Details of Drug

Drug General Information (ID: D0230)
Drug Name	Cabozantinib
Drug Type	Small molecule
Drug Synonymous	Cabometyx; Cometriq Click to Show/Hide
Disease Class	2D10: Thyroid cancer; 2C73: Ovarian cancer
Therapeutic Class	Vegf/Vegfr Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C28H24FN3O5
InChI	1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
InChIKey	ONIQOQHATWINJY-UHFFFAOYSA-N
Canonical SMILES	COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
External Link
	Pubchem ID	25102847
	CAS Number	849217-68-1
	CHEBI ID	72317
	TTD ID	D0IQ6P
	INTEDE ID	DR0254

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects BM047 Additive thrombogenic effects BM050 Increased risk of bleeding BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Cabozantinib
Affected cellular transport
	Transporter inhibition					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[33]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[13], [1], [54]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[222], [223]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[12], [1], [228], [229]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[13], [277]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[280]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[281]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[13], [1], [30], [2]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[286], [287]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[289]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[303]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[304]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[13], [1], [305]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[13], [1], [2], [25]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[13], [1], [2], [25]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[13], [1], [2], [25]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[13], [1], [2], [25]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[47]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[12], [13], [1], [48], [49], [50], [23]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[13], [1], [2], [25]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[13], [1], [2], [25]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[13], [1], [2], [25]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[13], [1], [2], [25]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[13], [1], [2], [25]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[13], [1], [2], [25]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[13], [1], [2], [25]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[13], [1], [2], [25]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[13], [1], [2], [25]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[13], [1], [2], [25]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[13], [1], [2], [25]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[13], [1], [2], [25]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[13], [1], [2], [25]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[13], [1], [2], [25]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[13], [1], [2], [25]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[2]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[227]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[2]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[2]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[235]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[13], [1], [237]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[2]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[2]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[2]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[2]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[2]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[2]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[2]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[2]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[2]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[2]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[2]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[2]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[2]
	CYP450 enzyme induction					Drug Num: 43
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[30], [2]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[30], [2]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[30], [2], [39]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[30], [2]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[30], [2]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[30], [2]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[30], [2]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[30], [2]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[30], [2]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[30], [2]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[30], [2], [39]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[30], [2]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[30], [2]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[30], [2]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[30], [2]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[30], [2]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[30], [2]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1], [233]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[13], [234]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[30], [2]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[30], [2]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[30], [2]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[30], [2]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[30], [2]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[30], [2]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[30], [2], [279]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[30], [2]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[30], [2]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[30], [2]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[30], [2]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[30], [2]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[30], [2]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[30], [2]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[30], [2], [279]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[30], [2]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[13], [1], [30], [2]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[30], [2]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[30], [2]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[30], [2]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[30], [2]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[30], [2]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[30], [2], [279]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[30], [2]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1855		Palifermin	NA	NA	Moderate		Inter Info	[291]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206]
	Increased risk of bleeding					Drug Num: 99
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[2]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[3], [2]
D0047		Alteplase	NA	NA	Major		Inter Info	[2]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[2]
D0088		Anistreplase	NA	NA	Major		Inter Info	[2]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[2]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[2]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[2]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[2]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[29]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[3], [2]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[1], [31]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[2]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Major		Inter Info	[2]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[2]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[2]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[2]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[1], [34], [35]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[44]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[1], [45], [46]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[2]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[2]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[2]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[2]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[2]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[2]
D0415		Danaparoid	NA	NA	Major		Inter Info	[2]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[34], [80]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[2]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[2]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[3], [2]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[2]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[2]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[86]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[2]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[2]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[2]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[2]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[2]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[2]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[2]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[2]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[3], [2]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[2]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[2]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[2]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[2]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[2]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[3], [2]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[2]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[2]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[2]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[2]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[3], [2]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[2]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[2]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[2]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[2]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[2]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[156]
