Details of Drug

Details of Drug

 Drug General Information (ID: D0511)
  Drug Name
Docetaxel
  Drug Type Small molecule
  Drug Synonymous
EmDOC; TXL; Taxotere; Docetaxel anhydrous; ANX-514; Docetaxel (INN); Docetaxel, Trihydrate; RP-56976; SDP-014; Taxotere (TN); Taxotere(R); XRP-6976L; Docetaxel 114977-28-5; N-debenzoyl-N-Boc-10-deacetyl taxol; N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel; N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol; (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; 4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
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  Disease Class 2A00-2F9Z: Solid tumour/cancer
  Therapeutic Class Antineoplastics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C43H53NO14
  InChI 1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
  InChIKey ZDZOTLJHXYCWBA-VCVYQWHSSA-N
  Canonical SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
  External Link
Pubchem ID 148124
CAS Number 114977-28-5
CHEBI ID 4672
TTD ID D0O5WP
INTEDE ID DR0520
VARIDT ID DR00251

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM006  Altered intestinal mucosa
BM010  Transporter inhibition
BM012  Competitive inhibition of transporters
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM024  Competitive inhibition of metabolic enzyme
BM043  Additive immunosuppressive effects
BM044  Additive myelosuppressive effects
BM047  Additive thrombogenic effects
BM074  Increased risk of peripheral neuropathy
BM100  Antagonize the effect of vaccine/toxoid
BM105  Antagonize the effect of probiotics
BM106  Diminish the response to diagnostic skin test antigens
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Docetaxel
      Affected gastrointestinal absorption
   Altered intestinal mucosa Drug Num:  13
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0340
 
Cinoxacin
 
C12H10N2O5
 
2762 
Minor    Inter Info   
[138]
D0438
 
Delafloxacin
 
C18H12ClF3N4O4
 
487101 
Minor    Inter Info   
[138]
D0573
 
Enoxacin
 
C15H17FN4O3
 
3229 
Minor    Inter Info   
[138]
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Minor    Inter Info   
[138]
D0716
 
Gemifloxacin
 
C18H20FN5O4
 
9571107 
Minor    Inter Info   
[138]
D0919
 
Levofloxacin
 
C18H20FN3O4
 
149096 
Minor    Inter Info   
[138]
D0943
 
Lomefloxacin
 
C17H19F2N3O3
 
3948 
Minor    Inter Info   
[138]
D1092
 
Moxifloxacin
 
C21H24FN3O4
 
152946 
Minor    Inter Info   
[138]
D1102
 
Nalidixic acid
 
C12H12N2O3
 
4421 
Minor    Inter Info   
[138]
D1155
 
Norfloxacin
 
C16H18FN3O3
 
4539 
Minor    Inter Info   
[138]
D1165
 
Ofloxacin
 
C18H20FN3O4
 
4583 
Minor    Inter Info   
[138]
D1499
 
Sparfloxacin
 
C19H22F2N4O3
 
60464 
Minor    Inter Info   
[138]
D1657
 
Trovafloxacin
 
C20H15F3N4O3
 
62959 
Minor    Inter Info   
[138]
      Affected cellular transport
   Transporter inhibition Drug Num:  18
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0139
 
Azithromycin
 
C38H72N2O12
 
447043 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0267
 
Carvedilol
 
C24H26N2O4
 
2585 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[9], [72], [73]
D0251
 
Capmatinib
 
C23H17FN6O
 
25145656 
Moderate    Inter Info   
[85]
D0408
 
Daclatasvir
 
C40H50N8O6
 
25154714 
Moderate    Inter Info   
[9], [86]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Moderate    Inter Info   
[93]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[8], [9], [95]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[96]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Moderate    Inter Info   
[9]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1423
 
