Details of Drug

Drug General Information (ID: D0192)
Drug Name	Boceprevir
Drug Type	Small molecule
Drug Synonymous	Boceprevir; Victrelis; 394730-60-0; SCH 503034; EBP 520; UNII-89BT58KELH; SCH-503034; 89BT58KELH; CHEBI:68621; (1R,2S,5S)-N-(4-amino-1-cyclobutyl-3,4-dioxobutan-2-yl)-3-[N-(tert-butylcarbamoyl)-3-methyl-L-valyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; 3-{[(1R,2S,5S)-3-[(2S)-2-[(tert-butylcarbamoyl)amino]-3,3-dimethylbutanoyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-yl]formamido}-4-cyclobutyl-2-oxobutanamide Click to Show/Hide
Disease Class	1E50-1E51: Hepatitis virus infection
Therapeutic Class	Protease Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C27H45N5O5
InChI	1S/C27H45N5O5/c1-25(2,3)20(30-24(37)31-26(4,5)6)23(36)32-13-15-17(27(15,7)8)18(32)22(35)29-16(19(33)21(28)34)12-14-10-9-11-14/h14-18,20H,9-13H2,1-8H3,(H2,28,34)(H,29,35)(H2,30,31,37)/t15-,16?,17-,18-,20+/m0/s1
InChIKey	LHHCSNFAOIFYRV-DOVBMPENSA-N
Canonical SMILES	CC1(C2C1C(N(C2)C(=O)C(C(C)(C)C)NC(=O)NC(C)(C)C)C(=O)NC(CC3CCC3)C(=O)C(=O)N)C
External Link
	Pubchem ID	10324367
	CAS Number	394730-60-0
	CHEBI ID	68621
	TTD ID	D0V3YT
	INTEDE ID	DR0218
	VARIDT ID	DR01333

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM085 Antagonize the effect of antithrombotic agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Boceprevir
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[482]
Affected cellular transport
	Transporter inhibition					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[17], [41], [42], [43]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[420]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[15], [17], [422]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[429]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[434], [435], [436]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[440]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Moderate		Inter Info	[444]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[457], [458], [459], [460]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[457], [459], [460]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[457], [458], [459], [460]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[15], [17], [533]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 297
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[15], [16]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[16]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[15], [17], [18], [19]
D0108		Artemether	C16H26O5	68911	Major		Inter Info	[15], [17], [20]
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[16]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[15], [19], [22]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[15], [17], [23], [19]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[24]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[25]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[26], [27], [28]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[29]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[30]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[15], [17], [31], [19]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[32]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[15], [19], [33]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[34]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[17], [35], [36]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[39], [40], [36]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[44], [40], [36]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[15], [17], [45], [19]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[46]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[17], [47], [48], [49]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[17], [50]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[51]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[17], [52]
D0683		Fluticasone	C22H27F3O4S	5311101	Major		Inter Info	[53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Major		Inter Info	[79], [80], [92]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[93]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[94]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[95]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[15], [96], [19]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[97], [40], [36]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[15], [17], [98], [19]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[99], [36]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[15], [17], [100]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[40], [101], [36]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[15], [102]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[103]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[104]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[105]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[106]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[15], [17], [107], [19]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[108], [15], [109]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[15], [17], [110], [19]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[111], [112]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[113], [40], [36]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[114]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[115]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[116]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[117], [36]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[118]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[15], [17], [119]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[120], [36]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[17], [121]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[15], [122]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[123]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[124], [36]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[125]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[15], [126]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[127]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[15], [128]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[129]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[15], [17], [130]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[131]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[132]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[134]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[15], [19], [135]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[136], [111], [137]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[138]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[15], [17], [139], [19]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[140], [15], [17], [57], [141], [142], [143], [144], [66], [145], [70], [146], [38], [16], [147], [148]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[149]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[150]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[17], [151], [152], [153]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[15], [154], [19]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[155], [156], [157], [15], [17], [158], [159], [160], [161], [162], [163], [164], [165], [38], [19], [16], [166], [167], [168], [169], [170], [171], [172]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[15], [173], [19], [174]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[15], [19], [175]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[15], [38], [16]
D0424		Darifenacin	C28H30N2O2	444031	Major		Inter Info	[15], [176], [177], [19]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[178]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[179], [180], [181], [182], [17], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [38], [194], [195], [79], [196], [197], [16], [198], [199], [200], [201], [202], [203]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[16]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[204], [15], [17], [205], [206], [19], [207], [208], [209], [210]
