Details of Drug

Details of Drug

 Drug General Information (ID: D0488)
  Drug Name
Difenoxin
  Drug Type Small molecule
  Drug Synonymous
Difenoxin; Diphenoxylic acid; Difenoxine; Motofen; Difenoxinum; Diphenoxin; Lyspafen; 28782-42-5; Difenoxina; diphenoxilic acid; 1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid; UNII-3ZZ5BJ9F2Q; 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid; MCN-JR-15,403-11; ISONIPECOTIC ACID, 1-(3-CYANO-3,3-DIPHENYLPROPYL)-4-PHENYL-; 3ZZ5BJ9F2Q; CHEBI:4534; 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-; R 15,403 [AS HYDROCHLORIDE]; R-15403; Difenossina [DCIT]; Difenossina; Difenoxilic acid; Difenoxylic acid; Difenoxinum [INN-Latin]; Difenoxina [INN-Spanish]; Difenoxin [USAN:INN:BAN]; McN-JR 15403-11; McN-JR 15,403-11; Motofen (Salt/Mix); 1-(3-Cyan-3,3-diphenylpropyl)-4-phenyl-4-piperidincarbonsaeure; Acscn-9168; Difenoxin (USAN/INN); SCHEMBL123801; R-15403 (Salt/Mix); GTPL7592; IDS-ND-007; Diphenoxylate related compound a; CHEMBL1201321; DTXSID0022931; ZINC601317; Difenoxin hydrochloride (Salt/Mix); McN-JR-15403-11; 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid; DB01501; R-15403 [aS hydrochloride] (Salt/Mix); C07871; D03809; SR-01000944433; Q5275251; SR-01000944433-1; 1-[3-cyano-3,3-di(phenyl)propyl]-4-phenylpiperidine-4-carboxylic acid
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  Therapeutic Class Antidiarrheals
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C28H28N2O2
  InChI InChI=1S/C28H28N2O2/c29-22-28(24-12-6-2-7-13-24,25-14-8-3-9-15-25)18-21-30-19-16-27(17-20-30,26(31)32)23-10-4-1-5-11-23/h1-15H,16-21H2,(H,31,32)
  InChIKey UFIVBRCCIRTJTN-UHFFFAOYSA-N
  Canonical SMILES C1CN(CCC1(C2=CC=CC=C2)C(=O)O)CCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4
  External Link
Pubchem ID 34328

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM035  Additive antimotility effects
BM038  Additive CNS depression effects
  Relation Graph
 Full list of drugs interacting with Difenoxin
      Pharmacodynamic additive effects
   Additive antimotility effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0909
 
Levacetylmethadol
 
C23H31NO2
 
15130 
Moderate    Inter Info   
[2]
   Additive CNS depression effects Drug Num:  56
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0098
 
Apraclonidine
 
C9H10Cl2N4
 
2216 
Moderate    Inter Info   
[1], [2], [3]
D0143
 
Baclofen
 
C10H12ClNO2
 
2284 
Moderate    Inter Info   
[4], [5], [6]
D0205
 
Brimonidine (ophthalmic)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[1], [2], [3]
D0206
 
Brimonidine (topical)
 
C11H10BrN5
 
2435 
Moderate    Inter Info   
[1], [2], [3]
D0212
 
Bromocriptine
 
C32H40BrN5O5
 
31101 
Moderate    Inter Info   
[4], [5], [6]
D0263
 
Carisoprodol
 
C12H24N2O4
 
2576 
Moderate    Inter Info   
[4], [5], [6]
D0305
 
Cetirizine
 
C21H25ClN2O3
 
2678 
Moderate    Inter Info   
[7], [8], [9]
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Moderate    Inter Info   
[4], [5], [6]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[4], [5], [6]
D0365
 
Clorazepic acid
 
C16H11ClN2O3
 
2809 
Moderate    Inter Info   
[4], [5], [6]
D0466
 
Dextromethorphan
 
C18H25NO
 
5360696 
Moderate    Inter Info   
[4], [5], [6]
D0471
 
Diamorphine
 
C21H23NO5
 
5462328 
Moderate    Inter Info   
[4], [5], [6]
D0208
 
Brivaracetam
 
C11H20N2O2
 
9837243 
Moderate    Inter Info   
[4], [5], [6]
D0248
 
Cannabidiol
 
C21H30O2
 
644019 
Moderate    Inter Info   
[4], [5], [6]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[4], [5], [6]
D0311
 
Chloral hydrate
 
C2H3Cl3O2
 
2707 
Moderate    Inter Info   
[4], [5], [6]
D0359
 
Clofedanol
 
C17H20ClNO
 
2795 
Moderate    Inter Info   
[4], [5], [6]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Moderate    Inter Info   
[4], [5], [6]
D0452
 
