Drug General Information (ID: D0390)
  Drug Name
Copper gluconate
  Drug Type Small molecule
  Drug Synonymous
Copper gluconate; 527-09-3; Copper(II)gluconate; Copper(II) gluconate; Copper di-D-gluconate; CUPRIC GLUCONATE; Copper(II) D-gluconate; UNII-RV823G6G67; Copper gluconate [USP]; Copper(II) (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate; RV823G6G67; copper;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate; Copper gluconate (USP); 13005-35-1; Gluconates; Gluconic Acid Copper(II) Salt; Cupric gluconate monohydrate; Copper, bis(D-gluconato)-; coppergluconate; Copper D-gluconate (1:2); CCRIS 3652; HSDB 261; Bis(D-gluconato-O1,O2)copper; Gluconic acid, copper(2+) salt; Gluconic acid, copper(2+) salt (2:1), D-; Copper, bis(D-gluconato-O1,O2)-; EINECS 208-408-2; Copper(2+) D-gluconate, (1:2); Bis(D-gluconato)copper; Chelates of copper gluconate; SCHEMBL23076; Copper Gluconate 14% 40M; DTXSID4035960; CHEBI:31431; Copper,bis(D-gluconato-kO1,kO2)-; AKOS015901520; CS-W011576; DB11246; AS-14692; Copper, bis(D-gluconato-kappaO1,kappaO2)-; G0275; Gluconic acid, copper(2+) salt (2:1) D-; D02395; Copper, bis (D-gluconato-O(sup 1),O(sup 2))-; Q3109285
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  Therapeutic Class Minerals And Electrolytes
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C12H22CuO14
  InChI InChI=1S/2C6H12O7.Cu/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1
  InChIKey OCUCCJIRFHNWBP-IYEMJOQQSA-L
  Canonical SMILES C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Cu+2]
  External Link
Pubchem ID 10692

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
BM003  Complex formation
  Relation Graph
 Full list of drugs interacting with Copper gluconate
      Affected gastrointestinal absorption
   Complex formation Drug Num:  18
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0034
 
