Details of Drug

Details of Drug

 Drug General Information (ID: D0549)
  Drug Name
Edetate calcium disodium anhydrous
  Drug Type Small molecule
  Drug Synonymous
Edetate calcium disodium; Calcium disodium versenate; UNII-5M645317UB; Disodium ((ethylenedinitrilo)tetraacetato)calciate(2-) hydrate; 5M645317UB; 23411-34-9; Edetate calcium disodium [USAN:USP]; Calciate(2-), ((N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycinato))(4-)-N,N',O,O',ON,ON')-, disodium, hydrate, (OC-6-21)-; Calciate (2-), ((N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycinato))(4-)-N,N',O,O',O(sup N),O(sup N)')-, disodium, hydrate, (OC-6-21)-; 50322-16-2
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  Therapeutic Class Chelating Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C10H12CaN2Na2O8
  InChI 1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
  InChIKey SHWNNYZBHZIQQV-UHFFFAOYSA-J
  Canonical SMILES C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Ca+2]
  External Link
Pubchem ID 6093170
CAS Number 62-33-9
CHEBI ID 4757
TTD ID D00PRI

Drug-Drug Interaction Network
  Sunburst Graph
AM005  Affected excretion pathways
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM027  Decreased renal excretion due to nephrotoxicity
BM072  Increased risk of nephrotoxicity
BM089  Antagonize the effect of antihypertensive agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Edetate calcium disodium anhydrous
      Affected excretion pathways
   Decreased renal excretion due to nephrotoxicity Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1389
 
Remdesivir
 
C27H35N6O8P
 
121304016 
Moderate    Inter Info   
[8], [14], [15]
      Pharmacodynamic additive effects
   Increased risk of nephrotoxicity Drug Num:  12
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0335
 
Cidofovir
 
C8H14N3O6P
 
60613 
Major    Inter Info   
[4]
D0472
 
Diatrizoate
 
C11H9I3N2O4
 
2140 
Major    Inter Info   
[5], [6], [7]
D0805
 
Inotersen
 
C230H318N69O121P19S19
 
121492004 
Major    Inter Info   
[8], [9]
D0831
 
Iodipamide
 
C20H14I6N2O6
 
3739 
Major    Inter Info   
[5], [6], [7]
D0832
 
Iodixanol
 
C35H44I6N6O15
 
3724 
Major    Inter Info   
[5], [6], [7]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[5], [6], [7]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[5], [6], [7]
D0836
 
Iopromide
 
C18H24I3N3O8
 
3736 
Major    Inter Info   
[5], [6], [7]
D0837
 
Iothalamic acid
 
C11H9I3N2O4
 
3737 
Major    Inter Info   
[5], [6], [7]
D0838
 
Ioversol
 
C18H24I3N3O9
 
3741 
Major    Inter Info   
[5], [6], [7]
D0839
 
Ioxilan
 
C18H24I3N3O8
 
3743 
Major    Inter Info   
[5], [6], [7]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Moderate    Inter Info   
[13]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0296
 
Ceftriaxone
 
C18H18N8O7S3
 
5479530 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antihypertensive agents Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0069
 
Amlodipine
 
C20H25ClN2O5
 
2162 
Moderate    Inter Info   
[10], [11], [12]
D0170
 
Bepridil
 
C24H34N2O
 
2351 
Moderate    Inter Info   
[10], [11], [12]
D0497
 
Diltiazem
 
C22H26N2O4S
 
39186 
Moderate    Inter Info   
[10], [11], [12]
D0640
 
Felodipine
 
C18H19Cl2NO4
 
3333 
Moderate    Inter Info   
[10], [11], [12]
D0865
 
Isradipine
 
C19H21N3O5
 
3784 
Moderate    Inter Info   
[10], [11], [12]
D0911
 
Levamlodipine
 
C20H25ClN2O5
 
9822750 
Moderate    Inter Info   
[10], [11], [12]
D1130
 
Nicardipine
 
C26H29N3O6
 
4474 
Moderate    Inter Info   
[10], [11], [12]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Moderate    Inter Info   
[10], [11], [12]
D1138
 
Nimodipine
 
C21H26N2O7
 
4497 
Moderate    Inter Info   
[10], [11], [12]
D1141
 
Nisoldipine
 
C20H24N2O6
 
4499 
Moderate    Inter Info   
[10], [11], [12]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Moderate    Inter Info   
[10], [11], [12]
References
1 Product Information. Rocephin (ceftriaxone). Roche Laboratories, Nutley, NJ.
2 Bradley JS, Wassel RT, Lee L, Nambiar S "Intravenous Ceftriaxone and Calcium in the Neonate: Assessing the Risk for Cardiopulmonary Adverse Events." Pediatrics (2009):. [PMID: 19289450]
3 CDER. Center for Drug Evaluation and Research. FDA. U.S. Food and Drug Admninistration "Information for health care professionals: ceftriaxone (marketed as Rocephin and its generics)."
4 Product Information. Vistide (cidofovir). Gilead Sciences, Foster City, CA.
5 Bentley ML, Corwin HL, Dasta J "Drug-induced acute kidney injury in the critically ill adult: recognition and prevention strategies." Crit Care Med 38(6 Suppl) (2010): S169-74. [PMID: 20502171]
6 Dubrovskaya Y, Prasad N, Lee Y, Esaian D, Figueroa DA, Tam VH "Risk factors for nephrotoxicity onset associated with polymyxin B therapy." J Antimicrob Chemother 70 (2015): 1903-7. [PMID: 25652747]
7 Kellum JA, Leblanc M, Venkataraman R "Acute renal failure." BMJ Clin Evid 9 (2008): 2001. [PMID: 19445797]
8 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9 Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
10 Woie L, Storstein L "Successful treatment of suicidal verapamil poisoning with calcium gluconate." Eur Heart J 2 (1981): 239-42
11 Oszko MA, Klutman NE "Use of calcium salts during cardiopulmonary resuscitation for reversing verapamil-associated hypotension." Clin Pharm 6 (1987): 448-9
12 Lipman J, Jardine I, Roos C, Dreosti L "Intravenous calcium chloride as an antidote to verapamil-induced hypotension." Intensive Care Med 8 (1982): 55-7
13 Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
14 European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
15 Gilead Sciences, Inc "About Remdesivir.".