Details of Drug | MecDDI

Drug General Information (ID: D0492)
Drug Name		Digoxin Immune Fab (Ovine)
Drug Type		Monoclonal antibody
Drug Synonymous		DB00076; Digitalis antitoxin; Digoxin Immune Fab (Ovine); Digoxin Immune Fab, Ovine; Digoxin-specific Antibody Fragments; Ovine digoxin immune fab Click to Show/Hide
Therapeutic Class		Antidotes

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM081 Increased risk of ventricular arrhythmias
Relation Graph

Full list of drugs interacting with Digoxin Immune Fab (Ovine)
Pharmacodynamic additive effects
					Increased risk of ventricular arrhythmias																																																																Drug Num: 16
Drug ID															Drug Name															Formula															Pubchem ID															Severity Level															Interaction Detail													REF
D0066															Amiodarone															C25H29I2NO3															2157															Major															Inter Info													[1], [2], [3]
D0107															Arsenic trioxide															As2O3															14888															Major															Inter Info													[4], [5]
D0513															Dofetilide															C19H27N3O5S2															71329															Major															Inter Info													[6]
D0534															Dronedarone															C31H44N2O5S															208898															Major															Inter Info													[7]
D1292															Pimozide															C28H29F2N3O															16362															Major															Inter Info													[8], [9]
D1726															Ziprasidone															C21H21ClN4OS															60854															Major															Inter Info													[10], [11], [12]
D0067															Amisulpride															C17H27N3O4S															2159															Moderate															Inter Info													[13], [14]
D0324															Chlorpromazine															C17H19ClN2S															2726															Moderate															Inter Info													[13], [14]
D0508															Disopyramide															C21H29N3O															3114															Moderate															Inter Info													[14], [15], [16]
D0678															Fluphenazine															C22H26F3N3OS															3372															Moderate															Inter Info													[13], [14]
D0750															Haloperidol															C21H23ClFNO2															3559															Moderate															Inter Info													[13], [14]
D1215															Paliperidone															C23H27FN4O3															115237															Moderate															Inter Info													[13], [14]
D1351															Promazine															C17H20N2S															4926															Moderate															Inter Info													[13], [14]
D1413															Risperidone															C23H27FN4O2															5073															Moderate															Inter Info													[13], [14]
D1574															Thioridazine															C21H26N2S2															5452															Moderate															Inter Info													[13], [14]
D1637															Trifluoperazine															C21H24F3N3S															5566															Moderate															Inter Info													[13], [14]

References
1	Antonelli D, Atar S, Freedberg NA, Rosenfeld T "Torsade de pointes in patients on chronic amiodarone treatment: contributing factors and drug interactions." Isr Med Assoc J 7 (2005): 163-5. [PMID: 15792261]
2	Libersa CC, Brique SA, Motte KB, et al. "Dramatic inhibition of amiodarone metabolism induced by grapefruit juice." Br J Clin Pharmacol 49 (2000): 373-8. [PMID: 10759694]
3	Product Information. Amiodarone Hydrochloride (amiodarone). Bedford Laboratories, Bedford, OH.
4	Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
5	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
6	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
7	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
8	Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57. [PMID: 10668858]
9	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
10	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
11	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
12	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
13	Cerner Multum, Inc. "Australian Product Information.".
14	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
15	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
16	Multum Information Services, Inc. Expert Review Panel.