Details of Drug

Drug General Information (ID: D0413)
Drug Name	Dalfopristin
Drug Type	Small molecule
Drug Synonymous	5-(2-DIETHYLAMINO-ETHANESULFONYL)-21-HYDROXY-10-ISOPROPYL-11,19-DIMETHYL-9,26-DIOXA-3,15,28-TRIAZA-TRICYCLO[23.2.1.00,255]OCTACOSA-1(27),12,17,19,25(28)-PENTAENE-2,8,14,23-TETRAONE Click to Show/Hide
Disease Class	1A00-1C4Z: Bacterial infection
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C34H50N4O9S
InChI	1S/C34H50N4O9S/c1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b10-9+,12-11+,23-18+/t24-,25-,28-,31-,32-/m1/s1
InChIKey	SUYRLXYYZQTJHF-VMBLUXKRSA-N
Canonical SMILES	CCN(CC)CCS(=O)(=O)C1CCN2C1C(=O)OC(C(C=CC(=O)NCC=CC(=CC(CC(=O)CC3=NC(=CO3)C2=O)O)C)C)C(C)C
External Link
	Pubchem ID	6323289
	CAS Number	112362-50-2
	CHEBI ID	4309
	TTD ID	D05AFC

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Dalfopristin
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[193], [194]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[193], [194]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[120]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 261
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[4], [5], [6]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[4], [5], [6]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[4], [5], [6]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[4], [5], [6]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[7], [8]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[9], [10], [11]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[4], [5], [6]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[12], [13], [14]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[15]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[16], [17]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[9], [18]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[19], [9], [20]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[21], [22]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[19], [9], [23]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[9], [24]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[9], [25]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[26]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[27]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[9], [28]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[29]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[9], [30], [31]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[9], [32], [33]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[36]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[19], [37], [38]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[8]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[39]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[19], [9], [40]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[41]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[9], [42]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[43], [19], [44]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[19], [9], [45]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[46], [47]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[48]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[49]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[46], [50]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[51], [8]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[19], [46], [52]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[53]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[54]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[55]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[19], [9], [56]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[57]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[4], [5], [6]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[4], [5], [6]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[4], [5], [6]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[58]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[4], [5], [6]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[59]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[19], [60], [61]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[9], [62], [63]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[64], [65], [66]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[67], [68], [69]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[4], [5], [6]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[70], [8]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[19], [9], [71]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[72], [73], [38]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[4], [5], [6]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[74], [75]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[4], [5], [6]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[4], [5], [6]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[4], [5], [6]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[76]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[6]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[34], [9], [77]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[78], [79]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[80], [81], [82]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[83]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[84], [85], [86]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[6]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[87]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[88], [19], [9]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[88], [19], [9]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[89]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[6]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[84], [85], [86]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[90]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[6]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[19], [8]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[6]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[6]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[6]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[6]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[6]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[6]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[6]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[91], [92], [6]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[93]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[34], [9], [94]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[9], [95]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[9], [96]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[97]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[98]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[99]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[9], [100]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[101]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[102]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[103]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[19], [9], [104]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[105]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[106]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[107]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[9], [108], [109]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[110]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[111]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[112]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[19], [113], [114]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Moderate		Inter Info	[19], [113], [114]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[78], [79]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[115]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[9], [116]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[117], [37]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[9], [113], [37]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[118], [119]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[121]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[46], [122]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[123]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[19], [9], [124]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[125], [126]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[34], [9], [77]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[127]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[128]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[129], [130]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[9], [131]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[132], [133]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[132], [134]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[135], [8]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[9], [136]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[137], [132], [138]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[132], [139]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[132], [140]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[141]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[142]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[143]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[19], [144], [145]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[146]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[19], [46], [147]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[19], [9], [148]