Details of Drug

Drug General Information (ID: D0338)
Drug Name	Cinacalcet
Drug Type	Small molecule
Drug Synonymous	Cinacalcet [INN]; AMG 073; AMG073; Cinacalcet (USAN); Mimpara (TN); Sensipar (TN); N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine; N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine; (R)-alpha-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine Click to Show/Hide
Disease Class	5A51: Hyper-parathyroidism; GC2Z: Urinary system disease
Therapeutic Class	Calcimimetics
Structure
Structure	3D Structure		2D Structure
Formula	C22H22F3N
InChI	1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1
InChIKey	VDHAWDNDOKGFTD-MRXNPFEDSA-N
Canonical SMILES	CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
External Link
	Pubchem ID	156419
	CAS Number	226256-56-0
	CHEBI ID	48390
	TTD ID	D03YGR

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM063 Increased risk of hypocalcemia
Relation Graph

Full list of drugs interacting with Cinacalcet
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 101
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1], [2], [3]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[4]
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[5]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[6], [7]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[9]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[10], [7]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[11], [12], [8], [13], [14], [2]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[8], [15]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[16]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[18]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [7], [45], [46], [47], [48], [49], [50], [51], [52]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [7], [63], [64]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[12], [65], [66]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[12], [65], [66]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[12], [65], [66]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[66]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[67]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[12], [65], [66]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[68]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[12], [65], [66]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[69]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[66]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[66]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[12], [65], [66]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[66]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[12], [65], [66]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[66]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[72]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[73], [74]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[12], [65], [66]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[12], [65], [66]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[12], [65], [66]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[12], [65], [66]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[75]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[8], [77]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[78]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[12], [65], [66]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[66]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[79]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[8], [80]
D0778		Hydroxyamphetamine (ophthalmic)	C9H13NO	3651	Moderate		Inter Info	[12], [65], [66]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[66]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[66]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[66]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[81]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[82], [83], [84]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[66]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[12], [65], [66]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[12], [65], [66]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[12], [65], [66]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[66]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[66]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[8], [87], [7]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[66]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[12], [65], [66]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[12], [65], [66]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[66]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[66]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[66]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[12], [65], [66]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[89], [90], [91], [92], [93], [94], [7], [95], [96], [97], [98], [99], [100]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[66]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[101], [102]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[66]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[12], [8], [103], [104], [102], [105]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[12], [65], [66]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[106], [107]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[66]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[12], [65], [66]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[12], [65], [66]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[12], [65], [66]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[12], [65], [66]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[12], [65], [66]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[66]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[12], [65], [66]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[12], [65], [66]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[12], [65], [66]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[66]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[66]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[12], [65], [66]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[12], [65], [66]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[12], [65], [66]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[12], [65], [66]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[12], [65], [66]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[12], [65], [66]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[12], [65], [66]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[12], [65], [66]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[108], [109], [110], [7]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[66]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[12], [65], [66]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[111], [112], [113]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[12], [65], [66]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[12], [65], [66]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[12], [65], [66]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[12], [65], [66]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[12], [65], [66]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[12], [65], [66]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[66]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[114], [115], [7]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[116], [7], [117], [118]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[119]
	CYP450 enzyme induction					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[70]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[76]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[85]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[86]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[8], [88]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[17]
	Increased risk of hypocalcemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0615		Etelcalcetide	C38H73N21O10S2	71511839	Major		Inter Info	[8]
D0221		Burosumab	NA	NA	Moderate		Inter Info	[71]

References
1	Belle DJ, Ernest CS, Sauer JM, Smith BP, Thomasson HR, Witcher JW "Effect of potent CYP2D6 inhibition by paroxetine on atomoxetine pharmacokinetics." J Clin Pharmacol 42 (2002): 1219-27. [PMID: 12412820]
2	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
3	Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
4	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
5	Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
6	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
7	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
8	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9	Product Information. Fanapt (iloperidone). Vanda Pharmaceuticals Inc, Rockville, MD.
10	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
11	Canadian Pharmacists Association.
12	Cerner Multum, Inc. "Australian Product Information.".
13	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
14	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
15	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
16	Product Information. Xenazine (tetrabenazine). Prestwick Pharmaceuticals Inc, Washington DC, VA.
17	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
18	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
19	Amchin J, Ereshefsky L, Zarycranski W, Taylor K, Albano D, Klockowski PM "Effect of venlafaxine versus fluoxetine on metabolism of dextromethorphan, a CYP2D6 probe." J Clin Pharmacol 41 (2001): 443-51. [PMID: 11304901]
20	Aubert RE, Stanek EJ, Yao J, et al "Increased risk of breast cancer recurrence in women initiating tamoxifen with CYP2D6 inhibitors".
