Details of Drug

Details of Drug

 Drug General Information (ID: D0556)
  Drug Name
Elbasvir
  Drug Type Small molecule
  Drug Synonymous
MK 8742; 632L571YDK; MK8742; Elbasvir [USAN:INN]; MK8742; Elbasvir
    Click to Show/Hide
  Disease Class 1D64-1D65: COVID-19
  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C49H55N9O7
  InChI 1S/C49H55N9O7/c1-27(2)41(54-48(61)63-5)45(59)56-20-10-14-37(56)43-50-25-34(52-43)30-17-19-36-32(22-30)23-39-33-18-16-31(24-40(33)65-47(58(36)39)29-12-8-7-9-13-29)35-26-51-44(53-35)38-15-11-21-57(38)46(60)42(28(3)4)55-49(62)64-6/h7-9,12-13,16-19,22-28,37-38,41-42,47H,10-11,14-15,20-21H2,1-6H3,(H,50,52)(H,51,53)(H,54,61)(H,55,62)/t37-,38-,41-,42-,47-/m0/s1
  InChIKey BVAZQCUMNICBAQ-PZHYSIFUSA-N
  Canonical SMILES CC(C)C(C(=O)N1CCCC1C2=NC=C(N2)C3=CC4=C(C=C3)N5C(OC6=C(C5=C4)C=CC(=C6)C7=CN=C(N7)C8CCCN8C(=O)C(C(C)C)NC(=O)OC)C9=CC=CC=C9)NC(=O)OC
  External Link
Pubchem ID 71661251
CAS Number 1370468-36-2
CHEBI ID 132967
TTD ID D0GT5W
INTEDE ID DR0561

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM007  Pharmacodynamic antagonistic effects
BM010  Transporter inhibition
BM022  CYP450 enzyme induction
BM085  Antagonize the effect of antithrombotic agents
  Relation Graph
 Full list of drugs interacting with Elbasvir
      Affected cellular transport
   Transporter inhibition Drug Num:  8
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Major    Inter Info   
[1], [2], [3]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[4], [5]
D0176
 
Betrixaban
 
C23H22ClN5O3
 
10275777 
Moderate    Inter Info   
[10]
D0182
 
Binimetinib
 
C17H15BrF2N4O3
 
10288191 
Moderate    Inter Info   
[4], [7], [11]
D0963
 
Lusutrombopag
 
C29H32Cl2N2O5S
 
49843517 
Moderate    Inter Info   
[12]
D1407
 
Rimegepant
 
C28H28F2N6O3
 
51049968 
Moderate    Inter Info   
[13], [14]
D1532
 
Talazoparib
 
C19H14F2N6O
 
135565082 
Moderate    Inter Info   
[15]
D1663
 
Ubrogepant
 
C29H26F3N5O3
 
68748835 
Moderate    Inter Info   
[16], [17]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme induction Drug Num:  19
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0061
 
Aminoglutethimide
 
C13H16N2O2
 
2145 
Moderate    Inter Info   
[6]
D0071
 
Amobarbital
 
C11H18N2O3
 
2164 
Moderate    Inter Info   
[6]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Moderate    Inter Info   
[6]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[6]
D0555
 
Elagolix
 
C32H30F5N3O5
 
11250647 
Moderate    Inter Info   
[6]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[6]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Moderate    Inter Info   
[6]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[6]
D0741
 
Griseofulvin
 
C17H17ClO6
 
441140 
Moderate    Inter Info   
[6]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[6]
D1050
 
Metreleptin
 
NA
 
NA
Moderate    Inter Info   
[6]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[6]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[6]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Moderate    Inter Info   
[6]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[6]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[6]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[6]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[6]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Moderate    Inter Info   
[6]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antithrombotic agents Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[7], [8], [9]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[7], [8], [9]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[7], [8], [9]
References
1 Ace LN, Jaffe JM, Kunka RL "Effect of food and an antacid on quinidine bioavailability." Biopharm Drug Dispos 4 (1983): 183-90. [PMID: 6882885]
2 Min DI, Ku YM, Geraets DR, Lee HC "Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers." J Clin Pharmacol 36 (1996): 469-76. [PMID: 8739026]
3 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
4 Cerner Multum, Inc. "Australian Product Information.".
5 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
6 Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
7 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
9 Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
10 Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
11 Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
12 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
13 Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
14 Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
15 Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
16 Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
17 Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.