Details of Drug

Drug General Information (ID: D0209)
Drug Name	Brodalumab
Drug Type	Monoclonal antibody
Drug Synonymous	AMG 827 Click to Show/Hide
Disease Class	EA90: Psoriasis; CA23: Asthma
Therapeutic Class	Interleukin Inhibitors
External Link
External Link	TTD ID	D05CEO

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM043 Additive immunosuppressive effects BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Brodalumab
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[10], [11], [12]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[11], [13]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [14]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[18]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[11], [19]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[20]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[21], [22]
D1111		Natalizumab	NA	NA	Major		Inter Info	[23]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[21], [22]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[24]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[15], [25], [26]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[27]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[28], [29], [30]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[36]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[36]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[37]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[28], [29], [30]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[48]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[36]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[49]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[51]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[28], [29], [30]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[11], [52]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[53]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[15], [10], [16]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[17]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[7], [8], [9]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[7], [8], [9]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[7], [8], [9]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[15], [31], [32]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[15], [31], [32]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[15], [31], [32]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[15], [31], [32]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[38], [15], [10], [39], [40], [41], [31], [42], [43], [44], [32]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[15], [31], [32]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[15], [31], [32]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[15], [31], [32]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[15], [31], [32]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[15], [31], [32]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[15], [31], [32]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[50]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[15], [31], [32]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[33], [34], [35]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[33], [34], [35]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[45], [46], [47]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[45], [46], [47]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[45], [46], [47]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[45], [46], [47]
	Antagonize the effects of immunosuppressants					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Minor		Inter Info	[54], [55], [56]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[54], [55], [56]
D1723		Zinc chloride	Cl2Zn	5727	Minor		Inter Info	[54], [55], [56]
D1703		Vitamin E	C29H50O2	14985	Minor		Inter Info	[54], [55], [56]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[54], [55], [56]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[54], [55], [56]

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24	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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31	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
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46	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
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