Details of Drug

Drug General Information (ID: D0416)
Drug Name	Danazol
Drug Type	Small molecule
Drug Synonymous	Anatrol; Chronogyn; Cyclomen; Danatrol; Danazant; Danazole; Danazolum; Danocrine; Danogen; Danokrin; Danol; Danoval; Danzol; Ladogal; Norciden; Panacrine; Winobanin; Alphapharm Brand of Danazol; Antigen Brand of Danazol; Kendrick Brand of Danazol; Ratiopharm Brand of Danazol; Sanofi Brand of Danazol; Sanofi Synthelabo Brand ofDanazol; Sanofi Winthrop Brand of Danazol; WIN 17757; Danazol-ratiopharm; Danazolum [INN-Latin]; Danocrine (TN); WIN 17,757; WIN-17757; Win 17, 757; Danazol (JAN/USP/INN); Danazol [USAN:BAN:INN:JAN];[1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol; (1R,3aS,3bR,10aR,10bS,12aS)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol; (1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9-trien-17-ol; 1-Ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol; 17-alpha-2,4-Pregnadien-20-yno(2,3-d)isoxazol-17-ol; 17-alpha-Pregn-4-en-20-yno(2,3-d)isoxazol-17-ol; 17-alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol; 17.Alpha.-Pregna-2, {4-dien-20-yno[2,3-d]isoxazol-17-ol}; 17alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol Click to Show/Hide
Disease Class	GA20: Menstrual cycle bleeding disorder; 2C60-2C6Y: Breast cancer
Therapeutic Class	Fertility Agents
Structure
Structure	3D Structure		2D Structure
Formula	C22H27NO2
InChI	1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17+,18+,20+,21+,22+/m1/s1
InChIKey	POZRVZJJTULAOH-LHZXLZLDSA-N
Canonical SMILES	CC12CCC3C(C1CCC2(C#C)O)CCC4=CC5=C(CC34C)C=NO5
External Link
	Pubchem ID	28417
	CAS Number	17230-88-5
	CHEBI ID	4315
	TTD ID	D09IPV
	INTEDE ID	DR2401

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM047 Additive thrombogenic effects BM055 Increased risk of hepatotoxicity BM083 Potentiated the pharmacological effects (Unspecific) BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Danazol
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 138
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0303		Cerivastatin	C26H34FNO5	446156	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[19], [23]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[24]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[25]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[21], [27]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[32], [33], [34], [35], [36]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[37], [25]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[19], [38], [11], [39], [40], [41], [42], [43], [44]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[1], [2], [3], [4], [7]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[48], [49], [21], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[64]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[65]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[77]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[78]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[79], [19], [21], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[79], [19], [21]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[93]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[94], [95]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[96]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[107], [108], [109], [110]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[111], [59]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[21], [112]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[21], [113]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[21], [115]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[19], [21], [117]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[21], [119]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[120]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[121]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[126]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[127]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[128]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[129]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[130]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[131]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[132]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[133]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[134], [59]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[135]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[136]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[21], [137]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[138]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[139], [140]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[141], [59]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[21], [143]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[144], [145]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[146]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[19], [21], [147]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[148]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[152]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[153]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[19], [21], [154], [59]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[155]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[156]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[157]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[158], [159]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[160]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[161]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[21], [162]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[163]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[21], [164]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[165], [166]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[167]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[21], [172]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[173]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[174]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[175]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[19], [21], [179]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[19], [180], [21], [181]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[19], [182]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[21], [183]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[184]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[185]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[186]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[21], [50], [187]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[19], [188]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[189]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[190]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[192]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[19], [21], [193]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[194]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[195]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[196], [59]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[197]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[198], [199], [200], [201], [202], [11], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[222], [19], [21], [223], [224], [225], [226], [227], [228]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[229]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[230]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[233]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[204], [206], [217]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[198], [199], [200], [201], [202], [11], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[235], [236], [237], [238], [62]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[239], [240]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[21], [241]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[242]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[243]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[21], [244]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[245], [246], [247], [248], [249], [250], [251], [252]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[204], [206], [217]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[204], [206], [217]