Details of Drug

Drug General Information (ID: D0288)
Drug Name	Cefpodoxime
Drug Type	Small molecule
Drug Synonymous	CPDX; Cefpodoxima; Cefpodoximum; Epoxim; Cefpodoxim acid; Cefpodoxima [Spanish]; Cefpodoximum [Latin]; RU 51807; Cefpodoxime (INN); Cefpodoxime [INN:BAN]; Epoxim (TN); Vantin (TN); (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-[(methyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-{[(2-amino-1,3-thiazol-4-yl)(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Click to Show/Hide
Disease Class	1A00-1C4Z: Bacterial infection
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C15H17N5O6S2
InChI	1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1
InChIKey	WYUSVOMTXWRGEK-HBWVYFAYSA-N
Canonical SMILES	COCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)O
External Link
	Pubchem ID	6335986
	CAS Number	80210-62-4
	CHEBI ID	3504
	TTD ID	D0W6CA
	INTEDE ID	DR2661
	VARIDT ID	DR00974

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM003 Complex formation BM005 Altered gastric pH BM014 Interference of cell/tissue uptake BM028 Competitive inhibition of renal tubular secretion BM031 Increased renal excretion (Unspecific) BM050 Increased risk of bleeding BM072 Increased risk of nephrotoxicity BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Cefpodoxime
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[71], [72]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[71], [72]
	Complex formation					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[1], [102]
	Altered gastric pH					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[56], [57], [58], [59]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[56], [57], [58], [59]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[56], [57], [58], [59]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[56], [57], [58], [59]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[56], [57], [58], [59]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[56], [57], [58], [59]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[56], [57], [58], [59]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[56], [57], [58], [59]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[56], [57], [58], [59]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[56], [57], [58], [59]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[56], [57], [58], [59]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[56], [57], [58], [59]
D1151		Nizatidine	C12H21N5O2S2	3033637	Moderate		Inter Info	[56], [57], [58], [59]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[56], [57], [58], [59]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[56], [57], [58], [59]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[56], [57], [58], [59]
D1381		Ranitidine	C13H22N4O3S	3001055	Moderate		Inter Info	[56], [57], [58], [59]
D1382		Ranitidine (bismuth citrate)	C13H22N4O3S	3001055	Moderate		Inter Info	[57], [58], [59]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[56], [57], [58], [59]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[60]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[67]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[73]
D1341		Probenecid	C13H19NO4S	4911	Moderate		Inter Info	[74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101]
	Increased renal excretion (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[48], [49], [52]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[48], [49], [52]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[44], [45], [46]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[44], [45], [46]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[44], [45], [46]
	Increased risk of nephrotoxicity					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[14], [22], [43]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[11], [1]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[11], [1]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[1], [2], [3]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[4]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[47]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[61], [62], [63]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[64], [65], [66]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[68], [69], [70]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[68], [69], [70]

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47	Product Information. Colazal (balsalazide) Salix Pharmaceuticals, Palo Alto, CA.
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60	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
61	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
62	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
63	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
64	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
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67	Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.
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71	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
72	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
73	Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
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