Details of Drug

Details of Drug

 Drug General Information (ID: D0234)
  Drug Name
Calcitriol
  Drug Type Small molecule
  Drug Synonymous
calcitriol; Rocaltrol; 32222-06-3; Calcijex; Topitriol; 1alpha,25-Dihydroxyvitamin D3; Silkis; Soltriol; 1alpha,25-Dihydroxycholecalciferol; Calcitriolum; Dihydroxyvitamin D3; 1,25-DHCC; 1,25-Dihydroxyvitamin D; Vectical; 1,25-DIHYDROXYCHOLECALCIFEROL; 1,25-Dihydroxyvitamin D3; 1alpha,25-Dihydroxyvitamin D; 1-alpha,25-Dihydroxyvitamin D3; Calcitriolum [INN-Latin]; UNII-FXC9231JVH; 1alpha,25(OH)2D3; DN-101; 1,25-Dihydroxycholecaliferol; CCRIS 5522; Ro 21-5535; HSDB 3482; 1-alpha,25-Dihydroxycholecalciferol; EINECS 250-963-8; DN 101; Calcitriol (chemotherapy-induced alopecia); Calcitriol (chemotherapy-induced alopecia), Cytotech Labs; Calcitriol (API-31543, drug-induced alopecia), Cytotech Labs; 1alpha,25 dihydroxyvitamin D(3)
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  Disease Class LC30: Hair/hair growth developmental defect
  Therapeutic Class Vitamins
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C27H44O3
  InChI 1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
  InChIKey GMRQFYUYWCNGIN-NKMMMXOESA-N
  Canonical SMILES CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
  External Link
Pubchem ID 5280453
CAS Number 32222-06-3
CHEBI ID 17823
TTD ID D0T2PL
INTEDE ID DR0260

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM008  Altered Fat-soluble drugs absorption
BM022  CYP450 enzyme induction
BM059  Increased risk of hypermagnesemia
BM107  Attenuated pharmacological effects (Unspecific)
BM108  Increased risk of hypercalcemia
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Calcitriol
      Affected gastrointestinal absorption
   Altered Fat-soluble drugs absorption Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0329
 
Cholestyramine
 
C27H47ClN2
 
137699107 
Moderate    Inter Info   
[13], [2], [14], [15], [6], [16]
D0381
 
Colesevelam
 
C31H67Cl3N4O
 
160051 
Moderate    Inter Info   
[13], [2], [14], [15], [6], [16]
D0382
 
Colestipol
 
C11H28ClN5O
 
62816 
Moderate    Inter Info   
[13], [2], [14], [15], [6], [16]
D1069
 
Mineral oil
 
NA
 
NA
Moderate    Inter Info   
[18]
D1462
 
Sevelamer
 
C6H12ClNO
 
3085017 
Moderate    Inter Info   
[13], [2], [14], [15], [6], [16]
D1187
 
Orlistat
 
C29H53NO5
 
3034010 
Minor    Inter Info   
[19]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme induction Drug Num:  17
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0071
 
Amobarbital
 
C11H18N2O3
 
2164 
Moderate    Inter Info   
[3], [4], [6], [7]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[3], [4], [6], [7]
D0225
 
Butalbital
 
C11H16N2O3
 
2481 
Moderate    Inter Info   
[3], [4], [6], [7]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[3], [4], [6], [7]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[3], [4], [6], [7]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[3], [4], [6], [7]
D0858
 
Isoniazid
 
C6H7N3O
 
3767 
Moderate    Inter Info   
[3], [4], [6], [7]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[3], [6], [7]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[3], [4], [6], [7]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[3], [4], [6], [7]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Moderate    Inter Info   
[3], [4], [6], [7]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[3], [4], [6], [7]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Moderate    Inter Info   
[3], [4], [6], [7]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Moderate    Inter Info   
[3], [6], [7]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Moderate    Inter Info   
[3], [4], [6], [7]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[3], [4], [6], [7]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[3], [4], [6], [7]
      Pharmacodynamic additive effects
   Increased risk of hypermagnesemia Drug Num:  8
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0968
 
Magnesium carbonate
 
CMgO3
 
11029 
Moderate    Inter Info   
[3], [4], [6], [7]
D0969
 
Magnesium chloride
 
Cl2H12MgO6
 
643991 
Moderate    Inter Info   
[3], [4], [6], [7]
D0970
 
Magnesium citrate
 
C12H10Mg3O14
 
6099959 
Moderate    Inter Info   
[3], [4], [6], [7]
D0971
 
Magnesium gluconate
 
C12H22MgO14
 
11418570 
Moderate    Inter Info   
[3], [4], [6], [7]
D0972
 
Magnesium glycinate
 
C4H8MgN2O4
 
84645 
Moderate    Inter Info   
[3], [4], [6], [7]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[3], [4], [6], [7]
D0974
 