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[254], [255]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[29], [19], [21]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[19], [21], [257]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[258], [259], [19], [260], [261], [262], [263], [226]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[258], [259], [19]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[264], [265], [266], [267], [268], [269], [270], [271], [272]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[273], [274], [275], [276]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[19], [21], [277], [278], [279], [59], [280]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[279], [281]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[282]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[285], [286]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[287]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[288]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[289], [59]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[19], [21], [290]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[291], [292], [293], [294], [295], [296], [297]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[298], [299]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[300]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[301], [302]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[19], [303], [304]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[305]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[306]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[307]
D0948		Lopinavir	C37H48N4O5	92727	Minor		Inter Info	[21], [308], [309]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[310]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[21], [311]
D1664		Ulipristal	C28H35NO3	13559281	Minor		Inter Info	[21], [312]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[313], [314], [315], [316]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[301], [302]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[19], [303], [304]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[317]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[318]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[319], [320], [321], [322], [323], [324], [325]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[326]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[327], [328], [329], [330]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[19], [20], [21]
D0385		Conestat alfa	NA	NA	Moderate		Inter Info	[122], [123], [124], [125]
D0762		Human C1-esterase inhibitor	NA	NA	Moderate		Inter Info	[122], [124], [125]
	Increased risk of hepatotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[26]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[28]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[29], [30], [31]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[29], [30], [31]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[66], [67], [68], [19], [21], [69], [70], [71], [72], [73], [74], [75], [76]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[106]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[66], [67], [68], [19], [21], [69], [70], [71], [72], [73], [74], [75], [76]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[114]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[116]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[66], [67], [68], [19], [21], [69], [70], [71], [72], [73], [74], [75], [76]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[21], [118]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[142]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[168], [169], [170], [171]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[19], [21], [176], [177], [178]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[21], [191]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[231], [232]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[19], [21], [234]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[168], [169], [170], [171]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[168], [169], [170], [171]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[21], [253]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[256]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[66], [67], [68], [19], [21], [69], [70], [71], [72], [73], [74], [75], [76]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[283], [284]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[149], [150], [151]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[149], [150], [151]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[149], [150], [151]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[149], [150], [151]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[45], [46], [47]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[45], [46], [47]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[45], [46], [47]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[45], [46], [47]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[45], [46], [47]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[45], [46], [47]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[45], [46], [47]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[45], [46], [47]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[45], [46], [47]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[45], [46], [47]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[45], [46], [47]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[45], [46], [47]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[45], [46], [47]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[45], [46], [47]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[45], [46], [47]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[45], [46], [47]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[45], [46], [47]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[45], [46], [47]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[45], [46], [47]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[45], [46], [47]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[45], [46], [47]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[45], [46], [47]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[45], [46], [47]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[45], [46], [47]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[45], [46], [47]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[45], [46], [47]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[45], [46], [47]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[45], [46], [47]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[45], [46], [47]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[45], [46], [47]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[45], [46], [47]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[45], [46], [47]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[45], [46], [47]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[45], [46], [47]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[45], [46], [47]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[45], [46], [47]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[45], [46], [47]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[45], [46], [47]
	Antagonize the effect of antihypertensive agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[45], [46], [47]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[45], [46], [47]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[45], [46], [47]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0752		Hemin	C34H32FeN4O4	26945	Major		Inter Info	[22]

References
1	Andreou ER, Ledger S "Potential drug interaction between simvastatin and danazol causing rhabdomyolysis." Can J Clin Pharmacol 10 (2003): 172-4. [PMID: 14712320]
2	Dallaire M, Chamberland M "Severe rhabdomyolysis in a patient receiving lovastatin, danazol and doxycycline." Can Med Assoc J 150 (1994): 1991-4. [PMID: 8199978]
3	Gruer PJK, Vega JM, Mercuri MF, Dobrinska MR, Tobert JA "Concomitant use of cytochrome P450 3A4 inhibitors and simvastatin." Am J Cardiol 84 (1999): 811-5. [PMID: 10513779]
4	Neuvonen PJ, Backman JT, Niemi M "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin." Clin Pharmacokinet 47 (2008): 463-74. [PMID: 18563955]