D1395		Reteplase	NA	NA	Major		Inter Info	[2]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[2]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[2]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[2]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[2]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[2]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[2]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[2]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[211]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[2]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[2]
D1613		Tositumomab	NA	NA	Major		Inter Info	[2]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[3], [2]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[3], [2]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[2]
D1669		Urokinase	NA	NA	Major		Inter Info	[2]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[2]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[224], [225], [226]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[1], [274]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[34], [282]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[224], [225], [226]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[224], [225], [226]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[224], [225], [226]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[288]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[224], [225], [226]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[224], [225], [226]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[34], [292]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[224], [225], [226]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[238], [239], [240], [241], [13], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [77], [258], [259], [260], [90], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273]
	Increased risk of prolong QT interval					Drug Num: 155
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0003		Abarelix	C72H95ClN14O14	16131215	Major		Inter Info	[1], [2]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1], [2]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[1], [2]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[1], [2], [11]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[12], [13], [1], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[12], [13], [1], [26]
D0097		Apomorphine	C17H17NO2	6005	Major		Inter Info	[1], [2]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[1], [2]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[1], [2]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1], [2]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1], [2]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[12], [13], [1], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[1], [2]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[1], [2]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[1], [2]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[32]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1], [2]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[1], [2]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[1], [2]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[1], [2]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[38]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1], [2]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[1], [2], [11]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[40]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[41]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[1], [2]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[42]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[1], [2]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[1], [2]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[1], [51]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Major		Inter Info	[1], [2]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[1], [2]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[12], [13], [1], [53]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[55], [1], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[1], [2]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1], [2]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[12], [13], [1], [8], [74], [75]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[12], [13], [1], [76], [77], [23], [78]
D0358		Clofazimine	C27H22Cl2N4	2794	Major		Inter Info	[1], [2]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[79]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1], [2]
D0429		Daunorubicin	C27H29NO10	30323	Major		Inter Info	[1], [2]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[1], [2], [11]
D0437		Degarelix	C82H103ClN18O16	16136245	Major		Inter Info	[1], [2]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[1], [2], [11]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[12], [13], [1], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[12], [13], [1], [81]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[12], [13], [1], [82]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[1], [2], [11]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[1], [2]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[12], [13], [1], [83]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[12], [13], [1], [84], [85], [23]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[87]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[1], [2]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[1], [2]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1], [2]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[12], [88], [13], [1], [89], [90], [23]
D0632		Ezogabine	C16H18FN3O2	121892	Major		Inter Info	[1], [2]
D0664		Flecainide	C17H20F6N2O3	3356	Major		Inter Info	[1], [2]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1], [2]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[1], [2]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[1], [2]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1], [2]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1], [2]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[92], [93], [94], [12], [13], [1], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[1], [2]
D0737		Goserelin	C59H84N18O14	5311128	Major		Inter Info	[1], [2]
D0738		Granisetron	C18H24N4O	5284566	Major		Inter Info	[1], [2]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[93], [12], [13], [1], [115], [116], [117]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[12], [13], [1], [118], [119], [120], [121], [122], [123], [23]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[1], [2]
D0758		Histrelin	C66H86N18O12	25077993	Major		Inter Info	[1], [2]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Major		Inter Info	[1], [2]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[12], [13], [1], [124]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[12], [13], [1], [125], [23]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[1], [2]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1], [2]
D0908		Leuprolide	C59H84N16O12	657181	Major		Inter Info	[1], [2]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[1], [129], [23]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1], [2]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[1], [2]
D0942		Lofexidine	C11H12Cl2N2O	30668	Major		Inter Info	[1], [2]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[1], [2]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Major		Inter Info	[13], [1], [130]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[1], [2]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[1], [2]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[12], [13], [1], [131], [23]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[12], [13], [1], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [23]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[1], [2]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[1], [2]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[92], [93], [94], [12], [13], [1], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[12], [13], [1], [142]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1], [2]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[1], [2]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[1], [2]
D1181		Ondansetron	C18H19N3O	4595	Major		Inter Info	[1], [2]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[1], [2]
D1210		Oxytocin	C43H66N12O12S2	439302	Major		Inter Info	[1], [2]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[1], [2]
D1216		Palonosetron	C19H24N2O	6337614	Major		Inter Info	[1], [2]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[143]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[144], [145], [146], [147], [148], [149], [150], [151]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[12], [13], [1], [152]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[1], [2]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1], [2]
D1254		Perflutren	C3F8	6432	Major		Inter Info	[153], [154]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[1], [2]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[1], [84], [155], [23]
D1339		Primaquine	C15H21N3O	4908	Major		Inter Info	[1], [2]
D1342		Probucol	C31H48O2S2	4912	Major		Inter Info	[1], [2]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[12], [13], [1], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[1], [2]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[1], [2]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[1], [2]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1], [2]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[1], [2]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[12], [13], [1], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1], [2]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[1], [2]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[1], [2]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[181], [182], [12], [13], [1], [183], [184]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[1], [2]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[1], [2]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1], [2]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[12], [13], [1], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[93], [12], [13], [1], [185], [186], [97], [99], [101], [187], [102], [103], [188], [105], [106], [107], [108], [189], [112], [117], [190]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1], [2]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1], [2]
