Details of Drug

Details of Drug

 Drug General Information (ID: D0368)
  Drug Name
Clove
  Drug Type Natural product
  Drug Synonymous
5,7-dihydroxy-2-methyl-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; 8-b-D-Glucopyranosyl-5,7-dihydroxy-2-methyl-4H-1-benzopyran-4-one; 8-C-Glucopyranosylnoreugenin; 8-Glucosyl-5,7-dihydroxy-2-methylchromone; CHEBI:175535; Clove 3; Isobiflorin; chromium(3+) trichloride; Chromium(III); chloride
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  Therapeutic Class Herbal Products

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM050  Increased risk of bleeding
  Relation Graph
 Full list of drugs interacting with Clove
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  67
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0005
 
Abciximab
 
NA
 
NA
Minor    Inter Info   
[1], [2], [3], [4]
D0017
 
Acetylsalicylic acid
 
C9H8O4
 
2244 
Minor    Inter Info   
[5], [2], [3]
D0047
 
Alteplase
 
NA
 
NA
Minor    Inter Info   
[1], [2], [3], [4]
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Minor    Inter Info   
[1], [2], [3], [4]
D0087
 
Anisindione
 
C16H12O3
 
2197 
Minor    Inter Info   
[1], [2], [3], [4]
D0088
 
Anistreplase
 
NA
 
NA
Minor    Inter Info   
[1], [2], [3], [4]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Minor    Inter Info   
[1], [2], [3], [4]
D0102
 
Ardeparin
 
C26H42N2O37S5
 
772 
Minor    Inter Info   
[1], [2], [3], [4]
D0104
 
Argatroban
 
C23H36N6O5S
 
92722 
Minor    Inter Info   
[1], [2], [3], [4]
D0189
 
Bivalirudin
 
C98H138N24O33
 
16129704 
Minor    Inter Info   
[1], [2], [3], [4]
D0210
 
Bromfenac
 
C15H12BrNO3
 
60726 
Minor    Inter Info   
[1], [2], [3], [4]
D0247
 
Cangrelor
 
C17H25Cl2F3N5O12P3S2
 
9854012 
Minor    Inter Info   
[1], [2], [3], [4]
D0250
 
Caplacizumab
 
NA
 
NA
Minor    Inter Info   
[1], [2], [3], [4]
D0336
 
Cilostazol
 
C20H27N5O2
 
2754 
Minor    Inter Info   
[1], [2], [3], [4]
D0364
 
Clopidogrel
 
C16H16ClNO2S
 
60606 
Minor    Inter Info   
[1], [2], [3], [4]
D0092
 
Antithrombin Alfa
 
NA
 
NA
Minor    Inter Info   
[5], [2], [3]
D0093
 
Antithrombin III human
 
NA
 
NA
Minor    Inter Info   
[5], [2], [3]
D0176
 
Betrixaban
 
C23H22ClN5O3
 
10275777 
Minor    Inter Info   
[1], [2], [3], [4]
D0331
 
Choline salicylate
 
C12H19NO4
 
54686350 
Minor    Inter Info   
[1], [2], [3], [4]
D0447
 
Desirudin
 
C287H440N80O110S6
 
16129703 
Minor    Inter Info   
[1], [2], [3], [4]
D1272
 
Phenyl salicylate
 
C13H10O3
 
8361 
Minor    Inter Info   
[5], [2], [3]
D0414
 
Dalteparin
 
C26H42N2O37S5
 
772 
Minor    Inter Info   
[1], [2], [3], [4]
D0415
 
Danaparoid
 
NA
 
NA
Minor    Inter Info   
[1], [2], [3], [4]
D0435
 
Defibrotide
 
C20H21N4O6P
 
135565962 
Minor    Inter Info   
[1], [2], [3], [4]
D0476
 
Diclofenac
 
C14H11Cl2NO2
 
3033 
Minor    Inter Info   
[1], [2], [3], [4]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Minor    Inter Info   
[5], [2], [3]
D0489
 
