Details of Drug

Drug General Information (ID: D0196)
Drug Name	Botulinum toxin type A
Drug Type	Protein/peptide
Drug Synonymous	Botox; Botulinum A Toxin; Botulinum Neurotoxin A; Botulinum Neurotoxin Type A; Botulinum Toxin A; Botulinum Toxin Type A; botulinum toxin-A; Botulinum Toxins, Type A; Clostridium botulinum A Toxin; Clostridium Botulinum Toxin Type A; Meditoxin; Neuronox; Neurotoxin A, Botulinum; Oculinum; Onabotulinumtoxin A; OnabotulinumtoxinA; Toxin A, Botulinum; Toxin, Botulinum AVistabelVistabex Click to Show/Hide
Therapeutic Class	Muscle Relaxants
External Link
External Link	TTD ID	D0D1RM

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM033 Additive anticholinergic effects BM045 Additive neuromuscular blocking effects
Relation Graph

Full list of drugs interacting with Botulinum toxin type A
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 68
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[4], [1], [5]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[4], [1], [5]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[4], [1], [5]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[4], [1], [5]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[4], [1], [5]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[4], [1], [5]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[4], [1], [5]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[4], [1], [5]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[4], [1], [5]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[4], [1], [5]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[4], [1], [5]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[4], [1], [5]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[4], [1], [5]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[4], [1], [5]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[4], [1], [5]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[4], [1], [5]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[4], [1], [5]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[4], [1], [5]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[4], [1], [5]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[4], [1], [5]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[4], [1], [5]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[4], [1], [5]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[4], [1], [5]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[4], [1], [5]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[4], [1], [5]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[4], [1], [5]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[4], [1], [5]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[4], [1], [5]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[4], [1], [5]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[4], [1], [5]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[4], [1], [5]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[4], [1], [5]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[4], [1], [5]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[4], [1], [5]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[4], [1], [5]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[4], [1], [5]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[4], [1], [5]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[4], [1], [5]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[4], [1], [5]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[4], [1], [5]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[4], [1], [5]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[4], [1], [5]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[4], [1], [5]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[4], [1], [5]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[4], [1], [5]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[4], [1], [5]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[4], [1], [5]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[4], [1], [5]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[4], [1], [5]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[4], [1], [5]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[4], [1], [5]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[4], [1], [5]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[4], [1], [5]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[4], [1], [5]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[4], [1], [5]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[4], [1], [5]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[4], [1], [5]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[4], [1], [5]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[4], [1], [5]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[4], [1], [5]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[4], [1], [5]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[4], [1], [5]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[4], [1], [5]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[4], [1], [5]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[4], [1], [5]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[4], [1], [5]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[4], [1], [5]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[4], [1], [5]
	Additive neuromuscular blocking effects					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3]
D0122		Atracurium	C53H72N2O12+2	47319	Major		Inter Info	[1], [2], [3]
D0343		Cisatracurium	C53H72N2O12+2	62887	Major		Inter Info	[1], [2], [3]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Major		Inter Info	[1], [2], [3]
D0522		Doxacurium	C56H78N2O16+2	60169	Major		Inter Info	[1], [2], [3]
D0718		Gentamicin	C21H43N5O7	3467	Major		Inter Info	[1], [2], [3]
D0876		Kanamycin	C18H36N4O11	6032	Major		Inter Info	[1], [2], [3]
D1047		Metocurine	C40H48N2O6+2	21233	Major		Inter Info	[1], [2], [3]
D1080		Mivacurium	C58H80N2O14+2	5281042	Major		Inter Info	[1], [2], [3]
D1120		Neomycin	C23H46N6O13	8378	Major		Inter Info	[1], [2], [3]
D1126		Netilmicin	C21H41N5O7	441306	Major		Inter Info	[1], [2], [3]
D1219		Pancuronium	C35H60N2O4+2	441289	Major		Inter Info	[1], [2], [3]
D1295		Pipecuronium	C35H62N4O4+2	50192	Major		Inter Info	[1], [2], [3]
D1304		Plazomicin	C25H48N6O10	42613186	Major		Inter Info	[1], [2], [3]
D1310		Polymyxin B	C56H98N16O13	49800004	Major		Inter Info	[1], [2], [3]
D1384		Rapacuronium	C37H61N2O4+	5311399	Major		Inter Info	[1], [2], [3]
D1420		Rocuronium	C32H53N2O4+	441290	Major		Inter Info	[1], [2], [3]
D1500		Spectinomycin	C14H24N2O7	15541	Major		Inter Info	[1], [2], [3]
D1507		Streptomycin	C21H39N7O12	19649	Major		Inter Info	[1], [2], [3]
D1510		Succinylcholine	C14H30N2O4+2	5314	Major		Inter Info	[1], [2], [3]
D1597		Tobramycin	C18H37N5O9	36294	Major		Inter Info	[1], [2], [3]
D1659		Tubocurarine	C37H41N2O6+	6000	Major		Inter Info	[1], [2], [3]
D1684		Vecuronium	C34H57N2O4+	39765	Major		Inter Info	[1], [2], [3]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[1], [5], [2]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[1], [5], [2]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[1], [5], [2]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[1], [5], [2]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[1], [5], [2]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[1], [5], [2]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[1], [5], [2]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[1], [5], [2]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[1], [5], [2]

References
1	Product Information. Myobloc (botulinum toxin type B) Elan Pharmaceuticals, S. San Francisco, CA.
2	Product Information. Dysport (abobotulinumtoxinA). Tercica Inc, Brisbane, CA.
3	Product Information. Jeuveau (prabotulinumtoxinA). Evolus, Inc., Santa Barbara, CA.
4	Product Information. Botox (onabotulinumtoxin A). Allergan Inc, Irvine, CA.
5	Product Information. Xeomin (botulinum toxin type A (obsolete) (botulinum toxin type A)). Merz Pharmaceuticals, Greensboro, NC.

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