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[149]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[9], [150], [151]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[152]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[9], [30], [153]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[154]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[155]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[9], [156]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[19], [9], [157]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[158]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[9], [159], [160]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[6]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[161]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[34], [30], [162]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[6]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[9], [163]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[19], [164]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[6]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[6]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[6]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[165], [166], [167]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[6]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[168], [169], [170]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[171]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[172]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[6]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[173]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[165], [166], [167]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[6]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[177], [178], [179]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[6]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[6]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[6]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[6]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[6]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[180], [181]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[6]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[6]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[6]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[6]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[19], [9], [182]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[6]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[19], [9], [183]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[19], [9], [183]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[6]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[6]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[6]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[9], [184]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[6]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[6]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[84], [85], [86]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[6]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[185], [186], [187]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[165], [166], [167]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[6]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[6]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[6]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[132], [188], [189]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[190], [191], [192]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[6]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[6]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[6]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[6]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[6]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[6]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[34], [19], [9]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[6]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[195], [196], [19]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[195], [196], [19]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[6]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[6]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[6]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[6]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[6]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[197], [8], [198]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[19], [199], [200]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[201], [202], [203]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[6]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[6]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[6]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[204], [205], [206]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[84], [85], [86]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[132], [207]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[6]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[208], [16]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[209], [210], [211]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[6]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[6]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[6]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[212], [213]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[132], [214]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[6]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[6]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[215]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[46], [132], [216]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[19], [9], [217]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[6]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[6]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[6]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[6]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[6]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[6]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[218], [219], [220]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[221], [222], [22]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[223], [224]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[225], [226], [22]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[19], [227], [228]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[9], [229]
D0425		Darolutamide	C19H19ClN6O2	67171867	Minor		Inter Info	[230]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[231]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[232]
D0638		Fedratinib	C27H36N6O3S	16722836	Minor		Inter Info	[233], [46], [122]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[234]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[235]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[9], [236]
D1664		Ulipristal	C28H35NO3	13559281	Minor		Inter Info	[9], [132], [237]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[238], [239], [240]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[225], [226], [22]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[19], [227], [228]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[241]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[242]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[243], [244], [245]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[246], [247], [248]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[249], [250], [251]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[34], [35]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[174], [175], [176]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[174], [175], [176]

References
1	Product Information. Alfenta (alfentanil). Janssen Pharmaceutica, Titusville, NJ.
2	Yate PM, Thomas D, Short SM, Sebel PS, Morton J "Comparison of infusions of alfentanil or pethidine for sedation of ventilated patients on the ITU." Br J Anaesth 58 (1986): 1091-9. [PMID: 2876719]
3	Yun CH, Wood M, Wood AJ, Guengerich FP "Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4: an explanation of the variable elimination clearance." Anesthesiology 77 (1992): 467-74. [PMID: 1519785]
4	Bailey DG, Dresser GR, Kreeft JH, Munoz C, Freeman DJ, Bend JR "Grapefruit-felodipine interaction: Effect of unprocessed fruit and probable active ingredients." Clin Pharmacol Ther 68 (2000): 468-77. [PMID: 11103749]
5	Honig PK, Wortham DC, Zamani K, et al "Terfenadine-ketoconazole interaction: pharmacokinetic and electrocardiographic consequences." JAMA 269 (1993): 1513-8. [PMID: 8445813]
6	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
7	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
8	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
9	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
10	Suri A, Bramer SL "Effect of omeprazole on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 53-9. [PMID: 10702887]
11	Suri A, Forbes WP, Bramer SL "Effects of CYP3A inhibition on the metabolism of cilostazol." Clin Pharmacokinet 37 (1999): 61-8. [PMID: 10702888]
12	Dogukan A, Oymak FS, Taskapan H, Guven M, Tokgoz B, Utas C "Acute fatal colchicine intoxication in a patient on continuous ambulatory peritoneal dialysis (CAPD). Possible role of clarithromycin administration." Clin Nephrol 55 (2001): 181-2. [PMID: 11269688]
13	Severe colchicine-macrolide interactions. Prescrire Int 12 (2003): 18-9. [PMID: 12602385]
14	Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ "Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation." Biochem Pharmacol 53 (1996): 111-6. [PMID: 8960070]
