Details of Drug

Drug General Information (ID: D0385)
Drug Name		Conestat alfa
Drug Type		Protein/peptide
Drug Synonymous		C1 Esterase Inhibitor (Recombinant); C1 Inhibitor (Recombinant); Complement C1 esterase inhibitor; Conestat alfa; DB09228; Human C1-inhibitor (recombinant, rabbit derived); Recombinant complement C1 esterase inhibitor; Recombinant human C1 inhibitor; Recombinant human C1-inhibitor; Recombinant human C1-inhibitor rabbit milk derived Click to Show/Hide
Therapeutic Class		Hereditary Angioedema Agents

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM047 Additive thrombogenic effects BM085 Antagonize the effect of antithrombotic agents
Relation Graph

Full list of drugs interacting with Conestat alfa
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[1], [2], [3]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[3], [4], [5]
D1312		Pomalidomide	C13H11N3O4	134780	Major		Inter Info	[6], [7], [8]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[3], [6], [9]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[10], [11], [12], [13]
D1327		Prasterone enantate	C26H40O3	163331	Moderate		Inter Info	[10], [12], [13]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[10], [11], [12], [13]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[10], [12], [13]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[10], [11], [12], [13]
D0423		Darbepoetin alfa	NA	NA	Moderate		Inter Info	[10], [11], [12], [13]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[10], [12], [13]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[10], [11], [12], [13]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[10], [11], [12], [13]
D0598		Erythropoietin	C22H22ClKN6O	11751549	Moderate		Inter Info	[10], [12], [13]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[10], [11], [12], [13]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[10], [12], [13]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[10], [11], [12], [13]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[10], [12], [13]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[10], [12], [13]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[10], [12], [13]
D0677		Fluoxymesterone	C20H29FO3	6446	Moderate		Inter Info	[10], [11], [12], [13]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[10], [12], [13]
D1042		Methyltestosterone	C20H30O2	6010	Moderate		Inter Info	[10], [11], [12], [13]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[10], [11], [12], [13]
D1195		Oxandrolone	C19H30O3	5878	Moderate		Inter Info	[10], [11], [12], [13]
D1207		Oxymetholone	C21H32O3	5281034	Moderate		Inter Info	[10], [11], [12], [13]
D1236		Peginesatide	NA	NA	Moderate		Inter Info	[10], [11], [12], [13]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[10], [11], [12], [13]
D1376		Raloxifene	C28H27NO4S	5035	Moderate		Inter Info	[10], [11], [12], [13]
D1503		Stanozolol	C21H32N2O	25249	Moderate		Inter Info	[10], [11], [12], [13]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[10], [11], [12], [13]
D1557		Testolactone	C19H24O3	13769	Moderate		Inter Info	[10], [11], [12], [13]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[10], [11], [12], [13]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[10], [12], [13]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[10], [11], [12], [13]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0047		Alteplase	NA	NA	Moderate		Inter Info	[3]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[3]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[3]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[3]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[3]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[3]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Kyprolis (carfilzomib). Onyx Pharmaceuticals Inc, South San Francisco, CA.
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Revlimid (lenalidomide). Celgene Corporation, Summit, NJ.
5	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
6	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
7	Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
8	Therapeutic Research Faculty "Natural Medicines Comprehensive Database."
9	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
10	Product Information. Berinert (complement C1 esterase inhibitor). CSL Behring, King of Prussia, PA.
11	Product Information. Cinryze (complement C1 esterase inhibitor). ViroPharma Incorporated, Exton, PA.
12	Product Information. Ruconest (conestat alfa). Valeant Pharmaceuticals, Costa Mesa, CA.
13	Gandhi PK, Gentry WM, Bottorff MB "Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: investigation from the United States Food and Drug Administration adverse event reporting system database." Pharmacotherapy 32 (2012): 902-9. [PMID: 23033229]

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