Details of Drug

Drug General Information (ID: D0095)
Drug Name	Apalutamide
Drug Type	Small molecule
Drug Synonymous	Arn-509 (AR inhibitor) Click to Show/Hide
Disease Class	2A60: Acute myeloid leukaemia; 2C82: Prostate cancer
Therapeutic Class	Antiandrogens
Structure
Structure	3D Structure		2D Structure
Formula	C21H15F4N5O2S
InChI	1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)
InChIKey	HJBWBFZLDZWPHF-UHFFFAOYSA-N
Canonical SMILES	CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CC(=C(N=C4)C#N)C(F)(F)F)F
External Link
	Pubchem ID	24872560
	CAS Number	956104-40-8
	TTD ID	D0S7LG
	INTEDE ID	DR0121

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM069 Increased risk of lowers seizure threshold BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Apalutamide
Affected cellular transport
	Transporter induction					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1490		Sofosbuvir	C22H29FN3O9P	45375808	Major		Inter Info	[4], [5], [265], [266], [267]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[316]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[344], [345]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[4], [113], [5], [352]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[5], [309]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[5], [309]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[5], [309]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[5], [309]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[5], [309]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[5], [309]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[5], [309]
D0631		Ezetimibe	C24H21F2NO3	150311	Moderate		Inter Info	[5], [309]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[5], [309]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[5], [309]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[5], [309]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[5], [309]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[5], [309]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[5], [309]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[5], [309]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[5], [309]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[5], [309]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[5], [309]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[5], [309]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[5], [309]
D1402		Rifaximin	C43H51N3O11	6436173	Moderate		Inter Info	[5], [309]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[5], [309]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[5], [309]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[5], [309]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[5], [309], [451]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[5], [309]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[5], [309]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[5], [309]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[5], [309]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[5], [309]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[43]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[46]
	CYP450 enzyme induction					Drug Num: 292
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[2]
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[16], [17], [18]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[20]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Major		Inter Info	[21]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[5], [22]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[16], [23], [17]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[24]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[25]
D0425		Darolutamide	C19H19ClN6O2	67171867	Major		Inter Info	[26]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[27]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[28], [29]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[5], [30]
D0589		Eravacycline	C27H31FN4O8	54726192	Major		Inter Info	[28], [31]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[32]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[5], [33]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[4], [34], [35]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[36]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[37]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[38]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[39]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[4], [5], [40]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[41]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[42]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[5], [45]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[47]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[48]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[49]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[5], [51]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[53]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[54]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[55]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[56]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[57], [28], [58]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[59]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[5], [60]
D0099		Apremilast	C22H24N2O7S	11561674	Major		Inter Info	[61]
D0108		Artemether	C16H26O5	68911	Major		Inter Info	[4], [5], [64]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[65], [66]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[5], [67]
D0181		Bictegravir	C21H18F3N3O5	90311989	Major		Inter Info	[5], [68], [69]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[70]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[5], [71], [72], [73], [74], [75]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[76]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[91], [92], [93]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[3], [4], [5], [94], [95], [96], [16], [23], [17], [97]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[98], [99]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[100]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[101]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[4], [5], [109], [110], [111]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[4], [5], [112]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[4], [113], [5], [114]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[5], [115], [116]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[4], [5], [117]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[118], [119], [120]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Major		Inter Info	[4], [5], [123], [124], [125]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[4], [128]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Major		Inter Info	[129], [110], [111]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[130]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[134]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[3], [4], [5], [135], [136]
D0640		Felodipine	C18H19Cl2NO4	3333	Major		Inter Info	[16], [17], [18]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[3], [4], [5], [94], [95], [96], [16], [23], [17], [97]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[138]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[28], [162]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[5], [166], [167]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[3], [4], [5], [94], [95], [96], [16], [23], [17], [97]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[5], [174]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[176]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[178], [3], [4], [5], [179], [180]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[189], [192], [194]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[197]
D0865		Isradipine	C19H21N3O5	3784	Major		Inter Info	[16], [17], [18]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[198]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[5], [199], [200]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[4], [5], [201], [202], [203], [116]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Major		Inter Info	[204]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Major		Inter Info	[16], [17], [18]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[206]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[207]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[208], [209]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[210]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[224], [225]
D1101		Naldemedine	C32H34N4O6	54732242	Major		Inter Info	[227]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[4], [228]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[4], [34], [35]
D1130		Nicardipine	C26H29N3O6	4474	Major		Inter Info	[16], [17], [18]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[16], [17], [18]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[229]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[230], [231]
D1141		Nisoldipine	C20H24N2O6	4499	Major		Inter Info	[16], [17], [18]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[4], [5], [232]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[4], [5], [233]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[3], [4], [5], [94], [95], [96], [16], [23], [17], [97]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[4], [5], [234]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[235]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[5], [246]