15	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
16	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
17	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
18	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
19	Cerner Multum, Inc. "Australian Product Information.".
20	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
21	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
22	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
23	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
24	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
25	Product Information. Emflaza (deflazacort). Marathon Pharmaceuticals, Deerfield, IL.
26	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
27	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
28	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
29	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
30	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
31	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
32	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
33	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
34	Canadian Pharmacists Association.
35	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
36	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
37	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
38	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
39	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
40	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
41	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
42	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
43	Abbas R, Hug BA, Leister C, Burns J, Sonnichsen D "Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects." Br J Clin Pharmacol 71 (2011): 522-7. [PMID: 21395644]
44	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
45	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
46	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
47	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
48	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
49	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
50	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
51	Multum Information Services, Inc. Expert Review Panel.
52	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
53	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
54	Product Information. Belsomra (suvorexant). Merck &amp Company Inc, Whitehouse Station, NJ.
55	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
56	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
57	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
58	Product Information. Inspra (eplerenone). Searle, Chicago, IL.
59	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
60	Labroo RB, Paine MF, Thummel KE, Kharasch ED "Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implicaitons for interindividual variability in disposition, efficacy, and drug interactions." Drug Metab Dispos 25 (1997): 1072-80. [PMID: 9311623]
61	Product Information. Actiq (fentanyl). Abbott Pharmaceutical, Abbott Park, IL.
62	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
63	Product Information. Tenex (guanfacine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
64	Charbit B, Becquemont L, Lepere B, Peytavin G, Funck-Bretano C "Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine." Clin Pharmacol Ther 72 (2002): 514-23. [PMID: 12426515]
65	Giao PT, de Vries PJ "Pharmacokinetic interactions of antimalarial agents." Clin Pharmacokinet 40 (2001): 343-73. [PMID: 11432537]
66	Product Information. Halfan (halofantrine). GlaxoSmithKline, Philadelphia, PA.
67	Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA "CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes." Br J Clin Pharmacol 57 (2004): 287-97. [PMID: 14998425]
68	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
69	Vizcaychipi MP, Walker S, Palazzo M "Serotonin syndrome triggered by tramadol." Br J Anaesth 99 (2007): 919. [PMID: 18006535]
70	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
71	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
72	Flockhart DA, Drici MD, Kerbusch T, et al "Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with tourette syndrome." J Clin Psychopharmacol 20 (2000): 317-24. [PMID: 10831018]
73	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
74	European Medicines Agency "CHMP Assessment Report for Latixa. International nonproprietary name: ranolazine.".
75	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
76	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
77	Sasaki M, Maeda A, Fujimura A "Influence of diltiazem on the pharmacokinetics of amlodipine in elderly hypertensive patients." Eur J Clin Pharmacol 57 (2001): 85-6. [PMID: 11372598]
78	Product Information. Emend (aprepitant). Merck &amp Company Inc, West Point, PA.
79	Product Information. Emend for Injection (fosaprepitant). Merck &amp Company Inc, West Point, PA.
80	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
81	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
82	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
83	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
84	Andreou ER, Ledger S "Potential drug interaction between simvastatin and danazol causing rhabdomyolysis." Can J Clin Pharmacol 10 (2003): 172-4. [PMID: 14712320]
85	Ayanian JZ, Fuchs CS, Stone RM "Lovastatin and rhabdomyolysis." Ann Intern Med 109 (1988): 682-3. [PMID: 3421582]
86	Yeo KR, Yeo WW, Wallis EJ, Ramsay LE "Enhanced cholesterol reduction by simvastatin in diltiazem-treated patients." Br J Clin Pharmacol 48 (1999): 610-5. [PMID: 10583033]
87	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
88	Bolland MJ, Bagg W, Thomas MG, Lucas JA, Ticehurst R, Black PN "Cushing's syndrome due to interaction between inhaled corticosteroids and itraconazole." Ann Pharmacother 38 (2004): 46-9. [PMID: 14742792]
89	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
90	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
91	Ducharme MP, Warbasse LH, Edwards DJ "Disposition of intravenous and oral cyclosporine after administration with grapefruit juice." Clin Pharmacol Ther 57 (1995): 485-91. [PMID: 7768070]
92	Min DI, Ku YM, Perry PJ, Ukah FO, Ashton K, Martin MF, Hunsicker LG "Effect of grapefruit juice on cyclosporine pharmacokinetics in renal transplant patients." Transplantation 62 (1996): 123-5. [PMID: 8693526]
93	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
94	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
95	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
96	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
97	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
98	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
99	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
100	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
101	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
102	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
103	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
104	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
105	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
106	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
107	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
108	Han TH, Gopal AK, Ramchandren R, et al. "CYP3A-mediated drug-drug interaction potential and excretion of brentuximab vedotin, an antibody-drug conjugate, in patients with CD30-positive hematologic malignancies." J Clin Pharmacol 53 (2013): 866-77. [PMID: 23754575]
109	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
110	Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
111	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
112	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
113	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
114	St Clair K, Maguire JD "Role of fluconazole in a case of rapid onset ritonavir and inhaled fluticasone-associated secondary adrenal insufficiency." Int J STD AIDS 23 (2012): 371-2. [PMID: 22648897]
115	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
116	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
117	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
118	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
119	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
120	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
121	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
122	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
123	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
124	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
125	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
126	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
127	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
128	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
129	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
130	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
131	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
132	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
133	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
134	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
135	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
136	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
137	Hamberg P, Woo MM, Chen LC, et al. "Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor." Cancer Chemother Pharmacol 68 (2011): 805-13. [PMID: 21706316]
