Details of Drug

Details of Drug

 Drug General Information (ID: D0113)
  Drug Name
Asparaginase Erwinia chrysanthemi
  Drug Type Protein/peptide
  Drug Synonymous
Erwinaze (TN)
    Click to Show/Hide
  Disease Class 2A85: Mature B-cell lymphoma
  Therapeutic Class Antineoplastics
  External Link
TTD ID D0H5XB

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM020  Decreased metabolism due to hepatotoxicity
BM043  Additive immunosuppressive effects
BM044  Additive myelosuppressive effects
BM047  Additive thrombogenic effects
BM050  Increased risk of bleeding
BM055  Increased risk of hepatotoxicity
BM057  Increased risk of hyperglycemia
BM086  Antagonize the effect of antidiabetic agents
BM089  Antagonize the effect of antihypertensive agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Asparaginase Erwinia chrysanthemi
      Affected intra/extra-hepatic metabolism
   Decreased metabolism due to hepatotoxicity Drug Num:  8
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0485
 
Dienogest
 
C20H25NO2
 
68861 
Moderate    Inter Info   
[26], [2], [30]
D1157
 
Norgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[26], [2], [30]
D0536
 
Drospirenone
 
C24H30O3
 
68873 
Moderate    Inter Info   
[26], [2], [30]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[26], [2], [30]
D0922
 
Levonorgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[26], [2], [30]
D0990
 
Medroxyprogesterone acetate
 
C24H34O4
 
6279 
Moderate    Inter Info   
[26], [2], [30]
D1154
 
Norethisterone
 
C20H26O2
 
6230 
Moderate    Inter Info   
[26], [2], [30]
D1156
 
Norgestimate
 
C23H31NO3
 
6540478 
Moderate    Inter Info   
[26], [2], [30]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1174
 
Omacetaxine mepesuccinate
 
C29H39NO9
 
285033 
Moderate    Inter Info   
[62]
   Additive thrombogenic effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Major    Inter Info   
[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
   Increased risk of bleeding Drug Num:  43
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0017
 
Acetylsalicylic acid
 
C9H8O4
 
2244 
Moderate    Inter Info   
[38], [2], [39]
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0102
 
Ardeparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0176
 
Betrixaban
 
C23H22ClN5O3
 
10275777 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0551
 
Edoxaban
 
C24H30ClN7O4S
 
10280735 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0210
 
Bromfenac
 
C15H12BrNO3
 
60726 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0247
 
Cangrelor
 
C17H25Cl2F3N5O12P3S2
 
9854012 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0250
 
Caplacizumab
 
NA
 
NA
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0336
 
Cilostazol
 
C20H27N5O2
 
2754 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0364
 
Clopidogrel
 
C16H16ClNO2S
 
60606 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0414
 
Dalteparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0415
 
Danaparoid
 
NA
 
NA
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[38], [2], [39]
D0489
 
Diflunisal
 
C13H8F2O3
 
3059 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0506
 
Dipyridamole
 
C24H40N8O4
 
3108 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0574
 
Enoxaparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0624
 
Etodolac
 
C17H21NO3
 
3308 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0645
 
Fenoprofen
 
C15H14O3
 
3342 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0680
 
Flurbiprofen
 
C15H13FO2
 
3394 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0690
 
Fondaparinux
 
C31H53N3O49S8
 
5282448 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0753
 
Heparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0754
 
Heparin (flush)
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[38], [2], [39]
D0786
 
Ibuprofen
 
C13H18O2
 
3672 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0800
 
Indomethacin
 
C19H16ClNO4
 
3715 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0881
 
Ketoprofen
 
C16H14O3
 
3825 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0882
 
Ketorolac
 
C15H13NO3
 
3826 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0988
 
Meclofenamic acid
 
C14H11Cl2NO2
 
4037 
Moderate    Inter Info   
[38], [2], [39]
D0991
 
Mefenamic acid
 
C15H15NO2
 
4044 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D0995
 
Meloxicam
 
C14H13N3O4S2
 
54677470 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1097
 
Nabumetone
 
C15H16O2
 
4409 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1109
 
Naproxen
 
C14H14O3
 
156391 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1196
 
Oxaprozin
 
C18H15NO3
 
4614 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1300
 
Piroxicam
 
C15H13N3O4S
 
54676228 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1328
 
Prasugrel
 
C20H20FNO3S
 
6918456 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1442
 
Salsalate
 
C14H10O5
 
5161 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1520
 
Sulindac
 
C20H17FO3S
 
1548887 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1581
 
Ticlopidine
 
C14H14ClNS
 
5472 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1588
 
Tinzaparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1606
 
Tolmetin
 
C15H15NO3
 
5509 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[38], [26], [2], [39], [40], [41], [42], [30], [31], [32], [33], [43], [44]
   Increased risk of hepatotoxicity Drug Num:  210
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Major    Inter Info   
[1]
D0900
 