D0524		Doxazosin	C23H25N5O5	3157	Major		Inter Info	[15], [16]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[15], [211], [19]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[15], [17], [212], [213], [214], [16], [215]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[216]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[15], [217], [19]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[179], [180], [181], [182], [17], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [38], [194], [195], [79], [196], [197], [16], [198], [199], [200], [201], [202], [203]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[218], [219]
D0612		Eszopiclone	C17H17ClN6O3	969472	Major		Inter Info	[220], [221], [222], [223], [224]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[15], [226], [227], [19]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[15], [228], [229], [230], [19], [231], [13]
D0655		Fesoterodine	C26H37NO3	6918558	Major		Inter Info	[15], [19], [232], [233]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[234]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[17], [235]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[26], [27]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[236]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[182], [15], [17], [237], [238], [239], [240]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[17], [237], [238]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[241]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[15], [17], [242], [243], [244], [245]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[246]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[15], [247], [19]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[248]
D0947		Loperamide	C29H33ClN2O2	3955	Major		Inter Info	[249], [250], [251], [252], [253], [254]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[255], [256], [257], [258], [259], [222], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [16], [285], [286], [287], [288], [289], [290], [291], [292], [293]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[294]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[15], [17], [295], [19]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[296]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[179], [183], [185]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[297], [298], [299], [300], [301], [302], [303], [304]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[179], [183], [185]
D1060		Midazolam	C18H13ClFN3	4192	Major		Inter Info	[38], [16]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[305], [306]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[307], [308]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[309]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[310]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[15], [17], [311]
D1212		Paclitaxel	C47H51NO14	36314	Major		Inter Info	[312], [313], [21], [314], [207], [315], [316]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Major		Inter Info	[312], [314], [207]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[317], [318]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[15], [19], [319]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[320]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[321], [322], [323], [324], [325], [326], [327], [328], [329]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[16]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[15], [17], [330], [19]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[38], [16]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[15], [17], [21], [19], [331]
D1440		Salmeterol	C25H37NO4	5152	Major		Inter Info	[15], [17], [332], [19]
D1465		Sildenafil	C22H30N6O4S	135398744	Major		Inter Info	[333], [334], [335], [336], [337], [338], [189], [191], [193], [38], [194], [79], [196], [339], [197], [340], [16], [198], [341]
D1466		Silodosin	C25H32F3N3O4	5312125	Major		Inter Info	[15], [16]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[15], [342], [19]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[255], [256], [257], [258], [259], [222], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [16], [285], [286], [287], [288], [289], [290], [291], [292], [293]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[15], [343], [344], [345], [346], [347], [19], [40], [16]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[15], [17], [19], [232], [348]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[15], [38], [16]
D1527		Tadalafil	C22H19N3O4	110635	Major		Inter Info	[349], [38], [16]
D1534		Tamsulosin	C20H28N2O5S	129211	Major		Inter Info	[15], [16]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[15], [17], [351], [19]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[15], [173], [19], [174]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[352]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[15], [17], [353]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[297], [354], [355], [298], [356], [357], [358], [359], [360], [361], [362], [363]
D1632		Triazolam	C17H12Cl2N4	5556	Major		Inter Info	[38], [16]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[364], [16]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[365]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[366], [367], [368], [369], [370], [371], [182], [372], [15], [17], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [19], [393], [394], [395], [396], [397], [398], [399], [400], [401], [402]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[366], [367], [368], [369], [370], [371], [182], [372], [15], [17], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [19], [393], [394], [395], [396], [397], [398], [399], [400], [401], [402]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[369], [391], [393]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[366], [367], [368], [369], [370], [371], [182], [372], [15], [17], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [19], [393], [394], [395], [396], [397], [398], [399], [400], [401], [402]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[16]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[403]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[38], [16], [404]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[38], [16]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[297], [54], [140], [405], [406], [143], [298], [407], [408], [299], [62], [63], [409], [300], [301], [302], [410], [145], [411], [147], [148], [84], [412], [303], [304], [413], [414], [415], [91]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[416]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[182], [17], [417], [418]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[17], [40], [36]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[419]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[15], [17], [421]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[15], [19], [423]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[424]
