Details of Drug

Drug General Information (ID: D0158)
Drug Name	Bendroflumethiazide
Drug Type	Small molecule
Drug Synonymous	Aprinox; BHFT; Bendrofluazide; Bendroflumethazide; Bendroflumethiazidum; Bendroflumetiazida; Bendroflumetiazide; Bendrofumethiazide; Bentride; Benuron; Benzhydroflumethiazide; Benzydroflumethiazide; Benzylhydroflumethiazide; Benzylrodiuran; Berkozide; Bristuric; Bristuron; Centyl; Corzide; Flumersil; Flumesil; Intolex; Livesan; Naigaril; Nateretin; Naturetin; Naturine; Niagaril; Nikion; Orsile; Pluryl; Pluryle; Plusuril; Poliuron; Rauzide; Repicin; Salural; Salures; Sinesalin; Sodiuretic; Thiazidico; Urlea; Bendroflumethiazide [USP]; Bendroflumetiazide [DCIT]; Rautrax N; Relan beta; BL H368; FT 8; FT 81; Be 724-A; Bendroflumethiazidum [INN-Latin]; Bendroflumetiazida [INN-Spanish]; Benzy-rodiuran; NATURETIN-10; NATURETIN-5; Naturetin (TN); Neo-naclex; Neo-rontyl; Naturetin-2.5; Bendroflumethiazide (JAN/USP/INN); (+-)-3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-,1,1-dioxide; 3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide; 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide; 6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide Click to Show/Hide
Disease Class	BA00: Essential hypertension
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C15H14F3N3O4S2
InChI	1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)
InChIKey	HDWIHXWEUNVBIY-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)CC2NC3=C(C=C(C(=C3)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N2
External Link
	Pubchem ID	2315
	CAS Number	73-48-3
	CHEBI ID	3013
	TTD ID	D02PAH
	VARIDT ID	DR01028

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM003 Complex formation BM029 Altered urine pH BM032 Decreased renal excretion (Unspecific) BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM048 Increased risk of angioedema/anaphylactoid reactions BM053 Increased risk of fluid/electrolyte loss BM057 Increased risk of hyperglycemia BM059 Increased risk of hypermagnesemia BM062 Increased risk of hypertriglyceridemia BM065 Increased risk of hypokalemia BM066 Increased risk of hypomagnesemia BM067 Increased risk of hyponatremia BM070 Increased risk of metabolic acidosis BM072 Increased risk of nephrotoxicity BM075 Increased risk of photosensitivity reactions BM081 Increased risk of ventricular arrhythmias BM085 Antagonize the effect of antithrombotic agents BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM108 Increased risk of hypercalcemia BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Bendroflumethiazide
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0123		Atropine	C17H23NO3	174174	Minor		Inter Info	[267], [268]
D0154		Belladonna	C34H42N2O4	265028	Minor		Inter Info	[267], [268]
D0183		Biperiden	C21H29NO	2381	Minor		Inter Info	[267], [268]
D0353		Clidinium	C22H26NO3+	2784	Minor		Inter Info	[267], [268]
D0424		Darifenacin	C28H30N2O2	444031	Minor		Inter Info	[267], [268]
D0482		Dicyclomine	C19H35NO2	3042	Minor		Inter Info	[267], [268]
D0662		Flavoxate	C24H25NO4	3354	Minor		Inter Info	[267], [268]
D0733		Glycopyrronium	C19H28NO3+	3494	Minor		Inter Info	[267], [268]
D1000		Mepenzolate	C21H26NO3+	4057	Minor		Inter Info	[267], [268]
D1031		Methscopolamine	C18H24NO4+	71183	Minor		Inter Info	[267], [268]
D1202		Oxybutynin	C22H31NO3	4634	Minor		Inter Info	[267], [268]
D1354		Propantheline	C23H30NO3+	4934	Minor		Inter Info	[267], [268]
D1450		Scopolamine	C17H21NO4	3000322	Minor		Inter Info	[267], [268]
D1491		Solifenacin	C23H26N2O2	154059	Minor		Inter Info	[267], [268]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[267], [268]
D0160		Benzatropine	C21H25NO	1201549	Minor		Inter Info	[267], [268]
D0782		Hyoscyamine	C17H23NO3	154417	Minor		Inter Info	[267], [268]
D1347		Procyclidine	C19H29NO	4919	Minor		Inter Info	[267], [268]
D1641		Trihexyphenidyl	C20H31NO	5572	Minor		Inter Info	[267], [268]
D1656		Trospium	C25H30NO3+	5284632	Minor		Inter Info	[267], [268]
	Complex formation					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[142], [143], [144], [145]
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[143], [254], [255]
Affected excretion pathways
	Altered urine pH					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1020		Methenamine	C6H12N4	4101	Moderate		Inter Info	[230], [231], [232], [233], [234]
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[21], [22], [23]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[228], [243], [238]
	Additive hypotensive effects					Drug Num: 125
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[25]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[31]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[18], [32], [20]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[33], [34], [35]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[33], [34], [35]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[33], [34], [35]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[33], [34], [35]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[47], [20], [48]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[33], [34], [35]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[47], [50], [51]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[68], [69], [70]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[71], [13], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[33], [34], [35]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[96], [97], [98]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[96], [97], [98]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[33], [34], [35]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[33], [34], [35]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[33], [34], [35]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[33], [34], [35]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[113], [114], [115]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[71], [13], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[33], [34], [35]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[33], [34], [35]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[33], [34], [35]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[33], [34], [35]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[113], [114], [115]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[18], [32], [20]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[13], [199], [200]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[33], [34], [35]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[33], [34], [35]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[33], [34], [35]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[33], [34], [35]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[18], [32], [20]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[33], [34], [35]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[33], [34], [35]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[33], [34], [35]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[113], [114], [115]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[71], [13], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[14], [202], [203]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[33], [34], [35]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[20], [205]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[33], [34], [35]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[33], [34], [35]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[71], [13], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[18], [32], [20]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[13], [14], [207]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[33], [34], [35]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[33], [34], [35]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[14], [202], [203]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[33], [34], [35]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [20], [221], [222]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[47], [50], [223]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [20], [221], [222]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[71], [13], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[14], [227], [228]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[33], [34], [35]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[229]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[33], [34], [35]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[33], [34], [35]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[33], [34], [35]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[71], [13], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[33], [34], [35]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[33], [34], [35]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[238], [239], [228]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[240], [241], [242]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[33], [34], [35]