Leflunomide
 
C12H9F3N2O2
 
3899 
Major    Inter Info   
[4]
D0944
 
Lomitapide
 
C39H37F6N3O2
 
9853053 
Major    Inter Info   
[5]
D1073
 
Mipomersen
 
C230H324N67O122P19S19
 
118984467 
Major    Inter Info   
[6]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Major    Inter Info   
[4]
D0001
 
Abacavir
 
C14H18N6O
 
441300 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0007
 
Abiraterone
 
C24H31NO
 
132971 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0011
 
Acetaminophen
 
C8H9NO2
 
1983 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0018
 
Acitretin
 
C21H26O3
 
5284513 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0030
 
Aldesleukin
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0053
 
Ambrisentan
 
C22H22N2O4
 
6918493 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0026
 
Afatinib
 
C24H25ClFN5O3
 
10184653 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0031
 
Alectinib
 
C30H34N4O2
 
49806720 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0149
 
Bedaquiline
 
C32H31BrN2O2
 
5388906 
Moderate    Inter Info   
[45]
D0191
 
Blinatumomab
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0248
 
Cannabidiol
 
C21H30O2
 
644019 
Moderate    Inter Info   
[2], [46]
D0251
 
Capmatinib
 
C23H17FN6O
 
25145656 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0261
 
Carfilzomib
 
C40H57N5O7
 
11556711 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0499
 
Dimethyl fumarate
 
C6H8O4
 
637568 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0507
 
Diroximel fumarate
 
C11H13NO6
 
73330464 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0643
 
Fenofibric acid
 
C17H15ClO4
 
64929 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0724
 
Givosiran
 
C78H139N11O30
 
119058042 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[48]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0903
 
Lenvatinib
 
C21H19ClN4O4
 
9823820 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0962
 
Lurbinectedin
 
C41H44N4O10S
 
57327016 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0966
 
Macitentan
 
C19H20Br2N6O4S
 
16004692 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1085
 
Monomethyl fumarate
 
C5H6O4
 
5369209 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1139
 
Nintedanib
 
C31H33N5O4
 
135423438 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1239
 
Peginterferon beta-1a
 
NA
 
NA
Moderate    Inter Info   
[49], [50], [51], [52]
D1306
 
Polatuzumab vedotin
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1313
 
Ponatinib
 
C29H27F3N6O
 
24826799 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1324
 
Pralsetinib
 
C27H32FN9O2
 
129073603 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1327
 
Prasterone enantate
 
C26H40O3
 
163331 
Moderate    Inter Info   
[24], [26], [33]
D1387
 
Regorafenib
 
C21H15ClF4N4O3
 
11167602 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1389
 
Remdesivir
 
C27H35N6O8P
 
121304016 
Moderate    Inter Info   
[26], [2], [53], [54], [55]
D1447
 
Sarilumab
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1448
 
Satralizumab
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1653
 
Troleandomycin
 
C41H67NO15
 
202225 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0119
 
Atomoxetine
 
C17H21NO
 
54841 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0120
 
Atorvastatin
 
C33H35FN2O5
 
60823 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0121
 
Atovaquone
 
C22H19ClO3
 
74989 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0153
 
Belinostat
 
C15H14N2O4S
 
6918638 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0180
 
Bicalutamide
 
C18H14F4N2O4S
 
2375 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0193
 
Bortezomib
 
C19H25BN4O4
 
387447 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0195
 
Bosutinib
 
C26H29Cl2N5O3
 
5328940 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0199
 
Brentuximab vedotin
 
NA
 
NA
Moderate    Inter Info   
[56]
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0254
 