5	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
6	Product Information. Mevacor (lovastatin). Merck & Co, Inc, West Point, PA.
7	Product Information. Zocor (simvastatin). Merck & Co, Inc, West Point, PA.
8	Bedford TA, Rowbotham DJ "Cisapride: drug interactions of clinical significance." Drug Saf 15 (1996): 167-75. [PMID: 8879971]
9	Bran S, Murray WA, Hirsch IB, Palmer JP "Long QT syndrome during high-dose cisapride." Arch Intern Med 155 (1995): 765-8. [PMID: 7695465]
10	Desta Z, Soukhova N, Mahal SK, Flockhart DA "Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies." Drug Metab Dispos 28 (2000): 789-800. [PMID: 10859153]
11	Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57. [PMID: 10668858]
12	Gray VS "Syncopal episodes associated with cisapride and concurrent drugs." Ann Pharmacother 32 (1998): 648-51. [PMID: 9640482]
13	Hill SL, Evangelista JK, Pizzi AM, Mobassaleh M, Fulton DR, Berul CI "Proarrhythmia associated with cisapride in children." Pediatrics 101 (1998): 1053-6. [PMID: 9606235]
14	Lewin MB, Bryant RM, Fenrich AL, Grifka RG "Cisapride-induced long QT interval." J Pediatr 128 (1996): 279-81. [PMID: 8636830]
15	Michalets EL "Update: clinically significant cytochrome P-450 drug interactions." Pharmacotherapy 18 (1998): 84-112. [PMID: 9469685]
16	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
17	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
18	Thomas AR, Chan LN, Bauman JL, Olopade CO "Prolongation of the QT interval related to cisapride-diltiazem interaction." Pharmacotherapy 18 (1998): 381-5. [PMID: 9545159]
19	Cerner Multum, Inc. "Australian Product Information.".
20	Product Information. Kyprolis (carfilzomib). Onyx Pharmaceuticals Inc, South San Francisco, CA.
21	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
22	Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ.
23	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
24	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
25	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
26	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
27	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
28	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
29	Canadian Pharmacists Association.
30	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
31	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
32	Abernethy DR, Wesche DL, Barbey JT, et al. "Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation." Br J Clin Pharmacol 51 (2001): 231-7. [PMID: 11298069]
33	Baune B, Flinois JP, Furlan V, et al. "Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5." J Pharm Pharmacol 51 (1999): 419-26. [PMID: 10385214]
34	Charbit B, Becquemont L, Lepere B, Peytavin G, Funck-Bretano C "Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine." Clin Pharmacol Ther 72 (2002): 514-23. [PMID: 12426515]
35	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
36	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
37	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
38	Desta Z, Kerbusch T, Flockhart DA "Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)." Clin Pharmacol Ther 65 (1999): 10-20. [PMID: 9951426]
39	Flockhart DA, Drici MD, Kerbusch T, et al "Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with tourette syndrome." J Clin Psychopharmacol 20 (2000): 317-24. [PMID: 10831018]
40	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
41	Krahenbuhl S, Sauter B, Kupferschmidt H, Krause M, Wyss PA, Meier PJ "Case report: reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication." Am J Med Sci 309 (1995): 315-6. [PMID: 7771501]
42	Mangum EM, Graham KK "Lopinavir-Ritonavir: a new protease inhibitor." Pharmacotherapy 21 (2001): 1352-63. [PMID: 11714208]
43	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
44	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
45	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
46	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
47	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
48	Bartkowski RR, Goldberg ME, Larijani GE, Boerner T "Inhibition of alfentanil metabolism by erythromycin." Clin Pharmacol Ther 46 (1989): 99-102. [PMID: 2501060]
49	Bartkowski RR, McDonnell TE "Prolonged alfentanil effect following erythromycin administration." Anesthesiology 73 (1990): 566-8. [PMID: 2203286]
50	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
51	Kharasch ED, Thummel KE "Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?" Anesth Analg 76 (1993): 1033-9. [PMID: 8484504]
52	Kharasch ED, Walker A, Hoffer C, Sheffels P "Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis." Clin Pharmacol Ther 76 (2004): 452-66. [PMID: 15536460]
53	Klees TM, Sheffels P, Dale O, Kharasch ED "Metabolism of alfentanil by cytochrome P4503A enzymes." Drug Metab Dispos 33 (2005): 303-11. [PMID: 15557344]
54	Klees TM, Sheffels P, Thummel KE, Kharasch ED "Pharmacogenetic Determinants of Human Liver Microsomal Alfentanil Metabolism and the Role of Cytochrome P450 3A5." Anesthesiology 102 (2005): 550-556. [PMID: 15731592]
55	Koehntop DE, Noormohamed SE, Fletcher CV "Effects of long-term drugs on alfentanil clearance in patients undergoing renal transplantation." Pharmacotherapy 14 (1994): 592-9. [PMID: 7997393]
56	Labroo RB, Thummel KE, Kunze KL, Podoll T, Trager WF, Kharasch ED "Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism." Drug Metab Dispos 23 (1995): 490-6. [PMID: 7600917]
57	Palkama VJ, Isohanni MH, Neuvonen PJ, Olkkola KT "The effect of intravenous and oral fluconazole on the pharmacokinetics and pharmacodynamics of intravenous alfentanil." Anesth Analg 87 (1998): 190-4. [PMID: 9661572]