D1533		Tamoxifen	C26H29NO	2733526	Major		Inter Info	[1], [2]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [2]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[1], [2]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[1], [2]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[12], [13], [1], [207], [84], [208], [209], [210], [23]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1], [2]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[12], [13], [1], [45]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[1], [2]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[1], [2]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[1], [2]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2]
D1651		Triptorelin	C64H82N18O13	25074470	Major		Inter Info	[1], [2]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[12], [13], [1], [212]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[1], [2]
D1683		Vasopressin	C46H65N15O12S2	644077	Major		Inter Info	[1], [2]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[13], [1], [216], [217], [218], [219], [220], [221]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[13], [1], [290]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[293], [294], [295], [296], [297], [298], [299], [300], [301], [302]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[13], [306], [307], [308]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[12], [13], [1], [309], [310], [311], [312]
	Increased risk of ventricular arrhythmias					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0025		Adenosine	C10H13N5O4	60961	Major		Inter Info	[4], [1], [5], [6], [7], [8], [9], [10]
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[24]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[27], [28]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[1], [36], [37]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[43]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[13], [52]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[12], [13], [1], [91], [78]
D0859		Isoprenaline	C11H17NO3	3779	Major		Inter Info	[126], [127], [128]
D1185		Orciprenaline	C11H17NO3	4086	Major		Inter Info	[126], [127], [128]
D1414		Ritodrine	C17H21NO3	33572	Major		Inter Info	[126], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [127], [175], [176], [177], [178], [128], [179], [180]
D1554		Terbutaline	C12H19NO3	5403	Major		Inter Info	[126], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [127], [175], [176], [177], [178], [128], [179], [180]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[126], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [213], [214], [169], [170], [171], [172], [173], [215], [174], [127], [175], [176], [177], [178], [128], [179], [180]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[12], [13], [1], [230], [231], [232]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[12], [13], [1], [230], [231], [232]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[13], [1], [232]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[12], [13], [1], [230], [231], [232]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[12], [13], [1], [230], [231], [232]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[213], [175], [178]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[12], [13], [1], [230], [231], [232]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[12], [13], [1], [230], [231], [232]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[12], [13], [1], [230], [231], [232]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[126], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [213], [214], [169], [170], [171], [172], [173], [215], [174], [127], [175], [176], [177], [178], [128], [179], [180]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[1], [275], [276]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[1], [275], [276]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[13], [1], [232]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[1], [275], [276]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[213], [175], [178]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[12], [13], [1], [283], [284], [285]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[126], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [213], [214], [169], [170], [171], [172], [173], [215], [174], [127], [175], [176], [177], [178], [128], [179], [180]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[12], [13], [1], [283], [284], [285]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[126], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [213], [214], [169], [170], [171], [172], [173], [215], [174], [127], [175], [176], [177], [178], [128], [179], [180]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[12], [13], [1], [230], [231], [232]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[12], [13], [1], [230], [231], [232]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[126], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [213], [214], [169], [170], [171], [172], [173], [215], [174], [127], [175], [176], [177], [178], [128], [179], [180]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[12], [13], [1], [283], [284], [285]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[161], [167], [172]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[126], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [213], [214], [169], [170], [171], [172], [173], [215], [174], [127], [175], [176], [177], [178], [128], [179], [180]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[12], [13], [1], [283], [284], [285]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[236]
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[278]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
3	Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
4	Celiker A, Tokel K, Cil E, Ozkutlu S, Ozme S "Adenosine induced torsades de pointes in a child with congenital long QT syndrome." Pacing Clin Electrophysiol 17 (1994): 1814-7. [PMID: 7838793]
5	Teodorovich N, Margolin E, Kogan Y, Paz O, Swissa M. Torsades de pointes after adenosine administration. J Electrocardiol. 2016;49(2):171-173. [PMID: 26850499]
6	Harrington GR, Froelich EG "Adenosine-induced torsades de pointes." Chest 103 (1993): 1299-1301. [PMID: 8131497]
7	Mallet ML "Proarrhythmic effects of adenosine: a review of the literature." Emerg Med J 21 (2004): 408-10. [PMID: 15208219]
8	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
9	Tachakra SS, Robinson S "Adenosine and cardiac arrhythmias." BMJ 305 (1992): 422. [PMID: 1392935]
10	Wesley RC Jr, Turnquest P "Torsades de pointe after intravenous adenosine in the presence of prolonged QT syndrome." Am Heart J 123 (1992): 794-6. [PMID: 1539535]
11	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
12	Canadian Pharmacists Association.
13	Cerner Multum, Inc. "Australian Product Information.".
14	Maxa JL, Hebeler RF, Adeeko MA "Torsades de pointes following concurrent amiodarone and levofloxacin therapy." Proc (Bayl Univ Med Cent) 19 (2006): 345-6. [PMID: 17106497]
15	Product Information. Betapace (sotalol). Berlex, Richmond, CA.
16	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
17	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
18	Product Information. Procan SR (procainamide). Parke-Davis, Morris Plains, NJ.
19	Product Information. Quiniglute (quinidine). Berlex, Richmond, CA.
20	Product Information. Vascor (bepridil). McNeil Pharmaceutical, Raritan, NJ.
21	Trujillo TC, Nolan PE "Antiarrhythmic agents - Drug interactions of clinical significance." Drug Safety 23 (2000): 509-32. [PMID: 11144659]
22	Yamreudeewong W, DeBisschop M, Martin L, Lower D "Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs." Drug Saf 26 (2003): 421-38. [PMID: 12688833]
23	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
24	Product Information. Barhemsys (amisulpride). Acacia Pharma, Inc, Indianapolis, IN.
25	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
26	Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
27	Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
28	Product Information. Trisenox (arsenic trioxide) Cephalon Inc, West Chester, PA.
29	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
30	Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
31	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
32	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
33	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
34	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
35	Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
36	Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
37	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
38	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
39	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
40	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
41	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
42	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
43	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
44	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
45	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
46	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
47	Product Information. Orgovyx (relugolix). Myovant Sciences, Inc., Brisbane, CA.
48	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
49	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
50	Abbas R, Hug BA, Leister C, Sonnichsen D "A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects." Int J Cancer 131 (2012): Epub. [PMID: 22065400]
51	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
52	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
53	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
54	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
55	Harper KM, Knapp DJ, Criswell HE, Breese GR "Vasopressin and alcohol: A multifaceted relationship." Psychopharmacology (Berl) 235 (2018): 3363-79. [PMID: 32936259]
56	Javelot H, El-Hage W, Meyer G, Becker G, Michel B, Hingray C "COVID-19 and (hydroxy)chloroquine-azithromycin combination: should we take the risk for our patients?" Br J Clin Pharmacol Apr 29 (2020): epub ahead of print. [PMID: 32350872]