Rolapitant
 
C25H26F6N2O2
 
10311306 
Moderate    Inter Info   
[111]
D1471
 
Simeprevir
 
C38H47N5O7S2
 
24873435 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1608
 
Tolvaptan
 
C26H25ClN2O3
 
216237 
Moderate    Inter Info   
[8], [9], [120], [121]
D0740
 
Grepafloxacin
 
C19H22FN3O3
 
72474 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1501
 
Spironolactone
 
C24H32O4S
 
5833 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1714
 
Zafirlukast
 
C31H33N3O6S
 
5717 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
   Competitive inhibition of transporters Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1791
 
Gadobenic acid
 
C22H28GdN3O11
 
9852779 
Moderate    Inter Info   
[129], [130]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  73
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Major    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0497
 
Diltiazem
 
C22H26N2O4S
 
39186 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Major    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1653
 
Troleandomycin
 
C41H67NO15
 
202225 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0799
 
Indinavir
 
C36H47N5O4
 
5362440 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Major    Inter Info   
[7], [8], [9], [10], [11], [16], [12], [13], [14], [15]
D0100
 
Aprepitant
 
C23H21F7N4O3
 
135413536 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0180
 
Bicalutamide
 
C18H14F4N2O4S
 
2375 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0337
 
Cimetidine
 
C10H16N6S
 
2756 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[71]
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0413
 
Dalfopristin
 
C34H50N4O9S
 
6323289 
Moderate    Inter Info   
[7], [12], [13]
D0416
 
Danazol
 
C22H27NO2
 
28417 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[87], [88]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0693
 
Fosaprepitant
 
C23H22F7N4O6P
 
135413538 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0696
 
Fosnetupitant
 
C31H35F6N4O5P
 
71544786 
Moderate    Inter Info   
[7], [12], [13]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[94]
D0735
 
Goldenseal
 
NA
 
NA
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[97]
D0906
 
Letermovir
 
C29H28F4N4O4
 
45138674 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1127
 
Netupitant
 
C30H32F6N4O
 
6451149 
Moderate    Inter Info   
[7], [12], [13]
D1189
 
Osilodrostat
 
C13H10FN3
 
44139752 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1214
 
Palbociclib
 
C24H29N7O2
 
5330286 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1709
 
Voxelotor
 
C19H19N3O3
 
71602803 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1057
 
Miconazole
 
C18H14Cl4N2O
 
4189 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1134
 
Nifedipine
 
C17H18N2O6
 
4485 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Moderate    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15]
   CYP450 enzyme induction Drug Num:  46
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0061
 
Aminoglutethimide
 
C13H16N2O2
 
2145 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0178
 
Bexarotene
 
C24H28O2
 
82146 
Moderate    Inter Info   
[9], [66], [67]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0225
 
Butalbital
 
C11H16N2O3
 
2481 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0071
 
Amobarbital
 
C11H18N2O3
 
2164 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[81]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[8], [91]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[92]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[9], [112]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[7], [59], [12]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1502
 
St. John's Wort
 
NA
 
NA
Moderate    Inter Info   
[114], [115]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Moderate    Inter Info   
[9], [117]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0741
 
Griseofulvin
 
C17H17ClO6
 
441140 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[7], [59], [12]
D1078
 
Mitotane
 
C14H10Cl4
 
4211 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1099
 
Nafcillin
 
C21H22N2O5S
 
8982 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Moderate    Inter Info   
[7], [59], [12]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[7], [59], [12]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[7], [59], [60], [11], [12]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Minor    Inter Info   
[139], [140], [141], [142], [143]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Minor    Inter Info   
[139], [140], [141], [142], [143]
   Competitive inhibition of metabolic enzyme Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Moderate    Inter Info   
[118], [119]
D1476
 
Sirolimus
 
C51H79NO13
 
5284616 
Moderate    Inter Info   
[118], [119]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Moderate    Inter Info   
[118], [119]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  69
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0023
 