58	Product Information. Alfenta (alfentanil). Janssen Pharmaceutica, Titusville, NJ.
59	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
60	Yate PM, Thomas D, Short SM, Sebel PS, Morton J "Comparison of infusions of alfentanil or pethidine for sedation of ventilated patients on the ITU." Br J Anaesth 58 (1986): 1091-9. [PMID: 2876719]
61	Yun CH, Wood M, Wood AJ, Guengerich FP "Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4: an explanation of the variable elimination clearance." Anesthesiology 77 (1992): 467-74. [PMID: 1519785]
62	Ibrahim AE, Feldman J, Karim A, Kharasch ED "Simultaneous Assessment of Drug Interactions with Low- and High-Extraction Opioids: Application to Parecoxib Effects on the Pharmacokinetics and Pharmacodynamics of Fentanyl and Alfentanil." Anesthesiology 98 (2003): 853-861. [PMID: 12657846]
63	Kharasch ED, Russell M, Mautz D, Thummel KE, Kunze KL, Bowdle A, Cox K "The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions." Anesthesiology 87 (1997): 36-50. [PMID: 9232132]
64	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
65	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
66	Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
67	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
68	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
69	Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
70	Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
71	Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
72	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
73	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
74	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
75	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
76	Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
77	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
78	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
79	Bolland MJ, Bagg W, Thomas MG, Lucas JA, Ticehurst R, Black PN "Cushing's syndrome due to interaction between inhaled corticosteroids and itraconazole." Ann Pharmacother 38 (2004): 46-9. [PMID: 14742792]
80	Daveluy A, Raignoux C, Miremont-Salame G, et al. "Drug interactions between inhaled corticosteroids and enzymatic inhibitors." Eur J Clin Pharmacol (2009):. [PMID: 19399485]
81	De Wachter E, Malfroot A, De Schutter I, Vanbesien J, De Schepper J "Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450." J Calif Dent Assoc 2 (2003): 72-5. [PMID: 15463853]
82	De Wachter E, Vanbesien J, De Schutter I, Malfroot A, De Schepper J "Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide." Eur J Pediatr (2003):. [PMID: 12719971]
83	Edsbacker S, Andersson T "Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease." Clin Pharmacokinet 43 (2004): 803-21. [PMID: 15355126]
84	Jonsson G, Astrom A, Andersson P "Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver." Drug Metab Dispos 23 (1995): 137-42. [PMID: 7720517]
85	Kedem E, Shahar E, Hassoun G, Pollack S "Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient." J Asthma 47 (2010): 830-1. [PMID: 20653496]
86	Main KM, Skov M, Sillesen IB, et al. "Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient." Acta Paediatr 91 (2002): 1008-11. [PMID: 12412882]
87	Molimard M, Girodet PO, Pollet C, et al. "Inhaled corticosteroids and adrenal insufficiency: prevalence and clinical presentation." Drug Saf 31 (2008): 769-74. [PMID: 18707191]
88	Product Information. Entocort (budesonide). AstraZeneca Pharma Inc, Mississauga, ON.
89	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
90	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
91	Raaska K, Niemi M, Neuvonen M, Neuvonen PJ, Kivisto KT "Plasma concentrations of inhaled budesonide and its effects on plasma cortisol are increased by the cytochrome P4503A4 inhibitor itraconazole." Clin Pharmacol Ther 72 (2002): 362-369. [PMID: 12386638]
92	Skov M, Main KM, Sillesen IB, Muller J, Koch C, Lanng S "Iatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonide." Eur Respir J 20 (2002): 127-33. [PMID: 12166560]
93	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
94	Kramer G, Theisohn M, von Unruh GE, Eichelbaum M "Carbamazepine-danazol drug interaction: its mechanism examined by a stable isotope technique." Ther Drug Monit 8 (1986): 387-92. [PMID: 3824425]
95	Zielinski JJ, Lichten EM, Haidukewych D "Clinically significant danazol-carbamazepine interaction." Ther Drug Monit 9 (1987): 24-7. [PMID: 3107168]
96	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
97	Hedaya MA, El-Afify DR, El-Maghraby GM "The effect of ciprofloxacin and clarithromycin on sildenafil oral bioavailability in human volunteers." Biopharm Drug Dispos 27 (2006): 103-10. [PMID: 16372380]
98	Herrlin K, Segerdahl M, Gustafsson LL, Kalso E "Methadone, ciprofloxacin, and adverse drug reactions." Lancet 356 (2000): 2069-70. [PMID: 11145498]
99	McLellan RA, Drobitch RK, Monshouwer M, Renton KW "Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human." Drug Metab Dispos 24 (1996): 1134-8. [PMID: 8894516]