138	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
139	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
140	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
141	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
142	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
143	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
144	Cerner Multum, Inc. "Canadian Product Information.".
145	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
146	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
147	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
148	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
149	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
150	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
151	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
152	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
153	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
154	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
155	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
156	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
157	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
158	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
159	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
160	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
161	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
162	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
163	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
164	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
165	Francis H, Tyndall A, Webb J "Severe vascular spasm due to erythromycin-ergotamine interaction." Clin Rheumatol 3 (1984): 243-6. [PMID: 6236021]
166	Horowitz RS, Dart RC, Gomez HF "Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction." Arch Intern Med 156 (1996): 456-8. [PMID: 8607732]
167	Spiegel M, Schmidauer C, Kampfl A, Sarcletti M, Poewe W "Cerebral ergotism under treatment with ergotamine and ritonavir." Neurology 57 (2001): 743-4. [PMID: 11524501]
168	Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91. [PMID: 6779990]
169	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
170	Starr SP, Hammann F, Gotta V, et al. "Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity." Br J Clin Pharmacol 450 (2016): 22-27. [PMID: 27868228]
171	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
172	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
173	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
174	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
175	Barnett ML "Inhibition of oral contraceptive effectiveness by concurrent antibiotic administration." J Periodontol 56 (1985): 18-20. [PMID: 3882930]
176	King VJ "OC failure rates and oral antibiotics." J Fam Pract 45 (1997): 104-5. [PMID: 9267366]
177	Becquemont L, Mouajjah S, Escaffre O, Beaune P, Funck-Bretano C, Jaillon P "Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism." Drug Metab Dispos 27 (1999): 1068-73. [PMID: 10460808]
178	Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57. [PMID: 10668858]
179	Product Information. Imovane (zopiclone). Rhone-Poulenc Rorer Canada Inc, Laval, IN.
180	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
181	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
182	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
183	Corona G, Vaccher E, Sandron S, et al. "Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma." Clin Pharmacol Ther 83 (2008): 601-6. [PMID: 17713471]
184	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
185	Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
186	Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
187	Moody DE, Alburges ME, Parker RJ, Collings JM, Strong JM "The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone." Drug Metab Dispos 25 (1997): 1347-53. [PMID: 9394023]
188	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
189	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
190	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
191	Sitsen JM, Maris FA, Timmer CJ "Concomitant use of mirtazapine and cimetidine: a drug-drug interaction study in healthy male subjects." Eur J Clin Pharmacol 56 (2000): 389-94. [PMID: 11009047]
192	Stormer E, von Moltke LL, Shader RI, Greenblatt DJ "Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4" Drug Metab Dispos 28 (2000): 1168-75. [PMID: 10997935]
193	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
194	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
195	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
196	Bun SS, Ciccolini J, Bun H, Aubert C, Catalin J "Drug interactions of paclitaxel metabolism in human liver microsomes." J Chemother 15 (2003): 266-74. [PMID: 12868554]