57	National Institutes of Health (NIH) "Coronavirus Disease 2019 (COVID-19) Treatment Guidelines.".
58	Product Information. Chloroquine Phosphate (chloroquine). West-Ward Pharmaceutical Corporation, Eatontown, NJ.
59	Product Information. Hydroxychloroquine Sulfate (hydroxychloroquine). Prasco Laboratories, Cincinnati, OH.
60	Product Information. Plaquenil (R). (hydroxychloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.
61	Roden DM, Harrington RA, Poppas A, Russo AM "Considerations for drug interactions on QTc in exploratory COVID-19 (Coroanvirus disease 2019) treatment." Heart Rhythm Apr 14 (2020): epub ahead of print. [PMID: 32302703]
62	Sacher F, Fauchier L, Boveda S, et.al "Use of drugs with potential cardiac effect in the setting of SARS-CoV-2 infection." Arch Cardiovasc Dis Apr 24 (2020): epub ahead of print. [PMID: 32354666]
63	Saleh M, Gabriels J, ChangD, et.al "The effect of chloroquine, hydroxychloroquine and azithromycin on the corrected QT interval in patients with SARS-CoV-2 infection." Circ Arrhythm Electrophysiol Apr 29 (2020): epub ahead of print. [PMID: 32347743]
64	Sapp JL, Alqarawi W, MacIntyre CJ, et.al "Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: A statement from the Canadian Heart Rhythm Society." Can J Cardiol Apr 8 (2020): epub ahead of print. [PMID: 32299753]
65	Smit C, Peeters MYM, van den Anker JN, Knibbe CAJ "Chloroquine for SARS-CoV-2: Implications of its unique pharmacokinetic and safety properties." Clin Pharmacokinet Ar 18 (2020): epub ahead of print. [PMID: 32306288]
66	Bessiere F, Roccia H, Deliniere A, et.al "Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit." JAMA Cardiol May 1 (2020): epub ahead of print. [PMID: 32936266]
67	Borba MGS, Val FFA, Sampaio VS, et.al "Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 1 (SARS-CoV-2) infection: A randomized clinical trial." JAMA Netw Open Apr 1 (2020): epub ahead of print. [PMID: 32330277]
68	Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ "Urgent guidance for navigating and circumventing the QTc-prolonging and torsadogenic potential of possible pharmacotherapies for coronavirus disease 19 (COVID-19)" Mayo Clin Proc Apr 7 (2020): epub ahead of print. [PMID: 32359771]
69	Kapoor A, Pandurangi U, Arora V, et.al "Cardiovascular risks of hydroxychloroquine in treatment and prophylaxis of COVID-19 patients: A scientific statement from the Indian Heart Rhythm Society." Indian Pacing Electorphysiol J Apr 8 (2020): epub ahead of print. [PMID: 32278018]
70	Mercuro NJ, Yen CF, Shim DJ, et.al "Risk of QT interval prolongation associated with the use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19)" JAMA Cardiol May 1:e201834 (2020): epub ahead of print. [PMID: 32936252]
71	mitra RL, Greenstein SA, Epstein lm "An algorithm for managing QT prolongation in coronavirus disease 2019 (COVID-19) patients treated with either chloroquine or hydroxychloroquine in conjunction with azithromycin Possible benefits of intravenous lidocaine." HeartRythm Case Rep Apr 1 (2020): epub ahead of print. [PMID: 32363145]
72	US Food and Drug Administration "FACT SHEET FOR HEALTH CARE PROVIDERS EMERGENCY USE AUTHORIZATION (EUA) OF CHLOROQUINE PHOSPHATE SUPPLIED FROM THE STRATEGIC NATIONAL STOCKPILE FOR TREATMENT OF COVID-19 IN CERTAIN HOSPITALIZED PATIENTS. Available from: URL: https://www.fda.gov/media/13653" ([2020, Apr 27]):.
73	US Food and Drug Administration "Hydroxychloroquine or Chloroquine for COVID-19: Drug Safety Communication - FDA Cautions Against Use Outside of the Hospital Setting or a Clinical Trial Due to Risk of Heart Rhythm Problems.".
74	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
75	Trinkle R "Comment: syncopal episodes associated with cisapride." Ann Pharmacother 33 (1999): 251. [PMID: 10084425]
76	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide).".
