Details of Drug

Drug General Information (ID: D0171)
Drug Name	Berotralstat
Drug Type	Small molecule
Drug Synonymous	UNII-XZA0KB1BDQ; XZA0KB1BDQ; 1809010-50-1; BCX7353; BCX-7353; Berotralstat (USAN); Berotralstat [USAN]; 1-[3-(aminomethyl)phenyl]-N-(5-{(R)-(3-; cyanophenyl)[(cyclopropylmethyl)amino]methyl}-2-; fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-; Orladeyo; Berotralstat [INN]; Berotralstat [USAN:INN]; SCHEMBL21974728; GTPL11347; WHO 10907; D11673; 1-(3-(Aminomethyl)phenyl)-N-(5-((R)-(3-cyanophenyl)((cyclopropylmethyl)amino)methyl)-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; 1H-pyrazole-5-carboxamide, 1-(3-(aminomethyl)phenyl)-N-(5-((R)-(3-cyanophenyl)((cyclopropylmethyl); 1H-Pyrazole-5-carboxamide, 1-(3-(aminomethyl)phenyl)-N-(5-((R)-(3-cyanophenyl)((cyclopropylmethyl)amino)methyl)-2-fluorophenyl)-3-(trifluoromethyl)-; 2-[3-(aminomethyl)phenyl]-N-[5-[(R)-(3-cyanophenyl)-(cyclopropylmethylamino)methyl]-2-fluorophenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide Click to Show/Hide
Disease Class	4A00: Innate/adaptive immunodeficiency
Therapeutic Class	Hereditary Angioedema Agents
Structure
Structure	3D Structure		2D Structure
Formula	C30H26F4N6O
InChI	1S/C30H26F4N6O/c31-24-10-9-22(28(37-17-18-7-8-18)21-5-1-3-19(11-21)15-35)13-25(24)38-29(41)26-14-27(30(32,33)34)39-40(26)23-6-2-4-20(12-23)16-36/h1-6,9-14,18,28,37H,7-8,16-17,36H2,(H,38,41)/t28-/m1/s1
InChIKey	UXNXMBYCBRBRFD-MUUNZHRXSA-N
Canonical SMILES	C1CC1CNC(C2=CC(=C(C=C2)F)NC(=O)C3=CC(=NN3C4=CC=CC(=C4)CN)C(F)(F)F)C5=CC=CC(=C5)C#N
External Link
	Pubchem ID	137528262
	CAS Number	1809010-50-1
	TTD ID	DQ1S0B