Alendronic acid
 
C4H13NO7P2
 
2088 
Moderate    Inter Info   
[1], [2], [3]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0144
 
Baloxavir marboxil
 
C27H23F2N3O7S
 
124081896 
Moderate    Inter Info   
[36]
D0438
 
Delafloxacin
 
C18H12ClF3N4O4
 
487101 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0433
 
Deferiprone
 
C7H9NO2
 
2972 
Moderate    Inter Info   
[37]
D0561
 
Eltrombopag
 
C25H22N4O4
 
135449332 
Moderate    Inter Info   
[38], [39]
D0623
 
Etidronic acid
 
C2H8O7P2
 
3305 
Moderate    Inter Info   
[2], [40], [3]
D0712
 
Gatifloxacin
 
C19H22FN3O4
 
5379 
Moderate    Inter Info   
[17], [18], [31]
D0716
 
Gemifloxacin
 
C18H20FN5O4
 
9571107 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D0783
 
Ibandronate
 
C9H23NO7P2
 
60852 
Moderate    Inter Info   
[41], [42], [1], [2], [43], [3]
D0919
 
Levofloxacin
 
C18H20FN3O4
 
149096 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1092
 
Moxifloxacin
 
C21H24FN3O4
 
152946 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1155
 
Norfloxacin
 
C16H18FN3O3
 
4539 
Moderate    Inter Info   
[17], [18], [31]
D1165
 
Ofloxacin
 
C18H20FN3O4
 
4583 
Moderate    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35]
D1245
 
Penicillamine
 
C5H11NO2S
 
5852 
Moderate    Inter Info   
[44], [45], [46], [47], [48], [49], [50], [25]
D1412
 
Risedronic acid
 
C7H11NO7P2
 
5245 
Moderate    Inter Info   
[1], [2], [3]
D1635
 
Triethylenetetramine
 
C6H18N4
 
5565 
Moderate    Inter Info   
[51]
D1657
 
Trovafloxacin
 
C20H15F3N4O3
 
62959 
Moderate    Inter Info   
[17], [18], [31]
References
1 Product Information. Bonefos (clodronate). Rhone-Poulenc Rorer Canada Inc, Laval, QC.
2 Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
3 Product Information. Skelid (tilundronate). Sanofi Winthrop Pharmaceuticals, New York, NY.
4 Akerele JO, Okhamafe AO "Influence of oral co-administered metallic drugs on ofloxacin pharmacokinetics." J Antimicrob Chemother 28 (1991): 87-94. [PMID: 1663108]
5 Allen A, Vousden M, Porter A, Lewis A "Effect of Maalox((R)) on the bioavailability of oral gemifloxacin in healthy volunteers." Chemotherapy 45 (1999): 504-11. [PMID: 10567782]
6 Campbell NR, Kara M, Hasinoff BB, Haddara WM, McKay DW "Norfloxacin interaction with antacids and minerals." Br J Clin Pharmacol 33 (1992): 115-6. [PMID: 1540482]
7 Frost RW, Lasseter KC, Noe AJ, Shamblen EC, Lettieri JT "Effects of aluminum hydroxide and calcium carbonate antacids on the bioavailability of ciprofloxacin." Antimicrob Agents Chemother 36 (1992): 830-2. [PMID: 1503446]
8 Garrelts JC, Godley PJ, Peterie JD, Gerlach EH, Yakshe CC "Sucralfate significantly reduces ciprofloxacin concentrations in serum." Antimicrob Agents Chemother 34 (1990): 931-3. [PMID: 2360833]
9 Grasela TH Jr, Schentag JJ, Sedman AJ, et al "Inhibition of enoxacin absorption by antacids or ranitidine." Antimicrob Agents Chemother 33 (1989): 615-7. [PMID: 2751276]
10 Honig PK, Gillespie BK "Clinical significance of pharmacokinetic drug interactions with over-the-counter (OTC) drugs." Clin Pharmacokinet 35 (1998): 167-71. [PMID: 9784931]
11 Johnson RD, Dorr MB, Talbot GH, Caille G "Effect of Maalox on the oral absorption of sparfloxacin." Clin Ther 20 (1998): 1149-58. [PMID: 9916608]
12 Kamberi M, Nakashima H, Ogawa K, Oda N, Nakano S "The effect of staggered dosing of sucralfate on oral bioavailability of sparfloxacin." Br J Clin Pharmacol 49 (2000): 98-103. [PMID: 10671902]
13 Lehto P, Kivisto KT "Different effects of products containing metal ions on the absorption of lomefloxacin." Clin Pharmacol Ther 56 (1994): 477-82. [PMID: 7955811]
14 Lehto P, Kivisto KT "Effect of sucralfate on absorption of norfloxacin and ofloxacin." Antimicrob Agents Chemother 38 (1994): 248-51. [PMID: 8192452]
15 Lober S, Ziege S, Rau M, Schreiber G, Mignot A, Koeppe P, Lode H "Pharmacokinetics of gatifloxacin and interaction with an antacid containing aluminum and magnesium." Antimicrob Agents Chemother 43 (1999): 1067-71. [PMID: 10223915]
16 Nix DE, Watson WA, Lener ME, et al "Effects of aluminum and magnesium antacids and ranitidine on the absorption of ciprofloxacin." Clin Pharmacol Ther 46 (1989): 700-5. [PMID: 2598571]
