Details of Drug

Details of Drug

 Drug General Information (ID: D0258)
  Drug Name
Carbidopa
  Drug Type Small molecule
  Drug Synonymous
Atamet; Carbidopum; Lodosin; Lodosyn; Methyldopahydrazine; Stalevo; Carbidopa Monohydrate; Carbidopa anhydrous; Carbidopa hydrate; Carbidopum monohydricum; MK 486; Alpha-Methyldopahydrazine; C-126; C-DOPA; Carbidopa (anhydrous); Carbidopum [INN-Latin]; Lodosyn (TN); Lodosyn, Carbidopa; MK-485; MK-486; N-Aminomethyldopa; Carbidopa [USAN:INN:BAN]; Carbidopa-1-wasser; Hadrazino-alpha-methyldopa; L-alpha-Methyldopahydrazine; Carbidopa, (S)-Isomer; Carbidopa, Entacapone, & Levodopa; S(-)-CARBIDOPA; S-(-)-Carbidopa; L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate; Alpha-Hydrazino-alpha-methyl-beta-(3,4-dihydroxyphenyl)propionic acid; L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid; L-alpha-Methyl-alpha-hydrazino-beta-(3,4-dihydroxyphenylpropionic acid; L-alpha-Methyl-beta-(3,4-dihydroxyphenyl)-alpha-hydrazinopropionic acid; S(-)-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate; S-(-)-alpha-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid; Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, monohydrate, (S); KINSON, 3-(3,4-DIHYDROXY-PHENYL)-2-HYDRAZINO-2-METHYL-PROPIONIC ACID; Hydrocinnamic acid, (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, monohydrate; (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid; (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate; (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid; (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid; (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate; (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate; (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid-water (1/1); (S)-(-)-carbidopa; (S)-(-)-carbidopa hydrate; (S)-alpha-Hydrazino-3,4-dihydroxy-alpha-methyl-benzenepropanoic acid monohydrate; (S)-carbidopa; (S)-carbidopahydrate; (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid; (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate
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  Disease Class 8A00: Parkinsonism
  Therapeutic Class Antiparkinson Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C10H14N2O4
  InChI 1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
  InChIKey TZFNLOMSOLWIDK-JTQLQIEISA-N
  Canonical SMILES CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN
  External Link
Pubchem ID 34359
CAS Number 28860-95-9
CHEBI ID 39585
TTD ID D0P7JZ

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM040  Additive dopaminergic effects
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Carbidopa
      Pharmacodynamic additive effects
   Additive dopaminergic effects Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1200
 
Oxitriptan
 
C11H12N2O3
 
439280 
Moderate    Inter Info   
[2], [3], [4]
D1492
 
Solriamfetol
 
C10H14N2O2
 
10130337 
Moderate    Inter Info   
[5]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0538
 
Droxidopa
 
C9H11NO5
 
92974 
Moderate    Inter Info   
[1]
References
1 Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
2 Hardman JG, Limbird LE, Gilman AG, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 10th ed." New York, NY: McGraw-Hill (2001):.
3 Sternberg EM, Van Woert MH, Young SN, Magnussen I, Baker H, Gauthier S, Osterland CK "Development of a scleroderma-like illness during therapy with L-5- hydroxytryptophan and carbidopa." N Engl J Med 303 (1980): 782-7. [PMID: 6997735]
4 Magnussen I, Van Woert MH "Human pharmacokinetics of long term 5-hydroxytryptophan combined with decarboxylase inhibitors." Eur J Clin Pharmacol 23 (1982): 81-6. [PMID: 6182005]
5 Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.