Captopril
 
C9H15NO3S
 
44093 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0264
 
Carmustine
 
C5H9Cl2N3O2
 
2578 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0268
 
Caspofungin
 
C52H88N10O15
 
2826718 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0303
 
Cerivastatin
 
C26H34FNO5
 
446156 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0310
 
Chenodeoxycholic acid
 
C24H40O4
 
10133 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0327
 
Chlorzoxazone
 
C7H4ClNO2
 
2733 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0350
 
Clavulanic acid
 
C8H9NO5
 
5280980 
Moderate    Inter Info   
[24], [26], [33]
D0357
 
Clofarabine
 
C10H11ClFN5O3
 
119182 
Moderate    Inter Info   
[57]
D0367
 
Clotrimazole
 
C22H17ClN2
 
2812 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0404
 
Cytarabine
 
C9H13N3O5
 
6253 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0407
 
Dacarbazine
 
C6H10N6O
 
135398738 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0416
 
Danazol
 
C22H27NO2
 
28417 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0417
 
Dantrolene
 
C14H10N4O5
 
6914273 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0478
 
Diclofenac (topical)
 
C14H11Cl2NO2
 
3033 
Moderate    Inter Info   
[24], [26], [33]
D0483
 
Didanosine
 
C10H12N4O3
 
135398739 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0509
 
Disulfiram
 
C10H20N2S4
 
3117 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0530
 
Doxycycline
 
C22H24N2O8
 
54671203 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[58], [59]
D0561
 
Eltrombopag
 
C25H22N4O4
 
135449332 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0566
 
Emtricitabine
 
C8H10FN3O3S
 
60877 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0567
 
Enalapril
 
C20H28N2O5
 
5388962 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Moderate    Inter Info   
[26], [2], [60]
D0595
 
Erlotinib
 
C22H23N3O4
 
176870 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0616
 
Ethambutol
 
C10H24N2O2
 
14052 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0617
 
Ethanol
 
C2H6O
 
702 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1731
 
Ethionamide
 
C8H10N2S
 
2761171 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0637
 
Febuxostat
 
C16H16N2O3S
 
134018 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0642
 
Fenofibrate
 
C20H21ClO4
 
3339 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0677
 
Fluoxymesterone
 
C20H29FO3
 
6446 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0682
 
Flutamide
 
C11H11F3N2O3
 
3397 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0686
 
Fluvastatin
 
C24H26FNO4
 
446155 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0695
 
Fosinopril
 
C30H46NO7P
 
55891 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0713
 
Gefitinib
 
C22H24ClFN4O3
 
123631 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0714
 
Gemcitabine
 
C9H11F2N3O4
 
60750 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0717
 
Gemtuzumab ozogamicin
 
NA
 
NA
Moderate    Inter Info   
[24], [26], [33]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0802
 