D1183		Opium	NA	NA	Moderate		Inter Info	[33], [34], [35]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[33], [34], [35]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [20], [221], [222]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[33], [34], [35]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[244]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[71], [13], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [20], [221], [222]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[33], [34], [35]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[18], [32], [20]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[71], [13], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [20], [221], [222]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[33], [34], [35]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[250]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [20], [221], [222]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [20], [221], [222]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[14], [202], [203]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[33], [34], [35]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[18], [32], [20]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[33], [34], [35]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[71], [13], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[33], [34], [35]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[68], [69], [70]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[33], [34], [35]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[33], [34], [35]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[33], [34], [35]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[33], [34], [35]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[33], [34], [35]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[33], [34], [35]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[33], [34], [35]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[33], [34], [35]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[33], [34], [35]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[33], [34], [35]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[33], [34], [35]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[33], [34], [35]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[33], [34], [35]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[55], [56], [57], [58], [59], [27], [60], [61], [62], [63], [64]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[71], [13], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[18], [32], [20]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[33], [34], [35]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[68], [69], [70]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[33], [34], [35]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[14], [202], [203]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[33], [34], [35]
D0069		Amlodipine	C20H25ClN2O5	2162	Minor		Inter Info	[266]
D0711		Garlic	NA	NA	Minor		Inter Info	[272], [273]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Minor		Inter Info	[266]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[274], [275]
	Additive neuromuscular blocking effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[65], [66], [67]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[65], [66], [67]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[65], [66], [67]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[65], [66], [67]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[65], [66], [67]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[65], [66], [67]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[65], [66], [67]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[65], [66], [67]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0040		Allopurinol	C5H4N4O	135401907	Moderate		Inter Info	[44], [45], [46]
	Increased risk of fluid/electrolyte loss					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[99], [100], [101], [102], [103], [104], [105], [106], [107]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[99], [100], [106]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[99], [100], [101], [102], [103], [104], [105], [106], [107]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[99], [100], [106]
	Increased risk of hyperglycemia					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[36], [37], [38], [39], [40]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[36], [37], [38], [39], [40]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[36], [37], [38], [39], [40]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Moderate		Inter Info	[36], [37], [39]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[36], [37], [38], [39], [40]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[201]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[36], [37], [38], [39], [40]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Moderate		Inter Info	[36], [37], [39]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Moderate		Inter Info	[36], [37], [39]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[36], [37], [38], [39], [40]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[36], [37], [38], [39], [40]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[36], [37], [38], [39], [40]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[36], [37], [38], [39], [40]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[36], [37], [38], [39], [40]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[36], [37], [38], [39], [40]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[36], [37], [39]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[36], [37], [38], [39], [40]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[36], [37], [38], [39], [40]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Moderate		Inter Info	[36], [37], [39]
	Increased risk of hypermagnesemia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[13], [14], [235]
	Increased risk of hypokalemia					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0148		Beclomethasone dipropionate	C28H37ClO7	21700	Moderate		Inter Info	[41], [42], [43]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[14]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[14]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[14]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[14]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[52], [53], [54]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[41], [42], [43]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[41], [42], [43]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[41], [42], [43]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[41], [42], [43]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[41], [42], [43]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[52], [53], [54]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[41], [42], [43]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[52], [53], [54]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[52], [53], [54]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[224], [225], [226]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[41], [42], [43]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[52], [53], [54]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[52], [53], [54]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[52], [53], [54]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[41], [42], [43]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[41], [42], [43]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[52], [53], [54]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[52], [53], [54]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[52], [53], [54]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[41], [42], [43]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[41], [42], [43]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[52], [53], [54]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[256], [257], [99], [258], [259], [260], [261], [262], [263], [264]