D1330		Praziquantel	C19H24N2O2	4891	Major		Inter Info	[247], [4], [248], [249]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[250]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[251]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[252]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[253]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[4], [113], [5], [254]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[3], [4], [5], [255]
D1423		Rolapitant	C25H26F6N2O2	10311306	Major		Inter Info	[5], [256]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[261]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[262], [263]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[4], [5], [264]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[268]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[5], [179], [275], [276]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[4], [5], [277]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[278]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[279], [4], [5], [280], [281], [282], [283], [284], [285], [286]
D1536		Tasimelteon	C15H19NO2	10220503	Major		Inter Info	[287]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[5], [288], [289]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[4], [5], [290]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[293], [294]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[4], [295]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[5], [296]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[297], [4], [5], [298], [299]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[5], [300], [301]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[4], [5], [305]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[306]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[307]
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[5], [309]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[5], [309]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[317], [318], [319], [320]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[5], [309]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[5], [309]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[5], [309]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[5], [309]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[328], [329], [330], [3], [331], [332], [333], [334], [335], [336], [259], [337], [338], [339], [340], [341], [342]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[4], [5], [309], [343]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[5]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[346]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[5], [309]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[348]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[351]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[356]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[5], [357], [358], [359]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[387]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[328], [329], [330], [3], [331], [332], [333], [334], [335], [336], [259], [337], [338], [339], [340], [341], [342]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[388], [389], [390], [391], [392]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[393]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[5], [309]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[5], [309]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[394]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[395]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[5], [396]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[398]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[5], [309]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[399]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[5], [309]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[5], [309]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[5], [309]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[400], [401]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[5], [309]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[5], [309]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[5], [309]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[5], [309]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [447], [448]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[5], [309]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[4], [5], [449]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[5], [309]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[5], [309]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[450]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[328], [329], [330], [3], [331], [332], [333], [334], [335], [336], [259], [337], [338], [339], [340], [341], [342]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[4], [5], [343]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[5], [309]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[5], [309], [451]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[4], [5], [452]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[453], [454], [455], [456], [457]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[458]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[5], [459], [460], [461]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[459], [460], [461]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [447], [448]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[4], [5], [452]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[4], [5], [452]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[462], [463]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[5], [309]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [447], [448]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [447], [448]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[406], [416], [441]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[406], [416], [441]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[406], [416], [441]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[464]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[5], [309]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [447], [448]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[465]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[466], [467], [468], [469], [470], [17], [471], [472]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[473]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Moderate		Inter Info	[5], [309]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[5], [309]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[5], [309]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[328], [329], [330], [3], [331], [332], [333], [334], [335], [336], [259], [337], [338], [339], [340], [341], [342]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[462], [474]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[5], [309]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[5], [309]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[5], [309]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[5], [309]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[5], [309]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[328], [329], [330], [3], [331], [332], [333], [334], [335], [336], [259], [337], [338], [339], [340], [341], [342]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[5], [309]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[5], [309]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[5], [309]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[5], [309]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[483]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[5], [309]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[5], [309]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[5], [309]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[5], [309]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[5], [309]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [447], [448]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[485]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[5], [309]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[5], [309]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[486], [487], [448]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[5], [309]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[172]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[406], [416], [441]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[5], [309]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[4], [5], [452]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[4], [5], [452]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[488], [489], [490], [491]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[5], [309]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[5], [309]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[328], [329], [330], [3], [331], [332], [333], [334], [335], [336], [259], [337], [338], [339], [340], [341], [342]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[5], [309]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[3], [4], [5]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[406], [416], [441]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [447], [448]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[5], [309]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[493]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[5], [309]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[494], [495], [496], [497]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[494], [495], [496]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[5], [309]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[498]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[5], [309]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[503]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[4], [5], [504]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[5], [309]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [447], [448]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[406], [416], [441]