100	Product Information. Pletal (cilostazol). Otsuka American Pharmaceuticals, Rockville, MD.
101	Sawant RD "Rhabdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin." Can J Clin Pharmacol 16 (2009): e78-9. [PMID: 19151423]
102	Shahzadi A, Javed I, Aslam B, et al. "Therapeutic effects of ciprofloxacin on the pharmacokinetics of carbamazepine in healthy adult male volunteers." Pak J Pharm Sci 24 (2011): 63-8. [PMID: 21190921]
103	Sriwiriyajan S, Samaeng M, Ridtitid W, Mahatthanatrakul W, Wongnawa M "Pharmacokinetic interactions between ciprofloxacin and itraconazole in healthy male volunteers." Biopharm Drug Dispos 32 (2011): 168-74. [PMID: 21360715]
104	Suri A, Bramer SL "Effect of omeprazole on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 53-9. [PMID: 10702887]
105	Suri A, Forbes WP, Bramer SL "Effects of CYP3A inhibition on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 61-8. [PMID: 10702888]
106	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
107	Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50. [PMID: 2683269]
108	Moller BB, Ekelund B "Toxicity of cyclosporine during treatment with androgens." N Engl J Med 313 (1985): 1416. [PMID: 4058536]
109	Product Information. Sandimmune (cyclosporine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
110	Ross WB, Roberts D, Griffin PJA, Salaman JR "Cyclosporin interaction with danazol and norethisterone." Lancet 1 (1986): 330. [PMID: 2868196]
111	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
112	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
113	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
114	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
115	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
116	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
117	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
118	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
119	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
120	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
121	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
122	Product Information. Berinert (complement C1 esterase inhibitor). CSL Behring, King of Prussia, PA.
123	Product Information. Cinryze (complement C1 esterase inhibitor). ViroPharma Incorporated, Exton, PA.
124	Product Information. Ruconest (conestat alfa). Valeant Pharmaceuticals, Costa Mesa, CA.
125	Gandhi PK, Gentry WM, Bottorff MB "Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: investigation from the United States Food and Drug Administration adverse event reporting system database." Pharmacotherapy 32 (2012): 902-9. [PMID: 23033229]
126	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
127	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
128	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
129	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
130	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
131	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
132	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
133	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
134	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
135	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
136	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
137	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
138	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
139	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
140	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
141	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
142	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
143	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
144	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
145	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
146	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
147	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
148	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
149	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
150	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
151	Arafah BM "Decreased levothyroxine requirement in women with hypothyroidism during androgen therapy for breast cancer." Ann Intern Med 121 (1994): 247-51
152	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
153	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
154	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
155	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
156	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
157	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
158	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
159	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
160	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
161	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
162	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
163	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
164	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
165	Hamberg P, Woo MM, Chen LC, et al. "Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor." Cancer Chemother Pharmacol 68 (2011): 805-13. [PMID: 21706316]
