Details of Drug

Details of Drug

 Drug General Information (ID: D0412)
  Drug Name
Dalfampridine
  Drug Type Small molecule
  Drug Synonymous
Ampyra (TN)
    Click to Show/Hide
  Disease Class 8A40: Multiple sclerosis
  Therapeutic Class Cns Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C5H6N2
  InChI 1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
  InChIKey NUKYPUAOHBNCPY-UHFFFAOYSA-N
  Canonical SMILES C1=CN=CC=C1N
  External Link
Pubchem ID 1727
CAS Number 504-24-5
CHEBI ID 34385
TTD ID D08YIN
INTEDE ID DR0408

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM006  Pharmacodynamic additive effects
BM010  Transporter inhibition
BM069  Increased risk of lowers seizure threshold
  Relation Graph
 Full list of drugs interacting with Dalfampridine
      Affected cellular transport
   Transporter inhibition Drug Num:  19
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0337
 
Cimetidine
 
C10H16N6S
 
2756 
Moderate    Inter Info   
[23], [24], [25]
D0181
 
Bictegravir
 
C21H18F3N3O5
 
90311989 
Moderate    Inter Info   
[23], [27], [24]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[23], [27], [24]
D0515
 
Dolutegravir
 
C20H19F2N3O5
 
54726191 
Moderate    Inter Info   
[23], [24], [25]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[27], [28]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Moderate    Inter Info   
[27], [29], [30]
D0903
 
Lenvatinib
 
C21H19ClN4O4
 
9823820 
Moderate    Inter Info   
[23], [27], [24]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[23], [27], [24]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Moderate    Inter Info   
[23], [27], [24]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Moderate    Inter Info   
[23], [27], [24]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Moderate    Inter Info   
[23], [27], [24]
D0890
 
Lamotrigine
 
C9H7Cl2N5
 
3878 
Moderate    Inter Info   
[23], [24], [25]
D0993
 
Megestrol acetate
 
C24H32O4
 
11683 
Moderate    Inter Info   
[23], [27], [24]
D1015
 
Metformin
 
C4H11N5
 
4091 
Moderate    Inter Info   
[23], [27], [24]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[23], [27], [24]
D1383
 
Ranolazine
 
C24H33N3O4
 
56959 
Moderate    Inter Info   
[23], [27], [24]
D1645
 
Trimethoprim
 
C14H18N4O3
 
5578 
Moderate    Inter Info   
[23], [27], [24]
D1681
 
Vandetanib
 
C22H24BrFN4O2
 
3081361 
Moderate    Inter Info   
[23], [27], [24]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Moderate    Inter Info   
[23], [27], [24]
      Pharmacodynamic additive effects
   Increased risk of lowers seizure threshold Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Major    Inter Info   
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[16], [17], [18], [19], [20]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[16], [17], [18], [19], [20]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[21], [14], [13], [22]
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[24], [26]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[31], [32], [27]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[31], [32], [27]
D1488
 
Sodium sulfate
 
Na2O4S
 
24436 
Moderate    Inter Info   
[31], [32], [27]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[23], [27]
D0722
 
Ginkgo biloba
 
NA
 
NA
Moderate    Inter Info   
[33], [34], [35], [36], [37], [38], [39], [40]
D0932
 
Lindane
 
C6H6Cl6
 
727 
Moderate    Inter Info   
[41], [42], [43]
References
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29 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
30 Product Information. Tenex (guanfacine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
31 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
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43 Product Information. Kwell (lindane). Reed and Carnrick, Jersey City, NJ.