Adalimumab
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0348
 
Cladribine
 
C10H12ClN5O3
 
20279 
Major    Inter Info   
[9], [17]
D0146
 
Baricitinib
 
C16H17N7O2S
 
44205240 
Major    Inter Info   
[8], [9], [23]
D0304
 
Certolizumab pegol
 
NA
 
NA
Major    Inter Info   
[1], [5], [6]
D0661
 
Fingolimod
 
C19H33NO2
 
107970 
Major    Inter Info   
[26]
D0736
 
Golimumab
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Major    Inter Info   
[9], [27]
D1474
 
Siponimod
 
C29H35F3N2O3
 
44599207 
Major    Inter Info   
[8], [29]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Major    Inter Info   
[33], [34]
D1600
 
Tofacitinib
 
C16H20N6O
 
9926791 
Major    Inter Info   
[35]
D1666
 
Upadacitinib
 
C17H19F3N6O
 
58557659 
Major    Inter Info   
[36]
D0614
 
Etanercept
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0802
 
Infliximab
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4], [5], [6]
D0900
 
Leflunomide
 
C12H9F3N2O2
 
3899 
Major    Inter Info   
[33], [34]
D1111
 
Natalizumab
 
NA
 
NA
Major    Inter Info   
[37]
D0030
 
Aldesleukin
 
NA
 
NA
Moderate    Inter Info   
[9], [54], [55]
D0032
 
Alefacept
 
NA
 
NA
Moderate    Inter Info   
[30], [56], [57]
D0033
 
Alemtuzumab
 
NA
 
NA
Moderate    Inter Info   
[58]
D0085
 
Anakinra
 
C20H23N5O7S2
 
146171046 
Moderate    Inter Info   
[61], [62], [63]
D0136
 
Azathioprine
 
C9H7N7O2S
 
2265 
Moderate    Inter Info   
[8], [9]
D0190
 
Bleomycin
 
C55H84N17O21S3+
 
5360373 
Moderate    Inter Info   
[9], [54], [55]
D0223
 
Busulfan
 
C6H14O6S2
 
2478 
Moderate    Inter Info   
[9], [54], [55]
D0312
 
Chlorambucil
 
C14H19Cl2NO2
 
2708 
Moderate    Inter Info   
[9], [54], [55]
D0404
 
Cytarabine
 
C9H13N3O5
 
6253 
Moderate    Inter Info   
[9], [54], [55]
D0405
 
Cytarabine (liposomal)
 
C9H13N3O5
 
6253 
Moderate    Inter Info   
[9], [54], [55]
D0407
 
Dacarbazine
 
C6H10N6O
 
135398738 
Moderate    Inter Info   
[9], [54], [55]
D0429
 
Daunorubicin
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[9], [54], [55]
D0430
 
Daunorubicin (liposomal)
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[9], [54], [55]
D0157
 
Bendamustine
 
C16H21Cl2N3O2
 
65628 
Moderate    Inter Info   
[9], [54], [55]
D0246
 
Canakinumab
 
NA
 
NA
Moderate    Inter Info   
[61], [62], [63]
D0443
 
Denosumab
 
NA
 
NA
Moderate    Inter Info   
[89]
D0499
 
Dimethyl fumarate
 
C6H8O4
 
637568 
Moderate    Inter Info   
[90]
D0507
 
Diroximel fumarate
 
C11H13NO6
 
73330464 
Moderate    Inter Info   
[90]
D0851
 
Isatuximab
 
NA
 
NA
Moderate    Inter Info   
[9], [54], [55]
D0962
 
Lurbinectedin
 
C41H44N4O10S
 
57327016 
Moderate    Inter Info   
[9], [54], [55]
D1085
 
Monomethyl fumarate
 
C5H6O4
 
5369209 
Moderate    Inter Info   
[90]
D1140
 
Niraparib
 
C19H20N4O
 
24958200 
Moderate    Inter Info   
[98]
D1162
 
Ocrelizumab
 
NA
 
NA
Moderate    Inter Info   
[99]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[9], [100]
D1174
 