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[426]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[427]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[428]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[38], [16]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[17], [430]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[431]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[15], [17], [432]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[15], [19], [433]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[437]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[15], [17], [438]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[429]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[17], [298], [439]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[441]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[443]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[76], [36], [89]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[445], [446], [447]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[38], [448], [16]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[17], [48], [38]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[16]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[140], [15], [17]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[16]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[16]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[15], [449], [19]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[450]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[15]
D0333		Ciclesonide	C32H44O7	6918155	Moderate		Inter Info	[297], [298], [451], [452]
D0334		Ciclesonide (nasal)	C32H44O7	6918155	Moderate		Inter Info	[453], [454], [451]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[455]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[38], [16]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[456]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[16]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[16]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[38], [16]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[16]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[16]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[38], [16]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Moderate		Inter Info	[143], [407], [84]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[16]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[16]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[38], [16]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[461]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[297], [462], [15], [17], [463], [464], [465]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[466]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[467], [468]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[16]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[16]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[16]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[16]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[16]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[16]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[16]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[469]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[38], [16]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[297], [54], [140], [405], [406], [143], [298], [407], [408], [299], [62], [63], [409], [300], [301], [302], [410], [145], [411], [147], [148], [84], [412], [303], [304], [413], [414], [415], [91]
D0672		Flunisolide	C24H31FO6	82153	Moderate		Inter Info	[143], [407], [84]
D0673		Flunisolide (nasal)	C24H31FO6	82153	Moderate		Inter Info	[143], [407], [84]
D0674		Fluorometholone (ophthalmic)	C22H29FO4	9878	Moderate		Inter Info	[143], [407], [84]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[470], [471]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[472]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[467], [473]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[16]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[297], [54], [140], [405], [406], [143], [298], [407], [408], [299], [62], [63], [409], [300], [301], [302], [410], [145], [411], [147], [148], [84], [412], [303], [304], [413], [414], [415], [91]
D0774		Hydrocortisone (ophthalmic)	C21H30O5	5754	Moderate		Inter Info	[143], [407], [84]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[15]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[474]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[38], [16]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[38], [16]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[16]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[475], [40], [36]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[38], [16]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[15], [17], [476]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[16]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[16]
D0955		Loteprednol (ophthalmic)	C21H27ClO5	9865442	Moderate		Inter Info	[143], [407], [84]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[16]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[38], [16]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[477], [478], [479], [480], [481]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[38], [16]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[38], [16]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[38], [16]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[182], [15], [17]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[483]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[16]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[38], [16]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[297], [54], [140], [405], [406], [143], [298], [407], [408], [299], [62], [63], [409], [300], [301], [302], [410], [145], [411], [147], [148], [84], [412], [303], [304], [413], [414], [415], [91]
D1333		Prednisolone (ophthalmic)	C21H28O5	5755	Moderate		Inter Info	[143], [407], [84]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[297], [54], [140], [405], [406], [143], [298], [407], [408], [299], [62], [63], [409], [300], [301], [302], [410], [145], [411], [147], [148], [84], [412], [303], [304], [413], [414], [415], [91]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[16]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[16]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[484], [485]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[15], [17], [486], [487], [488], [489], [490], [491], [492], [493], [494]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[495]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[496], [497], [498], [499], [500], [501], [502]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[16]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[503], [40], [36]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[17], [504]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[505], [506], [231]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[182], [507]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[38], [16]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[16]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[16]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[16]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[16]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[508], [509]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[15], [510], [19]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[38], [16]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[511], [512], [513], [514], [515], [516], [517], [518], [519], [520], [521]
D1629		Triamcinolone (nasal)	C21H27FO6	31307	Moderate		Inter Info	[143], [407], [84]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[143], [407], [84]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[15], [17], [522]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[38], [16]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[38], [16]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[16]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[523], [524]
D0007		Abiraterone	C24H31NO	132971	Minor		Inter Info	[525]
D0053		Ambrisentan	C22H22N2O4	6918493	Minor		Inter Info	[526]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[15], [527], [528]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[17], [529]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[530]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[531]
