexia syndrome in combined treatment." Br J Psychiatry 154 (1989): 577-8. [PMID: 2590798]
157	Sternbach H "Danger of MAOI therapy after fluoxetine withdrawal." Lancet 2 (1988): 850-1. [PMID: 2902292]
158	Suchowersky O, deVries J "Possible interactions between deprenyl and prozac." Can J Neurol Sci 17 (1990): 352-3. [PMID: 2119870]
159	Suchowersky O, deVries JD "Interaction of fluoxetine and selegiline." Can J Psychiatry 35 (1990): 571-2. [PMID: 2119876]
160	Thomas JM, Rubin EH "Case report of a toxic reaction from a combination of tryptophan and phenelzine." Am J Psychiatry 141 (1984): 281-3. [PMID: 6691495]
161	Weiner LA, Smythe M, Cisek J "Serotonin syndrome secondary to phenelzine-venlafaxine interaction." Pharmacotherapy 18 (1998): 399-403. [PMID: 9545162]
162	White K, Pistole T, Boyd JL "Combined monoamine oxidase inhibitor-tricyclic antidepressant treatment: a pilot study." Am J Psychiatry 137 (1980): 1422-5. [PMID: 7435677]
163	White K, Simpson G "Combined MAOI-tricyclic antidepressant treatment: a reevaluation." J Clin Psychopharmacol 1 (1981): 264-82. [PMID: 7037873]
164	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
165	Vizcaychipi MP, Walker S, Palazzo M "Serotonin syndrome triggered by tramadol." Br J Anaesth 99 (2007): 919. [PMID: 18006535]
166	Mittino D, Mula M, Monaco F "Serotonin syndrome associated with tramadol-sertraline coadministration." Clin Neuropharmacol 27 (2004): 150-1. [PMID: 15190240]
167	Das PK, Warkentin DI, Hewko R, Forrest DL "Serotonin syndrome after concomitant treatment with linezolid and meperidine." Clin Infect Dis 46 (2008): 264-5. [PMID: 18171260]
168	Gillman PK "Possible serotonin syndrome with moclobemide and pethidine." Med J Aust 162 (1995): 554. [PMID: 7776924]
169	Shakoor M, Ayub S, Ahad A, Ayub Z "Transient serotonin syndrome caused by concurrent use of tramadol and selective serotonin reuptake inhibitor." Am J Case Rep 15 (2014): 562-4. [PMID: 25540831]
170	US Food and Drug Administration (FDA) "FDA Drug Safety Communication: FDA warns about several safety issues with opioid pain medicines requires label changes.".
171	Kesavan S, Sobala GM "Serotonin syndrome with fluoxetine plus tramadol." J R Soc Med 92 (1999): 474-5. [PMID: 10645303]
172	Lange-Asschenfeldt C, Weigmann H, Hiemke C, Mann K "Serotonin syndrome as a result of fluoxetine in a patient with tramadol abuse: plasma level-correlated symptomatology." J Clin Psychopharmacol 22 (2002): 440-1. [PMID: 12172351]
173	Gonzalez-Pinto A, Imaz H, De Heredia JL, Gutierrez M, Mico JA "Mania and tramadol-fluoxetine combination." Am J Psychiatry 158 (2001): 964-5. [PMID: 11384912]
174	Venlafaxine + tramadol: serotonin syndrome. Prescrire Int 13 (2004): 57. [PMID: 15148976]
175	Lantz MS, Buchalter EN, Giambanco V "Serotonin syndrome following the administration of tramadol with paroxetine." Int J Geriatr Psychiatry 13 (1998): 343-5. [PMID: 9658268]
176	Meyer D, Halfin V "Toxicity secondary to meperidine in patients on monoamine oxidase inhibitors: a case report and critical review." J Clin Psychopharmacol 1 (1981): 319-21. [PMID: 7334144]
177	Gnanadesigan N, Espinoza RT, Smith R, Israel M, Reuben DB "Interaction of serotonergic antidepressants and opioid analgesics: Is serotonin syndrome going undetected?" J Am Med Dir Assoc 6 (2005): 265-9. [PMID: 16005413]
178	Abadie D, Rousseau V, Logerot S, Cottin J, Montastruc JL, Montastruc F "Serotonin Syndrome: Analysis of Cases Registered in the French Pharmacovigilance Database." J Clin Psychopharmacol (2015):. [PMID: 26082973]
179	Houlihan DJ "Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine." Ann Pharmacother 38 (2004): 411-3. [PMID: 14970364]
180	Hillman AD, Witenko CJ, Sultan SM, Gala G "Serotonin syndrome caused by fentanyl and methadone in a burn injury." Pharmacotherapy 35 (2015): 112-7. [PMID: 25615513]
181	Davis JJ, Buck NS, Swenson JD, Johnson KB, Greis PE "Serotonin syndrome manifesting as patient movement during total intravenous anesthesia with propofol and remifentanil." J Clin Anesth 25 (2013): 52-4. [PMID: 23391344]
182	Guo SL, Wu TJ, Liu CC, Ng CC, Chien CC, Sun HL "Meperidine-induced serotonin syndrome in a susceptible patient." Br J Anaesth (2009):. [PMID: 19556270]
183	Mateo-Carrasco H, Munoz-Aguilera EM, Garcia-Torrecillas JM, Abu Al-Robb H "Serotonin Syndrome Probably Triggered by a Morphine-Phenelzine Interaction." Pharmacotherapy (2015):. [PMID: 25903219]
184	Kitson R, Carr B "Tramadol and severe serotonin syndrome." Anaesthesia 60 (2005): 934-5. [PMID: 16115263]
185	Zornberg GL, Bodkin JA, Cohen BM "Severe adverse interaction between pethidine and selegiline." Lancet 337 (1991): 246. [PMID: 1670882]
186	Mahlberg R, Kunz D, Sasse J, Kirchheiner J "Serotonin syndrome with tramadol and citalopram." Am J Psychiatry 161 (2004): 1129. [PMID: 15169709]
187	Larson KJ, Wittwer ED, Nicholson WT, Weingarten TN, Price DL, Sprung J "Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy." J Clin Anesth 27 (2015): 247-51. [PMID: 25499271]
188	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
189	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
190	Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
191	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
192	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
193	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
194	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
195	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
196	Product Information. Viramune (nevirapine). Boehringer-Ingelheim, Ridgefield, CT.
197	Product Information. Viramune XR (nevirapine). Boehringer Ingelheim, Ridgefield, CT.
198	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
199	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
200	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
201	Product Information. Banzel (rufinamide). Eisai Inc, Teaneck, NJ.
202	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
203	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
204	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
205	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
206	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
207	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
208	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
209	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
210	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
211	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
212	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]

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