77	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
78	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
79	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
80	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
81	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
82	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
83	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
84	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
85	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
86	Product Information. Xigris (drotrecogin alfa). Lilly, Eli and Company, Indianapolis, IN.
87	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
88	Castro VM, Clements CC, Murphy SN, et al. "QT interval and antidepressant use: a cross sectional study of electronic health records." BMJ 346 (2013): f288. [PMID: 23360890]
89	Do A, Noohi S, Elie D, et al. Health Canada Warning on Citalopram and Escitalopram--Its Effects on Prescribing in Consultation-Liaison Psychiatry.?Psychosomatics. 2016;57(1):57-63. [PMID: 26633294]
90	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
91	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
92	Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
93	Ball P "Quinolone-induced QT interval prolongation: a not-so-unexpected class effect." J Antimicrob Chemother 45 (2000): 557-9. [PMID: 10797074]
94	Bertino JS Jr, Owens RC Jr, Carnes TD, Iannini PB "Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors." Clin Infect Dis 34 (2002): 861-3. [PMID: 11830802]
95	Dale KM, Lertsburapa K, Kluger J, White CM "Moxifloxacin and torsade de pointes." Ann Pharmacother 41 (2007): 336-40. [PMID: 17284508]
96	Demolis JL, Kubitza D, Tenneze L, Funck-Bretano C "Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects." Clin Pharmacol Ther 68 (2000): 658-66. [PMID: 11180026]
97	Falagas ME, Rafailidis PI, Rosmarakis ES "Arrhythmias associated with fluoroquinolone therapy." Int J Antimicrob Agents 29 (2007): 374-9. [PMID: 17241772]
98	Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Pharmacotherapy 21 (2001): 1468-72. [PMID: 11765299]
99	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
100	Iannini PB, Circiumaru I "Gatifloxacin-induced QTc prolongation and ventricular tachycardia." Pharmacotherapy 21 (2001): 361-2. [PMID: 11253862]
101	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7. [PMID: 11141163]
102	Kang J, Wang L, Chen XL, Triggle DJ, Rampe D "Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG." Mol Pharmacol 59 (2001): 122-6. [PMID: 11125032]
103	Katritsis D, Camm AJ "Quinolones: cardioprotective or cardiotoxic." Pacing Clin Electrophysiol 26 (2003): 2317-20. [PMID: 14675020]
104	Noel GJ, Natarajan J, Chien S, Hunt TL, Goodman DB, Abels R "Effects of three fluoroquinolones on QT interval in healthy adults after single doses." Clin Pharmacol Ther 73 (2003): 292-303. [PMID: 12709719]
105	Oliphant CM, Green GM "Quinolones: a comprehensive review." Am Fam Physician 65 (2002): 455-64. [PMID: 11858629]
106	Owens RC "QT Prolongation with Antimicrobial Agents : Understanding the Significance." Drugs 64 (2004): 1091-124. [PMID: 15139788]
107	Owens RC "Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes." Pharmacotherapy 21 (2001): 301-19. [PMID: 11253855]
108	Owens RC Jr, Ambrose PG "Torsades de pointes associated with fluoroquinolones." Pharmacotherapy 22 (2002): 663-8 discussion 668-72. [PMID: 12013370]
109	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
110	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
111	Siepmann M, Kirch W "Drug points - Tachycardia associated with moxifloxacin." Br Med J 322 (2001): 23. [PMID: 11141146]
112	Stahlmann R "Clinical toxicological aspects of fluoroquinolones." Toxicol Lett 127 (2002): 269-77. [PMID: 12052667]
113	Tsikouris JP, Peeters MJ, Cox CD, Meyerrose GE, Seifert CF "Effects of three fluoroquinolones on QT analysis after standard treatment courses." Ann Noninvasive Electrocardiol 11 (2006): 52-6. [PMID: 16472283]
114	White CM, Grant EM, Quintiliani R "Moxifloxacin does increase the corrected QT interval." Clin Infect Dis 33 (2001): 1441-2. [PMID: 11565091]
115	Lode H, Vogel F, Elies W "Grepafloxacin: A review of its safety profile based on clinical trials and postmarketing surveillance." Clin Ther 21 (1999): 61-74. [PMID: 10090425]
116	Product Information. Raxar (grepafloxacin). Glaxo Wellcome, Research Triangle Park, NC.
117	Thomas M, Maconochie JG, Fletcher E "The dilemma of the prolonged QT interval in early drug studies." Br J Clin Pharmacol 41 (1996): 77-81. [PMID: 8838432]
118	Hatta K, Takahashi T, Nakamura H, Yamashiro H, Asukai N, Matsuzaki I, Yonezawa Y "The association between intravenous haloperidol and prolonged QT interval." J Clin Psychopharmacol 21 (2001): 257-61. [PMID: 11386487]
119	Huyse F, van Schijndel RS "Haloperidol and cardiac arrest." Lancet 2 (1988): 568-9. [PMID: 2900948]
120	Metzger E, Friedman R "Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill." J Clin Psychopharmacol 13 (1993): 128-32. [PMID: 8463445]
121	O'Brien JM, Rockwood RP, Suh KI "Haloperidol-induced torsade de pointes." Ann Pharmacother 33 (1999): 1046-9. [PMID: 10534216]