Omacetaxine mepesuccinate
 
C29H39NO9
 
285033 
Moderate    Inter Info   
[101]
D1375
 
Radium Ra 223 dichloride
 
NA
 
NA
Moderate    Inter Info   
[109]
D1403
 
Rilonacept
 
NA
 
NA
Moderate    Inter Info   
[61], [62], [63]
D1422
 
Roflumilast
 
C17H14Cl2F2N2O3
 
449193 
Moderate    Inter Info   
[9], [110]
D1434
 
Ruxolitinib
 
C17H18N6
 
25126798 
Moderate    Inter Info   
[9], [54], [55]
D1487
 
Sodium phosphate, monobasic (p32)
 
NA
 
NA
Moderate    Inter Info   
[113]
D1509
 
Strontium chloride Sr-89
 
Cl2Sr
 
5388879 
Moderate    Inter Info   
[8], [9], [116]
D1575
 
Thiotepa
 
C6H12N3PS
 
5453 
Moderate    Inter Info   
[9], [54], [55]
D1671
 
Ustekinumab
 
NA
 
NA
Moderate    Inter Info   
[122]
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[9], [54], [55]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[9], [54], [55]
D0553
 
Efalizumab
 
NA
 
NA
Moderate    Inter Info   
[125]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Moderate    Inter Info   
[9], [54], [55]
D0666
 
Floxuridine
 
C9H11FN2O5
 
5790 
Moderate    Inter Info   
[9], [54], [55]
D0675
 
Fluorouracil
 
C4H3FN2O2
 
3385 
Moderate    Inter Info   
[9], [54], [55]
D0714
 
Gemcitabine
 
C9H11F2N3O4
 
60750 
Moderate    Inter Info   
[9], [54], [55]
D0780
 
Hydroxyurea
 
CH4N2O2
 
3657 
Moderate    Inter Info   
[9], [54], [55]
D0788
 
Idarubicin
 
C26H27NO9
 
42890 
Moderate    Inter Info   
[9], [54], [55]
D0945
 
Lomustine
 
C9H16ClN3O2
 
3950 
Moderate    Inter Info   
[9], [54], [55]
D0996
 
Melphalan
 
C13H18Cl2N2O2
 
460612 
Moderate    Inter Info   
[9], [54], [55]
D1007
 
Mercaptopurine
 
C5H4N4S
 
667490 
Moderate    Inter Info   
[9], [54], [55]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[9], [54], [55]
D1077
 
Mitomycin
 
C15H18N4O5
 
5746 
Moderate    Inter Info   
[9], [54], [55]
D1079
 
Mitoxantrone
 
C22H28N4O6
 
4212 
Moderate    Inter Info   
[9], [54], [55]
D1855
 
Palifermin
 
NA
 
NA
Moderate    Inter Info   
[132]
D1508
 
Streptozocin
 
C8H15N3O7
 
29327 
Moderate    Inter Info   
[9], [54], [55]
D1548
 
Temozolomide
 
C6H6N6O2
 
5394 
Moderate    Inter Info   
[9], [54], [55]
D1589
 
Tioguanine
 
C5H5N5S
 
2723601 
Moderate    Inter Info   
[9], [54], [55]
D1610
 
Topotecan
 
C23H23N3O5
 
60700 
Moderate    Inter Info   
[135]
D1720
 
Zidovudine
 
C10H13N5O4
 
35370 
Moderate    Inter Info   
[8], [9], [137]
   Additive myelosuppressive effects Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Major    Inter Info   
[9], [18], [19]
D0433
 
Deferiprone
 
C7H9NO2
 
2972 
Major    Inter Info   
[8], [24], [25]
D1443
 
Samarium (153Sm) lexidronam
 
Sm
 
23951 
Major    Inter Info   
[28]
D1676
 
Valganciclovir
 
C14H22N6O5
 
135413535 
Moderate    Inter Info   
[8], [9], [123], [124]
D0710
 
Ganciclovir
 
C9H13N5O4
 
135398740 
Moderate    Inter Info   
[8], [9], [123], [124]
   Additive thrombogenic effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Major    Inter Info   
[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53]
   Increased risk of peripheral neuropathy Drug Num:  68
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0120
 
