Details of Drug

Drug General Information (ID: D0430)
Drug Name	Daunorubicin (liposomal)
Drug Type	Small molecule
Drug Synonymous	daunorubicin; Daunomycin; 20830-81-3; Rubidomycin; Cerubidine; Daunorubicine; Acetyladriamycin; Leukaemomycin C; Daunorubicinum; Daunarubicinum; Daunorrubicina; Daunamycin; Cerubidin; DaunoXome; Rubomycin C; (+)-Daunomycin; Daunoblastin; Anthracyline; Rubomycin; Daunorubicinum [INN-Latin]; RP 13057; Daunorubicin [INN:BAN]; RCRA waste no U059; FI6339; NSC-82151; DAUNORUBICIN HCL; DaunoXome (TN); UNII-ZS7284E0ZP; CCRIS 914; ZS7284E0ZP; CHEBI:41977; HSDB 5095; C27H29NO10; NCI-C04693; EINECS 244-069-7; Ondena; NSC 83142; Acetyladriamycin; Daunoblastine; Antibiotics from Streptomyces coeruleorubidus; DM1; FI 6339; Dauno-Rubidomycine; Daunorubicin (INN); Daunorubicin (liposomal); Daunorubicin, Hydrochloride; VS-103; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-(methyloxy)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside; (7S,9R)-9-Acetyl-7-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-oxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; Anthracycline Click to Show/Hide
Disease Class	2A60: Acute myeloid leukaemia; 2A00-2F9Z: Solid tumour/cancer; 2B57: Kaposi sarcoma
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C27H29NO10
InChI	1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1
InChIKey	STQGQHZAVUOBTE-VGBVRHCVSA-N
Canonical SMILES	CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)C)O)N)O
External Link
	Pubchem ID	30323
	CAS Number	20830-81-3
	CHEBI ID	41977
	TTD ID	D01XWG
	INTEDE ID	DR0424
	VARIDT ID	DR00284

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM006 Altered intestinal mucosa BM010 Transporter inhibition BM012 Competitive inhibition of transporters BM017 CYP450 enzyme inhibition BM038 Additive CNS depression effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM047 Additive thrombogenic effects BM049 Increased risk of atrioventricular block BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Daunorubicin (liposomal)
Affected gastrointestinal absorption
	Altered intestinal mucosa					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0340		Cinoxacin	C12H10N2O5	2762	Minor		Inter Info	[203]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[203]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[203]
D1102		Nalidixic acid	C12H12N2O3	4421	Minor		Inter Info	[203]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[203]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[203]
Affected cellular transport
	Transporter inhibition					Drug Num: 55
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[115], [116], [117]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[115], [116], [117]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[115], [116], [117]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[115], [116], [117]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[127]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[115], [116], [117]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[115], [116], [117]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[115], [116], [117]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[115], [116], [117]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[115], [116], [117]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[115], [116], [117]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[137], [138]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[115], [116], [117]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[115], [116], [117]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[115], [116], [117]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[4], [145], [146]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[149]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[115], [116], [117]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[115], [116], [117]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[115], [116], [117]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[115], [116], [117]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[115], [116], [117]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[115], [116], [117]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[115], [116], [117]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[115], [116], [117]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[115], [116], [117]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[162]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[115], [116], [117]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[115], [116], [117]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[115], [116], [117]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[115], [116], [117]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[115], [116], [117]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[115], [116], [117]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[115], [116], [117]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[115], [116], [117]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[115], [116], [117]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[115], [116], [117]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[115], [116], [117]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[115], [116], [117]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[115], [116], [117]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[115], [116], [117]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[115], [116], [117]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[115], [116], [117]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[115], [116], [117]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[115], [116], [117]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[115], [116], [117]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[115], [116], [117]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[115], [116], [117]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[115], [116], [117]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[115], [116], [117]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[115], [116], [117]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[115], [116], [117]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[115], [116], [117]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[115], [116], [117]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[115], [116], [117]
	Competitive inhibition of transporters					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1791		Gadobenic acid	C22H28GdN3O11	9852779	Moderate		Inter Info	[153], [154]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[151]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[141], [132], [133]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[185], [49]
	Additive immunosuppressive effects					Drug Num: 80
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[5], [13]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[4], [5], [27]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [2], [3]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[50], [51]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[50], [51]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[81]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[82]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3]
D1111		Natalizumab	NA	NA	Major		Inter Info	[94]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[5], [54], [105]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[72], [106], [107]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[108], [107]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[111], [112], [113]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[5], [54], [105]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[5], [54], [105]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[5], [54], [105]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[4], [5], [114]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[5], [54], [105]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[5], [54], [105]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[4], [5], [107]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[5], [54], [105]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[5], [54], [105]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[111], [112], [113]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[5], [54], [105]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[5], [54], [105]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[5], [54], [105]