122	Product Information. Haldol (haloperidol). McNeil Pharmaceutical, Raritan, NJ.
123	Wilt JL, Minnema AM, Johnson RF, Rosenblum AM "Torsade de pointes associated with the use of intravenous haloperidol." Ann Intern Med 119 (1993): 391-4. [PMID: 8338292]
124	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
125	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
126	Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
127	Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
128	Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
129	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
130	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
131	Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
132	De Bels D, Staroukine M, Devriendt J "Torsades de pointes due to methadone." Ann Intern Med 139 (2003): E156. [PMID: 12859181]
133	Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
134	Gil M, Sala M, Anguera I, et al. "QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone." Am J Cardiol 92 (2003): 995-7. [PMID: 14556883]
135	Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS "Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes." Pharmacotherapy 23 (2003): 802-5. [PMID: 12820821]
136	Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
137	Krantz MJ, Mehler PS "Synthetic opioids and QT prolongation." Arch Intern Med 163 (2003): 1615 author reply 1615. [PMID: 12860589]
138	Martell BA, Arnsten JH, Krantz MJ, Gourevitch MN "Impact of methadone treatment on cardiac repolarization and conduction in opioid users." Am J Cardiol 95 (2005): 915-8. [PMID: 15781034]
139	Mokwe EO, Ositadinma O "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966000]
140	Sala M, Anguera I, Cervantes M "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966001]
141	Walker PW, Klein D, Kasza L "High dose methadone and ventricular arrhythmias: a report of three cases." Pain 103 (2003): 321-4. [PMID: 12791438]
142	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
143	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
144	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
145	Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
146	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
147	Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
148	Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
149	Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
150	Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
151	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
152	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
153	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
154	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
155	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
156	Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
157	Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
158	Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
159	Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
160	Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
161	Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
162	Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
163	Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
164	Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
165	Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
166	Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
167	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
168	Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
169	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
170	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
171	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
172	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
173	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
174	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
175	Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
176	Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
177	Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
178	Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
179	Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
180	Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
181	Anson BD, Weaver JG, Ackerman MJ, et al. "Blockade of HERG channels by HIV protease inhibitors." Lancet 365 (2005): 682-686. [PMID: 15721475]
182	Biondi L "Health Canada endorsed important safety information on Invirase (saquinavir mesylate)." .
183	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
184	FDA. U.S. Food and Drug Administration "FDA drug safety communication: Ongoing safety review of Invirase (saquinavir) and possible association with abnormal heart rhythms.".
185	Demolis JL, Charransol A, Funck-Brentano C, Jaillon P "Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers." Br J Clin Pharmacol 41 (1996): 499-503. [PMID: 8799513]
186	Dupont H, Timsit JF, Souweine B, Gachot B, Wolff M, Regnier B "Torsades de pointe probably related to sparfloxacin." Eur J Clin Microbiol Infect Dis 15 (1996): 350-1. [PMID: 8781892]
187	Jaillon P, Morganroth J, Brumpt I, Talbot G "Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. Sparfloxacin Safety Group." J Antimicrob Chemother 37(suppl a) (1996): 161-7. [PMID: 8737135]
188	Lipsky BA, Dorr MB, Magner DJ, Talbot GH "Safety profile of sparfloxacin, a new fluoroquinolone antibiotic." Clin Ther 21 (1999): 148-59. [PMID: 10090432]
189	Product Information. Zagam (sparfloxacin). Rhone-Poulenc Rorer, Collegeville, PA.
190	Zix JA, GeerdesFenge HF, Rau M, Vockler J, Borner K, Koeppe P, Lode H "Pharmacokinetics of sparfloxacin and interaction with cisapride and sucralfate." Antimicrob Agents Chemother 41 (1997): 1668-72. [PMID: 9257738]
191	Bennett CL, Nebeker JR, Samore MH, et al "The Research on Adverse Drug Events and Reports (RADAR) project." JAMA 293 (2005): 2131-40. [PMID: 15870417]
192	Bennett CL, Schumock GT, Desai AA, et al "Thalidomide-associated deep vein thrombosis and pulmonary embolism." Am J Med 113 (2002): 603-6. [PMID: 12459408]
193	Cavo M, Zamagni E, Cellini C, et al. "Deep-vein thrombosis in patients with multiple myeloma receiving first-line thalidomide-dexamethasone therapy." Blood 100 (2002): 2272-3. [PMID: 12229885]
194	Escudier B, Lassau N, Leborgne S, Angevin E, Laplanche A "Thalidomide and venous thrombosis." Ann Intern Med 136 (2002): 711. [PMID: 11992318]
195	Figg WD, Arlen P, Gulley J, et al. "A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer." Semin Oncol 28(4 Suppl 15) (2001): 62-6. [PMID: 11685731]