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition
Relation Graph

Full list of drugs interacting with Berotralstat
Affected cellular transport
	Transporter inhibition					Drug Num: 66
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[2]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[2]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[2]
D0267		Carvedilol	C24H26N2O4	2585	Major		Inter Info	[2]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[2]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[2]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[2]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[2]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[2]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[30], [2]
D0425		Darolutamide	C19H19ClN6O2	67171867	Major		Inter Info	[2]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[32], [33], [2]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[2]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[2]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[32], [33], [2]
D0556		Elbasvir	C49H55N9O7	71661251	Major		Inter Info	[32], [33], [2]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[2]
D0561		Eltrombopag	C25H22N4O4	135449332	Major		Inter Info	[2]
D0568		Enasidenib	C19H17F6N7O	89683805	Major		Inter Info	[32], [33], [2]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[2]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[2]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[2]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Major		Inter Info	[4], [36], [5], [37]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Major		Inter Info	[32], [33], [2]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[2]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[2]
D0873		Ixabepilone	C27H42N2O5S	6445540	Major		Inter Info	[30], [2]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[2]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[2]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[2]
D1074		Mirabegron	C21H24N4O2S	9865528	Major		Inter Info	[2]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[2]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[2]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[2]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[2]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[2]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[2]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[2]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[2]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[2]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[2]
D1423		Rolapitant	C25H26F6N2O2	10311306	Major		Inter Info	[2]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[2]
D1437		Safinamide	C17H19FN2O2	131682	Major		Inter Info	[2]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[2]
D1445		Sarecycline	C24H29N3O8	54681908	Major		Inter Info	[2]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[2]
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[2]
D1539		Tedizolid	C17H15FN6O3	11234049	Major		Inter Info	[2]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[32], [33], [2]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[32], [33], [2]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[2]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[32], [33], [2]
D1664		Ulipristal	C28H35NO3	13559281	Major		Inter Info	[2]
D1686		Velpatasvir	C49H54N8O8	67683363	Major		Inter Info	[32], [33], [2]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[2]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[2]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[2]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[62]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[2]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[2]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[2]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[2]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[201]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[247]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[2]
	Transporter induction					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1], [2]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1], [2]
D0280		Cefiderocol	C30H34ClN7O10S2	77843966	Major		Inter Info	[1], [2]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[1], [2]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[1], [2]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [2]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1], [2]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1], [2]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[1], [2]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 215
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[3]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[4], [5], [6], [7]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[8]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[5], [9], [10], [11]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[12]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[5], [31]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[5], [34]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[35]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[38]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[5], [39]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[5], [40], [41]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[4], [42]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[4], [43], [7]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[44]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[4], [5], [45]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[5], [46]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[4], [5], [47]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[4], [5], [48]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[49]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[4], [50]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[51]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[52]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[53]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[54], [55], [56]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[4], [5], [57]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[58], [4], [5], [59], [60]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[2]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[5], [61]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[63]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[4], [5], [64]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[2]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[65], [4], [5], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[65], [4], [5]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[79]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[80]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[81]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[2]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[2]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[2]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[2]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[2]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[2]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[2]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[2]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[2]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[2]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[2]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[82]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[2]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[2]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[2]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[2]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[2]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[108], [4], [5], [109], [110], [111], [112], [113], [114]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[115]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[2]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[2]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[2]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[2]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[2]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[2]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[2]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[116]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[2]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[117]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[2]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[2]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[2]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[2]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[118], [119], [120], [5], [88], [121], [122]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[2]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[2]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[2]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[2]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[2]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[2]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[123]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[2]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[2]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[2]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[2]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[4], [5], [6], [124], [125], [126], [127]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Moderate		Inter Info	[4], [124], [126]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[2]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[128], [129]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[5], [130]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[131]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[2]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[2]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[2]
D0778		Hydroxyamphetamine (ophthalmic)	C9H13NO	3651	Moderate		Inter Info	[2]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[132]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[2]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[2]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[133]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[2]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[58], [4], [5], [134], [135], [136], [137]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[4], [5], [134]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[138]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[2]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[2]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[2]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [88], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[202]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[2]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[203]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[2]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[2]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[2]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[2]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[2]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[204], [205], [206], [207], [208], [209], [210], [211]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[2]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[90], [92], [103]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[2]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[2]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[2]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[212], [213]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[214], [215]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[216], [217], [218], [219], [220]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[2]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[2]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[2]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[2]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[221]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[2]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[2]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[58], [4], [5]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[2]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[2]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[2]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[2]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[2]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[2]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[222], [223]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[2]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[2]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[224]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[2]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[2]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[2]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[225]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[2]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[226]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[2]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[2]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[2]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[2]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[2]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[2]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[227], [228], [229], [230], [231], [232], [233]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[2]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[4], [36], [5], [234]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[2]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[2]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[2]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[5], [235]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[236], [237], [238], [239]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[240]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [88], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[4], [5], [241], [242], [243], [186], [244]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[245]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[2]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[2]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[4], [5], [241], [242], [243], [186], [244]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[246]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[2]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[2]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[248]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[249]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[2]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[2]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[2]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[5], [250]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[2]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[251], [252], [253]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[2]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[4], [5], [254]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[2]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[255]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[5], [256], [257]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[2]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[2]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[2]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[2]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[2]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[258]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[2]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[259], [186]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[2]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[2]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[2]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[2]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[2]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[2]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[2]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[2]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[2]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[260], [261], [262], [263], [264], [265], [266]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[267], [268]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[5], [269]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[270], [218], [271], [272]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[273]
D0638		Fedratinib	C27H36N6O3S	16722836	Minor		Inter Info	[5], [274], [275]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[276]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[4], [277], [278]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[279]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[280]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[281], [282], [283], [284], [285], [286], [287]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[5], [288]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[289], [290], [291]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[292], [293], [294], [295]

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184	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
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238	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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245	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
246	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
247	Product Information. Talzenna (talazoparib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
248	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
249	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
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