Details of Drug

Details of Drug

 Drug General Information (ID: D0448)
  Drug Name
Desloratadine
  Drug Type Small molecule
  Drug Synonymous
Aerius; Allex; Azomyr; Claramax; Clarinex; Denosin; Desalex; Descarboethoxyloratadine; Descarboethoxyoratidine; Desloratidine; Neoclarityn; Opulis; Clarinex RediTabs; Desloratadine [USAN]; Essex brand of desloratadine; Schering brand of desloratadine; Sch 34117; Aerius (TN); Claramax (TN); Clarinex (TN); NeoClarityn (TN); Sch-34117; Schering-Plough brand of desloratadine; Desloratadine (USAN/INN); 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine; 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
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  Disease Class CA08: Vasomotor/allergic rhinitis
  Therapeutic Class Antiallergic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C19H19ClN2
  InChI 1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
  InChIKey JAUOIFJMECXRGI-UHFFFAOYSA-N
  Canonical SMILES C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
  External Link
Pubchem ID 124087
CAS Number 100643-71-8
CHEBI ID 291342
TTD ID D01GBY
INTEDE ID DR1761
VARIDT ID DR00497

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
AM007  Pharmacodynamic antagonistic effects
BM014  Interference of cell/tissue uptake
BM017  CYP450 enzyme inhibition
BM106  Diminish the response to diagnostic skin test antigens
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Desloratadine
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1822
 
Iodide I-123
 
I-
 
135300 
Moderate    Inter Info   
[6], [2], [7]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Minor    Inter Info   
[13]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Minor    Inter Info   
[13]
      Pharmacodynamic antagonistic effects
   Diminish the response to diagnostic skin test antigens Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1755
 
Candida albicans
 
C29H27N2O12P
 
118855431 
Moderate    Inter Info   
[1], [2], [3]
D1765
 
Coccidioides immitis spherule
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1912
 
Trichophyton mentagrophytes
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1913
 
Tuberculin purified protein derivative
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
   Attenuated pharmacological effects (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1807
 
Histamine
 
C5H9N3
 
774 
Moderate    Inter Info   
[4], [2], [5]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Moderate    Inter Info   
[8], [9], [2]
D1812
 
Hyaluronidase
 
C17H24BrNO2
 
91820602 
Minor    Inter Info   
[10], [11], [12]
References
1 Multum Information Services, Inc. Expert Review Panel.
2 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
3 NLM. National Library of Medicine. NIH. National Institutes of Health "Trichophyton for intradermal skin testing (trichophyton mentagrophytes and trichophyton rubrum) injection.".
4 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
5 Product Information. Histatrol (histamine phosphate). Center Laboratories, Port Washington, NY.
6 Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
7 Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
8 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9 Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
10 Fuhr U, Maier-Bruggemann A, Blume H, et al. "Grapefruit juice increases oral nimodipine bioavailability." Int J Clin Pharmacol Ther 36 (1998): 126-32. [PMID: 9562227]
11 Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
12 Product Information. Vitrase (hyaluronidase). Bausch and Lomb, Rochester, NY.
13 Product Information. Clarinex (desloratadine). Schering Corporation, Kenilworth, NJ.