D1350		Proguanil	C11H16ClN5	6178111	Moderate		Inter Info	[5], [309]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[5], [309]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [447], [448]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[515], [516], [17], [517], [518], [519]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[520]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[521]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[522], [523], [524]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[525]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[526], [527]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[528]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[529]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[530]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[5], [309]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[531], [532], [533], [534]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[5], [309]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[535]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[536]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[5], [537], [538]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[539], [298], [540], [541]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[5], [309]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[5], [309]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[5], [309]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[328], [329], [330], [3], [331], [332], [333], [334], [335], [336], [259], [337], [338], [339], [340], [341], [342]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[5], [309], [451]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[5], [309]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[5], [309]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[5], [309], [451]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[5], [309]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[5], [309], [451]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[5], [309]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[5], [309]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[543]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[544]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[545]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[4], [5], [309], [343]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[5], [309]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[5], [309]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[5], [546], [547], [548]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[549], [550]
D0571		Enfortumab vedotin	NA	NA	Minor		Inter Info	[5], [551], [552], [553]
D1306		Polatuzumab vedotin	NA	NA	Minor		Inter Info	[4], [554]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[555]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[556], [201], [116]
D0585		Eplerenone	C24H30O6	443872	Minor		Inter Info	[557], [4], [5], [558], [559]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[560]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[561], [562], [563], [564]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[568]
	UGT induction					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[50]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[5], [309]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[5], [309]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[5], [309]
D1377		Raltegravir	C20H21FN6O5	54671008	Moderate		Inter Info	[5], [309]
Pharmacodynamic additive effects
	Increased risk of lowers seizure threshold					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[77], [78], [3], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[181], [182], [183], [184], [185]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[181], [182], [183], [184], [185]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[302], [89], [88], [303]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[475], [476], [477], [478], [479], [480], [481], [482]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[3], [501], [502]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[3], [501], [502]
	Increased risk of prolong QT interval					Drug Num: 110
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[3], [4], [5], [19]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[3], [4], [5], [102], [103], [104]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[3], [4], [5], [105], [106], [15], [107]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[3], [4], [5], [108], [15]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[3], [4], [5], [121]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[3], [4], [5], [122]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[3], [4], [5], [126], [127], [15]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[3], [131], [4], [5], [132], [133], [15]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[139], [140], [141], [3], [4], [5], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[140], [3], [4], [5], [163], [164], [165]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[168], [3], [4], [5], [169], [170], [171], [172], [173]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[3], [4], [5], [175]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[3], [4], [5], [177], [15]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[5], [205], [15]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[3], [4], [5], [211], [15]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[3], [4], [5], [226]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[139], [140], [141], [3], [4], [5], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[236], [237], [238], [239], [240], [241], [242], [243]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[3], [4], [5], [244]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[5], [126], [245], [15]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[257], [258], [3], [4], [5], [259], [260]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[140], [3], [4], [5], [269], [270], [144], [146], [148], [271], [149], [150], [272], [152], [153], [154], [155], [273], [159], [165], [274]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[5], [291], [292]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[3], [4], [5], [304]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[3], [4], [5], [126], [308], [15]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[5], [321], [322]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[5], [321], [322]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[5], [321], [322]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[5], [321], [322]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[5], [321], [322]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[5], [321], [322]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[5], [321], [322]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[4], [5], [484]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[4], [5], [492]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[499], [500]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1342		Probucol	C31H48O2S2	4912	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[505], [506], [507], [508], [509], [510], [511], [512], [513], [514]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[5], [321], [322]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[5], [321], [322]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[5], [323], [324], [325], [326], [327], [321], [322]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[4], [565], [566], [567]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[3], [4], [5], [569], [570], [571], [572]
	Increased risk of ventricular arrhythmias					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[44]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[4], [52]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[62], [63]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[3], [4], [5], [137], [107]
D0025		Adenosine	C10H13N5O4	60961	Moderate		Inter Info	[3], [310], [4], [5], [311], [312], [313], [102], [314], [315]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[4], [5], [347]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[3], [4], [5], [349], [350], [347]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[353], [354], [355]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [353], [373], [374], [375], [376], [377], [378], [379], [380], [381], [354], [382], [383], [355], [384], [385], [386]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[3], [4], [5], [349], [350], [347]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[3], [4], [5], [349], [350], [347]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [353], [373], [374], [375], [376], [377], [378], [379], [380], [381], [354], [382], [383], [355], [384], [385], [386]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[3], [4], [5], [349], [350], [347]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [353], [373], [374], [375], [376], [377], [378], [379], [380], [381], [354], [382], [383], [355], [384], [385], [386]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [353], [373], [374], [375], [376], [377], [378], [379], [380], [381], [354], [382], [383], [355], [384], [385], [386]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[3], [4], [5], [349], [350], [347]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[3], [4], [5], [349], [350], [347]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[3], [4], [5], [349], [350], [347]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[353], [354], [355]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[3], [4], [5], [349], [350], [347]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [353], [373], [374], [375], [376], [377], [378], [379], [380], [381], [354], [382], [383], [355], [384], [385], [386]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[4], [5], [347]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [353], [373], [374], [375], [376], [377], [378], [379], [380], [381], [354], [382], [383], [355], [384], [385], [386]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[353], [354], [355]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [353], [373], [374], [375], [376], [377], [378], [379], [380], [381], [354], [382], [383], [355], [384], [385], [386]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [353], [373], [374], [375], [376], [377], [378], [379], [380], [381], [354], [382], [383], [355], [384], [385], [386]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[4], [5], [542]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[353], [354], [355]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1756		Capromab pendetide	C10H15N5O11P2	135509147	Moderate		Inter Info	[397]

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32	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
33	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
34	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
35	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
36	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
37	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
38	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
39	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
40	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
41	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
42	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
43	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
44	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
45	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
46	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
47	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
48	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
49	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
50	Product Information. Trodelvy (sacituzumab govitecan). Immunomedics, Morris Plains, NJ.
51	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
52	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
53	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
54	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
55	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
56	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
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59	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
60	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
61	Product Information. Otezla (apremilast). Celgene Corporation, Summit, NJ.
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66	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
67	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
68	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
69	Product Information. Descovy (emtricitabine-tenofovir). Gilead Sciences, Foster City, CA.
70	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
71	Hellmann A, Rule S, Walewski J, et al. "Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or Non-Hodgkin's lymphoma." Clin Pharmacokinet 50 (2011): 781-91. [PMID: 22087865]
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94	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
95	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
96	Product Information. Ionsys (fentanyl). Ortho McNeil Pharmaceutical, Raritan, NJ.
97	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
98	Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
99	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
100	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
101	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
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107	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
108	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
109	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
110	Product Information. Tybost (cobicistat). Gilead Sciences, Foster City, CA.
111	Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
112	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
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114	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
115	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
116	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
117	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
118	Borin MT, Chambers JH, Carel BJ, Freimuth WW, Aksentijevich S, Piergies AA "Pharmacokinetic study of the interaction between rifabutin and delavirdine mesylate in HIV-1 infected patients." Antiviral Res 35 (1997): 53-63. [PMID: 9224961]
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121	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
122	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
123	Product Information. Dovato (dolutegravir-lamivudine). ViiV Healthcare, Research Triangle Park, NC.
124	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
125	Product Information. Triumeq (abacavir/dolutegravir/lamiVUDine). ViiV Healthcare, Research Triangle Park, NC.
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127	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
128	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
129	Product Information. Genvoya (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
130	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
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133	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
134	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
135	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
136	Product Information. Zortress (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
137	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
138	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
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156	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
157	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
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172	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
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174	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
175	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
176	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
177	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
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180	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
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182	Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
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185	Product Information. Osmovist 240 (iotrolan). Berlex Canada Inc, Lachine, QC.
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192	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
193	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
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197	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
198	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
199	Portoles A, Terleira A, Calvo A, Martinez I, Resplandy G "Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial." J Clin Pharmacol 46 (2006): 1188-94. [PMID: 16988208]
200	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
201	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
202	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
203	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
204	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
205	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
206	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
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225	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
226	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
227	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
228	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
229	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
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253	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
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267	Product Information. Sovaldi (sofosbuvir). Gilead Sciences, Foster City, CA.
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326	Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
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376	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
377	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
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533	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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538	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
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544	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
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567	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
568	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
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