Details of Drug

Details of Drug

 Drug General Information (ID: D0405)
  Drug Name
Cytarabine (liposomal)
  Drug Type Small molecule
  Drug Synonymous
Alexan; AraC; Arabinocytidine; Arabinofuranosylcytosine; Arabinosylcytosine; Arabitin; Aracytidine; Aracytin; Aracytine; Arafcyt; Citarabina; Cytarabin; Cytarabina; Cytarabinoside; Cytarabinum; Cytarbel; Cytonal; Cytosar; Cytosinearabinoside; DepoCyte; Depocyt; Erpalfa; Iretin; Spongocytidine; Tarabine; Udicil; Arabinosyl Cytosine; Cytarabine liposome injection; Cytosine arabinofuranoside; Cytosine arabinose; Cytosine arabinoside; AR3; BTB15125; CHX 3311; U 19920A; Ara-C; Ara-Cytidine; Beta-Ara C; Beta-Arabinosylcytosine; Beta-cytosine arabinoside; Citarabina [INN-Spanish]; Cytarabinum [INN-Latin]; Cytosar-U; Cytosine arabinoside (VAN); Depocyt (TN); Depocyt (liposomal); Intrathecal (injected into the spinal fluid) DepoCyt; U-19920; Beta-D-Arabinosylcytosine; Cytosar-U (TN); Cytosine beta-D-arabinofuranoside; Cytosine beta-D-arabinofuranoside hydrochloride; Cytosine beta-D-arabinoside; Cytosine-beta-arabinoside; Intrathecal cytarabine (also known as ara-C); U-19,920; CYTARABINE (SEE ALSO CYTARABINE HYDROCHLORIDE 69-74-9); Cytarabine (JP15/USP/INN); Cytarabine [USAN:INN:BAN:JAN]; Cytosine 1-beta-D-arabinofuranoside; Cytosine, beta-D-arabinoside; Cytosine-beta-D-arabinofuranoside; Cytosine-1-beta-D-arabinofuranoside; Ara-C, Cytosine Arabinoside, Cytosar-U, Cytarabine; (beta-D-Arabinofuranosyl)cytosine; 1-.beta.-D-arabinofuranosyl-cytosine; 1-Arabinofuranosylcytosine; 1-beta-D-Arabinofaranosylcytosine; 1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone; 1-beta-D-Arabinofuranosylcytosine; 1-beta-D-Arabinofuranosylcytosine, Cytosine Arabinoside; 1-beta-D-Arabinosylcytosine; 1beta-Arabinofuranasylcytosine; 1beta-D-Arabinofuranosylcytosine; 1beta-D-Arabinosylcytosine; 2(1H)-Pyrimidinone, 4-amino-1-D-arabinofuranosyl-[CAS]; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin [Czech]; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine; 4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon [Czech]; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone; 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; 4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one
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  Disease Class 2A85: Mature B-cell lymphoma
  Therapeutic Class Antineoplastics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C9H13N3O5
  InChI 1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
  InChIKey UHDGCWIWMRVCDJ-CCXZUQQUSA-N
  Canonical SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
  External Link
Pubchem ID 6253
CAS Number 147-94-4
CHEBI ID 28680
TTD ID D07XSN
INTEDE ID DR0398
VARIDT ID DR00416

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM018  Non-CYP450 enzyme inhibition
BM043  Additive immunosuppressive effects
BM107  Attenuated pharmacological effects (Unspecific)
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Cytarabine (liposomal)
      Affected intra/extra-hepatic metabolism
   Non-CYP450 enzyme inhibition Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0270
 
Cedazuridine
 
C9H14F2N2O5
 
25267009 
Moderate    Inter Info   
[5], [6], [7]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  48
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0030
 
Aldesleukin
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0190
 
Bleomycin
 
C55H84N17O21S3+
 
5360373 
Moderate    Inter Info   
[1], [2], [3]
D0260
 
Carboplatin
 
C6H12N2O4Pt
 
426756 
Moderate    Inter Info   
[1], [2], [3]
D0264
 
Carmustine
 
C5H9Cl2N3O2
 
2578 
Moderate    Inter Info   
[1], [2], [3]
D0312
 
Chlorambucil
 
C14H19Cl2NO2
 
2708 
Moderate    Inter Info   
[1], [2], [3]
D0344
 
Cisplatin
 
Cl2H6N2Pt
 
5702198 
Moderate    Inter Info   
[1], [2], [3]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Moderate    Inter Info   
[1], [2], [3]
D0400
 