Infliximab
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0821
 
Interferon alfa-2a, Recombinant
 
NA
 
NA
Moderate    Inter Info   
[24], [26], [33]
D0822
 
Interferon alfa-2b
 
C16H17Cl3I2N3NaO5S
 
71306834 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0824
 
Interferon alfa-n1
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0823
 
Interferon alfacon-1
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0826
 
Interferon beta-1a
 
NA
 
NA
Moderate    Inter Info   
[49], [50], [51], [52]
D0827
 
Interferon beta-1b
 
NA
 
NA
Moderate    Inter Info   
[49], [50], [51], [52]
D0828
 
Interferon gamma-1b
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0841
 
Ipilimumab
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0863
 
Isotretinoin
 
C20H28O2
 
5282379 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0878
 
Kava
 
C14H16O3
 
5281052 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0884
 
Labetalol
 
C19H24N2O3
 
3869 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0889
 
Lamivudine
 
C8H11N3O3S
 
60825 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0902
 
Lenalidomide
 
C13H13N3O3
 
216326 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0919
 
Levofloxacin
 
C18H20FN3O4
 
149096 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0938
 
Lisinopril
 
C21H31N3O5
 
5362119 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0945
 
Lomustine
 
C9H16ClN3O2
 
3950 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0956
 
Lovastatin
 
C24H36O5
 
53232 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D0980
 
Maraviroc
 
C29H41F2N5O
 
3002977 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1003
 
Mephenytoin
 
C12H14N2O2
 
4060 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1007
 
Mercaptopurine
 
C5H4N4S
 
667490 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1014
 
Metaxalone
 
C12H15NO3
 
15459 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1021
 
Methimazole
 
C4H6N2S
 
1349907 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1035
 
Methyldopa
 
C10H13NO4
 
38853 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1042
 
Methyltestosterone
 
C20H30O2
 
6010 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1066
 
Milnacipran
 
C15H22N2O
 
65833 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1070
 
Minocycline
 
C23H27N3O7
 
54675783 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1082
 
Moexipril
 
C27H34N2O7
 
91270 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1092
 
Moxifloxacin
 
C21H24FN3O4
 
152946 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1106
 
Naltrexone
 
C20H23NO4
 
5360515 
Moderate    Inter Info   
[61]
D1111
 
Natalizumab
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1129
 
Niacin
 
C6H5NO2
 
938 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1132
 
Nicotinamide
 
C6H6N2O
 
936 
Moderate    Inter Info   
[24], [26], [33]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1137
 
Nilutamide
 
C12H10F3N3O4
 
4493 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1145
 
Nitrofurantoin
 
C8H6N4O5
 
6604200 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1187
 
Orlistat
 
C29H53NO5
 
3034010 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1193
 
Oxaliplatin
 
C8H14N2O4Pt
 
9887053 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1195
 
Oxandrolone
 
C19H30O3
 
5878 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1207
 
Oxymetholone
 
C21H32O3
 
5281034 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1221
 
Panobinostat
 
C21H23N3O2
 
6918837 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1230
 
Pasireotide
 
C58H66N10O9
 
9941444 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1237
 
Peginterferon alfa-2a
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1238
 
Peginterferon alfa-2b
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1243
 
Pemoline
 
C9H8N2O2
 
4723 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1256
 
Perindopril
 
C19H32N2O5
 
107807 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1261
 
Phenazopyridine
 
C11H11N5
 
4756 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1299
 
Pirfenidone
 
C12H11NO
 
40632 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1301
 
Pitavastatin
 
C25H24FNO4
 
5282452 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1323
 
Pralatrexate
 
C23H23N7O5
 
148121 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1329
 
Pravastatin
 
C23H36O7
 
54687 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1359
 
Propylthiouracil
 
C7H10N2OS
 
657298 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1364
 
Pyrazinamide
 
C5H5N3O
 
1046 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1369
 
Quinapril
 
C25H30N2O5
 
54892 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1379
 
Ramipril
 
C23H32N2O5
 
5362129 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Moderate    Inter Info   
[24], [26], [33]
D1404
 
Rilpivirine
 
C22H18N6
 
6451164 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1405
 
Riluzole
 
C8H5F3N2OS
 
5070 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1421
 
Rofecoxib
 
C17H14O4S
 
5090 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1473
 
Simvastatin
 
C25H38O5
 
54454 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1497
 
Sorafenib
 
C21H16ClF3N4O3
 
216239 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1503
 
Stanozolol
 
C21H32N2O
 
25249 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1504
 
Stavudine
 
C10H12N2O4
 
18283 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1513
 
Sulfadiazine
 
C10H10N4O2S
 
5215 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1514
 
Sulfadoxine
 
C12H14N4O4S
 
17134 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1515
 
Sulfamethizole
 
C9H10N4O2S2
 
5328 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1516
 
Sulfamethoxazole
 
C10H11N3O3S
 
5329 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1517
 
Sulfasalazine
 
C18H14N4O5S
 
5339 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1519
 
Sulfisoxazole
 
C11H13N3O3S
 
5344 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1522
 
Sunitinib
 
C22H27FN4O2
 
5329102 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1525
 
Tacrine
 
C13H14N2
 
1935 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1548
 
Temozolomide
 
C6H6N6O2
 
5394 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1553
 
Terbinafine
 
C21H25N
 
1549008 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1558
 
Testosterone
 
C19H28O2
 
6013 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1559
 
Testosterone (topical)
 
