Details of Drug

Drug General Information (ID: D0450)
Drug Name	Desogestrel
Drug Type	Small molecule
Drug Synonymous	Cerazette; Desogen; Desogestrelum; Organon Brand of Desogestrel; ORG 2969; Desogestrelum [INN-Latin]; Desogestrel (USAN/INN); Desogestrel [USAN:BAN:INN]; Alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17; (17alpha)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol; (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol; 13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol; 13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol; 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol; 17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol Click to Show/Hide
Disease Class	QA21: Contraceptive management
Therapeutic Class	Contraceptive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C22H30O
InChI	1S/C22H30O/c1-4-21-14-15(3)20-17-9-7-6-8-16(17)10-11-18(20)19(21)12-13-22(21,23)5-2/h2,8,17-20,23H,3-4,6-7,9-14H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1
InChIKey	RPLCPCMSCLEKRS-BPIQYHPVSA-N
Canonical SMILES	CCC12CC(=C)C3C(C1CCC2(C#C)O)CCC4=CCCCC34
External Link
	Pubchem ID	40973
	CAS Number	54024-22-5
	CHEBI ID	4453
	TTD ID	D06CGB
	INTEDE ID	DR0438

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM020 Decreased metabolism due to hepatotoxicity BM022 CYP450 enzyme induction BM023 UGT induction BM032 Decreased renal excretion (Unspecific) BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Desogestrel
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1068		Miltefosine	C21H46NO4P	3599	Moderate		Inter Info	[8], [9], [51]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[27], [28], [29]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[27], [28], [29]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[27], [28], [29]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[27], [28], [29]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[27], [28], [29]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[27], [28], [29]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[27], [28], [29]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[27], [28], [29]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[27], [28], [29]
	CYP450 enzyme inhibition					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[8], [9], [10]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[24], [25], [26]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[36], [20]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[41], [42], [43]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[44], [45], [46]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[47], [19], [48]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[9], [49]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[8], [9], [50]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[44], [52], [46]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[55], [56], [57]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[47], [58], [59]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[60], [46], [61]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[55], [56], [57]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[8], [9], [71]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[72], [73], [46]
D0120		Atorvastatin	C33H35FN2O5	60823	Minor		Inter Info	[81], [43]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[83], [84]
	Decreased metabolism due to hepatotoxicity					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[47], [19], [77]
	CYP450 enzyme induction					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3]
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[4], [5], [6]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[4], [7], [6]
D1198		Oxcarbazepine	C15H12N2O2	34312	Major		Inter Info	[13], [14], [15]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[16], [17], [18]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[4], [22], [23]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[4], [33], [34]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[4], [9], [35]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[9], [37]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[4], [38], [39]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[19], [40]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[19], [4], [44]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[19], [4], [54]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[19], [4], [44]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[19], [62]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[68], [69], [70]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[19], [4], [74]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[75], [4], [76]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[78], [79], [80]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[64], [65], [66], [67]
Affected excretion pathways
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1110		Naratriptan	C17H25N3O2S	4440	Minor		Inter Info	[8], [9], [82]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[30], [31], [32]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[30], [31], [32]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[30], [31], [32]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[30], [31], [32]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[30], [31], [32]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[30], [31], [32]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[30], [31], [32]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[30], [31], [32]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[30], [31], [32]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[30], [31], [32]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[30], [31], [32]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[30], [31], [32]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[30], [31], [32]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[30], [31], [32]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[30], [31], [32]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[30], [31], [32]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[30], [31], [32]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[30], [31], [32]
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[30], [31], [32]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[9], [11], [12]
D1894		Sugammadex	C72H112O48S8	6918585	Major		Inter Info	[19], [20], [21]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[53], [47]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[19], [63], [20]

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