	Increased risk of hypomagnesemia					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[198]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[198]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[198]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[198]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[198]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[198]
	Increased risk of hyponatremia					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[116], [117]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[204]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[146], [147], [149]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[146], [147], [33], [148], [149], [34], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
	Increased risk of metabolic acidosis					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[14], [235], [265]
	Increased risk of nephrotoxicity					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0833		Iohexol	C19H26I3N3O9	3730	Moderate		Inter Info	[208], [209], [210]
D0834		Iopamidol	C17H22I3N3O8	65492	Moderate		Inter Info	[208], [209], [210]
D0836		Iopromide	C18H24I3N3O8	3736	Moderate		Inter Info	[208], [209], [210]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Moderate		Inter Info	[208], [209], [210]
D0838		Ioversol	C18H24I3N3O9	3741	Moderate		Inter Info	[208], [209], [210]
D0839		Ioxilan	C18H24I3N3O8	3743	Moderate		Inter Info	[208], [209], [210]
D0472		Diatrizoate	C11H9I3N2O4	2140	Moderate		Inter Info	[208], [209], [210]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Minor		Inter Info	[269], [270], [271]
D1070		Minocycline	C23H27N3O7	54675783	Minor		Inter Info	[269], [270], [271]
D1564		Tetracycline	C22H24N2O8	54675776	Minor		Inter Info	[269], [270], [271]
D0530		Doxycycline	C22H24N2O8	54671203	Minor		Inter Info	[269], [270], [271]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[1], [2]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[13], [14], [49]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[13], [235], [1], [236], [237]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[13], [14], [49]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[248], [14], [249]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[14], [235], [1], [253]
	Increased risk of ventricular arrhythmias					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[3], [4]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[5], [6]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[7], [8], [9]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[10]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[11]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[12], [13], [14], [15], [16], [17]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[18], [19], [20]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[24]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[26]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[27]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[13], [14]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[13], [14]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[13], [14]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[13], [14]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[13], [14]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[13], [14]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[13], [14]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[13], [14]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[13], [14]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[13], [14]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[14], [235]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[13], [14]
	Increased risk of hypercalcemia					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1753		Calcipotriol (topical)	C27H40O3	5288783	Moderate		Inter Info	[108], [109]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[110], [111], [112]
D0237		Calcium chloride	CaCl2H4O2	24844	Moderate		Inter Info	[110], [111], [112]
D0238		Calcium citrate	C12H10Ca3O14	13136	Moderate		Inter Info	[110], [111], [112]
D0239		Calcium glubionate anhydrous	C18H32CaO19	64776	Moderate		Inter Info	[110], [111], [112]
D0241		Calcium gluconate	C12H22CaO14	9290	Moderate		Inter Info	[110], [111], [112]
D0243		Calcium lactate	C6H10CaO6	13144	Moderate		Inter Info	[110], [111], [112]
D0244		Calcium Phosphate	Ca3O8P2	24456	Moderate		Inter Info	[110], [111], [112]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[110], [111], [112]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[110], [111], [112]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[251], [252]
D0233		Calcifediol	C27H44O2	5283731	Moderate		Inter Info	[110], [111], [112]
D0234		Calcitriol	C27H44O3	5280453	Moderate		Inter Info	[110], [111], [112]
D1754		Calcitriol (topical)	C27H44O3	5280453	Moderate		Inter Info	[108], [109]
D0235		Calcium acetate	C4H6CaO4	6116	Moderate		Inter Info	[110], [111], [112]
D0240		Calcium glucoheptonate	C14H26CaO16	62859	Moderate		Inter Info	[110], [111], [112]
D0328		Cholecalciferol	C27H44O	5280795	Moderate		Inter Info	[110], [111], [112]
D0591		Ergocalciferol	C28H44O	5280793	Moderate		Inter Info	[110], [111], [112]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[93], [94], [95]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[93], [94], [95]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[93], [94], [95]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[93], [94], [95]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[93], [94], [95]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[93], [94], [95]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[93], [94], [95]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[93], [94], [95]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[245], [246], [247]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[245], [246], [247]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[93], [94], [95]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[245], [246], [247]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1711		Warfarin	C19H16O4	54678486	Minor		Inter Info	[276], [277], [278]
	Antagonize the effect of antidiabetic agents					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[28], [29], [30]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[28], [29], [30]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[28], [29], [30]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[28], [29], [30]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[28], [29], [30]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[28], [29], [30]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[28], [29], [30]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[28], [29], [30]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[28], [29], [30]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[28], [29], [30]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[28], [29], [30]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[28], [29], [30]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[28], [29], [30]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[28], [29], [30]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[28], [29], [30]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[28], [29], [30]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[28], [29], [30]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[28], [29], [30]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[28], [29], [30]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[28], [29], [30]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[28], [29], [30]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[28], [29], [30]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[28], [29], [30]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [29], [30]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [29], [30]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [29], [30]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [29], [30]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[28], [29], [30]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[28], [29], [30]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[28], [29], [30]
	Antagonize the effect of antihypertensive agents					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[28], [29], [30]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[206]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[118], [119], [120]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[28], [29], [30]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [99], [38], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141]

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