Details of Drug

Drug General Information (ID: D0542)
Drug Name	Dutasteride
Drug Type	Small molecule
Drug Synonymous	Avodart; Avolve; Duagen; Dutasteride [USAN]; GG 745; GI 198745; Avidart (TN); Avodart (TN); Avodart, Dutasteride; Avolve (TN); Duagen (TN); Duprost (TN); Dutagen (TN); Dutas (TN); GG-745; GI-198745; GI-198745X; Dutasteride (JAN/USAN/INN); N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide; Alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide; (1S,3aS,3bS,5aR,9aR,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide; (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide; (5-alpha,17-beta)-N-{2,5 bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide;dutasteride; (5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide Click to Show/Hide
Disease Class	GA90: Prostate hyperplasia; 2C82: Prostate cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C27H30F6N2O2
InChI	1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1
InChIKey	JWJOTENAMICLJG-QWBYCMEYSA-N
Canonical SMILES	CC12CCC3C(C1CCC2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CCC5C3(C=CC(=O)N5)C
External Link
	Pubchem ID	6918296
	CAS Number	164656-23-9
	CHEBI ID	521033
	TTD ID	D0A9YA
	INTEDE ID	DR0555

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM064 Increased risk of hypoglycemia
Relation Graph

Full list of drugs interacting with Dutasteride
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 75
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[5]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[1]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[1]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[7], [8]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[1]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[1]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[1]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[17]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[1]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[1]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[1]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[1]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[1]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[1]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[1]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[1]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[1]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[9], [2], [28], [29]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[2], [3], [4]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[6]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[9], [10]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[11], [9], [2], [12]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[13]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[18]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[19], [20]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[2], [21]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[9], [2], [22]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[9], [2], [23], [22]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[2], [24]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[27]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[9], [2], [30], [31]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[9], [2], [22]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[32], [33], [34], [35], [36]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[32], [33], [34], [35], [36]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[25], [26]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[25], [26]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[25], [26]
Pharmacodynamic additive effects
	Increased risk of hypoglycemia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[14], [15], [16]

References
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15	Vuksan V, Sievenpiper JL, Koo VY, et.al "Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo controlled trial." Arch Intern Med 160 (2000): 1009-13
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