D0405		Cytarabine (liposomal)	C9H13N3O5	6253	Moderate		Inter Info	[5], [54], [105]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[5], [54], [105]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[5], [54], [105]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[107], [140]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[142]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[142]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[5], [54], [105]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[5], [54], [105]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[5], [54], [105]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[5], [54], [105]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[5], [54], [105]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[5], [54], [105]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[5], [54], [105]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[5], [54], [105]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[5], [54], [105]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[5], [54], [105]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[5], [54], [105]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[5], [54], [105]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[142]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[5], [54], [105]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[5], [54], [105]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[167]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[168]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[5], [169]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[170]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[178]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[111], [112], [113]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[5], [179]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[5], [54], [105]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[181]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[4], [5], [115]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[5], [54], [105]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[5], [54], [105]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[183]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[184]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[186]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[5], [54], [105]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[5], [54], [105]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[5], [54], [105]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[5], [54], [105]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[5], [54], [105]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[5], [54], [105]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[5], [54], [105]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[5], [54], [105]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[194]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[5], [54], [105]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[5], [54], [105]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[5], [54], [105]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[5], [54], [105]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[5], [54], [105]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[4], [5], [202]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[14], [15], [16]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[4], [32], [33]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[68]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[4], [5], [155]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[4], [5], [155]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[78], [79], [80]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[5], [43], [191]
	Increased risk of prolong QT interval					Drug Num: 151
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[4], [5], [6]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[7], [8], [9]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[10], [11], [12]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[10], [17], [18]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[19], [20], [21]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[28]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[10], [17], [18]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[5], [29], [15]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[4], [5], [30]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[15], [31]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[4], [5], [34]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[10], [4], [35]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[36], [37], [38]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[40], [10], [41]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[4], [42], [43]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Major		Inter Info	[7], [8], [9]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[4], [5], [44]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[15], [47]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[15], [48], [49]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[5], [52], [53]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[4], [5], [54]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[15], [55], [49]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[4], [5], [56]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[4], [5], [57]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[10], [4], [5]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[15], [58], [49]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[60], [15], [49]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[61], [62], [63]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[4], [5], [64]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[5], [65], [66]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[10], [17], [18]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[10], [17], [18]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[10], [67], [53]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[4], [5], [69]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[70], [49]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[74], [75], [76]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[4], [5], [83]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[10], [4], [84]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[10], [17], [18]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[10], [4], [5]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[10], [85], [53]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[15], [86]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[4], [5], [87]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[10], [88], [89]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[4], [5], [90]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[91], [92], [93]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[40], [10], [41]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[10], [17], [18]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[5], [95], [96]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[10], [4], [54]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[10], [4], [99]
D0003		Abarelix	C72H95ClN14O14	16131215	Moderate		Inter Info	[5], [100], [101]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[10], [109], [53]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[110], [67], [53]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[110], [67], [53]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[110], [67], [53]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[110], [67], [53]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[110], [67], [53]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[110], [67], [53]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[5], [100], [101]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[10], [120], [53]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[4], [124], [125]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[10], [126], [53]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[5], [100], [101]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[110], [67], [53]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[110], [67], [53]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[131], [132], [133]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[110], [67], [53]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[4], [139]
D0437		Degarelix	C82H103ClN18O16	16136245	Moderate		Inter Info	[5], [100], [101]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[110], [67], [53]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[110], [67], [53]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[110], [67], [53]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[110], [67], [53]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[147], [15]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[5], [148]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[5], [100], [101]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[10], [4], [5]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[4], [5], [150]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[110], [67], [53]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[152]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[156], [157], [158]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[159]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[160]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[110], [67], [53]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[110], [67], [53]