17 Nix DE, Wilton JH, Ronald B, Distlerath L, Williams VC, Norman A "Inhibition of norfloxacin absorption by antacids." Antimicrob Agents Chemother 34 (1990): 432-5. [PMID: 2334155]
18 Noyes M, Polk RE "Norfloxacin and absorption of magnesium-aluminum." Ann Intern Med 109 (1988): 168-9. [PMID: 3382110]
19 Parpia SH, Nix DE, Hejmanowski LG, Goldstein HR, Wilton JH, Schentag JJ "Sucralfate reduces the gastrointestinal absorption of norfloxacin." Antimicrob Agents Chemother 33 (1989): 99-102. [PMID: 2712548]
20 Polk RE, Helay DP, Sahai J, Drwal L, Racht E "Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers." Antimicrob Agents Chemother 33 (1989): 1841-4. [PMID: 2610494]
21 Product Information. Baxdela (delafloxacin). Melinta Therapeutics, Lincolnshire, IL.
22 Product Information. Factive (gemifloxacin). GeneSoft Inc, San Francisco, CA.
23 Product Information. Levaquin (levofloxacin). Ortho Pharmaceutical Corporation, Raritan, NJ.
24 Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
25 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
26 Product Information. Trovan (trovafloxacin). Pfizer US Pharmaceuticals, New York, NY.
27 Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
28 Sahai J, Healy DP, Stotka J, Polk RE "The influence of chronic administration of calcium carbonate on the bioavailability of oral ciprofloxacin." Br J Clin Pharmacol 35 (1993): 302-4. [PMID: 8471407]
29 Shimada J, Shiba K, Oguma T, et al "Effect of antacid on absorption of the quinolone lomefloxacin." Antimicrob Agents Chemother 36 (1992): 1219-24. [PMID: 1329615]
30 Spivey JM, Cummings DM, Pierson NR "Failure of prostatitis treatment secondary to probable ciprofloxacin-sucralfate drug interaction." Pharmacotherapy 16 (1996): 314-6. [PMID: 8820479]
31 Teng R, Dogolo LC, Willavize SA, Friedman HL, Vincent J "Effect of Maalox and omeprazole on the bioavailability of trovafloxacin." J Antimicrob Chemother 39 Suppl B (1997): 93-7. [PMID: 9222077]
32 Wadworth AN, Goa KL "Lomefloxacin: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use." Drugs 42 (1991): 1018-60. [PMID: 1724637]
33 Yuk JH "Ciprofloxacin levels when receiving sucralfate." J Am Geriatr Soc 262 (1989): 901. [PMID: 2754785]
34 Zix JA, Geerdes-Fenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
35 Deppermann KM, Lode H, Hoffken G, Tschink G, Kalz C, Koeppe P "Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid." Antimicrob Agents Chemother 33 (1989): 1901-7. [PMID: 2610502]
36 Product Information. Xofluza (baloxavir marboxil). Genentech, South San Francisco, CA.
37 Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
38 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
39 Product Information. Promacta (eltrombopag). GlaxoSmithKline, Research Triangle Park, NC.
40 Product Information. Fosamax (alendronate). Merck &amp Co, Inc, West Point, PA.
41 Darcy PF "Nutrient-drug interactions." Adverse Drug React Toxicol Rev 14 (1995): 233-54. [PMID: 8845456]
42 Product Information. Actonel (risedronate). Procter and Gamble Pharmaceuticals, Cincinnati, OH.
43 Product Information. Fosamax (alendronate). Merck & Co, Inc, West Point, PA.
44 Haagsma CJ "Clinically important drug interactions with disease-modifying antirheumatic drugs." Drugs Aging 13 (1998): 281-9. [PMID: 9805209]
45 Harkness JA, Blake DR "Penicillamine nephropathy and iron." Lancet 2 (1982): 1368-9. [PMID: 6129465]
46 Joyce DA "D-penicillamine pharmacokinetics and pharmacodynamics in man." Pharmacol Ther 42 (1989): 405-27. [PMID: 2672052]
47 Lyle WH "Penicillamine and iron." Lancet 2 (1976): 420. [PMID: 73880]
48 Netter P, Bannwarth B, Pere P, Nicolas A "Clinical pharmacokinetics of D-penicillamine." Clin Pharmacokinet 13 (1987): 317-33. [PMID: 3319347]
49 Osman MA, Patel RB, Schuna A, Sundstrom WR, Welling PG "Reduction in oral penicillamine absorption by food, antacid and ferrous sulfate." Clin Pharmacol Ther 33 (1983): 465-70. [PMID: 6831825]
50 Product Information. Cuprimine (penicillamine). Merck & Co, Inc, West Point, PA.
51 Product Information. Syprine (trientine). Aton Pharma, Lawrenceville, NJ.