D0589		Eravacycline	C27H31FN4O8	54726192	Minor		Inter Info	[532]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Minor		Inter Info	[534]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[535]
D1127		Netupitant	C30H32F6N4O	6451149	Minor		Inter Info	[534]
D1253		Perampanel	C23H15N3O	9924495	Minor		Inter Info	[17], [536]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[537], [538]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[539], [479], [540], [541]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[542]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[15], [527], [528]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[543]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[544], [545], [546], [547], [548], [549], [550]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[551], [552], [553], [554]
	CYP450 enzyme induction					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[16]
D0485		Dienogest	C20H25NO2	68861	Major		Inter Info	[37], [38], [16]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[16]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[16]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[37], [38], [16]
D0626		Etonogestrel	C22H28O2	6917715	Major		Inter Info	[225], [38], [16]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[16]
D0922		Levonorgestrel	C21H28O2	13109	Major		Inter Info	[225], [38], [16]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Major		Inter Info	[37], [38], [16]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[16]
D1154		Norethisterone	C20H26O2	6230	Major		Inter Info	[37], [38], [16]
D1156		Norgestimate	C23H31NO3	6540478	Major		Inter Info	[37], [38], [16]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[16]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[16]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[16]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[16]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[16]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[15], [19], [350]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[38], [16]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[38], [16]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[15], [425]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[38], [16]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[38], [16]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[17], [442]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[38], [16]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[38], [16]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[38], [16]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[38], [16]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[38], [16]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[16]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[38], [16]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[38], [16]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[38], [16]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[38], [16]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[38], [16]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[38], [16]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[38], [16]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[38], [16]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[38], [16]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[38], [16]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[133]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[297], [15], [17], [298], [38], [342], [16]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[15], [21], [16]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[15], [21], [16]
D0948		Lopinavir	C37H48N4O5	92727	Major		Inter Info	[15], [21], [16]

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150	Product Information. Vraylar (cariprazine). Actavis Pharma, Inc., Parsippany, NJ.
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192	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
193	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
194	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
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196	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
197	Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
198	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
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213	Product Information. Slynd (drospirenone). Exeltis USA, Inc., Chatham, NJ.
214	Product Information. Symtuza (cobicistat/darunavir/emtricitabine/tenof). Janssen Pharmaceuticals, Titusville, NJ.
215	Product Information. Yasmin (drospirenone-ethinyl estradiol) Berlex Laboratories, Richmond, CA.
216	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
217	Product Information. Inspra (eplerenone). Searle, Chicago, IL.
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224	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
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234	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
235	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
236	Product Information. Fanapt (iloperidone). Vanda Pharmaceuticals Inc, Rockville, MD.
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240	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
241	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
242	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
243	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
244	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
245	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
246	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
247	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
248	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
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308	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
309	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
310	Product Information. Nimotop (nimodipine). Bayer, West Haven, CT.
311	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
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331	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
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340	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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346	Product Information. Noxafil (posaconazole). Schering-Plough Corporation, Kenilworth, NJ.
347	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
348	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
349	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
350	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
351	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
352	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
353	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
354	Albert NE, Kazi S, Santoro J, Dougherty R "Ritonavir and Epidural Triamcinolone as a Cause of Iatrogenic Cushing's Syndrome." Am J Med Sci (2012):. [PMID: 22543594]
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365	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
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392	Product Information. Oncovin (vincristine). Lilly, Eli and Company, Indianapolis, IN.
393	Product Information. Velban (vinblastine). Lilly, Eli and Company, Indianapolis, IN.
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403	Product Information. Axert (almotriptan) Pharmacia and Upjohn, Kalamazoo, MI.
404	Product Information. Xanax (alprazolam). Pharmacia and Upjohn, Kalamazoo, MI.
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416	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
417	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
418	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
419	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
420	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.
