Details of Drug

Details of Drug

 Drug General Information (ID: D0540)
  Drug Name
Dupilumab
  Drug Type Monoclonal antibody
  Drug Synonymous
REGN-668; REGN-668); Anti-IL-4 monoclonal antibody (asthma/atopic dermatitis), sanofi-aventis; Anti-IL-4 receptor antibody (VelocImmune, allergy/immune disorder), Regeneron/sanofi-aventis
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  Disease Class EA80: Atopic eczema; CA23: Asthma
  Therapeutic Class Interleukin Inhibitors
  External Link
TTD ID D07FUP

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM016  Altered formation of CYP450 enzymes
BM043  Additive immunosuppressive effects
BM100  Antagonize the effect of vaccine/toxoid
BM105  Antagonize the effect of probiotics
BM110  Antagonize the effects of immunosuppressants
  Relation Graph
 Full list of drugs interacting with Dupilumab
      Affected intra/extra-hepatic metabolism
   Altered formation of CYP450 enzymes Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Moderate    Inter Info   
[31]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[31]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  29
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0023
 
Adalimumab
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0146
 
Baricitinib
 
C16H17N7O2S
 
44205240 
Major    Inter Info   
[10], [11], [12]
D0304
 
Certolizumab pegol
 
NA
 
NA
Major    Inter Info   
[1], [5], [6]
D0348
 
Cladribine
 
C10H12ClN5O3
 
20279 
Major    Inter Info   
[11], [13]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[11], [14]
D1474
 
Siponimod
 
C29H35F3N2O3
 
44599207 
Major    Inter Info   
[10], [15]
D1666
 
Upadacitinib
 
C17H19F3N6O
 
58557659 
Major    Inter Info   
[19]
D0614
 
Etanercept
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0661
 
Fingolimod
 
C19H33NO2
 
107970 
Major    Inter Info   
[20]
D0736
 
Golimumab
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0802
 
Infliximab
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0900
 
Leflunomide
 
C12H9F3N2O2
 
3899 
Major    Inter Info   
[21], [22]
D1111
 
Natalizumab
 
NA
 
NA
Major    Inter Info   
[23]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Major    Inter Info   
[21], [22]
D1600
 
Tofacitinib
 
C16H20N6O
 
9926791 
Major    Inter Info   
[24]
D0032
 
Alefacept
 
NA
 
NA
Moderate    Inter Info   
[16], [25], [26]
D0033
 
Alemtuzumab
 
NA
 
NA
Moderate    Inter Info   
[27]
D0085
 
Anakinra
 
C20H23N5O7S2
 
146171046 
Moderate    Inter Info   
[28], [29], [30]
D0136
 
Azathioprine
 
C9H7N7O2S
 
2265 
Moderate    Inter Info   
[10], [11]
D0246
 
Canakinumab
 
NA
 
NA
Moderate    Inter Info   
[28], [29], [30]
D0443
 
Denosumab
 
NA
 
NA
Moderate    Inter Info   
[32]
D0499
 
Dimethyl fumarate
 
C6H8O4
 
637568 
Moderate    Inter Info   
[33]
D0507
 
Diroximel fumarate
 
C11H13NO6
 
73330464 
Moderate    Inter Info   
[33]
D1085
 
Monomethyl fumarate
 
C5H6O4
 
5369209 
Moderate    Inter Info   
[33]
D0553
 
Efalizumab
 
NA
 
NA
Moderate    Inter Info   
[37]
D1174
 
Omacetaxine mepesuccinate
 
C29H39NO9
 
285033 
Moderate    Inter Info   
[38]
D1403
 
Rilonacept
 
NA
 
NA
Moderate    Inter Info   
[28], [29], [30]
D1422
 
Roflumilast
 
C17H14Cl2F2N2O3
 
449193 
Moderate    Inter Info   
[11], [39]
D1671
 
Ustekinumab
 
NA
 
NA
Moderate    Inter Info   
[40]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1744
 
Bacillus calmette-guerin substrain tice live antigen
 
NA
 
NA
Major    Inter Info   
[7], [8], [9]
D1890
 
Smallpox (Vaccinia) Vaccine, Live
 
NA
 
NA
Major    Inter Info   
[16], [10], [17]
D1897
 
Talimogene laherparepvec
 
NA
 
NA
Major    Inter Info   
[18]
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[7], [8], [9]
D1920
 
Varicella Zoster Vaccine (Recombinant)
 
NA
 
NA
Major    Inter Info   
[7], [8], [9]
D1839
 
Measles virus vaccine live attenuated
 
NA
 
NA
Major    Inter Info   
[7], [8], [9]
D1849
 
Mumps virus strain B level jeryl lynn live antigen
 
NA
 
NA
Major    Inter Info   
[7], [8], [9]
D1881
 
Rotavirus vaccine
 
NA
 
NA
Major    Inter Info   
[7], [8], [9]
D1882
 
Rubella virus vaccine
 
NA
 
NA
Major    Inter Info   
[7], [8], [9]
D1922
 
Yellow Fever Vaccine
 
NA
 
NA
Major    Inter Info   
[7], [8], [9]
   Antagonize the effect of probiotics Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1749
 
Bifidobacterium longum infantis
 
NA
 
NA
Moderate    Inter Info   
[34], [35], [36]
D1827
 
Lactobacillus acidophilus
 
NA
 
NA
Moderate    Inter Info   
[34], [35], [36]
   Antagonize the effects of immunosuppressants Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0545
 
Echinacea
 
NA
 
NA
Minor    Inter Info   
[41], [42], [43]
D1722
 
Zinc acetate
 
C4H6O4Zn
 
11192 
Minor    Inter Info   
[41], [42], [43]
D1723
 
Zinc chloride
 
Cl2Zn
 
5727 
Minor    Inter Info   
[41], [42], [43]
D1703
 
Vitamin E
 
C29H50O2
 
14985 
Minor    Inter Info   
[41], [42], [43]
D1724
 
Zinc gluconate
 
C12H22O14Zn
 
443445 
Minor    Inter Info   
[41], [42], [43]
D1725
 
Zinc sulfate
 
O4SZn
 
24424 
Minor    Inter Info   
[41], [42], [43]
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