21	Bonanni B, Macis D, Maisonneuve P, et al. "Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian Tamoxifen Trial." J Clin Oncol 24 (2006): 3708-9. [PMID: 16877740]
22	Borges S, Desta Z, Li L, et al. "Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: Implication for optimization of breast cancer treatment." Clin Pharmacol Ther 80 (2006): 61-74. [PMID: 16815318]
23	Borgna JL, Rochefort H "Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues." J Biol Chem 256 (1981): 859-68. [PMID: 7451477]
24	Brauch H, Murdter TE, Eichelbaum M, Schwab M "Pharmacogenomics of tamoxifen therapy." Clin Chem 55 (2009): 1770-82. [PMID: 19574470]
25	Coller JK, Krebsfaenger N, Klein K, et al. "The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver." Br J Clin Pharmacol 54 (2002): 157-167. [PMID: 12207635]
26	Crewe HK, Lennard MS, Tucker GT, Woods FR, Haddock RE "The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes." Br J Clin Pharmacol 34 (1992): 262-5. [PMID: 1389951]
27	Dehal SS, Kupfer D "CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver." Cancer Res 57 (1997): 3402-6. [PMID: 9270005]
28	Desta Z, Flockhart DA "Germline pharmacogenetics of tamoxifen response: have we learned enough?" J Clin Oncol 25 (2007): 5147-9. [PMID: 18024859]
29	Desta Z, Ward BA, Soukhova NV, Flockhart DA "Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6." J Pharmacol Exp Ther (2004):. [PMID: 15159443]
30	Dezentje VO, Guchelaar HJ, Nortier JW, van de Velde CJ, Gelderblom H "Clinical implications of CYP2D6 genotyping in tamoxifen treatment for breast cancer." Clin Cancer Res 15 (2009): 15-21. [PMID: 19118028]
31	Gaston C, Kolesar J "Clinical Significance of CYP2D6 Polymorphisms and Tamoxifen in Women with Breast Cancer." Clin Adv Hematol Oncol 6 (2008): 825-33. [PMID: 19194367]
32	Goetz MP, Kamal A, Ames MM "Tamoxifen Pharmacogenomics: The Role of CYP2D6 as a Predictor of Drug Response." Clin Pharmacol Ther (2007):. [PMID: 17882159]
33	Goetz MP, Loprinzi CL "A hot flash on tamoxifen metabolism." J Natl Cancer Inst 95 (2003): 1734-5. [PMID: 14652227]
34	Goetz MP, Rae JM, Suman VJ, et al. "Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes." J Clin Oncol 23 (2005): 9312-8. [PMID: 16361630]
35	Henry NL, Stearns V, Flockhart DA, Hayes DF, Riba M "Drug interactions and pharmacogenomics in the treatment of breast cancer and depression." Am J Psychiatry 165 (2008): 1251-5. [PMID: 18829880]
36	Jin Y, Desta Z, Stearns V, et al. "CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment." J Natl Cancer Inst 97 (2005): 30-9. [PMID: 15632378]
37	Johnson MD, Zuo H, Lee KH, et al. "Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen." Breast Cancer Res Treat 85 (2004): 151-9. [PMID: 15111773]
38	Jordan VC "Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance." Breast Cancer Res Treat 2 (1982): 123-38. [PMID: 6184101]
39	Jordan VC, Collins MM, Rowsby L, Prestwich G "A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity." J Endocrinol 75 (1977): 305-16. [PMID: 591813]
40	Lash TL, Pedersen L, Cronin-Fenton D, et al "Tamoxifen's protection against breast cancer recurrence is not reduced by concurrent use of the SSRI citalopram." Br J Cancer 99 (2008): 616-21. [PMID: 20385012]
41	Lehmann D, Nelsen J, Ramanath V, Newman N, Duggan D, Smith A "Lack of attenuation in the antitumor effect of tamoxifen by chronic CYP isoform inhibition." J Clin Pharmacol 44 (2004): 861-5. [PMID: 15286089]
42	Lim HS, Ju Lee H, Seok Lee K, Sook Lee E, Jang IJ, Ro J "Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer." J Clin Oncol 25 (2007): 3837-45. [PMID: 17761971]
43	McCaffrey P "Genetics and drug interactions affect tamoxifen metabolism." Lancet Oncol 6 (2005): 72. [PMID: 15704296]
44	Ponzone R, Biglia N, Sismondi P "Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine." J Natl Cancer Inst 96 (2004): 883-4 author reply 884-5. [PMID: 15173274]
45	Rochat B "Role of cytochrome p450 activity in the fate of anticancer agents and in drug resistance : focus on tamoxifen, Paclitaxel and imatinib metabolism." Clin Pharmacokinet 44 (2005): 349-66. [PMID: 15828850]
46	Schroth W, Antoniadou L, Fritz P, et al. "Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes." J Clin Oncol 25 (2007): 5187-93. [PMID: 18024866]
47	Stearns V, Johnson MD, Rae JM, et al. "Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine." J Natl Cancer Inst 95 (2003): 1758-64. [PMID: 14652237]
48	Wegman P, Elingarami S, Carstensen J, Stal O, Nordenskjold B, Wingren S "Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer." Breast Cancer Res 9 (2007): R7. [PMID: 17244352]
49	Wegman P, Vainikka L, Stal O, et al "Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients." Breast Cancer Res 7 (2005): R284-90. [PMID: 15987423]
50	Young D "Genetics examined in tamoxifen's effectiveness: recurrence warning urged for labeling." Am J Health Syst Pharm 63 (2006): 2286, 2296. [PMID: 17105997]
51	Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM "Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen." Drug Metab Dispos 30 (2002): 869-74. [PMID: 12124303]
52	Ratliff B, Dietze EC, Bean GR, Moore C, Wanko S, Seewaldt VL "Re: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine." J Natl Cancer Inst 96 (2004): 883 author reply 884-5. [PMID: 15173275]
53	Abernethy DR, Greenblatt DJ, Steel K, Shader RI "Impairment of hepatic drug oxidation by propoxyphene." Ann Intern Med 97 (1982): 223-4. [PMID: 7103282]
54	Carrillo JA, Ramos SI, Herraiz AG, Llerena A, Agundez JAG, Berecz R, Duran M, Benitez J "Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients." J Clin Psychopharmacol 19 (1999): 494-9. [PMID: 10587283]
55	Fletcher GF, Kazamias TM "Cardiotoxic effects of Mellaril: conduction disturbances and supraventricular arrhythmias." Am Heart J 78 (1969): 135-8. [PMID: 5794785]
56	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
57	Greendyke RM, Gulya A "Effect of pindolol administration on serum levels of thioridazine, haloperidol, phenytoin, and phenobarbital." J Clin Psychiatry 49 (1988): 105-7. [PMID: 3346197]
58	Greendyke RM, Kanter DR "Plasma propranolol levels and their effect on plasma thioridazine and haloperidol concentrations." J Clin Psychopharmacol 7 (1987): 178-82. [PMID: 3597804]
59	Hartigan-Go K, Bateman DN, Nyberg G, Martensson E, Thomas SHL "Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans." Clin Pharmacol Ther 60 (1996): 543-53. [PMID: 8941027]
60	Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9. [PMID: 7663034]
61	Product Information. Mellaril (thioridazine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
62	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
63	Silver JM, Yudofsky SC, Kogan M, Katz BL "Elevation of thioridazine plasma levels by propranolol." Am J Psychiatry 143 (1986): 1290-2. [PMID: 3766793]
64	Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81. [PMID: 8838432]
65	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online.".
66	Product Information. Sensipar (cinacalcet). Amgen USA, Thousand Oaks, CA.
67	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
68	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
69	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
70	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
71	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
72	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
73	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
74	Skerjanec A, Wang J, Maren K, Rojkjaer L "Investigation of the pharmacokinetic interactions of deferasirox, a once-daily oral iron chelator, with midazolam, rifampin, and repaglinide in healthy volunteers." J Clin Pharmacol 50 (2010): 205-13. [PMID: 19940232]
75	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
76	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
77	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
78	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
79	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
80	Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
81	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
82	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
83	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
84	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
85	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
86	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
87	Product Information. Esbriet (pirfenidone). Intermune Inc, Brisbane, CA.
88	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
89	Caraco Y, Sheller J, Wood AJJ "Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects." J Pharmacol Exp Ther 290 (1999): 413-22. [PMID: 10381807]
90	Caraco Y, Sheller J, Wood JJ "Pharmacogenetic determination of the effects of codeine and prediction of drug interactions." J Pharmacol Exp Ther 278 (1996): 1165-74. [PMID: 8819499]
91	Desmeules J, Dayer P, Gascon MP, Magistris M "Impact of genetic and environmental factors on codeine analgesia." Clin Pharmacol Ther 45 (1989): 122. [PMID: 1782973]
92	Desmeules J, Gascon MP, Dayer P, Magistris M "Impact of environmental and genetic factors on codeine analgesia." Eur J Clin Pharmacol 41 (1991): 23-6. [PMID: 1782973]
93	Hersh EV, Moore PA "Drug interactions in dentistry: the importance of knowing your CYPs." J Am Dent Assoc 135 (2004): 298-311. [PMID: 15058617]
94	Poulsen L, Brosen K, Srendt-Nielsen L, Gram LF, Elbaek K, Sindrup SH "Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects." Eur J Clin Pharmacol 51 (1996): 289-95. [PMID: 9010701]
95	Sindrup SH, Arendt-Nielsen L, Brosen K, et al "The effect of quinidine on the analgesic effect of codeine." Eur J Clin Pharmacol 42 (1992): 587-92. [PMID: 1623898]
96	Sindrup SH, Brosen K, Bjerring P, et al. "Codeine increases pain threshold to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine." Clin Pharmacol Ther 49 (1991): 686-93. [PMID: 2249379]
97	Sindrup SH, Hofmann U, Asmussen J, Mikus G, Brosen K, Nielsen F, Ingwersen SH, Broen Christensen C "Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake." Eur J Clin Pharmacol 49 (1996): 503-9. [PMID: 8706777]
98	Thorn CF, Klein TE, Altman RB "Codeine and morphine pathway." Pharmacogenet Genomics 19 (2009): 556-8. [PMID: 19512957]
99	Vevelstad M, Pettersen S, Tallaksen C, Brors O "O-demethylation of codeine to morphine inhibited by low-dose levomepromazine." Eur J Clin Pharmacol 65 (2009): 795-801. [PMID: 19308365]
100	Zhou SF "Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II." Clin Pharmacokinet 48 (2009): 761-804. [PMID: 19902987]
101	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
102	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
103	Funck-Brentano C, Jacqz-Aigrain E, Leenhardt A, Roux A, Poirier JM, Jaillon P "Influence of amiodarone on genetically determined drug metabolism in humans." Clin Pharmacol Ther 50 (1991): 259-66. [PMID: 1914360]
104	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
105	Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
106	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
107	Skinner MH, Kuan HY, Pan A, et al. "Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers." Clin Pharmacol Ther 73 (2003): 170-7. [PMID: 12621382]
108	Franco-Salinas G, de la Rosette JJ, Michel MC "Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations." Clin Pharmacokinet 49 (2010): 177-88. [PMID: 20170206]
109	Kamimura H, Oishi S, Matsushima H, et al. "Identification of cytochrome P450 isozymes involved in metabolism of the alpha1-adrenoceptor blocker tamsulosin in human liver microsomes." Xenobiotica 28 (1998): 909-22. [PMID: 9849639]
110	Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT.
111	Edeki TI, He HB, Wood AJJ "Pharmacogenetic explanation for excessive beta-blockade following timolol eye drops: potential for oral-ophthalmic drug interaction." JAMA 274 (1995): 1611-3. [PMID: 7474246]
112	Fraunfelder FT, Fraunfelder FW Randall JA "Drug-Induced Ocular Side Effects 5th" Boston, MA: Butterworth-Heinemann (2001):.
113	Lewis RV, Lennard MS, Jackson PR, Tucker GT, Ramsay LE, Woods HF "Timolol and atenolol: relationships between oxidation phenotype, pharmacokinetics and pharmacodynamics." Br J Clin Pharmacol 19 (1985): 329-33. [PMID: 2859048]
114	Brynne N, Svanstrom C, AbergWistedt A, Hallen B, Bertilsson L "Fluoxetine inhibits the metabolism of tolterodin-pharmacokinetic implications and proposed clinical relevance." Br J Clin Pharmacol 48 (1999): 553-63. [PMID: 10583026]
115	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
116	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
117	Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8. [PMID: 10811561]
118	Tiseo PJ, Perdomo CA, Friedhoff LT "Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses." Br J Clin Pharmacol 46 (1998): 30-4. [PMID: 9839763]
119	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.

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