Deutetrabenazine
 
C19H27NO3
 
73437646 
Moderate    Inter Info   
[4], [5], [6]
D0600
 
Esketamine
 
C13H16ClNO
 
182137 
Moderate    Inter Info   
[8], [10], [11]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[4], [5], [6]
D0632
 
Ezogabine
 
C16H18FN3O2
 
121892 
Moderate    Inter Info   
[4], [5], [6]
D0901
 
Lemborexant
 
C22H20F2N4O2
 
56944144 
Moderate    Inter Info   
[4], [5], [6]
D0917
 
Levocetirizine
 
C21H25ClN2O3
 
1549000 
Moderate    Inter Info   
[7], [8], [9]
D0942
 
Lofexidine
 
C11H12Cl2N2O
 
30668 
Moderate    Inter Info   
[4], [5], [6]
D1182
 
Opicapone
 
C15H10Cl2N4O6
 
135565903 
Moderate    Inter Info   
[4], [5], [6]
D1252
 
Pentoxyverine
 
C20H31NO3
 
2562 
Moderate    Inter Info   
[4], [5], [6]
D1253
 
Perampanel
 
C23H15N3O
 
9924495 
Moderate    Inter Info   
[4], [5], [6]
D1431
 
Rotigotine
 
C19H25NOS
 
59227 
Moderate    Inter Info   
[4], [5], [6]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[4], [5], [6]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Moderate    Inter Info   
[4], [5], [6]
D1524
 
Suvorexant
 
C23H23ClN6O2
 
24965990 
Moderate    Inter Info   
[4], [5], [6]
D1536
 
Tasimelteon
 
C15H19NO2
 
10220503 
Moderate    Inter Info   
[4], [5], [6]
D1560
 
Tetrabenazine
 
C19H27NO3
 
6018 
Moderate    Inter Info   
[4], [5], [6]
D1673
 
Valbenazine
 
C24H38N2O4
 
24795069 
Moderate    Inter Info   
[4], [5], [6]
D1675
 
Valerian
 
NA
 
NA
Moderate    Inter Info   
[4], [5], [6]
D1719
 
Ziconotide
 
C102H172N36O32S7
 
16135415 
Moderate    Inter Info   
[4], [5], [6]
D0533
 
Dronabinol
 
C21H30O2
 
16078 
Moderate    Inter Info   
[4], [5], [6]
D0535
 
Droperidol
 
C22H22FN3O2
 
3168 
Moderate    Inter Info   
[4], [5], [6]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Moderate    Inter Info   
[4], [5], [6]
D0612
 
Eszopiclone
 
C17H17ClN6O3
 
969472 
Moderate    Inter Info   
[4], [5], [6]
D0878
 
Kava
 
C14H16O3
 
5281052 
Moderate    Inter Info   
[4], [5], [6]
D1053
 
Metyrosine
 
C10H13NO3
 
441350 
Moderate    Inter Info   
[4], [5], [6]
D1096
 
Nabilone
 
C24H36O3
 
5284592 
Moderate    Inter Info   
[4], [5], [6]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[4], [5], [6]
D1255
 
Pergolide
 
C19H26N2S
 
47811 
Moderate    Inter Info   
[4], [5], [6]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[4], [5], [6]
D1335
 
Pregabalin
 
C8H17NO2
 
5486971 
Moderate    Inter Info   
[4], [5], [6]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Moderate    Inter Info   
[4], [5], [6]
D1378
 
Ramelteon
 
C16H21NO2
 
208902 
Moderate    Inter Info   
[4], [5], [6]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[4], [5], [6]
D1390
 
Remifentanil
 
C20H28N2O5
 
60815 
Moderate    Inter Info   
[4], [5], [6]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[4], [5], [6]
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Moderate    Inter Info   
[8], [12], [11]
D1677
 
Valproic acid
 
C8H16O2
 
3121 
Moderate    Inter Info   
[4], [5], [6]
D1694
 
Vigabatrin
 
C6H11NO2
 
5665 
Moderate    Inter Info   
[4], [5], [6]
References
1 Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
4 Divoll M, Greenblatt DJ, Lacasse Y, Shader RI "Benzodiazepine overdosage: plasma concentrations and clinical outcome." Psychopharmacology (Berl) 73 (1981): 381-3. [PMID: 6789361]
5 Grabowski BS, Cady WJ, Young WW, Emery JF "Effects of acute alcohol administration on propranolol absorption." Int J Clin Pharmacol Ther Toxicol 18 (1980): 317-9. [PMID: 7429677]
6 Product Information. Belsomra (suvorexant). Merck &amp Company Inc, Whitehouse Station, NJ.
7 Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
8 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
9 Product Information. Xyzal (levocetirizine). UCB Pharma Inc, Smyrna, GA.
10 Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
11 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
12 Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.