Details of Drug

Drug General Information (ID: D0518)
Drug Name	Doravirine
Drug Type	Small molecule
Drug Synonymous	Doravirine; 1338225-97-0; UNII-913P6LK81M; MK1439; 913P6LK81M; MK 1439 Click to Show/Hide
Disease Class	1C60-1C62: Human immunodeficiency virus disease
Therapeutic Class	Antiviral Agents
Structure
Structure	3D Structure		2D Structure
Formula	C17H11ClF3N5O3
InChI	1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28)
InChIKey	ZIAOVIPSKUPPQW-UHFFFAOYSA-N
Canonical SMILES	CN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F
External Link
	Pubchem ID	58460047
	CAS Number	1338225-97-0
	TTD ID	D0R0TS
	INTEDE ID	DR0533

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction
Relation Graph

Full list of drugs interacting with Doravirine
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 81
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[7]
D0007		Abiraterone	C24H31NO	132971	Minor		Inter Info	[1]
D0066		Amiodarone	C25H29I2NO3	2157	Minor		Inter Info	[1]
D0069		Amlodipine	C20H25ClN2O5	2162	Minor		Inter Info	[1]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Minor		Inter Info	[1]
D0116		Atazanavir	C38H52N6O7	148192	Minor		Inter Info	[1]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Minor		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Minor		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Minor		Inter Info	[1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Minor		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Minor		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Minor		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Minor		Inter Info	[1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Minor		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Minor		Inter Info	[1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Minor		Inter Info	[4]
D0416		Danazol	C22H27NO2	28417	Minor		Inter Info	[1]
D0426		Darunavir	C27H37N3O7S	213039	Minor		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Minor		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Minor		Inter Info	[1]
D0171		Berotralstat	C30H26F4N6O	137528262	Minor		Inter Info	[1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Minor		Inter Info	[4]
D0735		Goldenseal	NA	NA	Minor		Inter Info	[1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Minor		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Minor		Inter Info	[1]
D1459		Selpercatinib	C29H31N7O3	134436906	Minor		Inter Info	[1]
D1653		Troleandomycin	C41H67NO15	202225	Minor		Inter Info	[1]
D1709		Voxelotor	C19H19N3O3	71602803	Minor		Inter Info	[1]
D0534		Dronedarone	C31H44N2O5S	208898	Minor		Inter Info	[1]
D0543		Duvelisib	C22H17ClN6O	50905713	Minor		Inter Info	[1]
D0577		Entrectinib	C31H34F2N6O2	25141092	Minor		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[1]
D0676		Fluoxetine	C17H18F3NO	3386	Minor		Inter Info	[1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Minor		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Minor		Inter Info	[1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Minor		Inter Info	[1]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Minor		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Minor		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Minor		Inter Info	[1]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Minor		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Minor		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[1]
D0891		Lanreotide	C54H69N11O10S2	71349	Minor		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Minor		Inter Info	[1]
D0906		Letermovir	C29H28F4N4O4	45138674	Minor		Inter Info	[1]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Minor		Inter Info	[1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Minor		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Minor		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Minor		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Minor		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Minor		Inter Info	[1]
D1127		Netupitant	C30H32F6N4O	6451149	Minor		Inter Info	[4]
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Minor		Inter Info	[1]
D1163		Octreotide	C49H66N10O10S2	448601	Minor		Inter Info	[1]
D1189		Osilodrostat	C13H10FN3	44139752	Minor		Inter Info	[1]
D1214		Palbociclib	C24H29N7O2	5330286	Minor		Inter Info	[1]
D1230		Pasireotide	C58H66N10O9	9941444	Minor		Inter Info	[1]
D1232		Pazopanib	C21H23N7O2S	10113978	Minor		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Minor		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Minor		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Minor		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Minor		Inter Info	[1]
D1505		Stiripentol	C14H18O3	5311454	Minor		Inter Info	[1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Minor		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Minor		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Minor		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Minor		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Minor		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[1]
D1714		Zafirlukast	C31H33N3O6S	5717	Minor		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 76
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[2], [1], [3]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[2], [1], [3]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[2], [1], [3]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[2], [1], [3]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[2], [1], [3]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Major		Inter Info	[2], [1], [3]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[2], [1], [3]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[4], [5]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[6]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[2], [1], [3]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[2], [1], [3]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[4], [5]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Major		Inter Info	[2], [4], [3]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[2], [1], [3]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[8]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1], [3]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1], [3]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1], [3]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1], [3]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[1], [3]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1], [3]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1], [3]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[9]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1], [3]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[10], [2], [11]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[10], [12]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1], [3]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[13]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[14]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[4], [3]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1], [3]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[15]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[16]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[1], [3]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[10], [2], [11]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[10], [2], [11]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1], [3]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[1], [3]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1], [3]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[10], [17]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[10], [2], [11]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[4], [3]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[10], [2], [11]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[1], [3]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[1], [3]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1], [3]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1], [3]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[18]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[19], [10], [20], [21]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1], [3]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1], [3]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[22]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[4], [3]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1], [3]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[1], [3]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[23]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1], [3]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[24]
D1476		Sirolimus	C51H79NO13	5284616	Minor		Inter Info	[2], [3]
D1526		Tacrolimus	C44H69NO12	445643	Minor		Inter Info	[2], [3]

References
1	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
4	Product Information. Pifeltro (doravirine). Merck &amp Company Inc, Whitehouse Station, NJ.
5	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
6	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
7	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
8	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
9	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
10	Cerner Multum, Inc. "Australian Product Information.".
11	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
12	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
13	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
14	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
15	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
16	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
17	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
18	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
19	Bittencourt PR, Gracia CM, Martins R, et al "Phenytoin and carbamazepine decrease oral bioavailability of praziquantel." Neurology 42 (1992): 492-6. [PMID: 1549207]
20	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
21	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
22	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
23	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
24	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.

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