Details of Drug

Drug General Information (ID: D0547)
Drug Name	Econazole (topical)
Drug Type	Small molecule
Drug Synonymous	Ecostatin; Palavale; Pevaryl; Ecostatin Vaginal Ovules; Ecostatin cream; Spectazole cream; SQ 13050; Ecostatin (TN); Gyno-Pevaryl 150; Gyno-pevaryl; Pevaryl (TN); Spectazole (TN); Econazole (USAN/INN); 1-[2,4-Dichloro-.beta.-[(p-chlorobenzyl)oxy]phenethyl]imidazole; 1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1-{2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole Click to Show/Hide
Disease Class	1F2D: Non-dermatophyte superficial dermatomycose; 1F23: Candidosis; 1F28: Dermatophytosis
Therapeutic Class	Antifungal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C18H15Cl3N2O
InChI	1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
InChIKey	LEZWWPYKPKIXLL-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
External Link
	Pubchem ID	3198
	CAS Number	27220-47-9
	CHEBI ID	82873
	TTD ID	D0EV8E
	VARIDT ID	DR00808

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism BM017 CYP450 enzyme inhibition
Relation Graph

Full list of drugs interacting with Econazole (topical)
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[1], [2], [3]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1], [2], [3]

References
1	Lang PG Jr, Leclercq AH "Increase in anticoagulant effect of warfarin in a patient using econazole cream." J Am Acad Dermatol 55(5 Suppl) (2006): S117-9. [PMID: 17052529]
2	Product Information. Spectazole (econazole). Ortho Pharmaceutical Corporation, Raritan, NJ.
3	Wey PF, Petitjeans F, Lions C, Ould-Ahmed M, Escarment J "Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion." Am J Geriatr Pharmacother 6 (2008): 173-7. [PMID: 18775393]