D0758		Histrelin	C66H86N18O12	25077993	Moderate		Inter Info	[5], [100], [101]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[110], [67], [53]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[110], [67], [53]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[4], [110], [163]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[5], [15], [49]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[110], [67], [53]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[4], [5], [164]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[165], [15], [166]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[110], [67], [53]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[110], [67], [53]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[4], [110], [163]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[110], [67], [53]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[110], [67], [53]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[15], [171], [49]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[110], [67], [53]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[110], [67], [53]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[110], [67], [53]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[15], [174], [49]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[110], [67], [53]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[110], [67], [53]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[110], [67], [53]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[110], [67], [53]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[175], [176], [177]
D1388		Relugolix	C29H27F2N7O5S	10348973	Moderate		Inter Info	[5], [100], [101]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[110], [67], [53]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[110], [67], [53]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[110], [67], [53]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[4], [5], [180]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[110], [67], [53]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[10], [4], [182]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[110], [67], [53]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[4], [5], [53]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[110], [67], [53]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[110], [67], [53]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[110], [67], [53]
D1651		Triptorelin	C64H82N18O13	25074470	Moderate		Inter Info	[5], [100], [101]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[110], [67], [53]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[110], [67], [53]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[110], [67], [53]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[110], [67], [53]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[110], [67], [53]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[110], [67], [53]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[5], [100], [101]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[110], [67], [53]
D0737		Goserelin	C59H84N18O14	5311128	Moderate		Inter Info	[5], [100], [101]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[110], [67], [53]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[110], [67], [53]
D0908		Leuprolide	C59H84N16O12	657181	Moderate		Inter Info	[5], [100], [101]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[15], [192], [49]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[5], [100], [101]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[110], [67], [53]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[4], [5], [193]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[110], [67], [53]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[197], [198], [133]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[110], [67], [53]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[110], [67], [53]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[110], [67], [53]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[110], [67], [53]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[199], [200], [201]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[110], [67], [53]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[110], [67], [53]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[110], [67], [53]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[110], [67], [53]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[204], [205], [206]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[10], [4], [207]
	Increased risk of ventricular arrhythmias					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[22], [20], [23]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[39], [12]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[5], [45], [46]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[5], [59]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[4], [71], [49]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[102], [103], [104]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[121], [122], [123]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[4], [143], [144]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[121], [122], [123]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[121], [122], [123]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[121], [122], [123]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[121], [122], [123]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[121], [122], [123]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[121], [122], [123]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[5], [172], [173]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[121], [122], [123]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[5], [172], [173]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[121], [122], [123]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[4], [143], [144]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[121], [122], [123]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[121], [122], [123]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[5], [172], [173]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[121], [122], [123]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[121], [122], [123]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[4], [143], [144]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1621		Trastuzumab	NA	NA	Major		Inter Info	[4], [97], [98]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[161]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[24], [25], [26]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[24], [25], [26]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[24], [25], [26]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[24], [25], [26]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[24], [25], [26]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[72], [4], [73]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[77]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[24], [25], [26]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[24], [25], [26]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[24], [25], [26]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[72], [118], [119]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[72], [118], [119]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[72], [118], [119]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[72], [118], [119]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[72], [118], [119]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[72], [118], [119]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[72], [118], [119]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[72], [118], [119]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[72], [118], [119]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[72], [118], [119]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[72], [118], [119]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[72], [118], [119]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[190]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[128], [129], [130]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[128], [129], [130]
	Diminish the response to diagnostic skin test antigens					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[134], [135], [136]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[134], [135], [136]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[134], [135], [136]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[187], [188], [189]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[195], [196]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[187], [188], [189]

References
1	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
2	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
3	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Drug labels for the Tumor Necrosis Factor-alpha (TNFa) blockers now include warnings about infection with Legionella and Listeria bacteria. ".