Diflunisal
 
C13H8F2O3
 
3059 
Minor    Inter Info   
[1], [2], [3], [4]
D0506
 
Dipyridamole
 
C24H40N8O4
 
3108 
Minor    Inter Info   
[1], [2], [3], [4]
D0551
 
Edoxaban
 
C24H30ClN7O4S
 
10280735 
Minor    Inter Info   
[1], [2], [3], [4]
D0574
 
Enoxaparin
 
C26H42N2O37S5
 
772 
Minor    Inter Info   
[1], [2], [3], [4]
D0588
 
Eptifibatide
 
C35H49N11O9S2
 
448812 
Minor    Inter Info   
[1], [2], [3], [4]
D0624
 
Etodolac
 
C17H21NO3
 
3308 
Minor    Inter Info   
[1], [2], [3], [4]
D0645
 
Fenoprofen
 
C15H14O3
 
3342 
Minor    Inter Info   
[1], [2], [3], [4]
D0680
 
Flurbiprofen
 
C15H13FO2
 
3394 
Minor    Inter Info   
[1], [2], [3], [4]
D0690
 
Fondaparinux
 
C31H53N3O49S8
 
5282448 
Minor    Inter Info   
[1], [2], [3], [4]
D0753
 
Heparin
 
C26H42N2O37S5
 
772 
Minor    Inter Info   
[1], [2], [3], [4]
D0786
 
Ibuprofen
 
C13H18O2
 
3672 
Minor    Inter Info   
[1], [2], [3], [4]
D0800
 
Indomethacin
 
C19H16ClNO4
 
3715 
Minor    Inter Info   
[1], [2], [3], [4]
D0881
 
Ketoprofen
 
C16H14O3
 
3825 
Minor    Inter Info   
[1], [2], [3], [4]
D0882
 
Ketorolac
 
C15H13NO3
 
3826 
Minor    Inter Info   
[1], [2], [3], [4]
D0904
 
Lepirudin
 
C287H440N80O111S6
 
118856773 
Minor    Inter Info   
[1], [2], [3], [4]
D0988
 
Meclofenamic acid
 
C14H11Cl2NO2
 
4037 
Minor    Inter Info   
[5], [2], [3]
D0991
 
Mefenamic acid
 
C15H15NO2
 
4044 
Minor    Inter Info   
[1], [2], [3], [4]
D0995
 
Meloxicam
 
C14H13N3O4S2
 
54677470 
Minor    Inter Info   
[1], [2], [3], [4]
D1097
 
Nabumetone
 
C15H16O2
 
4409 
Minor    Inter Info   
[1], [2], [3], [4]
D1109
 
Naproxen
 
C14H14O3
 
156391 
Minor    Inter Info   
[1], [2], [3], [4]
D1196
 
Oxaprozin
 
C18H15NO3
 
4614 
Minor    Inter Info   
[1], [2], [3], [4]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Minor    Inter Info   
[1], [2], [3], [4]
D1300
 
Piroxicam
 
C15H13N3O4S
 
54676228 
Minor    Inter Info   
[1], [2], [3], [4]
D1328
 
Prasugrel
 
C20H20FNO3S
 
6918456 
Minor    Inter Info   
[1], [2], [3], [4]
D1395
 
Reteplase
 
NA
 
NA
Minor    Inter Info   
[1], [2], [3], [4]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Minor    Inter Info   
[1], [2], [3], [4]
D1439
 
Salicylic acid (sodium)
 
C7H6O3
 
338 
Minor    Inter Info   
[5], [2], [3]
D1442
 
Salsalate
 
C14H10O5
 
5161 
Minor    Inter Info   
[1], [2], [3], [4]
D1506
 
Streptokinase
 
C11H19NO2
 
9815560 
Minor    Inter Info   
[1], [2], [3], [4]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Minor    Inter Info   
[1], [2], [3], [4]
D1520
 
Sulindac
 
C20H17FO3S
 
1548887 
Minor    Inter Info   
[1], [2], [3], [4]
D1550
 
Tenecteplase
 
NA
 
NA
Minor    Inter Info   
[1], [2], [3], [4]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Minor    Inter Info   
[1], [2], [3], [4]
D1581
 
Ticlopidine
 
C14H14ClNS
 
5472 
Minor    Inter Info   
[1], [2], [3], [4]
D1588
 
Tinzaparin
 
C26H42N2O37S5
 
772 
Minor    Inter Info   
[1], [2], [3], [4]
D1593
 
Tirofiban
 
C22H36N2O5S
 
60947 
Minor    Inter Info   
[1], [2], [3], [4]
D1606
 
Tolmetin
 
C15H15NO3
 
5509 
Minor    Inter Info   
[1], [2], [3], [4]
D1669
 
Urokinase
 
NA
 
NA
Minor    Inter Info   
[1], [2], [3], [4]
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Minor    Inter Info   
[1], [2], [3], [4]
D1705
 
Vorapaxar
 
C29H33FN2O4
 
10077130 
Minor    Inter Info   
[1], [2], [3], [4]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Minor    Inter Info   
[1], [2], [3], [4]
References
1 Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
2 Saeed SA, Gilani AH "Antithrombotic activity of clove oil." J Pak Med Assoc 44 (1994): 112-5. [PMID: 8078176]
3 Srivasta KC "Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]" Prostaglandins Leukot Essent Fatty Acids 48 (1993): 363-72. [PMID: 8321872]
4 Srivstava KC, Malhotra N "Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets." Prostaglandins Leukot Essent Fatty Acids 42 (1991): 73-81. [PMID: 2011614]
5 Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]