C19H28O2
 
6013 
Moderate    Inter Info   
[24], [26], [33]
D1564
 
Tetracycline
 
C22H24N2O8
 
54675776 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1589
 
Tioguanine
 
C5H5N5S
 
2723601 
Moderate    Inter Info   
[63], [64]
D1592
 
Tipranavir
 
C31H33F3N2O5S
 
54682461 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1596
 
Tizanidine
 
C9H8ClN5S
 
5487 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1599
 
Tocilizumab
 
NA
 
NA
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1604
 
Tolcapone
 
C14H11NO5
 
4659569 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1608
 
Tolvaptan
 
C26H25ClN2O3
 
216237 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1615
 
Trabectedin
 
C39H43N3O11S
 
108150 
Moderate    Inter Info   
[2], [65]
D1618
 
Trandolapril
 
C24H34N2O5
 
5484727 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1623
 
Trastuzumab emtansine
 
NA
 
NA
Moderate    Inter Info   
[24], [26], [33]
D1626
 
Tretinoin
 
C20H28O2
 
444795 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1646
 
Trimetrexate
 
C19H23N5O3
 
5583 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1657
 
Trovafloxacin
 
C20H15F3N4O3
 
62959 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1674
 
Valdecoxib
 
C16H14N2O3S
 
119607 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1677
 
Valproic acid
 
C8H16O2
 
3121 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1698
 
Vincristine
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1699
 
Vincristine (liposome)
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[24], [26], [33]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1714
 
Zafirlukast
 
C31H33N3O6S
 
5717 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1715
 
Zalcitabine
 
C9H13N3O3
 
24066 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1720
 
Zidovudine
 
C10H13N5O4
 
35370 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
D1721
 
Zileuton
 
C11H12N2O2S
 
60490 
Moderate    Inter Info   
[23], [24], [25], [26], [2], [27], [28], [29], [30], [31], [32], [33], [34]
   Increased risk of hyperglycemia Drug Num:  7
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0436
 
Deflazacort
 
C25H31NO6
 
189821 
Moderate    Inter Info   
[32], [33], [47]
D0215
 
Budesonide
 
C25H34O6
 
5281004 
Moderate    Inter Info   
[32], [33], [47]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[32], [33], [47]
D0773
 
Hydrocortisone
 
C21H30O5
 
5754 
Moderate    Inter Info   
[32], [33], [47]
D1332
 
Prednisolone
 
C21H28O5
 
5755 
Moderate    Inter Info   
[32], [33], [47]
D1334
 
Prednisone
 
C21H26O5
 
5865 
Moderate    Inter Info   
[32], [33], [47]
D1628
 
Triamcinolone
 
C21H27FO6
 
31307 
Moderate    Inter Info   
[32], [33], [47]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0178
 
Bexarotene
 
C24H28O2
 
82146 
Major    Inter Info   
[2], [3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antidiabetic agents Drug Num:  36
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0009
 
Acarbose
 
C25H43NO18
 
41774 
Moderate    Inter Info   
[35], [36], [37]
D0013
 
Acetohexamide
 
C15H20N2O4S
 
1989 
Moderate    Inter Info   
[35], [36], [37]
D0042
 
Alogliptin
 
C18H21N5O2
 
11450633 
Moderate    Inter Info   
[35], [36], [37]
D0029
 
Albiglutide
 
C148H224N40O45
 
145994868 
Moderate    Inter Info   
[35], [36], [37]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[35], [36], [37]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[35], [36], [37]
D0809
 
Insulin degludec
 
C274H411N65O81S6
 
118984462 
Moderate    Inter Info   
[35], [36], [37]
D0941
 
Lixisenatide
 
C215H347N61O65S
 
90472060 
Moderate    Inter Info   
[35], [36], [37]
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Moderate    Inter Info   
[35], [36], [37]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[35], [36], [37]
D1784
 
Exenatide
 
C184H282N50O60S
 
45588096 
Moderate    Inter Info   
[35], [36], [37]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Moderate    Inter Info   
[35], [36], [37]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Moderate    Inter Info   
[35], [36], [37]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Moderate    Inter Info   
[35], [36], [37]
D0807
 
Insulin aspart (aspart protamine)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[35], [36], [37]
D0808
 
Insulin aspart (aspart)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[35], [36], [37]
D0811
 
Insulin glargine
 
C267H404N72O78S6
 
118984454 
Moderate    Inter Info   
[35], [36], [37]
D0812
 
Insulin glulisine
 
C258H384N64O78S6
 
16136701 
Moderate    Inter Info   
[35], [36], [37]
D0813
 
Insulin human
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[35], [36], [37]
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[35], [36], [37]
D0815
 
Insulin human (isophane)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[35], [36], [37]
D0816
 