Atorvastatin
 
C33H35FN2O5
 
60823 
Moderate    Inter Info   
[64], [54], [65]
D0126
 
Auranofin
 
C20H34AuO9PS
 
24199313 
Moderate    Inter Info   
[64], [54], [65]
D0193
 
Bortezomib
 
C19H25BN4O4
 
387447 
Moderate    Inter Info   
[68], [69], [70]
D0260
 
Carboplatin
 
C6H12N2O4Pt
 
426756 
Moderate    Inter Info   
[64], [54], [65]
D0303
 
Cerivastatin
 
C26H34FNO5
 
446156 
Moderate    Inter Info   
[64], [54], [65]
D0320
 
Chloroquine
 
C18H26ClN3
 
2719 
Moderate    Inter Info   
[64], [54], [65]
D0344
 
Cisplatin
 
Cl2H6N2Pt
 
5702198 
Moderate    Inter Info   
[64], [54], [65]
D0419
 
Dapsone
 
C12H12N2O2S
 
2955 
Moderate    Inter Info   
[64], [54], [65]
D0483
 
Didanosine
 
C10H12N4O3
 
135398739 
Moderate    Inter Info   
[64], [54], [65]
D0509
 
Disulfiram
 
C10H20N2S4
 
3117 
Moderate    Inter Info   
[64], [54], [65]
D0127
 
Aurothioglucose
 
C6H11AuO5S
 
454937 
Moderate    Inter Info   
[64], [54], [65]
D0162
 
Benznidazole
 
C12H12N4O3
 
31593 
Moderate    Inter Info   
[64], [54], [65]
D0199
 
Brentuximab vedotin
 
NA
 
NA
Moderate    Inter Info   
[64], [79], [80]
D0227
 
Cabazitaxel
 
C45H57NO14
 
9854073 
Moderate    Inter Info   
[64], [54], [65]
D0261
 
Carfilzomib
 
C40H57N5O7
 
11556711 
Moderate    Inter Info   
[64], [54], [65]
D0380
 
Colchicine
 
C22H25NO6
 
6167 
Moderate    Inter Info   
[64], [54], [65]
D0496
 
Diiodohydroxyquinoline
 
C9H5I2NO
 
3728 
Moderate    Inter Info   
[64], [54], [65]
D0501
 
Dinutuximab
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D0560
 
Elotuzumab
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D0571
 
Enfortumab vedotin
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D0594
 
Eribulin
 
C40H59NO11
 
11354606 
Moderate    Inter Info   
[64], [54], [65]
D0770
 
Hydralazine
 
C8H8N4
 
3637 
Moderate    Inter Info   
[64], [54], [65]
D0779
 
Hydroxychloroquine
 
C18H26ClN3O
 
3652 
Moderate    Inter Info   
[64], [54], [65]
D0841
 
Ipilimumab
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D0873
 
Ixabepilone
 
C27H42N2O5S
 
6445540 
Moderate    Inter Info   
[64], [54], [65]
D0874
 
Ixazomib
 
C14H19BCl2N2O4
 
25183872 
Moderate    Inter Info   
[64], [54], [65]
D1113
 
Naxitamab
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D1118
 
Nelarabine
 
C11H15N5O5
 
3011155 
Moderate    Inter Info   
[64], [54], [65]
D1301
 
Pitavastatin
 
C25H24FNO4
 
5282452 
Moderate    Inter Info   
[64], [54], [65]
D1306
 
Polatuzumab vedotin
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D1312
 
Pomalidomide
 
C13H11N3O4
 
134780 
Moderate    Inter Info   
[64], [54], [65]
D1452
 
Secnidazole
 
C7H11N3O3
 
71815 
Moderate    Inter Info   
[64], [54], [65]
D1479
 
Sodium aurothiomalate
 
C4H3AuNa2O4S
 
22318 
Moderate    Inter Info   