Magnesium oxide
 
MgO
 
14792 
Moderate    Inter Info   
[3], [4], [6], [7]
D0975
 
Magnesium sulfate
 
MgO4S
 
24083 
Moderate    Inter Info   
[3], [4], [6], [7]
   Increased risk of hypercalcemia Drug Num:  17
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0233
 
Calcifediol
 
C27H44O2
 
5283731 
Major    Inter Info   
[2], [3], [4]
D0328
 
Cholecalciferol
 
C27H44O
 
5280795 
Major    Inter Info   
[2], [3], [4]
D0495
 
Dihydrotachysterol
 
C28H46O
 
5311071 
Major    Inter Info   
[2], [3], [4]
D0527
 
Doxercalciferol
 
C28H44O2
 
5281107 
Major    Inter Info   
[2], [3], [4]
D0591
 
Ergocalciferol
 
C28H44O
 
5280793 
Major    Inter Info   
[2], [3], [4]
D1226
 
Paricalcitol
 
C27H44O3
 
5281104 
Major    Inter Info   
[2], [3], [4]
D0158
 
Bendroflumethiazide
 
C15H14F3N3O4S2
 
2315 
Moderate    Inter Info   
[8], [9], [10]
D0166
 
Benzthiazide
 
C15H14ClN3O4S3
 
2343 
Moderate    Inter Info   
[8], [9], [10]
D1753
 
Calcipotriol (topical)
 
C27H40O3
 
5288783 
Moderate    Inter Info   
[11], [12]
D0321
 
Chlorothiazide
 
C7H6ClN3O4S2
 
2720 
Moderate    Inter Info   
[8], [9], [10]
D0326
 
Chlorthalidone
 
C14H11ClN2O4S
 
2732 
Moderate    Inter Info   
[8], [9], [10]
D0771
 
Hydrochlorothiazide
 
C7H8ClN3O4S2
 
3639 
Moderate    Inter Info   
[8], [9], [10]
D0775
 
Hydroflumethiazide
 
C8H8F3N3O4S2
 
3647 
Moderate    Inter Info   
[8], [9], [10]
D0798
 
Indapamide
 
C16H16ClN3O3S
 
3702 
Moderate    Inter Info   
[8], [9], [10]
D1048
 
Metolazone
 
C16H16ClN3O3S
 
4170 
Moderate    Inter Info   
[8], [9], [10]
D1311
 
Polythiazide
 
C11H13ClF3N3O4S3
 
4870 
Moderate    Inter Info   
[8], [9], [10]
D1633
 
Trichlormethiazide
 
C8H8Cl3N3O4S2
 
5560 
Moderate    Inter Info   
[8], [9], [10]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0221
 
Burosumab
 
NA
 
NA
Major    Inter Info   
[1]
D0490
 
Digitoxin
 
C41H64O13
 
441207 
Moderate    Inter Info   
[2], [7], [17]
D0491
 
Digoxin
 
C41H64O14
 
2724385 
Moderate    Inter Info   
[2], [7], [17]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Major    Inter Info   
[5]
References
1 Product Information. Crysvita (burosumab). Ultragenyx Pharmaceutical, Novato, CA.
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Product Information. Hectorol (doxercalciferol). Genzyme Corporation, Cambridge, MA.
4 Product Information. One-Alpha (alfacalcidol). Pharmel Inc, Montreal, IN.
5 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
6 Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
7 Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
8 Santos F, Smith MJ, Chan JC "Hypercalciuria associated with long-term administration of calcitriol (1,25-dihydroxyvitamin D3). Action of hydrochlorothiazide." Am J Dis Child 140 (1986): 139-42
9 Drinka PJ, Nolten WE "Hazards of treating osteoporosis and hypertension concurrently with calcium, vitamin D, and distal diuretics." J Am Geriatr Soc 32 (1984): 405-7
10 Duarte CG, Winnacker JL, Becker KL, Pace A "Thiazide-induced hypercalcemia." N Engl J Med 284 (1971): 828-30
11 Product Information. Vectical (calcitriol topical). Galderma Laboratories Inc, Cranbury, NJ.
12 Product Information. Dovonex (calcipotriene). Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.
13 Cerner Multum, Inc. "Australian Product Information.".
14 Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21. [PMID: 20921291]
15 Product Information. Fosamax Plus D (alendronate-cholecalciferol). Merck & Company Inc, West Point, PA.
16 Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
17 Therapeutic Research Faculty "Natural Medicines Comprehensive Database."
18 Product Information. Hectorol (doxercalciferol) Genzyme Corporation, Cambridge, MA.
19 Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.