Details of Drug

Details of Drug

 Drug General Information (ID: D0108)
  Drug Name
Artemether
  Drug Type Small molecule
  Drug Synonymous
Artemetero; Artemether[inn]; Artemetheri; Artemetherum; Artemos; Artenam; Artesaph; Artesian; Artimist; Artmether; Falcidol; Gvither; Malartem; Paluther; Rither; Arteannuin ether; Artemether [INN]; Artemisininelactol methyl ether; Dihydroartemisinin methyl ether; Dihydroquinghaosu methyl ether; SM 224; SM 229; Alpha-Artemether; Alpha-Dihydroartemisinin methyl ether; Artemetero [INN-Spanish]; Artemether (INN); Artemetherum [INN-Latin]; Beta-Artemether; Beta-Dihydroartemisinin methyl ether; Methyl-dihydroartemisinine; O-Methyldihydroartemisinine; SM-224; Beta-Methylether of 11-epi-dihydroartemisinin; Artemether, (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,12aR*))-isomer; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin; (3alpha,5abeta,6beta,8abeta,9alpha,10beta,12beta,12aR*)-isomer of artemether; (3r,5as,6r,8as,9r,10r,12r,12ar)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene; (5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene; 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane; 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-tri
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  Disease Class 1F40-1F45: Malaria
  Therapeutic Class Antimalarial Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C16H26O5
  InChI 1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
  InChIKey SXYIRMFQILZOAM-HVNFFKDJSA-N
  Canonical SMILES CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC)C
  External Link
Pubchem ID 68911
CAS Number 71963-77-4
CHEBI ID 195280
TTD ID D0M9BW
INTEDE ID DR0140

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
BM014  Interference of cell/tissue uptake
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
  Relation Graph
 Full list of drugs interacting with Artemether
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1822
 
Iodide I-123
 
I-
 
135300 
Moderate    Inter Info   
[13], [14], [15]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  31
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Major    Inter Info   
[1], [2], [3]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Major    Inter Info   
[1], [2], [3]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Major    Inter Info   
[1], [2], [3]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Major    Inter Info   
[1], [2], [3]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Major    Inter Info   
[1], [2], [3]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Major    Inter Info   
[1], [2], [3]
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Major    Inter Info   
[1], [2], [3]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Major    Inter Info   
[1], [2], [3]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Major    Inter Info   
[1], [2], [3]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Major    Inter Info   
[1], [2], [3]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Major    Inter Info   
[1], [2], [3]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Major    Inter Info   
[1], [2], [3]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Major    Inter Info   
[1], [2], [3]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Major    Inter Info   
[1], [2], [3]
D1063
 
Mifepristone
 
C29H35NO2
 
55245 
Major    Inter Info   
[1], [2], [3]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Major    Inter Info   
[1], [2], [3]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Major    Inter Info   
[1], [2], [3]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Major    Inter Info   
[1], [2], [3]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Major    Inter Info   
[1], [2], [3]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Major    Inter Info   
[1], [2], [3]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Major    Inter Info   
[1], [2], [3]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[4]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Moderate    Inter Info   
[8]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Moderate    Inter Info   
[9], [10], [11]
D0655
 
Fesoterodine
 
C26H37NO3
 
6918558 
Moderate    Inter Info   
[12]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Moderate    Inter Info   
[16], [17], [18]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[1], [2], [19]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Moderate    Inter Info   
[21], [22], [23]
D1709
 
Voxelotor
 
C19H19N3O3
 
71602803 
Moderate    Inter Info   
[9], [10], [26]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[27], [28]
D1057
 
Miconazole
 
C18H14Cl4N2O
 
4189 
Moderate    Inter Info   
[32]
   CYP450 enzyme induction Drug Num:  51
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Major    Inter Info   
[1], [2], [3]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Major    Inter Info   
[1], [2], [3]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Major    Inter Info   
[1], [2], [3]
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Major    Inter Info   
[1], [2], [3]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Major    Inter Info   
[1], [2], [3]
D1078
 
Mitotane
 
C14H10Cl4
 
4211 
Major    Inter Info   
[1], [2], [3]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Major    Inter Info   
[1], [2], [3]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Major    Inter Info   
[1], [2], [3]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Major    Inter Info   
[1], [2], [3]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Major    Inter Info   
[1], [2], [3]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Major    Inter Info   
[1], [2], [3]
D1502
 
St. John's Wort
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D0061
 
Aminoglutethimide
 
C13H16N2O2
 
2145 
Moderate    Inter Info   
[1], [2], [3]
D0071
 
Amobarbital
 
C11H18N2O3
 
2164 
Moderate    Inter Info   
[1], [2], [3]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Moderate    Inter Info   
[1], [2], [3]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[5], [6], [7]
D0555
 
Elagolix
 
C32H30F5N3O5
 
11250647 
Moderate    Inter Info   
[1], [2], [3]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[1], [2], [3]
D0901
 
Lemborexant
 
C22H20F2N4O2
 
56944144 
Moderate    Inter Info   
[1], [2], [3]
D0905
 
Lesinurad
 
C17H14BrN3O2S
 
53465279 
Moderate    Inter Info   
[1], [2], [3]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[1], [2], [3]
D1157
 
Norgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[20], [10], [3]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Moderate    Inter Info   
[1], [2], [3]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[1], [2], [3]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[1], [2], [3]
D1538
 
Tazemetostat
 
C34H44N4O4
 
66558664 
Moderate    Inter Info   
[10], [24]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Moderate    Inter Info   
[2], [25]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[1], [2], [3]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[1], [2], [3]
D0225
 
Butalbital
 
C11H16N2O3
 
2481 
Moderate    Inter Info   
[1], [2], [3]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[1], [2], [3]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[1], [2], [3]
D0536
 
Drospirenone
 
C24H30O3
 
68873 
Moderate    Inter Info   
[20], [10], [3]
D0619
 
Ethinylestradiol
 
C20H24O2
 
5991 
Moderate    Inter Info   
[20], [10], [3]
D0626
 
Etonogestrel
 
C22H28O2
 
6917715 
Moderate    Inter Info   
[20], [10], [3]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[1], [2], [3]
D0741
 
Griseofulvin
 
C17H17ClO6
 
441140 
Moderate    Inter Info   
[1], [2], [3]
D0922
 
Levonorgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[20], [10], [3]
D0990
 
Medroxyprogesterone acetate
 
C24H34O4
 
6279 
Moderate    Inter Info   
[29], [30], [31]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[1], [2], [3]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Moderate    Inter Info   
[1], [2], [3]
D1099
 
Nafcillin
 
C21H22N2O5S
 
8982 
Moderate    Inter Info   
[1], [2], [3]
D1154
 
Norethisterone
 
C20H26O2
 
6230 
Moderate    Inter Info   
[20], [10], [3]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[1], [2], [3]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[1], [2], [3]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Moderate    Inter Info   
[1], [2], [3]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[1], [2], [3]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[1], [2], [3]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Moderate    Inter Info   
[1], [2], [3]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[1], [2], [3]
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