[64], [54], [65]
D1543
 
Telbivudine
 
C10H14N2O5
 
159269 
Moderate    Inter Info   
[64], [54], [65]
D1599
 
Tocilizumab
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D1615
 
Trabectedin
 
C39H43N3O11S
 
108150 
Moderate    Inter Info   
[64], [54], [65]
D1623
 
Trastuzumab emtansine
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D0616
 
Ethambutol
 
C10H24N2O2
 
14052 
Moderate    Inter Info   
[64], [54], [65]
D1731
 
Ethionamide
 
C8H10N2S
 
2761171 
Moderate    Inter Info   
[64], [54], [65]
D0627
 
Etoposide
 
C29H32O13
 
36462 
Moderate    Inter Info   
[64], [54], [65]
D0669
 
Fludarabine
 
C10H12FN5O4
 
657237 
Moderate    Inter Info   
[64], [54], [65]
D0686
 
Fluvastatin
 
C24H26FNO4
 
446155 
Moderate    Inter Info   
[64], [54], [65]
D0821
 
Interferon alfa-2a, Recombinant
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D0822
 
Interferon alfa-2b
 
C16H17Cl3I2N3NaO5S
 
71306834 
Moderate    Inter Info   
[64], [54], [65]
D0824
 
Interferon alfa-n1
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D0823
 
Interferon alfacon-1
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D0858
 
Isoniazid
 
C6H7N3O
 
3767 
Moderate    Inter Info   
[64], [54], [65]
D0918
 
Levodopa
 
C9H11NO4
 
6047 
Moderate    Inter Info   
[64], [54], [65]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Moderate    Inter Info   
[64], [54], [65]
D0956
 
Lovastatin
 
C24H36O5
 
53232 
Moderate    Inter Info   
[64], [54], [65]
D1051
 
Metronidazole
 
C6H9N3O3
 
4173 
Moderate    Inter Info   
[64], [54], [65]
D1145
 
Nitrofurantoin
 
C8H6N4O5
 
6604200 
Moderate    Inter Info   
[64], [54], [65]
D1193
 
Oxaliplatin
 
C8H14N2O4Pt
 
9887053 
Moderate    Inter Info   
[64], [54], [65]
D1212
 
Paclitaxel
 
C47H51NO14
 
36314 
Moderate    Inter Info   
[64], [54], [65]
D1213
 
Paclitaxel (protein-bound)
 
C47H51NO14
 
36314 
Moderate    Inter Info   
[64], [54], [65]
D1237
 
Peginterferon alfa-2a
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D1238
 
Peginterferon alfa-2b
 
NA
 
NA
Moderate    Inter Info   
[64], [54], [65]
D1329
 
Pravastatin
 
C23H36O7
 
54687 
Moderate    Inter Info   
[64], [54], [65]
D1430
 
Rosuvastatin
 
C22H28FN3O6S
 
446157 
Moderate    Inter Info   
[64], [54], [65]
D1473
 
Simvastatin
 
C25H38O5
 
54454 
Moderate    Inter Info   
[64], [54], [65]
D1504
 
Stavudine
 
C10H12N2O4
 
18283 
Moderate    Inter Info   
[64], [54], [65]
D1551
 
Teniposide
 
C32H32O13S
 
452548 
Moderate    Inter Info   
[64], [54], [65]
D1587
 
Tinidazole
 
C8H13N3O4S
 
5479 
Moderate    Inter Info   
[64], [54], [65]
D1697
 
Vinblastine
 
C46H58N4O9
 
13342 
Moderate    Inter Info   
[64], [54], [65]
D1698
 
Vincristine
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[64], [54], [65]
D1699
 