196	Fine HA, Wen PY, Maher EA, et al. "Phase II Trial of Thalidomide and Carmustine for Patients With Recurrent High-Grade Gliomas." J Clin Oncol 21 (2003): 2299-304. [PMID: 12805330]
197	Lee CK, Barlogie B, Munshi N, et al "DTPACE: an effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma." J Clin Oncol 21 (2003): 2732-9. [PMID: 12860952]
198	Osman K, Comenzo R, Rajkumar SV "Deep venous thrombosis and thalidomide therapy for multiple myeloma." N Engl J Med 344 (2001): 1951-2. [PMID: 11419443]
199	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
200	Rajkumar SV, Hayman S, Gertz MA, et al. "Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma." J Clin Oncol 20 (2002): 4319-23. [PMID: 12409330]
201	Urbauer E, Kaufmann H, Nosslinger T, Raderer M, Drach J "Thromboembolic events during treatment with thalidomide." Blood 99 (2002): 4247-8. [PMID: 12043695]
202	Weber D, Rankin K, Gavino M, Delasalle K, Alexanian R "Thalidomide alone or with dexamethasone for previously untreated multiple myeloma." J Clin Oncol 21 (2003): 16-9. [PMID: 12506164]
203	Zangari M, Anaissie E, Barlogie B, et al "Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy." Blood 98 (2001): 1614-5. [PMID: 11520815]
204	Zangari M, Barlogie B, Anaissie E, et al "Deep vein thrombosis in patients with mutiple myeloma treated with thalidomide and chemotherapy: effects of prophylactic and therapeutic anticoagulation." Br J Haematol 126 (2004): 715-21. [PMID: 15327525]
205	Zangari M, Siegel E, Barlogie B, et al "Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy." Blood 100 (2002): 1168-71. [PMID: 12149193]
206	Desai AA, Vogelzang NJ, Rini BI, Ansari R, Krauss S, Stadler WM "A high rate of venous thromboembolism in a multi-institutional Phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil and daily thalidomide in patients with metastatic renal cell carcinoma." Cancer 95 (2002): 1629-36. [PMID: 12365009]
207	Fletcher GF, Kazamias TM "Cardiotoxic effects of Mellaril: conduction disturbances and supraventricular arrhythmias." Am Heart J 78 (1969): 135-8. [PMID: 5794785]
208	Hartigan-Go K, Bateman DN, Nyberg G, Martensson E, Thomas SHL "Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans." Clin Pharmacol Ther 60 (1996): 543-53. [PMID: 8941027]
209	Liberatore MA, Robinson DS "Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy?" J Clin Psychopharmacol 4 (1984): 143-6. [PMID: 6145728]
210	Product Information. Mellaril (thioridazine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
211	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
212	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
213	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
214	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
215	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
216	Goodnick PJ, Jerry J, Parra F "Psychotropic drugs and the ECG: focus on the QTc interval." Expert Opin Pharmacother 3 (2002): 479-98. [PMID: 11996627]
217	Kane JM, Carson WH, Saha AR, et al. "Efficacy and safety of aripiprazole and haloperidol versus placebo in patients with schizophrenia and schizoaffective disorder." J Clin Psychiatry 63 (2002): 763-71. [PMID: 12363115]
218	Keck PE Jr, Marcus R, Tourkodimitris S, et al. "A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole in patients with acute bipolar mania." Am J Psychiatry 160 (2003): 1651-8. [PMID: 12944341]
219	Nelson S, Leung JG "Torsades de Pointes After Administration of Low-Dose Aripiprazole (February)." Ann Pharmacother (2013):. [PMID: 23362038]
220	Pigott TA, Carson WH, Saha AR, Torbeyns AF, Stock EG, Ingenito GG "Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia: a placebo-controlled 26-week study." J Clin Psychiatry 64 (2003): 1048-56. [PMID: 14628980]
221	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
222	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
223	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
224	Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
225	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
226	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
227	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
228	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
229	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
230	Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
231	Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
232	Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
233	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
234	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
235	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
236	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
237	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
238	Alderman CP, Moritz CK, Ben-Tovim DI "Abnormal platelet aggregation associated with fluoxetine therapy." Ann Pharmacother 26 (1992): 1517-9. [PMID: 1482806]
239	Alderman CP, Seshadri P, Ben-Tovim DI "Effects of serotonin reuptake inhibitors on hemostasis." Ann Pharmacother 30 (1996): 1232-4. [PMID: 8913401]
240	Aranth J, Lindberg C "Bleeding, a side effect of fluoxetine." Am J Psychiatry 149 (1992): 412. [PMID: 1536285]
241	Bannister SJ, Houser VP, Hulse JD, Kisicki JC, Rasmussen JG "Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin." Acta Psychiatr Scand Suppl 350 (1989): 102-6. [PMID: 2530759]
242	Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions. II." J Clin Psychopharmacol 10 (1990): 213-7. [PMID: 2198298]
243	Claire RJ, Servis ME, Cram DL Jr "Potential interaction between warfarin sodium and fluoxetine." Am J Psychiatry 148 (1991): 1604. [PMID: 1928485]
244	Dalton SO, Johansen C, Mellemkjaer L, Norgard B, Sorensen HT, Olsen JH "Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study." Arch Intern Med 163 (2003): 59-64. [PMID: 12523917]
245	de Abajo FJ, Jick H, Derby L, Jick S, Schmitz S "Intracranial haemorrhage and use of selective serotonin reuptake inhibitors." Br J Clin Pharmacol 50 (2000): 43-7. [PMID: 10886117]
246	de Abajo FJ, Rodriguez LA, Montero D "Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study." BMJ 319 (1999): 1106-9. [PMID: 10531103]
247	de Maistre E, Allart C, Lecompte T, Bollaert PE "Severe bleeding associated with use of low molecular weight heparin and selective serotonin reuptake inhibitors." Am J Med 113 (2002): 530-2. [PMID: 12427509]