197	Product Information. Rythmol SR (propafenone). GlaxoSmithKline, Research Triangle Park, NC.
198	Botsch S, Gautier JC, Beaune P, Eichelbaum M, Kroemer HK "Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites." Mol Pharmacol 43 (1993): 120-6. [PMID: 8423765]
199	Mirghani RA, Yasar U, Zheng T, et al "Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway." Drug Metab Dispos 30 (2002): 1368-71. [PMID: 12433805]
200	Wanwimolruk S, Paine MF, Pusek SN, Watkins PB "Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?" Br J Clin Pharmacol 54 (2002): 643-51. [PMID: 12492613]
201	Hatorp V, Hansen KT, Thomsen MS "Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide." J Clin Pharmacol 43 (2003): 649-60. [PMID: 12817528]
202	Khamaisi M, Leitersdorf E "Severe hypoglycemia from clarithromycin-repaglinide drug interaction." Pharmacotherapy 28 (2008): 682-4. [PMID: 18447665]
203	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
204	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
205	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
206	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
207	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
208	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
209	Franco-Salinas G, de la Rosette JJ, Michel MC "Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations." Clin Pharmacokinet 49 (2010): 177-88. [PMID: 20170206]
210	Kamimura H, Oishi S, Matsushima H, et al. "Identification of cytochrome P450 isozymes involved in metabolism of the alpha1-adrenoceptor blocker tamsulosin in human liver microsomes." Xenobiotica 28 (1998): 909-22. [PMID: 9849639]
211	Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT.
212	Brynne N, Forslund C, Hallen B, Gustafsson LL, Bertilsson L "Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity." Br J Clin Pharmacol 48 (1999): 564-72. [PMID: 10583027]
213	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
214	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
215	Product Information. Bextra (valdecoxib). Pharmacia Corporation, Peapack, NJ.
216	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
217	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
218	Greenblatt DJ, vonMoltke LL, Harmatz JS, Mertzanis P, Graf JA, Durol ALB, Counihan M, RothSchechter B, Shader RI "Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole." Clin Pharmacol Ther 64 (1998): 661-71. [PMID: 9871431]
219	Luurila H, Kivisto KT, Neuvonen PJ "Effect of itraconazole on the pharmacokinetics and pharmacodynamics of zolpidem." Eur J Clin Pharmacol 54 (1998): 163-6. [PMID: 9626922]
220	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
221	Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
222	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
223	Demarles D, Gillotin C, Bonaventure-Paci S, Vincent I, Fosse S, Taburet AM "Single-dose pharmacokinetics of amprenavir coadministered with grapefruit juice." Antimicrob Agents Chemother 46 (2002): 1589-1590. [PMID: 11959608]
224	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
225	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
226	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
227	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
228	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
229	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
230	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
231	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
232	Product Information. Pifeltro (doravirine). Merck &amp Company Inc, Whitehouse Station, NJ.
233	Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
234	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
235	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
236	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
237	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
238	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
239	Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8. [PMID: 10811561]
240	Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4. [PMID: 9839763]
241	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
242	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
243	Ekstrom G, Gunnarsson UB "Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes." Drug Metab Dispos 24 (1996): 955-61. [PMID: 8886604]
244	Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT "The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine." Anesth Analg 91 (2000): 1207-12. [PMID: 11049910]
245	Arlander E, Ekstrom G, Alm C, Carrillo JA, Bielenstein M, Bottiger Y, Bertilsson L, Gustafsson LL "Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors." Clin Pharmacol Ther 64 (1998): 484-91. [PMID: 9834040]
246	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
247	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
248	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
249	Miceli JJ, Smith M, Robarge L, Morse T, Laurent A "The effects of ketoconazole on ziprasidone pharmacokinetics--a placebo-controlled crossover study in healthy volunteers." Br J Clin Pharmacol 49(suppl 1) (2000): s71-6. [PMID: 10771458]
250	Wilner KD, Hansen RA, Folger CJ, Geoffroy P "The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid." Br J Clin Pharmacol 49(Suppl 1) (2000): 57S-60S. [PMID: 10771455]
251	Prakash C, Kamel A, Cui D, Whalen RD, Miceli JJ, Tweedie D "Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions." Br J Clin Pharmacol 49(Suppl 1) (2000): 35S-42S. [PMID: 10771452]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence