Details of Drug

Drug General Information (ID: D0333)
Drug Name	Ciclesonide
Drug Type	Small molecule
Drug Synonymous	Alvesco; Omnair; Omnaris; Osonase; Osonide; Alvesco HFA; Ciclesonide [INN]; Omnaris HFA; RPR 251526; Alvesco (TN); BTR-15; BTR-15K; BY-9010; BYK-20426; KS-1165; Omnaris (TN); Omniair (TN); TBN-15; B-9207-015; Ciclesonide (JAN/USAN/INN); (R)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate Click to Show/Hide
Disease Class	CB40-CB7Z: Respiratory system disease; CA23: Asthma
Therapeutic Class	Antiallergic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C32H44O7
InChI	1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1
InChIKey	LUKZNWIVRBCLON-GXOBDPJESA-N
Canonical SMILES	CC(C)C(=O)OCC(=O)C12C(CC3C1(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)OC(O2)C6CCCCC6
External Link
	Pubchem ID	6918155
	CAS Number	126544-47-6
	CHEBI ID	31397
	TTD ID	D0K7HU
	INTEDE ID	DR0319
	VARIDT ID	DR01408

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM009 Altered absorption (Unspecific) BM010 Transporter inhibition BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM065 Increased risk of hypokalemia BM067 Increased risk of hyponatremia
Relation Graph

Full list of drugs interacting with Ciclesonide
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[20], [21], [22]
Affected cellular transport
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[15]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[8], [9], [10], [11]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[8], [9], [10], [11]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[12]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[8], [9], [10], [11]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[8], [9], [10], [11]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[8], [9], [10], [11]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[14]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[8], [9], [10], [11]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[16], [17], [18]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[8], [9], [10], [11]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[8], [9], [10], [11]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[8], [9], [10], [11]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[8], [9], [10], [11]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[8], [9], [10], [11]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[8], [9], [10], [11]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[8], [9], [10], [11]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[8], [9], [10], [11]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[8], [9], [10], [11]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[8], [9], [10], [11]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[8], [9], [10], [11]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[8], [9], [10], [11]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[8], [9], [10], [11]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[8], [9], [10], [11]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[8], [9], [10], [11]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[8], [9], [10], [11]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[8], [9], [10], [11]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[8], [9], [10], [11]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[8], [9], [10], [11]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[8], [9], [10], [11]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[8], [9], [10], [11]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Moderate		Inter Info	[7], [13]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0203		Brexucabtagene autoleucel	NA	NA	Major		Inter Info	[1]
D0501		Dinutuximab	NA	NA	Major		Inter Info	[1]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [2]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[19]
	Increased risk of hypokalemia					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0103		Arformoterol	C19H24N2O4	3083544	Minor		Inter Info	[8], [7], [1], [23]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[8], [7], [1], [23]
D0924		Levosalbutamol	C13H21NO3	123600	Minor		Inter Info	[7], [1], [23]
D1374		Racepinephrine	C9H13NO3	838	Minor		Inter Info	[8], [7], [1], [23]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Minor		Inter Info	[7], [1], [23]
D0691		Formoterol	C19H24N2O4	3410	Minor		Inter Info	[8], [7], [1], [23]
D0854		Isoetharine	C13H21NO3	3762	Minor		Inter Info	[8], [7], [1], [23]
D0859		Isoprenaline	C11H17NO3	3779	Minor		Inter Info	[7], [1], [23]
D1185		Orciprenaline	C11H17NO3	4086	Minor		Inter Info	[7], [1], [23]
D1298		Pirbuterol	C12H20N2O3	4845	Minor		Inter Info	[8], [7], [1], [23]
D1414		Ritodrine	C17H21NO3	33572	Minor		Inter Info	[8], [7], [1], [23]
D1438		Salbutamol	C13H21NO3	2083	Minor		Inter Info	[7], [1], [23]
D1440		Salmeterol	C25H37NO4	5152	Minor		Inter Info	[8], [7], [1], [23]
D1554		Terbutaline	C12H19NO3	5403	Minor		Inter Info	[8], [7], [1], [23]
	Increased risk of hyponatremia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Major		Inter Info	[3], [1], [4], [5], [6], [7]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
3	Product Information. Stimate (desmopressin). Forest Pharmaceuticals, St. Louis, MO.
4	Product Information. Nocdurna (desmopressin). Ferring Inc, North York, ON.
5	Product Information. Noctiva (desmopressin). Avadel Pharmaceuticals, Chesterfield, MO.
6	Product Information. DDAVP (desmopressin). Rhone-Poulenc Rorer, Collegeville, PA.
7	Cerner Multum, Inc. "Australian Product Information.".
8	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
9	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
10	Product Information. Alvesco (ciclesonide). Nycomed USA, Florham Park, NJ.
11	Product Information. Omnaris (ciclesonide nasal). Sepracor Inc, Marlborough, MA.
12	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
13	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
14	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
15	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
16	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
17	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
18	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
19	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
20	Black DM, Filak AT "Hyperglycemia with non-insulin-dependent diabetes following intraarticular steroid injection." J Fam Pract 28 (1989): 462-3. [PMID: 2703816]
21	Greenstone MA, Shaw AB "Alternate day corticosteroid causes alternate day hyperglycaemia." Postgrad Med J 63 (1987): 761-4. [PMID: 3444801]
22	Product Information. EXUBERA (insulin inhalation, rapid acting). Pfizer U.S. Pharmaceuticals Group, New York, NY.
23	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.

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