166	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
167	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
168	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
169	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
170	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
171	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
172	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
173	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
174	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
175	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
176	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
177	Gilead Sciences, Inc "About Remdesivir.".
178	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
179	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
180	Cerner Multum, Inc. "Canadian Product Information.".
181	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
182	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
183	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
184	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
185	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
186	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
187	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
188	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
189	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
190	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
191	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
192	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
193	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
194	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
195	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
196	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
197	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
198	Ausband SC, Goodman PE "An unusual case of clarithromycin associated ergotism." J Emerg Med 4 (2001): 411-3. [PMID: 11728770]
199	Baldwin ZK, Ceraldi CC "Ergotism associated with HIV antiviral protease inhibitor therapy." J Vasc Surg 37 (2003): 676-8. [PMID: 12618710]
200	Bird PA, Sturgess AD "Clinical ergotism with severe bilateral upper limb ischaemia precipitated by an erythromycin - ergotamine drug interaction." Aust N Z J Med 30 (2000): 635-6. [PMID: 11108077]
201	Blanche P, Rigolet A, Gombert B, Ginsburg C, Salmon D, Sicard D "Ergotism related to a single dose of ergotamine tartrate in an AIDS patient treated with ritonavir." Postgrad Med J 75 (1999): 546-7. [PMID: 10616689]
202	Caballero-Granado FJ, Viciana P, Cordero E, Gomez-Vera MJ, del Nozal M, Lopez-Cortes LF "Ergotism related to concurrent administration of ergotamine tartrate and ritonavir in an AIDS patient." Antimicrob Agents Chemother 41 (1997): 1207. [PMID: 9145904]
203	Eadie MJ "Clinically significant drug interactions with agents specific for migraine attacks." Cns Drugs 15 (2001): 105-18. [PMID: 11460889]
204	Francis H, Tyndall A, Webb J "Severe vascular spasm due to erythromycin-ergotamine interaction." Clin Rheumatol 3 (1984): 243-6. [PMID: 6236021]
205	Hayton AC "Precipitation of acute ergotism by triacetyloleandomycin." N Z Med J 69 (1969): 42. [PMID: 5304704]
206	Horowitz RS, Dart RC, Gomez HF "Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction." Arch Intern Med 156 (1996): 456-8. [PMID: 8607732]
207	Leroy F, Asseman P, Pruvost P, Adnet P, Lacroix D, Thery C "Dihydroergotamine-erythromycin-induced ergotism." Ann Intern Med 109 (1988): 249. [PMID: 3389610]
208	Liaudet L "Severe ergotism associated with interaction between ritonavir and ergotamine." BMJ 318 (1999): 771. [PMID: 10082701]
209	Liaudet L, Buclin T, Jaccard C, Eckert P "Severe ergotism associated with interaction between ritonavir and ergotamine." Br Med J 318 (1999): 771. [PMID: 10082701]
210	Matthews NT, Havill JH "Ergotism with therapeutic doses of ergotamine tartrate." N Z Med J 89 (1979): 476-7. [PMID: 314074]
211	Montero A, Giovannoni AG, Tvrde PL "Leg ischemia in a patient receiving ritonavir and ergotamine." Ann Intern Med 130 (1999): 329. [PMID: 10068398]
212	Mortier E, Pouchet J, Vinceneux P, Lalande M "Ergotism related to interaction between nelfinavir and ergotamine." Am J Med 110 (2001): 594. [PMID: 11347624]
213	Product Information. Cafergot (caffeine-ergotamine). Novartis Pharmaceuticals, East Hanover, NJ.
214	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
215	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
216	Rosenthal E, Sala F, Chichmanian RM, Batt M, Cassuto JP "Ergotism related to concurrent administration of ergotamine tartrate and indinavir." JAMA 281 (1999): 987. [PMID: 10086430]
217	Spiegel M, Schmidauer C, Kampfl A, Sarcletti M, Poewe W "Cerebral ergotism under treatment with ergotamine and ritonavir." Neurology 57 (2001): 743-4. [PMID: 11524501]
218	Srisuma S, Lavonas EJ, Wananukul W "Ergotism and factitious hypotension associated with interaction of ergotamine with CYP3A4 inhibitors." Clin Toxicol (Phila) (2014): 1-4. [PMID: 24978905]
219	Tribble MA, Gregg CR, Margolis DM, Amirkhan R, Smith JW "Fatal ergotism induced by an HIV protease inhibitor." Headache 42 (2002): 694-5. [PMID: 12482227]
220	Vila A, Mykietiuk A, Bonvehi P, Temporiti E, Uruena A, Herrera F "Clinical ergotism induced by ritonavir." Scand J Infect Dis 33 (2001): 788-9. [PMID: 11728055]
221	Ghali R, De Lean J, Douville Y, Noel HP, Labbe R "Erythromycin-associated ergotamine intoxication: arteriographic and electrophysiologic analysis of a rare cause of severe ischemia of the lower extremities and associated ischemic neuropathy." Ann Vasc Surg 7 (1993): 291-6. [PMID: 8391300]
222	Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91. [PMID: 6779990]
223	Engels FK, Mathot RA, Loos WJ, van Schaik RH, Verweij J "Influence of high-dose ketoconazole on the pharmacokinetics of docetaxel." Cancer Biol Ther 5 (2006): 833-9. [PMID: 16775418]
224	McInnes GT, Brodie MJ "Drug interactions that matter: a critical reappraisal." Drugs 36 (1988): 83-110. [PMID: 3063497]
225	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
226	Starr SP, Hammann F, Gotta V, et al. "Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity." Br J Clin Pharmacol 450 (2016): 22-27. [PMID: 27868228]
227	Vodovar D, Arnaout M, Mongardon N, et al. "Severe docetaxel overdose induced by pharmacokinetic interaction with dronedarone." J Clin Oncol 29 (2011): e694-5. [PMID: 21730272]
228	Yong WP, Wang LZ, Tham LS, et al. "A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers." Cancer Chemother Pharmacol 62 (2008): 243-51. [PMID: 17909805]
229	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
230	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
231	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
232	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
233	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
234	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
235	Labroo RB, Paine MF, Thummel KE, Kharasch ED "Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implicaitons for interindividual variability in disposition, efficacy, and drug interactions." Drug Metab Dispos 25 (1997): 1072-80. [PMID: 9311623]
236	Product Information. Actiq (fentanyl). Abbott Pharmaceutical, Abbott Park, IL.
237	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
238	Tateishi T, Krivoruk Y, Ueng YF, Wood AJ, Guengerich FP, Wood M "Identification of human cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation." Anesth Analg 82 (1996): 167-72. [PMID: 8712396]
239	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
240	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
241	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
242	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
243	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
244	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
245	Bell J, Seres V, Bowron P, Lewis J, Batey R "The use of serum methadone levels in patients receiving methadone maintenance." Clin Pharmacol Ther 43 (1988): 623-9. [PMID: 3378383]
246	Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
247	Foster DJ, Somogyi AA, Bochner F "Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4." Br J Clin Pharmacol 47 (1999): 403-12. [PMID: 10233205]
248	Iribarne C, Berthou F, Baird S, Dreano Y, Picart D, Bail JP, Beaune P, Menez JF "Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes." Chem Res Toxicol 9 (1996): 365-73. [PMID: 8839037]
249	Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
250	Moody DE, Alburges ME, Parker RJ, Collings JM, Strong JM "The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone." Drug Metab Dispos 25 (1997): 1347-53. [PMID: 9394023]
251	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
252	Oda Y, Kharasch ED "Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation." J Pharmacol Exp Ther 298 (2001): 1021-32. [PMID: 11504799]
253	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
254	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
255	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
256	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
257	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
258	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
259	Bun SS, Ciccolini J, Bun H, Aubert C, Catalin J "Drug interactions of paclitaxel metabolism in human liver microsomes." J Chemother 15 (2003): 266-74. [PMID: 12868554]
260	Jamis-Dow CA, Klecker RW, Katki AG, Collins JM "Metabolism of Taxol by human liver microsomes and effect of inhibitors (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 34 (1993): a21981993.
261	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
262	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
263	Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
264	DeVane CL, Nemeroff CB "Clinical pharmacokinetics of quetiapine - An atypical antipsychotic." Clin Pharmacokinet 40 (2001): 509-22. [PMID: 11510628]
265	Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB "Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics." Br J Clin Pharmacol 61 (2006): 58-69. [PMID: 16390352]
266	Hantson P, Di Fazio V, Wallemacq P "Toxicokinetic interaction between quetiapine and antiretroviral therapy following quetiapine overdose." Drug Metab Lett 4 (2010): 7-8. [PMID: 20201782]
267	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
268	Quetiapine for schizophrenia. Med Lett Drugs Ther 39 (1997): 117-8. [PMID: 9422044]
269	Spina E, de Leon J "Metabolic drug interactions with newer antipsychotics: a comparative review." Basic Clin Pharmacol Toxicol 100 (2007): 4-22. [PMID: 17214606]
270	Spina E, Scordo MG, D'Arrigo C "Metabolic drug interactions with new psychotropic agents." Fundam Clin Pharmacol 17 (2003): 517-38. [PMID: 14703714]
271	Urichuk L, Prior TI, Dursun S, Baker G "Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions." Curr Drug Metab 9 (2008): 410-8. [PMID: 18537577]
272	Schulz-Du Bois C, Schulz-Du Bois AC, Bewig B, et al. "Major increase of quetiapine steady-state plasma concentration following co-administration of clarithromycin: confirmation of the pharmacokinetic interaction potential of quetiapine." Pharmacopsychiatry 41 (2008): 258-9. [PMID: 19067264]
273	Hyland R, Roe GH, Jones BC, Smith DA "Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil." Br J Clin Pharmaacol 51 (2001): 239-48. [PMID: 11298070]
274	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
275	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
276	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
277	Christians U, Schmidt G, Bader A, et al "Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes." Br J Clin Pharmacol 41 (1996): 187-90. [PMID: 8866917]
278	Product Information. Parlodel (bromocriptine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
279	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
280	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
281	Shapiro R, Venkataramanan R, Warty VS, et al "Fk 506 interaction with danazol." Lancet 341 (1993): 1344-5. [PMID: 7684106]
282	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
283	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
284	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
285	Brynne N, Forslund C, Hallen B, Gustafsson LL, Bertilsson L "Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity." Br J Clin Pharmacol 48 (1999): 564-72. [PMID: 10583027]
286	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
287	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
288	Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ.
289	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
290	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
291	Farkas D, Volak L, Harmatz J, von Moltke L, Court M, Greenblatt D "Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem." Clin Pharmacol Ther 85 (2009): 644-50. [PMID: 19242403]
292	Greenblatt DJ, von Moltke LL, Harmatz JS, et al. "Differential impairment of triazolam and zolpidem clearance by ritonavir." J Acquir Immune Defic Syndr 24 (2000): 129-36. [PMID: 10935688]
293	Greenblatt DJ, vonMoltke LL, Harmatz JS, Mertzanis P, Graf JA, Durol ALB, Counihan M, RothSchechter B, Shader RI "Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole." Clin Pharmacol Ther 64 (1998): 661-71. [PMID: 9871431]
294	Luurila H, Kivisto KT, Neuvonen PJ "Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem." Eur J Clin Pharmacol 54 (1998): 163-6. [PMID: 9626922]
295	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
296	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
297	Saari TI, Laine K, Leino K, Valtonen M, Neuvonen PJ, Olkkola KT "Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects." Br J Clin Pharmacol 63 (2007): 116-20. [PMID: 16822278]
298	Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
299	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
300	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
301	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
302	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
303	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
304	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
305	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
306	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
307	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
308	Dimartini A "Isoniazid, tricyclics and the ''cheese reaction''." Int Clin Psychopharmacol 10 (1995): 197-8. [PMID: 8675973]
309	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
310	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
311	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
312	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
313	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
314	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
315	Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8. [PMID: 10811561]
316	Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4. [PMID: 9839763]
317	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
318	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
319	Ekstrom G, Gunnarsson UB "Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes." Drug Metab Dispos 24 (1996): 955-61. [PMID: 8886604]
320	Halldin MM, Bredberg E, Angelin B, Arvidsson T, Askemark Y, Elofsson S, Widman M "Metabolism and excretion of ropivacaine in humans." Drug Metab Dispos 24 (1996): 962-8. [PMID: 8886605]
321	Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT "The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine." Anesth Analg 91 (2000): 1207-12. [PMID: 11049910]
322	McClure JH "Ropivacaine." Br J Anaesth 76 (1996): 300-7. [PMID: 8777115]
323	Oda Y, Furuichi K, Tanaka K, Hiroi T, Imaoka S, Asada A, Fujimori M, Funae Y "Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450." Anesthesiology 82 (1995): 214-20. [PMID: 7832304]
324	Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
325	Arlander E, Ekstrom G, Alm C, Carrillo JA, Bielenstein M, Bottiger Y, Bertilsson L, Gustafsson LL "Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors." Clin Pharmacol Ther 64 (1998): 484-91. [PMID: 9834040]
326	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
327	Miceli JJ, Smith M, Robarge L, Morse T, Laurent A "The effects of ketoconazole on ziprasidone pharmacokinetics--a placebo-controlled crossover study in healthy volunteers." Br J Clin Pharmacol 49(suppl 1) (2000): s71-6. [PMID: 10771458]
328	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
329	Wilner KD, Hansen RA, Folger CJ, Geoffroy P "The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid." Br J Clin Pharmacol 49(Suppl 1) (2000): 57S-60S. [PMID: 10771455]
330	Prakash C, Kamel A, Cui D, Whalen RD, Miceli JJ, Tweedie D "Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions." Br J Clin Pharmacol 49(Suppl 1) (2000): 35S-42S. [PMID: 10771452]

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