248	Dent LA, Orrock MW "Warfarin-fluoxetine and diazepam-fluoxetine interaction." Pharmacotherapy 17 (1997): 170-2. [PMID: 9017779]
249	Ford MA, Anderson ML, Rindone JP, Jaskar DW "Lack of effect of fluoxetine on the hypoprothrombinemic response of warfarin." J Clin Psychopharmacol 17 (1997): 110-2. [PMID: 10950474]
250	Hergovich N, Aigner M, Eichler HG, Entlicher J, Drucker C, Jilma B "Paroxetine decreases platelet serotonin storage and platelet function in human beings." Clin Pharmacol Ther 68 (2000): 435-42. [PMID: 11061584]
251	Humphries JE, Wheby MS, VandenBerg SR "Fluoxetine and the bleeding time." Arch Pathol Lab Med 114 (1990): 727-8. [PMID: 2363631]
252	Krivy J, Wiener J "Sertraline and platelet counts in idiopathic thrombocytopenia purpura." Lancet 345 (1995): 132. [PMID: 7815874]
253	Leung M, Shore R "Fluvoxamine-associated bleeding." Can J Psychiatry 41 (1996): 604-5. [PMID: 8946088]
254	Messiha FS "Fluoxetine - adverse effects and drug-drug interactions." J Toxicol Clin Toxicol 31 (1993): 603-30. [PMID: 8254702]
255	Ottervanger JP, Stricker BH, Huls J, Weeda JN "Bleeding attributed to the intake of paroxetine." Am J Psychiatry 151 (1994): 781-2. [PMID: 8166328]
256	Pai VB, Kelly MW "Bruising associated with the use of fluoxetine." Ann Pharmacother 30 (1996): 786-8. [PMID: 8826562]
257	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
258	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
259	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
260	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
261	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
262	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
263	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
264	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
265	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
266	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
267	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
268	Settle EC "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry 59 Suppl 16 (1998): 25-30. [PMID: 9796863]
269	Skop BP, Brown TM "Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors." Psychosomatics 37 (1996): 12-6. [PMID: 8600488]
270	Woolfrey S, Gammack NS, Dewar MS, Brown PJ "Fluoxetine-warfarin interaction." BMJ 307 (1993): 241. [PMID: 8369688]
271	Yaryura-Tobias JA, Kirschen H, Ninan P, Mosberg HJ "Fluoxetine and bleeding in obsessive-compulsive disorder." Am J Psychiatry 148 (1991): 949. [PMID: 2053641]
272	Layton D, Clark DWJ, Pearce GL, Shakir SAW "Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England." Eur J Clin Pharmacol 57 (2001): 167-76. [PMID: 11417450]
273	Tata LJ, Fortun PJ, Hubbard RB, et al. "Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding?" Aliment Pharmacol Ther 22 (2005): 175-81. [PMID: 16091054]
274	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
275	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
276	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
277	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
278	Product Information. Evenity (romosozumab). Amgen USA, Thousand Oaks, CA.
279	Skillman TG, Feldman JM "The pharmacology of sulfonylureas." Am J Med 70 (1981): 361-72. [PMID: 6781341]
280	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
281	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
282	Product Information. Kybella (deoxycholic acid). Kythera Biopharmaceuticals, Inc., Westlake Village, CA.
283	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
284	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
285	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
286	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
287	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
288	Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ.
289	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
290	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
291	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
292	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
293	Hanci V, Aydin M, Yurtlu BS, et.al "Anesthesia induction with sevoflurane and propofol: evaluation of P-wave dispersion, QT and corrected QT intervals." Kaohsiung J Med Sci 26 (2010): 470-7. [PMID: 20837343]
294	Kim DH, Kweon TD, Nam SB, Han DW, Cho WY, Lee JS "Effects of target concentration infusion of propofol and tracheal intubation on QTc interval." Anaesthesia 63 (2008): 1061-4. [PMID: 18717665]
295	Kleinsasser A, Kuenszberg E, Loeckinger A, et.al "Sevoflurane, but not propofol, significantly prolongs the Q-T interval." Anesth Analg 90 (2000): 25-7. [PMID: 10624970]
296	Kleinsasser A, Loeckinger A, Lindner KH, Keller C, Boehler M, Puehringer F "Reversing sevoflurane-associated Q-Tc prolongation by changing to propofol." Anaesthesia 56 (2001): 248-50. [PMID: 11251432]
297	Paventi S, Santevecchi A, Ranieri R "Effects of sevoflurane versus propofol on QT interval." Minerva Anestesiol 67 (2001): 637-40. [PMID: 11731753]
298	Scalese MJ, Herring HR, Rathburn RC, Skrepnek GH, Ripley TL "Propofol-associated QTc prolongation." Ther Adv Drug Saf 7 (2016): 68-78. [PMID: 27298717]
299	Staikou C, Stamelos M, Stavroulakis E "Impact of anaesthetic drugs and adjuvants on ECG markers of torsadogenicity." Br J Anaesth 112 (2014): 217-30. [PMID: 24305646]
300	Toyoda T, Terao Y, Oji M, Okada M, Fukusaki M, Sumikawa K "The interaction of antiemetic dose of droperidol with propofol on QT interval during anesthetic induction." J Anesth 27 (2013): 885-9. [PMID: 23660990]
301	Whyte SD, Booker PD, Buckley DG "The Effects of Propofol and Sevoflurane on the QT Interval and Transmural Dispersion of Repolarization in Children." Anesth Analg 100 (2005): 71-77. [PMID: 15616054]
302	Wutzler A, De Asmundis C, Matsuda H, et.al "Effects of propofol on ventricular repolarization and incidence of malignant arrhythmias in adults." J Electrocardiol 51 (2018): 170-4. [PMID: 29174097]
303	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
304	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
305	Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
306	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
307	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
308	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
309	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
310	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
311	Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
312	Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence