Details of Drug

Drug General Information (ID: D0100)
Drug Name	Aprepitant
Drug Type	Small molecule
Drug Synonymous	Aprepitant [USAN]; L 754030; MK 0869; Emend (TN); L-754030; MK-0869; ONO-7436; Aprepitant (JAN/USAN/INN); MK-869, L-754030, Emend, Aprepitant; 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-Delta(2)-1,2,4-triazolin-5-one; 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-delta(sup 2)-1,2,4-triazolin-5-one; 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one; 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one; 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one Click to Show/Hide
Disease Class	6A70-6A7Z: Depression; MD90: Nausea/vomiting; 2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Antiemetics
Structure
Structure	3D Structure		2D Structure
Formula	C23H21F7N4O3
InChI	1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
InChIKey	ATALOFNDEOCMKK-OITMNORJSA-N
Canonical SMILES	CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F
External Link
	Pubchem ID	135413536
	CAS Number	170729-80-3
	CHEBI ID	499361
	TTD ID	D0GU4K
	INTEDE ID	DR0125
	VARIDT ID	DR01398

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction
Relation Graph

Full list of drugs interacting with Aprepitant
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 289
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[1]
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[16]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[17], [18]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[19], [20], [21]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[22], [17], [23], [24]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[25]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[22], [17], [26]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[17], [27], [28], [29]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[30]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[48]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[49]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[22], [17], [50]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[51]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[52]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[22], [53], [54], [55], [24], [56], [14]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[57]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[17], [58]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[59], [60], [61], [62], [63]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[19], [20]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[64]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[17], [65], [66]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[17], [67], [68], [69], [70]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[22], [72]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[73], [74]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[22], [75], [24]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[74]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[76]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[22], [17], [77]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[78]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[17], [79]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[80], [22], [81]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[22], [17], [82]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[83], [84]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[17], [85]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[86]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[22], [87], [88], [89], [90], [91], [92], [93], [24]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[17], [94]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[95]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[22], [96]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[97]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[98]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[99]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[22], [17], [100]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[101]
D0115		Astemizole	C28H31FN4O	2247	Major		Inter Info	[102], [103]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[104]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[102], [103]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[22], [17], [105]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[106]
D1555		Terfenadine	C32H41NO2	5405	Major		Inter Info	[102], [103]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[102], [103]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[107]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[88], [108], [109], [102]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[110], [22], [17], [111], [112]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[113]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[114]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[110], [17], [115], [116]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[102], [103]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[102], [103]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[102], [103]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[17], [122], [123]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[124]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[102], [103]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [88], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [123], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[102], [103]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[102], [103]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[102], [103]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[102], [103]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[22], [17], [186]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[187], [22], [17], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[187], [22], [17]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[201]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[206]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[207]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[208]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[209]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[102], [103]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[88], [108], [109], [102]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[102], [103]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[210], [211]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[210], [211]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[212]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[213]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[102], [103]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[22], [17], [214]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[210], [211]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[102], [103]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[102], [103]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[88], [108], [109], [102]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[210], [211]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[102], [103]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[210], [211]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[215], [22], [17], [216], [217], [218], [219], [220], [221]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[202], [203], [205]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[222]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[224]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[225]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[226]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[17], [227], [228], [229]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[230]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[231], [232], [233]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[234], [235], [236], [237], [238], [88], [239], [231], [240], [232], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [233], [251], [252], [253], [254]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[88], [108], [109], [102]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[102], [103]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[102], [103]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[210], [211]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[210], [211]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[210], [211]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[102], [103]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[102], [103]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[257]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[102], [103]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[22], [17], [23], [64], [258], [259], [260]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Moderate		Inter Info	[22], [64], [259]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[102], [103]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[210], [211]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[261]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[262]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[263], [264]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[102], [103]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[22]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[102], [103]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[202], [203], [205]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[17], [265], [102], [103]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[102], [103]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[102], [103]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[266]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[22], [17], [267]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[268]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[102], [103]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[102], [103]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[110], [22], [17], [111], [112]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[17], [270]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[271]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[102], [103]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[102], [103]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[273], [274]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[275], [276]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[17], [277]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[102], [103]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[210], [211]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[102], [103]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[278]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[17], [279]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[280]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[102], [103]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[202], [203], [205]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[17], [281]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[282]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[102], [103]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[283]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[284]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[285]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[102], [103]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[286], [287]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[88], [108], [109], [102]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[288], [289], [290], [291], [292], [293], [294], [295], [296]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[102], [103]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[102], [103]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[102], [103]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[297], [298], [299], [300], [301], [302], [303]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[22], [304], [17], [305]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[22], [306]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[22], [17], [307]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[102], [103]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[102], [103]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[17], [308]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[309]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[102], [103]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[310]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[17], [65], [311]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[102], [103]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[102], [103]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[312]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[102], [103]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[313], [314], [315], [84]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[316]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[102], [103]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[102], [103]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[318]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[102], [103]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[17], [319]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[320]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[102], [103]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[88], [108], [109], [102]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[102], [103]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[321]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[322]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[323], [123]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[324]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[102], [103]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[102], [103]
D0218		Bupivacaine	C18H28N2O	2474	Moderate		Inter Info	[102], [103]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[102], [103]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [88], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [123], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[102], [103]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[102], [103]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[22]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[102], [103]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[88], [108], [109], [102]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[88], [108], [210]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[102], [103]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[102], [103]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[210], [211]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[102], [103]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[102], [103]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[325], [123]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[102], [103]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[234], [235], [236], [237], [238], [88], [239], [231], [240], [232], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [233], [251], [252], [253], [254]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[102], [103]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[102], [103]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[102], [103]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[326]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[102], [103]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[102], [103]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[327], [328], [329], [17], [88], [330], [331]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[102], [103]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[102], [103]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[102], [103]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[102], [103]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[102], [103]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[102], [103]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[102], [103]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[102], [103]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[102], [103]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[102], [103]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [88], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [123], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[210], [211]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[210], [211]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[332], [333], [334], [335], [336], [337], [338], [339]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[231], [232], [233]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[231], [232], [233]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[340], [341], [84], [342], [343]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[102], [103]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[102], [103]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[102], [103]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[102], [103]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[102], [103]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[210], [211]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[102], [103]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[344], [345], [346], [347]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [88], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [123], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[102], [103]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[210], [211]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[348]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[102], [103]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[22], [17], [349]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[102], [103]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[202], [203], [205]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[202], [203], [204], [102], [103], [205]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[102], [103]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[102], [103]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[22], [350], [351]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[17], [352]
D0425		Darolutamide	C19H19ClN6O2	67171867	Minor		Inter Info	[353]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[354]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[355], [84], [356], [357]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[358]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[359], [360]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[361]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[362]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[22], [350], [351]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[363]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[17], [364]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[365]
D1664		Ulipristal	C28H35NO3	13559281	Minor		Inter Info	[17], [366]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[359], [360]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[367]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[368], [369], [370], [371], [372], [373], [374]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[375], [376], [377], [378]
	CYP450 enzyme induction					Drug Num: 63
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[71]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[102], [103]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[102]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[102], [103]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[117], [118], [119], [102], [103], [120], [121]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[102], [103]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[223], [102], [103]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[102], [103]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[255], [210], [211]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[256]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[102], [103]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[102]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[102]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[102], [103]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[102]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[102]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[102]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[269]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[102], [103]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[102]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[102]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[102]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[272], [210], [211]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[102]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[102]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[255], [210], [211]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[223], [102], [103]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[102], [103]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[102], [103]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[102], [103]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[102], [103]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[102], [103]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[272], [210], [211]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[102], [103]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[102], [103]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[102], [103]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[17], [317]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[102], [103]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[117], [118], [119], [102], [103], [120], [121]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[102], [103]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[102], [103]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[102], [103]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[102], [103]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[102]
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[255], [210], [211]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[102]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[117], [118], [121]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[102]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[223], [102], [103]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[102]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[102], [103]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[102]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[223], [102], [103]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[102], [103]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[102], [103]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[102], [103]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[102], [103]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[102]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[102], [103]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[272], [210], [211]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[102], [103]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[102]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[102]

References
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69	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
70	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
71	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
72	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
73	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
74	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
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101	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
102	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
103	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
104	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
105	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
106	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
107	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
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170	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
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209	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
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211	Product Information. Emend for Injection (fosaprepitant). Merck &amp Company Inc, West Point, PA.
212	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
213	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
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225	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
226	Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
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229	Product Information. Padcev (enfortumab vedotin). Seattle Genetics Inc, Bothell, WA.
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248	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
249	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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257	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
258	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
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262	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
263	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
264	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
265	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
266	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
267	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
268	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
269	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
270	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
271	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
272	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
273	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
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275	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
276	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
277	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
278	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
279	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
280	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
281	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
282	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
283	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
284	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
285	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
286	Product Information. Rythmol SR (propafenone). GlaxoSmithKline, Research Triangle Park, NC.
287	Botsch S, Gautier JC, Beaune P, Eichelbaum M, Kroemer HK "Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites." Mol Pharmacol 43 (1993): 120-6. [PMID: 8423765]
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301	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
302	Tornio A, Niemi M, Neuvonen M, et al. "The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo." Clin Pharmacol Ther 84 (2008): 403-11. [PMID: 18388877]
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306	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
307	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
308	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
309	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
310	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
311	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
312	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
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316	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
317	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
318	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
319	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
320	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
321	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
322	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
323	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
324	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
325	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
326	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
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330	Product Information. Imovane (zopiclone). Rhone-Poulenc Rorer Canada Inc, Laval, IN.
331	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
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338	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
339	Oda Y, Kharasch ED "Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation." J Pharmacol Exp Ther 298 (2001): 1021-32. [PMID: 11504799]
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341	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
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345	Product Information. Revatio (sildenafil). Pfizer U.S. Pharmaceuticals Group, New York, NY.
346	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
347	Warrington JS, Shader RI, vonMoltke LL, Greenblatt DJ "In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions." Drug Metab Disposition 28 (2000): 392-7. [PMID: 10725306]
348	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
349	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
350	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
351	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
352	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
353	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
354	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
355	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
356	Rojas-Fernandez C, Fisher C "Drug interactions and donepezil." J Am Geriat Soc 40 (2000): 597-8. [PMID: 10811561]
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358	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
359	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
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