421	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
422	Product Information. Mektovi (binimetinib). Array BioPharma Inc., Boulder, CO.
423	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
424	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
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426	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
427	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
428	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
429	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
430	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
431	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
432	Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
433	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
434	Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
435	Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
436	Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.
437	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
438	Product Information. Adempas (riociguat). Bayer Pharmaceutical Inc, West Haven, CT.
439	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
440	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
441	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
442	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
443	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
444	Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir). Gilead Sciences, Foster City, CA.
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446	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
447	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
448	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
449	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
450	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
451	Product Information. Alvesco (ciclesonide). Nycomed USA, Florham Park, NJ.
452	Product Information. Omnaris (ciclesonide nasal). Sepracor Inc, Marlborough, MA.
453	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
454	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
455	Product Information. Sensipar (cinacalcet). Amgen USA, Thousand Oaks, CA.
456	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
457	Multum Information Services, Inc. Expert Review Panel.
458	Product Information. Cerubidine (daunorubicin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
459	Product Information. Daunoxome (daunorubicin liposomal). Nexstar Pharmaceuticals Inc, Boulder, CO.
460	Product Information. Idamycin (idarubicin). Pharmacia and Upjohn, Kalamazoo, MI.
461	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
462	Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
463	Lemma GL, Desta Z, Jones DR, Gorski JC, Hall SD "Droperidol is predominantly metabolized by human CYP3A enzymes." Clin Pharmacol Ther 73 (2003): 16.
464	Product Information. Droperidol (droperidol). Abbott Pharmaceutical, Abbott Park, IL.
465	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
466	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
467	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
468	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
469	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
470	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
471	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
472	Product Information. Reminyl (galantamine) Janssen Pharmaceuticals, Titusville, NJ.
473	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
474	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
475	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
476	Product Information. Vimpat (lacosamide). UCB Pharma Inc, Smyrna, GA.
477	Okubo M, Murayama N, Miura J, Chiba Y, Yamazaki H "Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients." Biochem Pharmacol 93 (2015): 104-9. [PMID: 25475885]
478	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
479	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
480	Sitsen JM, Maris FA, Timmer CJ "Concomitant use of mirtazapine and cimetidine: a drug-drug interaction study in healthy male subjects." Eur J Clin Pharmacol 56 (2000): 389-94. [PMID: 11009047]
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482	MHRA. Medicines and Healthcare Products Regulatory Agency "Orlistat: theoretical interaction with antiretroviral HIV medicines.".
483	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
484	Product Information. Rythmol SR (propafenone). GlaxoSmithKline, Research Triangle Park, NC.
485	Botsch S, Gautier JC, Beaune P, Eichelbaum M, Kroemer HK "Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites." Mol Pharmacol 43 (1993): 120-6. [PMID: 8423765]
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487	Mirghani RA, Hellgren U, Bertilsson L, Gustafsson LL, Ericsson O "Metabolism and elimination of quinine in healthy volunteers." Eur J Clin Pharmacol (2003):. [PMID: 12920491]
488	Mirghani RA, Hellgren U, Westerberg PA, Ericsson O, Bertilsson L, Gustafsson LL "The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo." Clin Pharmacol Ther 66 (1999): 454-60. [PMID: 10579472]
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490	Product Information. Qualaquin (quinine). AR Scientific Inc, Philadelphia, PA.
491	Wanwimolruk S, Paine MF, Pusek SN, Watkins PB "Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?" Br J Clin Pharmacol 54 (2002): 643-51. [PMID: 12492613]
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495	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
496	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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500	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
501	Tornio A, Niemi M, Neuvonen M, et al. "The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo." Clin Pharmacol Ther 84 (2008): 403-11. [PMID: 18388877]
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503	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
504	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
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506	Product Information. Sufenta (sufentanil). Janssen Pharmaceutica, Titusville, NJ.
507	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
508	Brynne N, Forslund C, Hallen B, Gustafsson LL, Bertilsson L "Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity." Br J Clin Pharmacol 48 (1999): 564-72. [PMID: 10583027]
509	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
510	Product Information. Kadcyla (ado-trastuzumab). Genentech, South San Francisco, CA.
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