Details of Drug

Details of Drug

 Drug General Information (ID: D0109)
  Drug Name
Artesunate
  Drug Type Small molecule
  Drug Synonymous
Arinate; Arsumax; Artesunato; Artesunatum; Artsuna; Dihydroqinghaosusuccinate; Nuartez; Plasmotrim; Plasmotrin; Qinghaozhi; Artesunic acid; Dihydroqinghasu hemsuccinate; Quinghaosu reduced succinate ester; Succinyl dihydroartemisinin; SM 804; WR 256283; Arsumax (TN); Artesunate (USAN); Artesunate (superseded RN); Artesunato [INN-Spanish]; Artesunatum [INN-Latin]; WR-256283; Dihydroartemisinine-12-alpha-succinate; Butanedioic acid, mono(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester; Butanedioic acid, mono((3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol, hydrogen succinate; 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano(4,3-j)-1,2-benzodioxepin-10-yl hydrogen butanedioate; 4-oxo-4-{[(3r,5as,6r,8as,9r,10r,12r,12ar)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid; 4-oxo-4-{[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid
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  Disease Class 1F40-1F45: Malaria
  Therapeutic Class Antimalarial Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C19H28O8
  InChI 1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1
  InChIKey FIHJKUPKCHIPAT-AHIGJZGOSA-N
  Canonical SMILES CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C
  External Link
Pubchem ID 6917864
CAS Number 88495-63-0
CHEBI ID 63918
TTD ID D0D4JO

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
BM010  Transporter inhibition
BM011  Transporter induction
BM022  CYP450 enzyme induction
BM023  UGT induction
  Relation Graph
 Full list of drugs interacting with Artesunate
      Affected cellular transport
   Transporter inhibition Drug Num:  35
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0739
 
Grazoprevir
 
C38H50N6O9S
 
44603531 
Major    Inter Info   
[1], [2], [3]
D0562
 
Eluxadoline
 
C32H35N5O5
 
11250029 
Major    Inter Info   
[1], [4], [5]
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[1], [6], [7]
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Moderate    Inter Info   
[9]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[1], [10], [11]
D0251
 
Capmatinib
 
C23H17FN6O
 
25145656 
Moderate    Inter Info   
[12]
D0425
 
Darolutamide
 
C19H19ClN6O2
 
67171867 
Moderate    Inter Info   
[13]
D0568
 
Enasidenib
 
C19H17F6N7O
 
89683805 
Moderate    Inter Info   
[14], [15]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[1], [16]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Moderate    Inter Info   
[17]
D0700
 
Fostemsavir
 
C25H26N7O8P
 
11319217 
Moderate    Inter Info   
[18]
D0725
 
Glasdegib
 
C21H22N6O
 
25166913 
Moderate    Inter Info   
[1], [19]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[20]
D1396
 
Revefenacin
 
C35H43N5O4
 
11753673 
Moderate    Inter Info   
[23], [2], [24]
D1423
 
Rolapitant
 
C25H26F6N2O2
 
10311306 
Moderate    Inter Info   
[25]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[26]
D1528
 
Tafamidis
 
C14H7Cl2NO3
 
11001318 
Moderate    Inter Info   
[1], [27], [28]
D1539
 
Tedizolid
 
C17H15FN6O3
 
11234049 
Moderate    Inter Info   
[1], [29]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Moderate    Inter Info   
[30]
D1710
 
Voxilaprevir
 
C40H52F4N6O9S
 
89921642 
Moderate    Inter Info   
[31]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Moderate    Inter Info   
[1], [33]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Moderate    Inter Info   
[34]
D0393
 
Crizotinib
 
C21H22Cl2FN5O
 
11626560 
Moderate    Inter Info   
[14], [1], [35]
D0408
 
Daclatasvir
 
C40H50N8O6
 
25154714 
Moderate    Inter Info   
[1], [36]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Moderate    Inter Info   
[37]
D0561
 
Eltrombopag
 
C25H22N4O4
 
135449332 
Moderate    Inter Info   
[38], [39], [14], [40], [41]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Moderate    Inter Info   
[1]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Moderate    Inter Info   
[44]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[45]
D0898
 
Ledipasvir
 
C49H54F2N8O6
 
67505836 
Moderate    Inter Info   
[46]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Moderate    Inter Info   
[47]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Moderate    Inter Info   
[1]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Moderate    Inter Info   
[48]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[14], [1]
D1608
 
Tolvaptan
 
C26H25ClN2O3
 
216237 
Moderate    Inter Info   
[14], [1], [49], [50]
   Transporter induction Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[1], [8]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[1], [21]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[42], [14], [1], [43]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Moderate    Inter Info   
[1], [22]
   UGT induction Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Moderate    Inter Info   
[32]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Moderate    Inter Info   
[32]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Moderate    Inter Info   
[32]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
3 Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
4 Davenport JM, Covington P, Bonifacio L, McIntyre G, Venitz J "Effect of uptake transporters OAT3 and OATPIBI and efflux transporter MRP2 on the pharmacokinetics of eluxadoline." J Clin Pharmacol 55 (2015): 534-42. [PMID: 25491493]
5 Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
6 Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
7 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
8 Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
9 Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
10 Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
11 Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
12 Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
13 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
14 Cerner Multum, Inc. "Australian Product Information.".
15 Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
16 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
17 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
18 Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
19 Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
20 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
21 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
22 Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
23 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
24 Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.
25 Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
26 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
27 Product Information. Vyndaqel (tafamidis). Pfizer U.S. Pharmaceuticals Group, New York, NY.
28 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
29 Product Information. Sivextro (tedizolid). Cubist Pharmaceuticals Inc, Lexington, MA.
30 Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
31 Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir). Gilead Sciences, Foster City, CA.
32 Product Information. Artesunate (artesunate). Amivas, Frederick, MD.
33 Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
34 Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
35 Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
36 Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
37 Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
38 Allred AJ, Bowen CJ, Park JW, et al. "Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers." Br J Clin Pharmacol 72 (2011): 321-9. [PMID: 21434975]
39 Canadian Pharmacists Association.
40 Kalliokoski A, Niemi M "Impact of OATP transporters on pharmacokinetics." Br J Pharmacol 158 (2009): 693-705. [PMID: 19785645]
41 Product Information. Promacta (eltrombopag). GlaxoSmithKline, Research Triangle Park, NC.
42 Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
43 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
44 Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
45 Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
46 Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
47 Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
48 Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
49 Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
50 Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.