4	Cerner Multum, Inc. "Australian Product Information.".
5	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6	Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
7	Product Information. Hydroxychloroquine Sulfate (hydroxychloroquine). Prasco Laboratories, Cincinnati, OH.
8	Mercuro NJ, Yen CF, Shim DJ, et.al "Risk of QT interval prolongation associated with the use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19)" JAMA Cardiol May 1:e201834 (2020): epub ahead of print. [PMID: 32936252]
9	US Food and Drug Administration "FACT SHEET FOR HEALTH CARE PROVIDERS EMERGENCY USE AUTHORIZATION (EUA) OF CHLOROQUINE PHOSPHATE SUPPLIED FROM THE STRATEGIC NATIONAL STOCKPILE FOR TREATMENT OF COVID-19 IN CERTAIN HOSPITALIZED PATIENTS. Available from: URL: https://www.fda.gov/media/13653" ([2020, Apr 27]):.
10	Canadian Pharmacists Association.
11	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide).".
12	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
13	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
14	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
15	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
16	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
17	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
18	Yamreudeewong W, DeBisschop M, Martin L, Lower D "Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs." Drug Saf 26 (2003): 421-38. [PMID: 12688833]
19	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
20	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
21	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
22	Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
23	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
24	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
25	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
26	Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
27	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
28	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
29	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
30	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
31	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
32	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
33	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
34	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
35	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
36	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
37	Castro VM, Clements CC, Murphy SN, et al. "QT interval and antidepressant use: a cross sectional study of electronic health records." BMJ 346 (2013): f288. [PMID: 23360890]
38	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
39	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
40	Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
41	Siepmann M, Kirch W "Drug points - Tachycardia associated with moxifloxacin." Br Med J 322 (2001): 23. [PMID: 11141146]
42	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
43	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
44	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
45	Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
46	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
47	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
48	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
49	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
50	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
51	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
52	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
53	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
54	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
55	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
56	Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
57	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
58	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
59	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
60	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
61	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
62	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
63	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
64	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
65	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
66	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
67	Witchel HJ, Hancox JC, Nutt DJ "Psychotropic drugs, cardiac arrhythmia, and sudden death." J Clin Psychopharmacol 23 (2003): 58-77. [PMID: 12544377]
68	Product Information. Quadramet (samarium sm 153 lexidronam) Berlex Laboratories, Richmond, CA.
69	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
70	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
71	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
72	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
73	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
74	Dupont H, Timsit JF, Souweine B, Gachot B, Wolff M, Regnier B "Torsades de pointe probably related to sparfloxacin." Eur J Clin Microbiol Infect Dis 15 (1996): 350-1. [PMID: 8781892]
75	Jaillon P, Morganroth J, Brumpt I, Talbot G "Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group." J Antimicrob Chemother 37(suppl a) (1996): 161-7. [PMID: 8737135]
76	Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81. [PMID: 8838432]
77	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
78	Figg WD, Arlen P, Gulley J, et al. "A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer." Semin Oncol 28(4 Suppl 15) (2001): 62-6. [PMID: 11685731]
79	Fine HA, Wen PY, Maher EA, et al. "Phase II Trial of Thalidomide and Carmustine for Patients With Recurrent High-Grade Gliomas." J Clin Oncol 21 (2003): 2299-304. [PMID: 12805330]
80	Zangari M, Siegel E, Barlogie B, et al "Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy." Blood 100 (2002): 1168-71. [PMID: 12149193]
81	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
82	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
83	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
84	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
85	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
86	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
87	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
88	Huyse F, van Schijndel RS "Haloperidol and cardiac arrest." Lancet 2 (1988): 568-9. [PMID: 2900948]
89	Product Information. Haldol (haloperidol). McNeil Pharmaceutical, Raritan, NJ.
90	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
91	Gil M, Sala M, Anguera I, et al. "QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone." Am J Cardiol 92 (2003): 995-7. [PMID: 14556883]
92	Krantz MJ, Mehler PS "Synthetic opioids and QT prolongation." Arch Intern Med 163 (2003): 1615 author reply 1615. [PMID: 12860589]
93	Mokwe EO, Ositadinma O "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966000]
94	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
95	Liberatore MA, Robinson DS "Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy?" J Clin Psychopharmacol 4 (1984): 143-6. [PMID: 6145728]
96	Product Information. Mellaril (thioridazine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
97	Strasser F, Betticher DC, Suter TM "Trastuzumab and breast cancer." N Engl J Med 345 (2001): 996.[PMID: 11575296]
98	Product Information. DOXOrubicin Hydrochloride (DOXOrubicin). Pfizer U.S. Pharmaceuticals Group, New York, NY.
99	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
100	Product Information. Vantas (histrelin). Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
101	Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
102	Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
103	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
104	Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
105	Product Information. Fluorouracil injection (fluorouracil). Roche Laboratories, Nutley, NJ.
106	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
107	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
108	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
109	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
110	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
111	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
112	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
113	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
114	Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21. [PMID: 1909542]
115	Multum Information Services, Inc. Expert Review Panel.
116	Product Information. Daunoxome (daunorubicin liposomal). Nexstar Pharmaceuticals Inc, Boulder, CO.
117	Product Information. Idamycin (idarubicin). Pharmacia and Upjohn, Kalamazoo, MI.
118	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
119	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
120	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
121	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
122	Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
123	Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
124	Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
125	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
126	Product Information. Saphris (asenapine). Schering-Plough Corporation, Kenilworth, NJ.
127	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
128	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
129	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
130	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
131	Product Information. Lamprene (clofazimine). Novartis Pharmaceuticals, East Hanover, NJ.
132	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
133	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
134	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
135	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
136	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
137	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
138	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
139	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
140	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
141	Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
142	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
143	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
144	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
145	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
146	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
147	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
148	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
149	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
150	Product Information. Pepcid (famotidine). Merck &amp Co, Inc, West Point, PA.
151	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
152	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
153	Product Information. Multihance (gadobenate dimeglumine). Bracco Diagnostics Inc, Princeton, NJ.
154	Huisman MT, Smit JW, Crommentuyn KM, et al. "Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs." AIDS 16 (2002): 2295-2301. [PMID: 12441801]
155	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
156	Ball P "Quinolone-induced QT interval prolongation: a not-so-unexpected class effect." J Antimicrob Chemother 45 (2000): 557-9. [PMID: 10797074]
157	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7. [PMID: 11141163]
158	Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
159	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
160	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
161	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
162	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
163	Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
164	Product Information. Lucemyra (lofexidine). US WorldMeds LLC, Louisville , KY.
165	Eggleston W, Clark KH, Marraffa JM "Loperamide abuse associated with cardiac dysrhythmia and death." Ann Emerg Med 69 (2017): 83-6. [PMID: 27140747]
166	US Food and Drug Administration "FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse.".
167	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
168	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
169	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
170	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
171	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
172	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
173	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
174	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
175	Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
176	Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
177	Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
178	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
179	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
180	Product Information. Ultane (sevoflurane). Abbott Pharmaceutical, Abbott Park, IL.
181	AnazaoHealth Corporation "P32 Sodium Phosphate."
182	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
183	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
184	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
185	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
186	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
187	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
188	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
189	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
190	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
191	Canadian Pharmacists Association "e-CPS."
192	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
193	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
194	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
195	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
196	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
197	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
198	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
199	Antonelli D, Atar S, Freedberg NA, Rosenfeld T "Torsade de pointes in patients on chronic amiodarone treatment: contributing factors and drug interactions." Isr Med Assoc J 7 (2005): 163-5. [PMID: 15792261]
200	Mazur A, Strasberg B, Kusniec J, Sclarovsky S "QT prolongation and polymorphous ventricular tachycardia associated with trasodone-amiodarone combination." Int J Cardiol 52 (1995): 27-9. [PMID: 8707432]
201	Product Information. Oleptro (traZODone). Labopharm Inc, Laval, AL.
202	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
203	Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42. [PMID: 2373666]
204	Giannini AJ, DeFrance DT "Metronidazole and alcohol: potential for combinative abuse." J Toxicol Clin Toxicol 20 (1983): 509-15. [PMID: 6668631]
205	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
206	Product Information. Benznidazole (benznidazole). Everett Laboratories Inc, West Orange, NJ.
207	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence