Details of Drug

Drug General Information (ID: D0545)
Drug Name		Echinacea
Drug Type		Natural product
Drug Synonymous		(1S,2S,3S,4R)-1,2,3-trihydroxycyclohexane-1,4-diyl (2E,2'E)bis[3-(3,4-dihydroxyphenyl)acrylate]; 9178AF; CHEMBL1533705; Cynarin (Echinacea)(1,3-Dicaffeoylquinic Acid); ZINC17263722 Click to Show/Hide
Therapeutic Class		Herbal Products

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Echinacea
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 45
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1385		Rasagiline	C12H13N	3052776	Major		Inter Info	[1], [2], [3]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10], [11]
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[12]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[13]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[12]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[14]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[15]
D0231		Caffeine	C8H10N4O2	2519	Moderate		Inter Info	[12]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[12]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[12]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[12]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[12]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[12]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[12]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[12]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[12]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[16], [17], [18], [19]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[12]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[12]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[12]
D0702		Frovatriptan	C14H17N3O	77992	Moderate		Inter Info	[12]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[12]
D0994		Melatonin	C13H16N2O2	896	Moderate		Inter Info	[12]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[12]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[12]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[12]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[12]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[12]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[12]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[12]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[20], [21]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[12]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[12]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[22]
D1405		Riluzole	C8H5F3N2OS	5070	Moderate		Inter Info	[12]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[2], [23], [24]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[12]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[12]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[12]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[25]
D1571		Thiabendazole	C10H7N3S	5430	Moderate		Inter Info	[12]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[12]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[12]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[12]
D1728		Zolmitriptan	C16H21N3O2	60857	Moderate		Inter Info	[2], [26]
	CYP450 enzyme induction					Drug Num: 263
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[1], [12]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[1], [12]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[1], [12]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[1], [12]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[1], [12]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[1], [12]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[1], [12]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1], [12]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[1], [12]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[1], [12]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[1], [12]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[1], [12]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[1], [12]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1], [12]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[1], [12]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[1], [12]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[1], [12]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[1], [12]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[1], [12]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[1], [12]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[1], [12]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[1], [12]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[1], [12]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1], [12]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[1], [12]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[1], [12]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[1], [12]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[1], [12]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[1], [12]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[1], [12]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[1], [12]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[1], [12]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[1], [12]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[1], [12]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[1], [12]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[1], [12]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[1], [12]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[1], [12]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[1], [12]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[1], [12]
D0333		Ciclesonide	C32H44O7	6918155	Moderate		Inter Info	[1], [12]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[1], [12]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[1], [12]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[1], [12]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[1], [12]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[1], [12]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[1], [12]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[1], [12]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[1], [12]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[1], [12]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[1], [12]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[1], [12]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[1], [12]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1], [12]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[1], [12]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[1], [12]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[1], [12]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[1], [12]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1], [12]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[1], [12]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[1], [12]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[1], [12]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1], [12]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[1], [12]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[1], [12]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[1], [12]
D0514		Dolasetron	C19H20N2O3	3033818	Moderate		Inter Info	[1], [12]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[1], [12]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[1], [12]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[1], [12]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1], [12]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[1], [12]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[1], [12]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[1], [12]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[1], [12]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[1], [12]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[1], [12]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[1], [12]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[1], [12]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[1], [12]
D0589		Eravacycline	C27H31FN4O8	54726192	Moderate		Inter Info	[1], [12]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[1], [12]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[1], [12]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[1], [12]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1], [12]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[1], [12]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[1], [12]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[1], [12]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[1], [12]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[1], [12]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[1], [12]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[1], [12]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[1], [12]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[1], [12]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[1], [12]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[1], [12]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[1], [12]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[1], [12]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[1], [12]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[1], [12]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[1], [12]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[1], [12]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[1], [12]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[1], [12]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[1], [12]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Moderate		Inter Info	[1], [12]
D0685		Fluticasone (topical)	C22H27F3O4S	5311101	Moderate		Inter Info	[1], [12]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[1], [12]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[1], [12]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[1], [12]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[1], [12]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[1], [12]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[1], [12]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[1], [12]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[1], [12]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[1], [12]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[1], [12]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[1], [12]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[1], [12]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[1], [12]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[1], [12]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[1], [12]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[1], [12]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[1], [12]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[1], [12]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[1], [12]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[1], [12]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[1], [12]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1], [12]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[1], [12]
D0871		Ivermectin (topical)	C48H74O14	6321424	Moderate		Inter Info	[1], [12]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[1], [12]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[1], [12]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[1], [12]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[1], [12]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1], [12]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[1], [12]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[1], [12]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[1], [12]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[1], [12]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[1], [12]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[1], [12]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[1], [12]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1], [12]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[1], [12]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[1], [12]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[1], [12]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[1], [12]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Moderate		Inter Info	[1], [12]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[1], [12]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[1], [12]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[1], [12]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[1], [12]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[1], [12]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[1], [12]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[1], [12]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[1], [12]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[1], [12]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[1], [12]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[1], [12]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[1], [12]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[1], [12]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[1], [12]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[1], [12]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[1], [12]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[1], [12]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[1], [12]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[1], [12]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1], [12]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[1], [12]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1], [12]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[1], [12]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[1], [12]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[1], [12]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[1], [12]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[1], [12]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[1], [12]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[1], [12]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[1], [12]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[1], [12]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[1], [12]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[1], [12]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[1], [12]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[1], [12]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1], [12]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Moderate		Inter Info	[1], [12]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[1], [12]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[1], [12]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[1], [12]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[1], [12]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[1], [12]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[1], [12]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[1], [12]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1], [12]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[1], [12]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[1], [12]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1], [12]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[1], [12]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Moderate		Inter Info	[1], [12]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[1], [12]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[1], [12]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[1], [12]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[1], [12]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[1], [12]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[1], [12]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[1], [12]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1], [12]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[1], [12]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[1], [12]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[1], [12]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[1], [12]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[1], [12]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[1], [12]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[1], [12]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[1], [12]
D1474		Siponimod	C29H35F3N2O3	44599207	Moderate		Inter Info	[1], [12]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[1], [12]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[1], [12]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[1], [12]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[1], [12]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[1], [12]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1], [12]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[1], [12]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[1], [12]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[1], [12]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[1], [12]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1], [12]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[1], [12]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[1], [12]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1], [12]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[1], [12]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[1], [12]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1], [12]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[1], [12]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[1], [12]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[1], [12]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[1], [12]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[1], [12]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[1], [12]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1], [12]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[1], [12]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[1], [12]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[1], [12]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1], [12]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[1], [12]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[1], [12]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[1], [12]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[1], [12]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[1], [12]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[1], [12]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1], [12]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[1], [12]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[1], [12]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[1], [12]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[1], [12]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[1], [12]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[1], [12]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[1], [12]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[1], [12]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[1], [12]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[1], [12]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[1], [12]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[1], [12]
Pharmacodynamic antagonistic effects
	Antagonize the effects of immunosuppressants					Drug Num: 59
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0004		Abatacept	NA	NA	Minor		Inter Info	[27], [28], [29]
D0023		Adalimumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0032		Alefacept	NA	NA	Minor		Inter Info	[27], [28], [29]
D0085		Anakinra	C20H23N5O7S2	146171046	Minor		Inter Info	[27], [28], [29]
D0091		Antilymphocyte immunoglobulin (horse)	NA	NA	Minor		Inter Info	[27], [28], [29]
D0094		Antithymocyte immunoglobulin (rabbit)	NA	NA	Minor		Inter Info	[27], [28], [29]
D0136		Azathioprine	C9H7N7O2S	2265	Minor		Inter Info	[27], [28], [29]
D0147		Basiliximab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0151		Belatacept	NA	NA	Minor		Inter Info	[27], [28], [29]
D0152		Belimumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0172		Betamethasone	C22H29FO5	9782	Minor		Inter Info	[27], [28], [29]
D0209		Brodalumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0215		Budesonide	C25H34O6	5281004	Minor		Inter Info	[27], [28], [29]
D0246		Canakinumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0304		Certolizumab pegol	NA	NA	Minor		Inter Info	[27], [28], [29]
D0402		Cyclosporine	C62H111N11O12	5284373	Minor		Inter Info	[27], [28], [29]
D0436		Deflazacort	C25H31NO6	189821	Minor		Inter Info	[27], [28], [29]
D0453		Dexamethasone	C22H29FO5	5743	Minor		Inter Info	[27], [28], [29]
D0540		Dupilumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0541		Durvalumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0997		Melphalan flufenamide	C24H30Cl2FN3O3	9935639	Minor		Inter Info	[27], [28], [29]
D1113		Naxitamab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1410		Risankizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1448		Satralizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0553		Efalizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0614		Etanercept	NA	NA	Minor		Inter Info	[27], [28], [29]
D0629		Everolimus	C53H83NO14	6442177	Minor		Inter Info	[27], [28], [29]
D0736		Golimumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0747		Guselkumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0773		Hydrocortisone	C21H30O5	5754	Minor		Inter Info	[27], [28], [29]
D0801		Inebilizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0802		Infliximab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0875		Ixekizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D0900		Leflunomide	C12H9F3N2O2	3899	Minor		Inter Info	[27], [28], [29]
D0996		Melphalan	C13H18Cl2N2O2	460612	Minor		Inter Info	[27], [28], [29]
D1041		Methylprednisolone	C22H30O5	6741	Minor		Inter Info	[27], [28], [29]
D1083		Mogamulizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1093		Muromonab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Minor		Inter Info	[27], [28], [29]
D1095		Mycophenolic acid	C17H20O6	446541	Minor		Inter Info	[27], [28], [29]
D1111		Natalizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1162		Ocrelizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1176		Omalizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1332		Prednisolone	C21H28O5	5755	Minor		Inter Info	[27], [28], [29]
D1334		Prednisone	C21H26O5	5865	Minor		Inter Info	[27], [28], [29]
D1403		Rilonacept	NA	NA	Minor		Inter Info	[27], [28], [29]
D1416		Rituximab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1447		Sarilumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1454		Secukinumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1467		Siltuximab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1476		Sirolimus	C51H79NO13	5284616	Minor		Inter Info	[27], [28], [29]
D1526		Tacrolimus	C44H69NO12	445643	Minor		Inter Info	[27], [28], [29]
D1549		Temsirolimus	C56H87NO16	6918289	Minor		Inter Info	[27], [28], [29]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Minor		Inter Info	[27], [28], [29]
D1583		Tildrakizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1599		Tocilizumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1628		Triamcinolone	C21H27FO6	31307	Minor		Inter Info	[27], [28], [29]
D1671		Ustekinumab	NA	NA	Minor		Inter Info	[27], [28], [29]
D1685		Vedolizumab	NA	NA	Minor		Inter Info	[27], [28], [29]

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