Details of Drug

Drug General Information (ID: D0408)
Drug Name	Daclatasvir
Drug Type	Small molecule
Drug Synonymous	1009119-64-5; Daclatasvir (BMS-790052); 1214735-16-6; CHEBI:82977; C40H50N8O6; methyl N-[(1S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carbonyl]-2-methyl-propyl]carbamate; Daclatasvir (USAN); cc-39; Daclatasvir BMS 790052; MLS006011140; SCHEMBL2756027; CHEMBL2023898; SCHEMBL17897804; KS-00000XPC; EX-A410 Click to Show/Hide
Disease Class	1E50-1E51: Hepatitis virus infection
Therapeutic Class	Ns5A Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C40H50N8O6
InChI	1S/C40H50N8O6/c1-23(2)33(45-39(51)53-5)37(49)47-19-7-9-31(47)35-41-21-29(43-35)27-15-11-25(12-16-27)26-13-17-28(18-14-26)30-22-42-36(44-30)32-10-8-20-48(32)38(50)34(24(3)4)46-40(52)54-6/h11-18,21-24,31-34H,7-10,19-20H2,1-6H3,(H,41,43)(H,42,44)(H,45,51)(H,46,52)/t31-,32-,33-,34-/m0/s1
InChIKey	FKRSSPOQAMALKA-CUPIEXAXSA-N
Canonical SMILES	CC(C)C(C(=O)N1CCCC1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)C6CCCN6C(=O)C(C(C)C)NC(=O)OC)NC(=O)OC
External Link
	Pubchem ID	25154714
	CAS Number	1009119-64-5
	CHEBI ID	82977
	TTD ID	D09SGV
	VARIDT ID	DR00144

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM085 Antagonize the effect of antithrombotic agents
Relation Graph

Full list of drugs interacting with Daclatasvir
Affected cellular transport
	Transporter inhibition					Drug Num: 81
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[4], [5], [6]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[8], [9]
D0562		Eluxadoline	C32H35N5O5	11250029	Major		Inter Info	[1], [10], [11]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[1], [12], [13]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[14]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[15], [1], [16]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1], [17], [18], [19]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[20], [1], [21], [22]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[1], [25], [26]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[1], [2], [27]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[1], [28]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[29], [30]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[1]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[31]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1], [2]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[1], [33], [34]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[1], [2]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[35]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[1], [2]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[15], [1], [36]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[1], [37], [38]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[39]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[1], [41]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[42]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[43]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[1], [44]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1], [2]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[45]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[1], [2]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[1], [2]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[1], [46]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[47], [12], [48]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[15], [49]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[50]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[54]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[55]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Moderate		Inter Info	[56]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[57], [58], [59], [60]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[57], [59], [60]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[61], [62], [2]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[1], [2]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1], [2]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[1], [2]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1], [2]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[1], [2]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[1], [2]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[63], [26]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[1], [2]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[1], [2], [27]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[1]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[57], [58], [59], [60]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1], [2]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[1], [2]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[1], [2]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[1], [2], [27]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[64]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[65]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[1], [2]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[1], [2]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1], [2]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[1], [2], [27]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[1], [2], [27]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1], [2]
D1402		Rifaximin	C43H51N3O11	6436173	Moderate		Inter Info	[1], [2]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[1], [2]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[66]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[1], [2], [27]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[1], [2]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[1], [2], [27]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[1], [2]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1], [2]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[1], [2]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[67]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[1], [2]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[1], [2]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[1], [2]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[1], [2]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[1], [2]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[15], [1], [72]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[73]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[74]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 47
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1], [2], [3]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1], [2]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2], [3]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1], [2], [3]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1], [2]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1], [2]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1], [2], [3]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1], [2]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1], [2], [3]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1], [2], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[15], [1], [2]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[15], [1], [2]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[15], [1], [2]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[15], [1], [2]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[15], [1], [2]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[15], [1], [2]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[32]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[15], [1], [2]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[15], [1], [2]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[15], [1], [2]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[15], [1], [2]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[51], [52]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[15], [1], [2]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[15], [1], [2]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[15], [1], [2]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[15], [1], [2]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[15], [1], [2]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[15], [1], [2]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[15], [1], [2]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[15], [1], [2]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[15], [1], [2]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[15], [1], [2]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[15], [1], [2]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[15], [1], [2]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[15], [1], [2]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[15], [1], [2]
	CYP450 enzyme induction					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1], [2]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1], [2]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[1], [2]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[1], [2]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1], [2], [7]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[1], [2]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[1], [2], [7]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[1], [2]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1], [2]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1], [2]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[15], [2]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1], [2]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1], [2]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[1], [2]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[1], [2]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[15], [2]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1], [2]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [2]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1], [2]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1], [2]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1], [2], [7]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1], [2]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[15], [40]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[15], [1], [53]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[15], [1], [53]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[15], [1], [53]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[1], [23], [24]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[1], [23], [24]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[68], [15], [1], [69], [24], [70], [71]

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25	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
26	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
27	Richter WO, Jacob BG, Schwandt P "Interaction between fibre and lovastatin." Lancet 338 (1991): 706. [PMID: 1679514]
28	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
29	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
30	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
31	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
32	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
33	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
34	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
35	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
36	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
37	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
38	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
39	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
40	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
41	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
42	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
43	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
44	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
45	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
46	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
47	Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
48	Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.
49	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
50	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
51	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
52	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
53	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
54	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
55	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
56	Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir). Gilead Sciences, Foster City, CA.
57	Multum Information Services, Inc. Expert Review Panel.
58	Product Information. Cerubidine (daunorubicin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
59	Product Information. Daunoxome (daunorubicin liposomal). Nexstar Pharmaceuticals Inc, Boulder, CO.
60	Product Information. Idamycin (idarubicin). Pharmacia and Upjohn, Kalamazoo, MI.
61	Becquemont L, Verstuyft C, Kerb R, et al. "Effect of grapefruit juice on digoxin pharmacokinetics in humans." Clin Pharmacol Ther 70 (2001): 311-6. [PMID: 11673746]
62	Darcy PF "Nutrient-drug interactions." Adverse Drug React Toxicol Rev 14 (1995): 233-54. [PMID: 8845456]
63	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
64	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
65	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
66	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
67	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
68	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
69	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
70	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
71	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
72	Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
73	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
74	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.

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