Vincristine (liposome)
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[64], [54], [65]
D1700
 
Vinorelbine
 
C45H54N4O8
 
5311497 
Moderate    Inter Info   
[64], [54], [65]
D1715
 
Zalcitabine
 
C9H13N3O3
 
24066 
Moderate    Inter Info   
[68], [136]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  23
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1744
 
Bacillus calmette-guerin substrain tice live antigen
 
NA
 
NA
Major    Inter Info   
[20], [21], [22]
D1839
 
Measles virus vaccine live attenuated
 
NA
 
NA
Major    Inter Info   
[20], [21], [22]
D1849
 
Mumps virus strain B level jeryl lynn live antigen
 
NA
 
NA
Major    Inter Info   
[20], [21], [22]
D1881
 
Rotavirus vaccine
 
NA
 
NA
Major    Inter Info   
[20], [21], [22]
D1882
 
Rubella virus vaccine
 
NA
 
NA
Major    Inter Info   
[20], [21], [22]
D1890
 
Smallpox (Vaccinia) Vaccine, Live
 
NA
 
NA
Major    Inter Info   
[30], [8], [31]
D1897
 
Talimogene laherparepvec
 
NA
 
NA
Major    Inter Info   
[32]
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[20], [21], [22]
D1920
 
Varicella Zoster Vaccine (Recombinant)
 
NA
 
NA
Major    Inter Info   
[20], [21], [22]
D1922
 
Yellow Fever Vaccine
 
NA
 
NA
Major    Inter Info   
[20], [21], [22]
D0089
 
Anthrax vaccine
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D0366
 
Clostridium tetani toxoid antigen (formaldehyde inactivated)
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D0755
 
Hepatitis A Vaccine
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D0756
 
Hepatitis B Vaccine (Recombinant)
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D0767
 
Human papillomavirus type 11 L1 capsid protein antigen
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D0803
 
Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D0804
 
Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D0999
 
Meningococcal polysaccharide vaccine group C
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D1259
 
Pfizer-BioNTech Covid-19 Vaccine
 
NA
 
NA
Moderate    Inter Info   
[102], [30], [8], [103], [104], [105], [74], [106], [107], [108], [75]
D1307
 
Poliovirus type 1 antigen (formaldehyde inactivated)
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D1662
 
Typhoid vaccine (inactivated)
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D1692
 
Vibrio cholerae CVD 103-HgR strain live antigen
 
NA
 
NA
Moderate    Inter Info   
[30], [74], [75]
D1838
 
Lyme disease vaccine (recombinant OspA)
 
NA
 
NA
Moderate    Inter Info   
[131]
   Antagonize the effect of probiotics Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1749
 
Bifidobacterium longum infantis
 
NA
 
NA
Moderate    Inter Info   
[76], [77], [78]
D1827
 
Lactobacillus acidophilus
 
NA
 
NA
Moderate    Inter Info   
[76], [77], [78]
   Diminish the response to diagnostic skin test antigens Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1755
 
Candida albicans
 
C29H27N2O12P
 
118855431 
Moderate    Inter Info   
[82], [83], [84]
D1765
 
Coccidioides immitis spherule
 
NA
 
NA
Moderate    Inter Info   
[82], [83], [84]
D1912
 
Trichophyton mentagrophytes
 
NA
 
NA
Moderate    Inter Info   
[82], [83], [84]
D1913
 
Tuberculin purified protein derivative
 
NA
 
NA
Moderate    Inter Info   
[82], [83], [84]
   Attenuated pharmacological effects (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0659
 
Filgrastim
 
NA
 
NA
Moderate    Inter Info   
[126], [127], [128]
D1235
 
Pegfilgrastim
 
C27H46N4O19
 
70683024 
Moderate    Inter Info   
[133], [134]
D1446
 
Sargramostim
 
NA
 
NA
Moderate    Inter Info   
[126], [127], [128]
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