Details of Drug

Drug General Information (ID: D0389)
Drug Name	Copanlisib
Drug Type	Small molecule
Drug Synonymous	Copanlisib; BAY-80-6946; Aliqopa; UNII-WI6V529FZ9; BAY80-6946; WI6V529FZ9; AK172384; BAY 80-6946 (Copanlisib); Copanlisib [USAN:INN]; Copanlisib (USAN/INN); GTPL7875; SCHEMBL1655478; SCHEMBL13084037; Copanlisib (BAY 80-6946); DTXS Click to Show/Hide
Disease Class	2A80: Follicular lymphoma; 2B33: Malignant haematopoietic neoplasm
Therapeutic Class	Pi3K Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C23H28N8O4
InChI	1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14,25H,2,5-12H2,1H3,(H2,24,26,27)
InChIKey	MWYDSXOGIBMAET-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=CC2=C3NCCN3C(=NC(=O)C4=CN=C(N=C4)N)N=C21)OCCCN5CCOCC5
External Link
	Pubchem ID	135565596
	CAS Number	1032568-63-0
	TTD ID	D0S5LD
	INTEDE ID	DR0378

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Copanlisib
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[7]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 48
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[7]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[7]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[7]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[7]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[7]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[7]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[7]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[7]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[7]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[7]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[7]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[7]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[7]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[7]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[7]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[7]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[7]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[7]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[7]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[7]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[7]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[7]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[7]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[7]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[7]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[7]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[7]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[11], [12], [50]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[7]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[7]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[7]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[7]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[7]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[7]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[7]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[7]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[7]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[7]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[7]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[7]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[7]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[11], [12], [69], [70]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[7]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[7]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[7]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[7]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[7]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[7]
	CYP450 enzyme induction					Drug Num: 52
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[7]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[7]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[7]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[7]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[27], [7]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[7]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[7]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[7]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[7]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[27], [7]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[7]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[7]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[7]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[7]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[7]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[7]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[7]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[7]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[7]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[7]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[7]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[7]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[7]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[7]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[7]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[12], [58]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[7]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[7]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[7]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[61]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[62]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[7]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[7]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[7]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[7]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[7]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[7]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[7]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[7]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[7]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[7]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[7]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[12], [75]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[7]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[7]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[7]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[7]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[7]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[7]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[7]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[7]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[7]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[11], [12], [13]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[12], [14]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[12], [17]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[21]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[24]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[25], [26]
D1111		Natalizumab	NA	NA	Major		Inter Info	[28]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[11], [30]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[25], [26]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[31]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[18], [35], [36]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[37]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[38], [39], [40]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[11], [12]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[38], [39], [40]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[49]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[49]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[59]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[49]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[60]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[71]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[72]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[12], [73]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[74]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[76]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[79]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[38], [39], [40]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[12], [80]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[81]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[11], [12], [82]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[83]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[84]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[11], [12], [85]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[12], [15], [16]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[11], [22], [23]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[29]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[11], [12], [66], [67]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[11], [12], [66], [67]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 42
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[32], [33], [34]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[32], [33], [34]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[32], [33], [34]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[32], [33], [34]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[32], [33], [34]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[32], [33], [34]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[32], [33], [34]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[32], [33], [34]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[32], [33], [34]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[32], [33], [34]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[32], [33], [34]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[32], [33], [34]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[32], [33], [34]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[32], [33], [34]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[32], [33], [34]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[32], [33], [34]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[32], [33], [34]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[32], [33], [34]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[32], [33], [34]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[32], [33], [34]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[32], [33], [34]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[32], [33], [34]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[32], [33], [34]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[32], [33], [34]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[32], [33], [34]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[32], [33], [34]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[32], [33], [34]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[32], [33], [34]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[32], [33], [34]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[32], [33], [34]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[32], [33], [34]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[32], [33], [34]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[32], [33], [34]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[32], [33], [34]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[32], [33], [34]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[32], [33], [34]
	Antagonize the effect of antihypertensive agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[32], [33], [34]
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[8], [9], [10]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[18], [11], [19]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[20]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[8], [9], [10]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[8], [9], [10]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[8], [9], [10]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[8], [9], [10]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[8], [9], [10]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[8], [9], [10]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[8], [9], [10]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[18], [41], [42]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[18], [41], [42]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[18], [41], [42]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[18], [41], [42]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[18], [41], [42]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[51], [18], [11], [52], [53], [54], [41], [55], [56], [57], [42]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[18], [41], [42]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[18], [41], [42]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[18], [41], [42]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[18], [41], [42]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[18], [41], [42]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[68]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[18], [41], [42]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[46], [47], [48]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[46], [47], [48]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[43], [44], [45]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[43], [44], [45]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[43], [44], [45]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[43], [44], [45]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[77], [78]

References
1	Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
2	Product Information. Enbrel (etanercept). Wyeth-Ayerst Laboratories, Philadelphia, PA.
3	Product Information. Humira (adalimumab). Abbott Pharmaceutical, Abbott Park, IL.
4	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
5	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
6	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Drug labels for the Tumor Necrosis Factor-alpha (TNFa) blockers now include warnings about infection with Legionella and Listeria bacteria. ".
7	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
8	Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998).
9	Product Information. Attenuvax (measles virus vaccine, live, attenuated). Merck &amp Co, Inc, West Point, PA.
10	Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
11	Cerner Multum, Inc. "Australian Product Information.".
12	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
13	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
14	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
15	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
16	Canadian Pharmacists Association "e-CPS."
17	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
18	CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
19	Product Information. Dryvax (smallpox vaccine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
20	Product Information. Imlygic (talimogene laherparepvec). Amgen USA, Thousand Oaks, CA.
21	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
22	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
23	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
24	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
25	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
26	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
27	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
28	Product Information. Tysabri (natalizumab). Elan Pharmaceutical/Athena Neurosciences Inc, South San Francisco, CA.
29	Product Information. Quadramet (samarium sm 153 lexidronam) Berlex Laboratories, Richmond, CA.
30	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
31	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
32	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
33	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
34	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
35	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
36	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
37	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
38	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
39	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
40	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
41	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
42	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
43	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
44	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
45	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
46	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
47	Schlegel L, Lemerle S, Geslin P "Lactobacillus species as opportunistic pathogens in immunocompromised patients." Eur J Clin Microbiol Infect Dis 17 (1998): 887-8. [PMID: 10052559]
48	Salminen MK, Tynkkynen S, Rautelin H, et al. "Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland." Clin Infect Dis 35 (2002): 1155-60. [PMID: 12410474]
49	Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
50	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
51	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
52	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
53	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
54	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
55	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
56	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
57	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
58	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
59	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
60	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
61	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
62	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
63	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
64	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
65	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
66	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
67	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
68	Shen AK, Mead PS, Beard CB. The Lyme disease vaccine--a public health perspective. Clin Infect Dis. 2011;52 Suppl 3:s247-s252. [PMID: 21217171]
69	He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7. [PMID: 9918590]
70	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
71	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
72	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
73	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
74	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
75	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
76	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
77	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
78	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
79	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
80	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
81	AnazaoHealth Corporation "P32 Sodium Phosphate."
82	Multum Information Services, Inc. Expert Review Panel.
83	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
84	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
85	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.

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