Insulin human (regular)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[35], [36], [37]
D0817
 
Insulin human (zinc extended)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[35], [36], [37]
D0818
 
Insulin human (zinc)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[35], [36], [37]
D0820
 
Insulin lispro (protamine)
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[35], [36], [37]
D0930
 
Linagliptin
 
C25H28N8O2
 
10096344 
Moderate    Inter Info   
[35], [36], [37]
D1015
 
Metformin
 
C4H11N5
 
4091 
Moderate    Inter Info   
[35], [36], [37]
D1294
 
Pioglitazone
 
C19H20N2O3S
 
4829 
Moderate    Inter Info   
[35], [36], [37]
D1326
 
Pramlintide
 
C171H267N51O53S2
 
70691388 
Moderate    Inter Info   
[35], [36], [37]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[35], [36], [37]
D1429
 
Rosiglitazone
 
C18H19N3O3S
 
77999 
Moderate    Inter Info   
[35], [36], [37]
D1449
 
Saxagliptin
 
C18H25N3O2
 
11243969 
Moderate    Inter Info   
[35], [36], [37]
D1477
 
Sitagliptin
 
C16H15F6N5O
 
4369359 
Moderate    Inter Info   
[35], [36], [37]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Moderate    Inter Info   
[35], [36], [37]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Moderate    Inter Info   
[35], [36], [37]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[35], [36], [37]
   Antagonize the effect of antihypertensive agents Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1779
 
Dulaglutide
 
NA
 
NA
Moderate    Inter Info   
[35], [36], [37]
D1782
 
Ertugliflozin
 
C22H25ClO7
 
44814423 
Moderate    Inter Info   
[35], [36], [37]
D1887
 
Semaglutide
 
C187H291N45O59
 
56843331 
Moderate    Inter Info   
[35], [36], [37]
References
1 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
4 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
5 Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
6 Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
7 Bennett CL, Nebeker JR, Samore MH, et al "The Research on Adverse Drug Events and Reports (RADAR) project." JAMA 293 (2005): 2131-40. [PMID: 15870417]
8 Bennett CL, Schumock GT, Desai AA, et al "Thalidomide-associated deep vein thrombosis and pulmonary embolism." Am J Med 113 (2002): 603-6. [PMID: 12459408]
9 Cavo M, Zamagni E, Cellini C, et al. "Deep-vein thrombosis in patients with multiple myeloma receiving first-line thalidomide-dexamethasone therapy." Blood 100 (2002): 2272-3. [PMID: 12229885]
10 Escudier B, Lassau N, Leborgne S, Angevin E, Laplanche A "Thalidomide and venous thrombosis." Ann Intern Med 136 (2002): 711. [PMID: 11992318]
11 Figg WD, Arlen P, Gulley J, et al. "A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer." Semin Oncol 28(4 Suppl 15) (2001): 62-6. [PMID: 11685731]
12 Fine HA, Wen PY, Maher EA, et al. "Phase II Trial of Thalidomide and Carmustine for Patients With Recurrent High-Grade Gliomas." J Clin Oncol 21 (2003): 2299-304. [PMID: 12805330]
13 Lee CK, Barlogie B, Munshi N, et al "DTPACE: an effective, novel combination chemotherapy with thalidomide for previously treated patients with myeloma." J Clin Oncol 21 (2003): 2732-9. [PMID: 12860952]
14 Osman K, Comenzo R, Rajkumar SV "Deep venous thrombosis and thalidomide therapy for multiple myeloma." N Engl J Med 344 (2001): 1951-2. [PMID: 11419443]
15 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
16 Rajkumar SV, Hayman S, Gertz MA, et al. "Combination therapy with thalidomide plus dexamethasone for newly diagnosed myeloma." J Clin Oncol 20 (2002): 4319-23. [PMID: 12409330]
17 Urbauer E, Kaufmann H, Nosslinger T, Raderer M, Drach J "Thromboembolic events during treatment with thalidomide." Blood 99 (2002): 4247-8. [PMID: 12043695]
18 Weber D, Rankin K, Gavino M, Delasalle K, Alexanian R "Thalidomide alone or with dexamethasone for previously untreated multiple myeloma." J Clin Oncol 21 (2003): 16-9. [PMID: 12506164]
19 Zangari M, Anaissie E, Barlogie B, et al "Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy." Blood 98 (2001): 1614-5. [PMID: 11520815]
20 Zangari M, Barlogie B, Anaissie E, et al "Deep vein thrombosis in patients with mutiple myeloma treated with thalidomide and chemotherapy: effects of prophylactic and therapeutic anticoagulation." Br J Haematol 126 (2004): 715-21. [PMID: 15327525]
21 Zangari M, Siegel E, Barlogie B, et al "Thrombogenic activity of doxorubicin in myeloma patients receiving thalidomide: implications for therapy." Blood 100 (2002): 1168-71. [PMID: 12149193]
22 Desai AA, Vogelzang NJ, Rini BI, Ansari R, Krauss S, Stadler WM "A high rate of venous thromboembolism in a multi-institutional Phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil and daily thalidomide in patients with metastatic renal cell carcinoma." Cancer 95 (2002): 1629-36. [PMID: 12365009]
23 Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
24 Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
25 Cerner Multum, Inc "ANVISA Bulario Eletrnico.".
26 Cerner Multum, Inc. "Australian Product Information.".
27 Christ TN, Stock W, Knoebel RW "Incidence of asparaginase-related hepatotoxicity, pancreatitis, and thrombotic events in adults with acute lymphoblastic leukemia treated with a pediatric-inspired regimen." J Oncol Pharm Pract 24 (2018): 299-308. [PMID: 28355969]
28 Jenkins R, Perlin E "Severe hepatotoxicity from Escherichia coli L-asparaginase." J Natl Med Assoc 79 (1987): 775-9. [PMID: 3305969]
29 Lu G, Karur V, Herrington JD, Walker MG "Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine" Proc (Bayl Univ Med Cent) 29 (2016): 46-7. [PMID: 26722167]
30 Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
31 Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
32 Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
33 Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
34 Burke PW, Aldoss I, Lunning MA, et.al "High-grade PEGylated asparaginase-related hepatotoxicity occurrence in a pediatric-inspired adult acute lymphoblastic leukemia regimen does not necessarily predict recurrent hepatotoxicity in subsequent cycles." Blood 122 (2013): 2671. [PMID: 29407583]
35 Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
36 Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
37 Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
38 Caruso V, Iacoviello L, Di Castelnuovo A, et.al "Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients." Blood 108 (2006): 2216-22. [PMID: 16804111]
39 Duarte X, Esteves S, Neto AM, Pereira F "Incidence and risk factors for central nervous system thrombosis in paediatric acute lymphoblastic leukaemia during intensive asparaginase treatment: a single-centre study." Br J Haematol 174 (2016): 280-91. [PMID: 27018199]
40 Elice F, Rodeghiero F "Hematologic malignancies and thrombosis." Thromb Res 129 (2012): 360-6. [PMID: 22197450]
41 Grace RF, DeAngelo DJ, Stevenson KE, et.al "The use of prophylactic anticoagulation during induction and consolidation chemotherapy in adults with acute lymphoblastic leukemia." J Thromb Thrombolysis 45 (2018): 306-14. [PMID: 29260426]
42 Kieslich M, Porto L, Lanfermann H, Jacobi G, Schwabe D, Bohles H "Cerebrovascular complications of L-asparaginase in the therapy of acute lymphoblastic leukemia." J Pediatr Hematol Oncol 25 (2003): 484-7. [PMID: 12794528]
43 Truelove E, Fielding AK, Hunt BJ "The coagulopathy and thrombotic risk associated with L-asparaginase treatment in adults with acute lymphoblastic leukaemia." Leukemia 27 (2013): 553-9. [PMID: 23099335]
44 Mitchell L, Andrew M, Hanna K, et.al "Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l-asparaginase for acute lymphoblastic leukemia. Results of the PAARKA study." Thromb Haemost 90 (2003): 235-44. [PMID: 12888870]
45 Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
46 Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
47 Kawedia JD, Liu C, Pei D, Cheng C, Fernandez CA, Howard SC, Campana D, Panetta JC, Bowman WP, Evans WE, Pui CH, Relling MV. Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia. Blood. 2012 Feb 16;119(7):1658-64.
48 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
49 Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
50 Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
51 Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
52 Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
53 European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
54 Gilead Sciences, Inc "About Remdesivir.".
55 US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
56 Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
57 Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
58 Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
59 Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
60 Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
61 Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
62 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
63 Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
64 Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
65 Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.