Details of Drug

Details of Drug

 Drug General Information (ID: D0319)
  Drug Name
Chloroprocaine
  Drug Type Small molecule
  Drug Synonymous
Chloroprocain; Chloroprocainum; Chlorprocaine; Chlorprocainum; Cloroprocaina; Halestyn; Nesacaine; Piocaine; Chloroprocaine [INN]; Chloroprocaine hydrochloride; Nesacaine MPF; Chlor-procaine; Chloroprocaine (INN); Chloroprocainum [INN-Latin]; Cloroprocaina [INN-Spanish]; Nesacaine (TN); Nesacaine-Ce; Nesacaine-MPF (TN); Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester; 2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate; 2-(Diethylaminoethyl)-4-amino-2-chlorobenzoate; 2-Chloroprocaine; 2-diethylaminoethyl 4-amino-2-chlorobenzoate; 4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester
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  Disease Class 9A76-9A78: Corneal disease
  Therapeutic Class Anesthetics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C13H19ClN2O2
  InChI 1S/C13H19ClN2O2/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14/h5-6,9H,3-4,7-8,15H2,1-2H3
  InChIKey VDANGULDQQJODZ-UHFFFAOYSA-N
  Canonical SMILES CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl
  External Link
Pubchem ID 8612
CAS Number 133-16-4
CHEBI ID 3636
TTD ID D07NAJ

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM038  Additive CNS depression effects
BM042  Additive hypotensive effects
BM071  Increased risk of methemoglobinemia
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Chloroprocaine
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  16
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[6], [7], [8]
D0317
 
Chlordiazepoxide
 
C16H14ClN3O
 
2712 
Moderate    Inter Info   
[6], [7], [8]
D0604
 
Estazolam
 
C16H11ClN4
 
3261 
Moderate    Inter Info   
[6], [7], [8]
D1367
 
Quazepam
 
C17H11ClF4N2S
 
4999 
Moderate    Inter Info   
[6], [7], [8]
D1391
 
Remimazolam
 
C21H19BrN4O2
 
9867812 
Moderate    Inter Info   
[6], [7], [8]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[6], [7], [8]
D0362
 
Clonazepam
 
C15H10ClN3O3
 
2802 
Moderate    Inter Info   
[6], [7], [8]
D0365
 
Clorazepic acid
 
C16H11ClN2O3
 
2809 
Moderate    Inter Info   
[6], [7], [8]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[6], [7], [8]
D0679
 
Flurazepam
 
C21H23ClFN3O
 
3393 
Moderate    Inter Info   
[6], [7], [8]
D0748
 
Halazepam
 
C17H12ClF3N2O
 
31640 
Moderate    Inter Info   
[6], [7], [8]
D0951
 
Lorazepam
 
C15H10Cl2N2O2
 
3958 
Moderate    Inter Info   
[6], [7], [8]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Moderate    Inter Info   
[6], [7], [8]
D1197
 
Oxazepam
 
C15H11ClN2O2
 
4616 
Moderate    Inter Info   
[6], [7], [8]
D1547
 
Temazepam
 
C16H13ClN2O2
 
5391 
Moderate    Inter Info   
[6], [7], [8]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Moderate    Inter Info   
[6], [7], [8]
   Additive hypotensive effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1752
 
Bupivacaine (liposome)
 
C18H28N2O
 
2474 
Major    Inter Info   
[1], [2]
   Increased risk of methemoglobinemia Drug Num:  15
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1148
 
Nitrous acid
 
HNO2
 
24529 
Major    Inter Info   
[3], [4], [5]
D0163
 
Benzocaine (topical)
 
C9H11NO2
 
2337 
Moderate    Inter Info   
[7], [9], [10]
D1514
 
Sulfadoxine
 
C12H14N4O4S
 
17134 
Moderate    Inter Info   
[7]
D1904
 
Tetracaine (ophthalmic)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[7], [9], [10]
D1562
 
Tetracaine (topical)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[7], [9], [10]
D0339
 
Cinchocaine (topical)
 
C20H29N3O2
 
3025 
Moderate    Inter Info   
[7], [9], [10]
D0377
 
Cocaine (nasal)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[7], [9], [10]
D0378
 
Cocaine (topical)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[7], [9], [10]
D1835
 
Lidocaine (ophthalmic)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[7], [9], [10]
D0928
 
Lidocaine (topical)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[7], [9], [10]
D1852
 
Oxybuprocaine (ophthalmic)
 
C17H28N2O3
 
4633 
Moderate    Inter Info   
[7], [9], [10]
D1870
 
Proparacaine (ophthalmic)
 
C16H26N2O3
 
4935 
Moderate    Inter Info   
[7], [9], [10]
D1513
 
Sulfadiazine
 
C10H10N4O2S
 
5215 
Moderate    Inter Info   
[7]
D1516
 
Sulfamethoxazole
 
C10H11N3O3S
 
5329 
Moderate    Inter Info   
[7]
D1517
 
Sulfasalazine
 
C18H14N4O5S
 
5339 
Moderate    Inter Info   
[7]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1909
 
Tilmanocept
 
NA
 
NA
Moderate    Inter Info   
[11]
References
1 Product Information. Exparel (bupivacaine liposome). Pacira Pharmaceuticals Inc, San Diego, CA.
2 Kharitonov V "A review of the compatibility of liposome bupivacaine with other drug products and commonly used implant materials." Postgrad Med 126 (2014): 129-38. [PMID: 24393760]
3 Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
4 Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
5 Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
6 Cerner Multum, Inc. "Australian Product Information.".
7 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
9 Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
10 Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.
11 Product Information. Lymphoseek (tilmanocept). Navidea Biopharmaceuticals, Dublin, OH.