Cyclophosphamide
 
C7H15Cl2N2O2P
 
2907 
Moderate    Inter Info   
[1], [2], [3]
D0157
 
Bendamustine
 
C16H21Cl2N3O2
 
65628 
Moderate    Inter Info   
[1], [2], [3]
D0223
 
Busulfan
 
C6H14O6S2
 
2478 
Moderate    Inter Info   
[1], [2], [3]
D0249
 
Capecitabine
 
C15H22FN3O6
 
60953 
Moderate    Inter Info   
[1], [2], [3]
D0431
 
Decitabine
 
C8H12N4O4
 
451668 
Moderate    Inter Info   
[1], [2], [3]
D0511
 
Docetaxel
 
C43H53NO14
 
148124 
Moderate    Inter Info   
[1], [2], [3]
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[1], [2], [3]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[1], [2], [3]
D0669
 
Fludarabine
 
C10H12FN5O4
 
657237 
Moderate    Inter Info   
[1], [2], [3]
D0780
 
Hydroxyurea
 
CH4N2O2
 
3657 
Moderate    Inter Info   
[1], [2], [3]
D0788
 
Idarubicin
 
C26H27NO9
 
42890 
Moderate    Inter Info   
[1], [2], [3]
D0790
 
Ifosfamide
 
C7H15Cl2N2O2P
 
3690 
Moderate    Inter Info   
[1], [2], [3]
D0851
 
Isatuximab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0945
 
Lomustine
 
C9H16ClN3O2
 
3950 
Moderate    Inter Info   
[1], [2], [3]
D0962
 
Lurbinectedin
 
C41H44N4O10S
 
57327016 
Moderate    Inter Info   
[1], [2], [3]
D0996
 
Melphalan
 
C13H18Cl2N2O2
 
460612 
Moderate    Inter Info   
[1], [2], [3]
D0997
 
Melphalan flufenamide
 
C24H30Cl2FN3O3
 
9935639 
Moderate    Inter Info   
[1], [2], [3]
D1079
 
Mitoxantrone
 
C22H28N4O6
 
4212 
Moderate    Inter Info   
[1], [2], [3]
D1113
 
Naxitamab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1118
 
Nelarabine
 
C11H15N5O5
 
3011155 
Moderate    Inter Info   
[1], [2], [3]
D1434
 
Ruxolitinib
 
C17H18N6
 
25126798 
Moderate    Inter Info   
[1], [2], [3]
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Moderate    Inter Info   
[1], [2], [3]
D1575
 
Thiotepa
 
C6H12N3PS
 
5453 
Moderate    Inter Info   
[1], [2], [3]
D0407
 
Dacarbazine
 
C6H10N6O
 
135398738 
Moderate    Inter Info   
[1], [2], [3]
D0410
 
Dactinomycin
 
C62H86N12O16
 
457193 
Moderate    Inter Info   
[1], [2], [3]
D0429
 
Daunorubicin
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[1], [2], [3]
D0430
 
Daunorubicin (liposomal)
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[1], [2], [3]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Moderate    Inter Info   
[1], [2], [3]
D0627
 
Etoposide
 
C29H32O13
 
36462 
Moderate    Inter Info   
[1], [2], [3]
D0666
 
Floxuridine
 
C9H11FN2O5
 
5790 
Moderate    Inter Info   
[1], [2], [3]
D0675
 
Fluorouracil
 
C4H3FN2O2
 
3385 
Moderate    Inter Info   
[1], [2], [3]
D0714
 
Gemcitabine
 
C9H11F2N3O4
 
60750 
Moderate    Inter Info   
[1], [2], [3]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[1], [2], [3]
D0986
 
Mechlorethamine
 
C5H11Cl2N
 
4033 
Moderate    Inter Info   
[1], [2], [3]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[1], [2], [3]
D1241
 
Pemetrexed
 
C20H21N5O6
 
135410875 
Moderate    Inter Info   
[1], [2], [3]
D1508
 
Streptozocin
 
C8H15N3O7
 
29327 
Moderate    Inter Info   
[1], [2], [3]
D1548
 
Temozolomide
 
C6H6N6O2
 
5394 
Moderate    Inter Info   
[1], [2], [3]
D1589
 
Tioguanine
 
C5H5N5S
 
2723601 
Moderate    Inter Info   
[1], [2], [3]
D1697
 
Vinblastine
 
C46H58N4O9
 
13342 
Moderate    Inter Info   
[1], [2], [3]
D1700
 
Vinorelbine
 
C45H54N4O8
 
5311497 
Moderate    Inter Info   
[1], [2], [3]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[8]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0348
 
Cladribine
 
C10H12ClN5O3
 
20279 
Moderate    Inter Info   
[1], [2], [4]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3 Product Information. Fluorouracil injection (fluorouracil). Roche Laboratories, Nutley, NJ.
4 Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
5 Bhatla D, Gerbing RB, Alonzo TA, et.al "Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia." Br J Haematol 144 (2009): 388-94. [PMID: 19036079]
6 Product Information. Inqovi (cedazuridine-decitabine). Taiho Oncology, Inc., Princeton, NJ.
7 Product Information. Xeloda (capecitabine). Roche Laboratories, Nutley, NJ.
8 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.